Up-to-date List of Hyponatraemia Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Hyponatraemia Medical Research Studies

1 Unknown  Hyponatremia Registry for Patients With Euvolemic and Hypervolemic Hyponatremia
Conditions: Euvolemic Hyponatremia;   Hypervolemic Hyponatremia
Outcome Measures: Change in serum sodium concentration from beginning of treatment period to the end of treatment period or discharge for a given hyponatremia treatment;   Duration of hospital stay from time of first presentation of hyponatremia (which will be taken as the time of first presentation of hyponatremia for the current admission) to discharge;   Time to initiation of hyponatremia treatment;   Relative proportions of etiologies associated with hyponatremia;   Profile of investigations performed in diagnosing hyponatremia;   Therapies used in the management of hyponatremia;   Effectiveness of individual therapies in correcting hyponatremia and time taken to achieve the correction.;   Effectiveness of individual therapies in achieving symptom improvement measured as the number of reported symptoms at the start and end of treatment with a specific therapy;   Medically necessary length of hospital stay and duration of intensive care unit (ICU) stay;   Impact of hyponatremia on medically necessary length of stay
2 Recruiting Fractional Urate Excretion in Nonedematous Hyponatremia
Conditions: Cerebral Hyponatremia;   SIADH;   Cerebral Salt-wasting Syndrome;   Reset Hypothalamic Osmostat
Intervention: Drug: Tolvaptan in euvolemic hyponatremia
Outcome Measure: Etiologic categorization of nonedematous hyponatremia
3 Recruiting Institutional Registry of Hyponatremia
Condition: Hyponatremia
Outcome Measure: clinical features
4 Recruiting Characterisation of Neuropsychological and Motoric Performance in Patients With Hyponatremia
Condition: Hyponatremia
Intervention: Other: Neuropsychological and motoric tests
Outcome Measure: Assessment of Performance in individual tests
5 Recruiting Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia
Condition: Hyponatremia
Interventions: Drug: Tolvaptan;   Drug: Placebo;   Behavioral: Hepatic Encephalopathy Assessment;   Behavioral: Quality of Life Assessment;   Biological: Vital signs;   Biological: Blood laboratory tests;   Procedure: Ascites Evaluation;   Procedure: Edema
Outcome Measures: Length of Hospital Stay;   Severity of Hepatic Encephalopathy;   Ascites;   Renal function [BUN and creatinine laboratory results];   Hospital Readmission Rate;   Survival;   Neutrophil function [results from the assay of neutrophils];   Tolerability of diuretic therapy
6 Not yet recruiting Relationship Between Heat Wave and Hyponatremia
Condition: Hyponatremia
Intervention: Other: Seasonality
Outcome Measures: Number of patients with moderate to severe hyponatremia;   Mortality;   Hospital length of stay
7 Unknown  Radiocontrast Media Induced Hyponatremia
Condition: Percutaneous Coronary Intervention
Outcome Measures: Incidence of contrast media induced translocational hyponatremia;   Renal function is affected by the incidence of translocational hyponatremia.
8 Unknown  Establishment of an Algorithm for a Clinical Classfication of Hypoosmolar Hyponatremia
Condition: Hyponatremia
Outcome Measure: Establishment of an clinical algorithm to differentiate the different causes of hyponatremia
9 Not yet recruiting An Extension Follow-up Trial to Evaluate the Long-term Safety of Children and Adolescent Subjects With Euvolemic or Hypervolemic Hyponatremia
Condition: Hyponatremia
Intervention: Drug: Tolvaptan
Outcome Measures: Adverse Events, including cases of dehydration.;   Vital signs of potential clinical relevance - Mean change from baseline to study completion.;   Body weight of potential clinical relevance - Mean change from baseline to study completion.;   Height of potential clinical relevance - Mean change from baseline to study completion.;   Growth percentiles of potential clinical relevance - Mean change from baseline to study completion.;   Tanner stages of potential clinical relevance - Mean change from baseline to study completion.;   Change in serum sodium from baseline at each visit while IMP is being administered.;   Plasma concentrations of tolvaptan and metabolites in subjects who have continued tolvaptan therapy for 8 consecutive weeks.
10 Unknown  Efficacy and Safety Study of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia
Condition: Non-hypovolemic Non-acute Hyponatremia
Interventions: Drug: Tolvaptan;   Drug: Placebo
Outcome Measures: The change of average daily Area Under the Curve (AUC) of serum sodium by day 4 and 7 comparing with baseline serum sodium level within the double-blind therapy period;   Percentage of patients with normalized serum sodium at Day 4;   Percentage of patients with normalized serum sodium at Day 7;   Time to first normalization in serum sodium;   Change from baseline in serum sodium at Day 4;   Change from baseline in serum sodium at Day 7;   Percentage of patients requiring fluid restriction at any time during the double-blind therapy period of the study;   24-hour urine output;   Change from baseline in body weight (hypervolemic patients only);   Fluid balance (hypervolemic patients only);   The percentage of patients who are designated as treatment failure due to the need for saline infusion, with or without fluid restriction;   For CHF patients, improvement of symptoms and relevant physical examination measures;   For hepatic edema patients, improvement of symptoms and relevant physical examination measures or ultrasound test findings
11 Unknown  The Efficacy of Oral Versus Intravenous Hypertonic Saline Administration in Runners With Exercise-Associated Hyponatremia
Condition: Exercise-associated Hyponatremia
Interventions: Other: Intravenous hypertonic Saline;   Other: Oral hypertonic saline
Outcome Measure: Blood sodium concentration post administration of oral or IV hypertonic saline.
12 Recruiting Efficacy and Safety of Tolvaptan in Cirrhotic Patients With Hyponatremia
Conditions: Liver Cirrhosis;   Hyponatremia
Intervention: Drug: Tolvaptan(OPC-41061)
Outcome Measures: the proportion of subjects with normal serum sodium level (135-145 mmol/l);   change in sodium level from baseline;   quality of life (EQ-5D-3L);   change in body weight;   edema;   renal function;   mortality and liver-related complications
13 Recruiting Bioimpedance Spectroscopy for the Differential Diagnosis of Hyponatremia
Condition: Hyponatremia
Outcome Measures: Accuracy of volume status measured by bioimpedance spectroscopy;   Laboratory data and echocardiography
14 Recruiting Outcome and Treatment Quality Study of Tolvaptan to Treat Hyponatremia in Patients With Heart Failure.
Condition: Heart Failure With Hyponatremia
Intervention: Drug: Tolvaptan
Outcome Measure: Average daily AUC of change from baseline in serum Na level to day 4 within the double-blind treatment period
15 Unknown  Pseudohyponatremia of Multiple Myeloma is True Hyponatremia
Condition: Hyponatremia of Multiple Myeloma
Intervention: Other: blood test
Outcome Measures: hyponatremia present or not;   hyponatremia
16 Not yet recruiting Study of the Safety and Effectiveness of SAMSCA® (Tolvaptan) in Children and Adolescents With Euvolemic or Hypervolemic Hyponatremia
Condition: Hyponatremia
Intervention: Drug: Tolvaptan
Outcome Measures: Change in serum sodium concentration.;   Overly rapid increase in serum sodium.;   Percentage of subjects requiring rescue medication.
17 Recruiting Hyponatremia and Myometrium Contractility. An Invitro Study
Condition: Hyponatremia
Outcome Measure: Contractility
18 Recruiting The Effect of Fluid Restriction in Congestive Heart Failure Complicated With Hyponatremia
Conditions: Heart Failure;   Hyponatremia
Intervention: Other: Fluid restriction
Outcome Measures: Change in plasma sodium from day 1 to day 4: - Normalization of plasma sodium or - A significant change in plasma sodium of a minimum of 5 mmol/L from baseline to day 4;   Change in plasma vasopressin and copeptin;   Change in blood pressure, heart rate, weight and oedemas;   Change in dyspnoea assessed by the patient;   Number of days until clinical stability;   The correlation between hospitalization time and plasma sodium;   Correlation between fluid restriction and change in kidney function;   Patient assessment of fluid restriction;   Patient compliance to fluid restriction
19 Recruiting Postoperative Hyponatremia - Are There Gender Differences?
Condition: Hyponatremia
Interventions: Procedure: Fluid administration;   Procedure: Perioperative fluid management based on Lean Body Mass
Outcome Measure: Change between preoperative and postoperative plasma sodium concentration
20 Not yet recruiting Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites
Conditions: Hyponatremia;   Ascites
Interventions: Drug: Tolvaptan;   Drug: placebo
Outcome Measures: the change in the average daily area under the curve (AUC) for the serum sodium concentration from baseline to day 28 after intervention;   the change in the average daily area under the curve (AUC) for the serum sodium concentration from baseline to day 4;   the time to normalization of the serum sodium concentration;   the time to first paracentesis, number of paracentesis, the volume of ascitic fluid obtained from paracentesis;   Abdominal discomfort based on a 100-mm visual analogue scales (VAS);   The change in the dose of concomitant diuretics from baseline at day 28;   the number of participants with serious adverse events;   the time to ascites improvement;   the time of worsening of ascites

These studies may lead to new treatments and are adding insight into Hyponatraemia etiology and treatment.

A major focus of Hyponatraemia research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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