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Hypovase Medical Research Studies

Up-to-date List of Hypovase Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Hypovase Medical Research Studies

Rank Status Study
1 Recruiting Prazosin Treatment for Disruptive Agitation in Alzheimer's Disease
Condition: Alzheimer's Disease
Interventions: Drug: Prazosin;   Drug: Placebo
Outcome Measures: Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change & Neuropsychiatric Inventory total score;   Number of study days completed & Brief Psychiatric Rating Scale total score
2 Recruiting The Effects of Prazosin on Dopamine in Healthy Humans: A PET Pilot Study
Condition: Healthy
Intervention: Drug: Prazosin Hydrochloride
Outcome Measure: Changes in [11C]-(+)-PHNO binding
3 Recruiting Study of the Medication Prazosin for Alcohol Dependence
Condition: Alcoholism
Interventions: Drug: Prazosin medication;   Drug: Placebo medication
Outcome Measure: Alcohol consumption and cravings
4 Recruiting Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
Conditions: Alcohol Dependence;   Stress Disorders, Post-Traumatic
Intervention: Drug: Prazosin
Outcome Measures: Drinking measures;   PTSD symptoms
5 Recruiting Prazosin to Reduce Stress-Induced Alcohol/Drug Craving and Relapse
Condition: Alcohol Dependence
Interventions: Drug: Prazosin;   Drug: placebo
Outcome Measures: alcohol and other drug use as measured by weekly urine drug screens/breathalyzer reports and self report of drug use and treatment adherence as measured by frequency of attendance and time to relapse data obtained twice weekly.;   Alcohol craving
6 Unknown  Prazosin Vibrostimulation Autonomic Dysreflexia and Spinal Cord Injury Study
Condition: Autonomic Dysreflexia
Intervention: Drug: Prazosin HCL
Outcome Measures: The hypothesis will be tested by measuring three parameters during prazosin and non-prazosin trials in which ejaculation occurs.;   Objective parameters: absolute beat-to-beat BP, differences between systolic and diastolic BP readings, heart rate variability, heart rate and ECG readings (looking for irregular rhythms) and visible signs of AD experienced by the subject;   Subjective parameters: subject perceived efficacy and side effects of the medication and willingness to use the medication at home;   Secondary outcomes will include the subject's knowledge of AD.
7 Recruiting Optimal Duration of Indwelling Urinary Catheter Following Pelvic Surgery
Condition: Urinary Retention
Intervention: Drug: Prazosin given 6 hours prior to catheter removal in the 24 hour group
Outcome Measures: Number of Participants with Acute urinary retention;   Number of participants with a symptomatic urinary tract infection
8 Recruiting Mechanisms of Increased Ambulatory Blood Pressure in Patients With Intradialytic Hypertension
Condition: Intradialytic Hypertension
Intervention: Drug: Carvedilol vs. Prazosin
Outcome Measures: Ratio of Extracellular Body Water to Total Body Water;   Change in Endothelin-1 from pre to post dialysis
9 Not yet recruiting Two Stepped Care Models for Posttraumatic Stress Disorder (PTSD) Among Cambodian Refugees With PTSD
Condition: Posttraumatic Stress Disorder (PTSD)
Interventions: Biological: Prazosin as first-line agent;   Behavioral: Cognitive Behavioral Therapy for PTSD
Outcome Measures: Change in the PTSD Checklist (PCL) at 12 weeks in Step II;   Change in the HSCL Anxiety Scale at 12 weeks in Step II;   Change in the HSCL Depression Scale at 12 weeks in Step II;   SCL Anger Severity;   Change in the Cambodian Culturally Sensitive Complaint Profile at 12 weeks in Step II;   Change in the SF-12 at 12 weeks in Step II
10 Recruiting Neural Mechanisms of Change During the Treatment of Alcohol Use Disorders With Prazosin
Condition: Alcohol Use Disorder
Interventions: Drug: Prazosin;   Drug: Placebo
Outcome Measure: drinking days per week and drinks per week
11 Unknown  Treatment for Prevention of Variceal Rebleeding Guided by the Hemodynamic Response
Conditions: Portal Hypertension;   Complications of Cirrhosis
Intervention: Other: Hemodynamic guided therapy
Outcome Measures: Rebleeding;   Survival;   Adverse effects
12 Recruiting Treatment of Supine Hypertension in Autonomic Failure
Condition: Hypertension
Interventions: Drug: Clonidine;   Drug: Nitroglycerin transdermal;   Drug: Dipyridamole/ Aspirin (Aggrenox);   Drug: Desmopressin (DDAVP);   Drug: Sildenafil;   Drug: Nifedipine;   Drug: Hydralazine;   Drug: Hydrochlorothiazide;   Drug: Placebo;   Drug: Bosentan;   Drug: Diltiazem;   Drug: Eplerenone;   Drug: guanfacine;   Dietary Supplement: L-arginine;   Drug: captopril;   Drug: carbidopa;   Drug: losartan;   Drug: metoprolol tartrate;   Drug: nebivolol hydrochloride;   Drug: prazosin hydrochloride;   Drug: tamsulosin hydrochloride;   Other: Head-up tilt.;   Drug: aliskiren;   Other: Local heat stress
Outcome Measures: Decrease in supine systolic blood pressure;   Decrease in pressure natriuresis
13 Unknown  Alfuzosin for Medical Expulsion Therapy of Ureteral Stones
Condition: Kidney Stones
Interventions: Drug: Alfuzosin;   Drug: nifedipine;   Drug: doxazosin;   Drug: prazosin
Outcome Measure: The primary measures are percent of stones passed and rates of occurrence of various side effects (categorical variables), and time to pass, pain scale, and amount of pain medication taken (continuous variables).
14 Unknown  Doxazosin an a1 Antagonist for Alcohol Dependence
Conditions: Alcohol Dependence;   Anxiety
Interventions: Drug: Doxazosin;   Drug: Placebo
Outcome Measures: drinking days per week (DDW);   drinks per week (DPW);   alcohol craving;   anxiety;   Adverse Events
15 Recruiting Stress Reactivity in Veterans Receiving Pharmacological Treatment for PTSD and Alcohol Dependence
Conditions: Post-traumatic Stress Disorder;   Alcohol Dependence
Intervention: Behavioral: stress
Outcome Measures: Anxiety, craving for alcohol and hormone levels;   treatment efficacy
16 Recruiting Improving Community Ambulation After Hip Fracture
Condition: Hip Fracture
Interventions: Dietary Supplement: Nutrition (D3, calcium, multivitamin, counseling);   Behavioral: PUSH;   Behavioral: PULSE
Outcome Measures: Ability to walk 300 meters or more in six minutes;   Endurance;   Balance;   Quadriceps muscle strength;   Lower extremity function;   Fast walking speed;   Cost effectiveness: health care utilization

These studies may lead to new treatments and are adding insight into Hypovase etiology and treatment.

A major focus of Hypovase research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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