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I.v Medical Research Studies

Up-to-date List of I.v Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest I.v Medical Research Studies

Rank Status Study
1 Recruiting Mini-Mental State (MMS-LS) and Sign Language
Conditions: Prelingual Deafness;   Retention Disorders, Cognitive
Intervention: Behavioral: application of the mini-mental state test
Outcome Measures: Assessement of internal consistency of MMS-LS test for the diagnosis of cognitive impairment among deaf patients by a correlation analysis followed by Cronbach's alpha test;   Description of MMS-LS test results;   Diagnostic performance and predictive values of MMS-LS test for acquired dementia.;   Correlation between MMS-LS score and CDR level;   Diagnostic performance and predictive values of MMS-LS test for suspected dementia.
2 Unknown  Effects of 'Seroquel-XR' on the Improvement of Neurocognitive Function in People At-risk Mental States(ARMS)
Conditions: Abnormal Mental State;   Schizophrenia
Intervention: Drug: Quetiapine(Seroquel-XR) 50~800mg a day
Outcome Measures: California Verbal Learning Test;   verbal & spatial 2-back test, Digit Span, 3-7 CPT, WCST, Rey-CFT, TMT A & B, COWAT, SOPS, PANSS, SAS, PAS, AIHQ, BIS
3 Recruiting Stress Biomarkers Among Patients Undergoing Treatment for Excited Delirium and Severe Pain in the Emergency Department
Conditions: Agitation;   Excited Delirium;   Pain
Intervention:
Outcome Measures: Change in Altered Mental Status Score;   Change in Visual Analog Scale Pain Score;   Change in Serum Total Catecholamines;   Length of Hospital Stay;   Mortality;   Complications;   Change in Heart Rate;   Change in Systolic Blood Pressure;   Change in Mean Arterial Pressure;   Disposition;   Change in Body Temperature;   Change in end tidal carbon dioxide;   Change in Oxygen Saturation
4 Recruiting Happy Nurse Project: Lifestyle Interventions to Maintain Healthy Mental State in Hospital Nurses
Conditions: Depressive Disorder;   Anxiety Disorders
Interventions: Behavioral: Mindfulness-based stress management program;   Dietary Supplement: Omega-3 fatty acids pills;   Behavioral: Psychoeducation leaflet;   Dietary Supplement: Placebo pills
Outcome Measures: Blindly-rated depression and anxiety severity: Hospital Anxiety and Depression Scale (HADS);   Major depressive episode: Primary Care Evaluation of Mental Disorders (PRIME-MD);   Depression severity: Personal Health Questionnaire-9 (PHQ-9);   Anxiety severity: Generalized Anxiety Disorder Assessment (GAD-7);   Insomnia severity: Insomnia Severity Index (ISI);   Somatic symptoms: The Bradford Somatic Inventory (BSI);   Presenteeism: World Health Organization Heath and Work Performance Questionnaire (HPQ);   Burnout: Maslach Burnout Inventory (MBI);   Quality of Life: EuroQol (EQ-5D)
5 Recruiting Postoperative Cognitive Dysfunction in Elderly
Condition: Postoperative Cognitive Dysfunction
Intervention: Other: battery neuropsychological tests
Outcome Measures: frequency of occurrence of post-operative cognitive dysfunction;   assess risk factors and causal factors in the onset of post-operative cognitive dysfunction
6 Not yet recruiting Efficacy Side-effect Score (ESS): Development and Evaluation of a New Tool for Patients After Surgery
Conditions: Postoperative Pain;   Postoperative Vomiting and Nausea;   Postoperative Complications;   Mental Status Changes Postoperative
Intervention:
Outcome Measure: Number of Participants with Adverse Events as a Measure of Safety and Efficacy of postoperative treatment.
7 Recruiting Dietary Supplement for the Prevention of Cognitive Decline in a Very Elderly Population.
Condition: Mild Cognitive Impairment
Intervention: Dietary Supplement: Omega-3 fatty acid supplementation
Outcome Measures: Mini Mental State Examination;   Short Portable Mental Status Questionnaire (SPMSQ);   Verbal fluency test;   Clock-drawing test
8 Recruiting Effectiveness of Adherence Therapy for Schizophrenia
Conditions: Schizophrenia;   Schizophreniform Disorder;   Schizoaffective Disorder
Intervention: Behavioral: Adherence therapy
Outcome Measures: re-hospitalization rate;   level of medication adherence;   mental status;   insight into treatment;   functioning
9 Recruiting Evaluating the Impact of Cerebral Ischemic And Degenerative Changes On Cognition
Condition: Cognitive Decline
Intervention:
Outcome Measures: Correlate quantitative measures of cerebral atrophic and ischemic changes with level of cognition using Mental Status Exam and Brain MRI exam;   Establish reliable imaging criteria to identify normal age induced changes versus pathologic process comparing Mental Status Exam with Brain MRI(measuring CSF and Brain volumes)
10 Not yet recruiting Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy
Conditions: Depressive Symptoms;   Impaired Cognition;   Electroconvulsive Therapy
Interventions: Drug: ketamine and propofol;   Drug: propofol  and normal saline
Outcome Measures: Mini-Mental State examination score;   Effects on Antidepression (Hamilton Depression Rating Scale(HDRS);   Seizure Duration and Seizure Energy Index;   Brief Psychiatric Rating Scale(BPRS);   Adverse Effects include nausea, vomit, headache, tachycardia and increased blood pressure.
11 Recruiting Dose Response of Functionally Critical Brain Regions for Brain Radiotherapy
Condition: Brain Tumors
Intervention: Procedure: fMRI Evaluation
Outcome Measures: fMRI to Measure Functional Changes of Criticial Brain Regions Over Time;   MMSE - expanded (Mini-Mental Status Examination)- to Document Changes in Functionality of Critical Brain Regions
12 Recruiting Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.)
Conditions: Hepatic Encephalopathy;   HE;   Cirrhosis;   Altered Mental Status;   AMS
Interventions: Drug: Lactulose;   Drug: Polyethylene Glycol 3350
Outcome Measures: Improvement of cognition;   Duration of hospital stay
13 Recruiting Functional Prehabilitation and Major Elective Surgery
Conditions: Surgical Complication;   Physical Therapy;   Timed Up and Go
Interventions: Procedure: Functional Assessment;   Procedure: Prehabilitation
Outcome Measures: Post-operative Functional Assessment;   Discharge status;   Post-operative complications;   Functional and mental battery scores postoperatively
14 Recruiting Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction(POCD)
Condition: Cardiac Surgery Patients
Intervention:
Outcome Measures: single nucleotide polymorphisms(SNPs) of each patient;   mini-mental state examination scale
15 Not yet recruiting Brain Changes by Rivastigmine According to Butyrylcholinesterase Alleles
Condition: Alzheimer's Disease
Intervention: Drug: Rivastigmine
Outcome Measures: the mean changes of Standardized Uptake Values (SUVmean) in PET imaging;   the mean changes of serum BuChE activity between BuChE wild type and K-variant type;   the mean changes of cortical thickness in brain MRI;   the cognitive changes in Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog);   the cognitive changes in Mini-Mental State Exam (MMSE);   the daily function changes by Alzheimer's Disease Cooperative Study - Activities of Daily Living (ADCS-ADL);   the behavioural changes by Caregiver-Administered Neuropsychiatric Inventory (NPI);   the disease severity changes by Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB) between BuChE wild type and K-variant type
16 Recruiting Oral Prednisone Taper Versus Placebo for the Treatment of Acute Relapses in Multiple Sclerosis
Condition: Multiple Sclerosis
Interventions: Drug: Prednisone;   Drug: Placebo
Outcome Measures: Expanded Disability Status Scale (EDSS);   Multiple Sclerosis Functional Composite Score (MSFC);   Gd-enhancing lesions on T1-weighted images;   number of new T2-hyperintense lesions;   mental status (MUSIC);   Euroqol-5D (EQ-5D;   Functional Assessment Multiple Sclerosis (FAMS);   Beck Depression Inventory Second edition (BDI-II);   Fatigue Scale for Motor and Cognitive functions (FSMC)
17 Recruiting Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)
Condition: Delirium
Interventions: Other: Mini-Mental State Examination;   Other: Self-Administered Gerocognitive Examination;   Other: Geriatric Depression Scale;   Other: Charlson Comorbidity Index;   Other: Short Form (36) Health Survey;   Other: Confusion Assessment Method;   Other: Memorial Delirium Assessment Scale
Outcome Measure: Reduction in the incidence of Post-Operative Delirium (%)
18 Unknown  Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
Condition: Normal Pressure Hydrocephalus
Intervention: Other: CSF collection
Outcome Measures: TGF beta-1 levels;   Mini-mental status exam;   Modified barthel index;   Tinetti mobility assessment;   Programmable shunt setting
19 Not yet recruiting Neurological and Psychiatric Comorbidities Patients With FSHD 1 and 2
Condition: Muscular Dystrophy, Facioscapulohumeral
Intervention: Behavioral: Psychiatric test
Outcome Measures: Montgomery and Asberg Depression Rating Scale;   Hamilton Depression Rating Scale;   Hamilton Anxiety Rating Scale;   Quick inventory of depressive symptomatology Self report;   Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form;   Mini Mental Status Evaluation;   Wechsler Adult Intelligence Scale
20 Recruiting Safety and Effects of Autologous Adipose-Derived Stromal Cells in Patients With Diffuse Lesions in the Brain
Condition: Brain Lesion (General)
Intervention: Procedure: harvesting and implantation of adipose derived stem cells
Outcome Measures: Improvement in standardized Gross Motor Function Measure evaluation compared to baseline;   Number of participants with adverse events;   Improved cognitive function as measured by the mini mental state exam;   Improved cognitive function as measured by the mini mental state exam compared to baseline;   Reduced depressive symptoms measured by the Beck Depression Inventory compared to baseline;   number of brain lesions by MRI compared to baseline;   Improved quality of life scores compared to baseline

These studies may lead to new treatments and are adding insight into I.v etiology and treatment.

A major focus of I.v research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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