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Imiglucerase Medical Research Studies

Up-to-date List of Imiglucerase Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Imiglucerase Medical Research Studies

Rank Status Study
1 Recruiting Intra-monocyte Imiglucerase Kinetics in Gaucher Disease
Condition: Gaucher Disease
Intervention: Drug: Imiglucérase (drug) pharmacokinetics
Outcome Measures: Enzyme intra-monocyte activity (sum of endogenous enzyme activities and therapeutic enzyme)in patients treated with Imiglucerase;   Residual rate;   Endogeneous intra-monocyte glucocérébrosidase activity from untreated patients;   Biomarker dosages will provide serum concentration values
2 Unknown  The Safety and Efficacy Study of ISU302 in Patient With Type I Gaucher Disease
Condition: Gaucher Disease
Interventions: Drug: Cerezyme®;   Drug: ISU302
Outcome Measures: change in splenic volume compared to baseline;   change in organ parameters and biochemical value compared to baseline
3 Recruiting Thrombocytopathy in Gaucher Disease Patients
Conditions: Gaucher Disease;   Thrombocytopathy
Intervention:
Outcome Measures: Measure thrombocytopathy in a cohort of 70 Gaucher patients using a set of platelet function tests.;   Evaluating the impact of Imiglucerase treatment on platelet function
4 Recruiting International Collaborative Gaucher Group (ICGG) Gaucher Registry
Conditions: Gaucher Disease;   Cerebroside Lipidosis Syndrome;   Glucocerebrosidase Deficiency Disease;   Glucosylceramide Beta-Glucosidase Deficiency Disease
Intervention:
Outcome Measure: To provide the Gaucher medical community with recommendations for monitoring patients and to provide reports on patient outcomes to help optimize patient care.
5 Recruiting Positron Emission Tomography (PET) Imaging in People With Gaucher Mutations
Conditions: Glucocerebrosidase Mutations;   Gaucher Disease
Intervention:
Outcome Measure:
6 Unknown  Phase II Study of Glucocerebrosidase in Patients With Gaucher Disease
Condition: Gaucher's Disease
Intervention: Drug: glucocerebrosidase
Outcome Measure:
7 Not yet recruiting An Open-Label, Dose Escalation Study to Evaluate the Safety and the Pharmacokinetics of Oral PRX-112
Condition: Gaucher Disease
Intervention: Drug: PRX-112
Outcome Measures: Area under the curve;   Adverse Events
8 Recruiting Biomarker for Gaucher Disease
Conditions: Lysosomal Storage Diseases;   Gaucher Disease;   Sphingolipidoses
Intervention:
Outcome Measure:
9 Recruiting Exploration of Immunity in Gaucher Disease
Condition: Gaucher Disease
Intervention:
Outcome Measure: Macrophages from patients with GD and primary immune hypo/dysfunction will show higher level of activation markers.

These studies may lead to new treatments and are adding insight into Imiglucerase etiology and treatment.

A major focus of Imiglucerase research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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