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Incontinence Medical Research Studies

Up-to-date List of Incontinence Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Incontinence Medical Research Studies

Rank Status Study
1 Unknown  A Study to Estimate the Efficacy and Safety of Solifenacin in Female With Stress Urinary Incontinence and Urgency Urinary Incontinence
Conditions: Stress Urinary Incontinence;   Urgency Urinary Incontinence
Intervention: Drug: solifenacin
Outcome Measures: Changes in the number of urge urinary Incontinence episodes per 24 hours between baseline and week 12;   Percent change in the mean number of urge urinary Incontinence episodes per 24 hours;   Change in the mean number of urge urinary Incontinence episodes per 24 hours;   Change in the mean frequency of urination per 24 hours;   Percent change in the mean frequency of urination;   Changes in the mean and sum rating on the Bladder Sensation Scale per 24 hours;   Change in the mean number of severe urgency episodes per 24 hours;   Changes in overactive bladder symptom score (OABSS) questionnaire;   Changes in short urogenital distress inventory (UDI-6);   Changes in short Incontinence impact questionnaire (IIQ-7);   Safety assessed by the incidence and severity of side effects
2 Unknown  Vulvar Contact Dermatitis Resulting From Urine Incontinence
Conditions: Urinary Incontinence;   Vulvar Pruritus;   Vulvar Contact Dermatitis
Intervention: Other: Questionnaires, gynecological exam , vaginal smear, and measurement of urine leakage
Outcome Measures: Prevalence of vulvar contact dermatitis among patients with urinary Incontinence;   Risk factors for urinary Incontinence induced vulvar contact dermatitis
3 Unknown  Imodium Syrup Versus Imodium Tablets for Faecal Incontinence
Condition: Fecal Incontinence
Interventions: Drug: Imodium (Loperamide Hydrochloride) syrup;   Drug: Imodium (Loperamide hydrochloride) tablets
Outcome Measures: To evaluate the use of imodium as tablets or syrup in the treatment of faecal Incontinence in order to improve the scores of patients with faecal Incontinence as seen with continence and quality of life questionnaires;   To reduce to number of patients suffering from faecal Incontinence;   Number of episodes of total, urge and passive Incontinence;   Total number of patient incontinent days;   Use of pads and other medications;   Ability to defer defaecation;   Adverse effects relating to medication;   Determining the direct medical costs, direct non-medical costs, indirect non-medical costs associated with the treatment of Faecal Incontinence, and cost effectiveness of treatment with syrup and tablets
4 Recruiting Prevalence and Treatment of Anal Incontinence in Primiparous Women
Condition: Incontinence
Interventions: Other: Pelvic floor muscle training;   Other: Control group
Outcome Measures: Anal Incontinence;   St. Mark's score;   Urinary Incontinence;   Quality of Life
5 Recruiting EPIC :Anal Incontinence After Delivery. Secondary Prevention With Caesarean Section.
Condition: Fecal Incontinence
Interventions: Procedure: caesarean section;   Procedure: vaginal delivery
Outcome Measures: The primary endpoint is comparison of median Incontinence score of VAIZEY in the two arms after 6 months.;   Incontinence scores in the two arms after 6/8 weeks and 6 month, transitional anal Incontinence after delivery urinary Incontinence 6 and 12 month after the delivery, sexual score(IFSI)global morbidity between the two arms after anal endoscopy
6 Recruiting Percutaneous Tibial Nerve Stimulation for Patients With Fecal Incontinence
Condition: Fecal Incontinence
Intervention: Procedure: Percutaneous tibial nerve stimulation (pTNS)
Outcome Measures: Fecal Incontinence;   Anorectal manometric measurements;   Quality of Life;   Cost;   Adverse Events;   Urinary Incontinence
7 Not yet recruiting Comparison of PTNS and Biofeedback for Fecal Incontinence
Condition: Fecal Incontinence
Interventions: Procedure: Posterior tibial nerve stimulation;   Procedure: Biofeedback
Outcome Measures: Weekly episodes of fecal Incontinence;   Severity of fecal Incontinence;   Quality of life associated with fecal Incontinence;   Anal function
8 Unknown  Treatment of Faecal Incontinence With Sacral Nerve Stimulation - Improved Function With Stimulation Bilaterally?
Condition: Fecal Incontinence
Intervention: Device: Medtronic INTERSIM II - 3058
Outcome Measures: Number of faecal Incontinence episodes per week.;   Days with faecal soiling.;   Days with faecal urgency.;   Wexner Incontinence score.;   Anal physiological changes during SNS bilateral versus unilateral.;   Quality of life assessment (Rockwood - Fecal Incontinence quality of life)
9 Recruiting Treatment of Stress Urinary Incontinence Via Smartphone
Condition: Female Stress Urinary Incontinence
Intervention: Behavioral: Smartphone treatment with PFMT
Outcome Measures: Change in the International Consultation on Incontinence Modular Questionnaire Urinary Incontinence Short Form (ICIQ-UI SF);   Change in the International Consultation on Incontinence Modular Questionnaire Lower Urinary Tract Symptoms Quality of Life (ICIQ-LUTSqol);   Change in usage of Incontinence Aids;   Patient Satisfaction;   Change in Incontinence Episode Frequency (IEF);   Patient`s Global Impression of Improvement Scale (PGI-I)
10 Recruiting The Effect of Pre-operative Pelvic Floor Muscle Exercise on Surgical Outcomes in Women With Stress Urinary Incontinence
Condition: Stress Urinary Incontinence
Intervention: Other: Pelvic Floor muscle strengthening exercises
Outcome Measures: Change in International Consultation on Incontinence Questionnaire: Female Lower Urinary Tract Symptoms (FLUTS);   Change in International Consultation on Incontinence Questionnaire - Short form score;   Change in pad weight on a standardized 20 minute pad test;   Change in International Consultation on Incontinence Questionnaire Quality of Life module score
11 Unknown  Pharmacological vs Surgical Treatment for Mixed Incontinence
Conditions: Mixed Urinary Incontinence;   Urinary Incontinence, Stress;   Urinary Incontinence, Urge
Interventions: Drug: Tolterodine;   Procedure: tension free vaginal tape
Outcome Measures: improvement in subjective and objective measures of urinary Incontinence;   assessment of pre-treatment predictors of success or failure of treatment;   assessment of pre-treatment predictors of requirement for alternative treatment
12 Recruiting Medical and Economic Evaluation of a Magnetic Anal Sphincter for Patients With Severe Anal Incontinence
Conditions: Fecal Incontinence.;   Anal Incontinence.
Interventions: Device: magnetic anal sphincter;   Device: sacral nerve stimulation
Outcome Measures: Average number of fecal Incontinence episodes;   Overall cost for the health care system;   Respective complications of the two therapeutic approaches;   Functional results at 6 and 12 months, compared with baseline;   Quality of life and overall satisfaction;   Anorectal manometry data
13 Recruiting Female Patients With Signs of uRgE and Stress Urinary Incontinence Study of Propiverine Hydrochloride
Condition: Urinary Incontinence
Intervention: Drug: Propiverine Hydrochloride
Outcome Measures: Occurrence of Incontinence;   The number of protective pad used;   Reduction ratio of the occurrence for Incontinence;   ICIQ-Short Form(SF) scores;   I-QOL scores;   IPSS-QOL scores;   IPSS symptom scores;   OABSS symptom scores;   Blood pressure;   Pulse rate;   Safety assessment
14 Recruiting A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period
Condition: Faecal Incontinence
Interventions: Drug: 1R, 2S-methoxamine hydrochloride;   Drug: Placebo
Outcome Measures: Evaluate the efficacy of NRL001 in faecal Incontinence by assessing the improvement of the Incontinence status after 4 weeks of treatment compared to baseline by means of the Wexner score;   To provide data on the efficacy of NRL001 in patients with faecal Incontinence over an 8 week treatment period;   To provide preliminary data on the safety and tolerability of NRL001 (5mg, 7.5mg and 10mg) over an 8 week treatment period compared to placebo;   To evaluate the population pharmacokinetics and to establish any pharmacokinetic/pharmacodynamic relationship with adverse events;   To evaluate the dose-response relationship in order to identify the appropriate dose(s) of NRL001 for future studies;   To evaluate the effect of treatment according to the patient's Faecal Incontinence Quality of Life questionnaire at 4 and 8 weeks;   To evaluate the effect of treatment according to the Vaizey score at 4 and 8 weeks
15 Recruiting Effect of Exercise and Biofeedback on Symptoms of Incontinence in Women With Stress Urinary Incontinence
Condition: Stress Urinary Incontinence
Intervention: Other: Pelvic floor muscle exercises with biofeedback
Outcome Measures: Change in the ability to contract the pelvic floor muscles from baseline to the midpoint and completion of the study;   Change in the number of incontinent episodes per week from baseline to the midpoint and conclusion of the study;   Change in quality of life from the baseline to the midpoint and completion of the study
16 Recruiting Effect of Electroacupuncture Versus PFMT Plus Solifenacin for Mixed Urinary Incontinence
Condition: Urinary Incontinence
Interventions: Procedure: acupuncture;   Drug: solifenacin;   Procedure: PFMT
Outcome Measures: Percentage of change from baseline in 72-h Incontinence episode frequency (IEF) (week 12);   Percentage of change from baseline in 72-h IEF;   Percentage of participants with ≥50% decrease in average 72-h Incontinence episode frequency;   Change from baseline in 72-h Incontinence episode frequency;   Change from baseline in the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) score;   Change from baseline in the amount of urine leakage;   Change from baseline in average 72-h urgencies/urination/nocturia episodes;   Change from the baseline in the number of pads used in one week;   Percentage of change from the baseline in 72-h IEF of subgroups;   Satisfaction degree;   Patient global impression improvement;   Electroacupuncture acceptance assessment
17 Recruiting Treatment of Fecal Incontinence by Injection of Autologous Muscle Fibers Into the Anal Sphincter
Conditions: Fecal Incontinence;   Anal Incontinence
Interventions: Procedure: Injection of autologous muscle fibers into the anal sphincter.;   Procedure: Pelvic floor muscle training;   Behavioral: Dietary intervention;   Drug: Analgesia
Outcome Measures: Efficacy of the treatment using fecal Incontinence score: Wexner score.;   Safety
18 Recruiting Urinary Urinary Nerve Growth Factor (NGF) as a Biomarker for Mixed Urinary Incontinence
Condition: Mixed Urinary Incontinence
Intervention: Procedure: Midurethral slings (MUS)
Outcome Measures: Difference in the baseline urinary NGF level between patients with and without urgency Incontinence at 6 months after midurethral slings;   Baselinec cut-off value of urinary NGF level which can predict the patients whose urgency Incontinence will be cured and whose urgency Incontinence will not be cured.;   Difference in urinary NGF level between pure SUI and MUI patients;   Changes in OAB symptoms (including urgency Incontinence) and SUI after midurethral slings;   Correlation between changes in urinary NGF and OAB symptoms (including urgency Incontinence) after midurethral slings
19 Unknown  Anterior Vaginal Wall Repair With Mesh in Combination With TVT-O to Reduce Urinary Stress Incontinence
Condition: Pelvic Organ Prolapse
Intervention: Procedure: Preventive transobturator tension free vaginal tape
Outcome Measures: Stress Incontinence;   Surgical complications;   post surgery urgency or urge Incontinence
20 Recruiting The Effect of Physiotherapy for the Treatment of Fecal Incontinence.
Condition: Fecal Incontinence
Interventions: Behavioral: Individual supervised pelvic floor muscle exercises;   Other: Massage of the neck and back;   Behavioral: Standard information and guidance
Outcome Measures: Patient Global Impression of Improvement Scale (PGI-I Scale);   Fecal Incontinence Severity Index;   St. Marks Incontinence Score (Vaizey Score);   Anal manometry;   Rectal capacity measurement;   Incontinence dairy;   Fecal Incontinence Quality of Life

These studies may lead to new treatments and are adding insight into Incontinence etiology and treatment.

A major focus of Incontinence research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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