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Indocyanine Medical Research Studies

Up-to-date List of Indocyanine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Indocyanine Medical Research Studies

Rank Status Study
1 Recruiting Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
Conditions: Atherosclerosis;   Atherosclerotic Plaque;   Carotid Stenosis
Intervention: Drug: Indocyanine green
Outcome Measures: Tissue uptake of Indocyanine green in carotid plaque;   Relationship of Indocyanine green uptake to carotid plaque histology
2 Recruiting Monocentric Prospective Pilot Study Evaluating the Value of Indocyanine Green (ICG, Indocyanine Green) During a Surgical Resection of Cancerous Lesions Peritoneal Colorectal Origin.
Condition: Colorectal Cancer Metastatic
Intervention: Drug: Indocyanine green
Outcome Measures: Sensitivity (true positive) of the fluorescence ex vivo compared to histological analysis s detected by fluorescence ex vivo;   Specificity (true negative) of the in-vivo fluorescence compared to histological analysis s detected by fluorescence ex vivo peritoneal cancer index (PCI) score with and without fluorescence;   Specificity (true negative) of the in-vivo fluorescence compared to histological analysis s detected by fluorescence ex vivo PCI score with and without fluorescence
3 Recruiting Intraoperative Imaging of Thoracic Malignancies With Indocyanine Green
Condition: Lung Neoplasms
Intervention: Drug: Indocyanine Green
Outcome Measure: Imaging effectiveness of ICG and imaging system.
4 Recruiting Lymph Node Mapping Using Indocyanine Green Solution in Diagnosing Patients With Malignant Melanoma
Conditions: Recurrent Melanoma;   Stage IA Melanoma;   Stage IB Melanoma;   Stage IIA Melanoma;   Stage IIB Melanoma;   Stage IIC Melanoma;   Stage IIIA Melanoma;   Stage IIIB Melanoma;   Stage IIIC Melanoma;   Stage IV Melanoma
Interventions: Drug: Indocyanine green solution;   Drug: isosulfan blue;   Procedure: lymph node mapping;   Procedure: sentinel lymph node biopsy
Outcome Measure: Mapping of the Sentinel Lymph Nodes (SLN)
5 Recruiting Use of Indocyanine Green Cholangiography and Methylene Blue to Detect Postoperative Biliary Fistula After Hepatectomy
Condition: Liver Disease
Interventions: Procedure: Indocyanine green fluorescent cholangiography;   Drug: methylene blue
Outcome Measure: biliary fistula rate
6 Unknown  Brilliant Blue Versus Indocyanine Green
Conditions: Macular Pucker;   Macular Hole;   Vitreoretinal Surgery
Interventions: Procedure: Indocyanine green;   Procedure: Brilliant blue arm
Outcome Measures: Best corrected far visual acuity (ETDRS);   Reading ability (Radner);   Optical coherence tomography
7 Not yet recruiting Diffuse Optical Imaging With Indocyanine Green Solution in Imaging Pelvic Lymph Nodes in Patients With Stage II Prostate Cancer Undergoing Surgery
Conditions: Stage IIA Prostate Cancer;   Stage IIB Prostate Cancer
Interventions: Drug: Indocyanine green solution;   Other: diffuse optical imaging;   Procedure: robot-assisted laparoscopic surgery;   Procedure: therapeutic lymphadenectomy
Outcome Measures: Intraoperative detection of fluorescence in pelvic lymphatic tissue by near-infrared imaging technology on the da Vinci Surgical System following direct injection of ICG into the prostate;   Quality of fluorescence as detected by near-infrared technology on the da Vinci Surgical System of lymphatic tissue at varying safe doses of ICG;   Lymph node yield;   Number of positive lymph nodes (nodes that contain cancer on final pathology)
8 Not yet recruiting Non-invasive Measuring of Cerebral Perfusion After Severe Brain Injury With Near-infrared-spectroscopy and ICG
Conditions: Subarachnoid Hemorrhage, Aneurysmal;   Intracerebral Hemorrhage (ICH);   Traumatic Brain Injury
Intervention: Procedure: measuring cerebral perfusion by NIRS with ICG
Outcome Measures: with near-infrared-spectroscopy detected cerebral perfusion deficit;   Determining a threshold value for cerebral autoregulation measured with near-infrared-spectroscopy as a predictive value for the clinical outcome
9 Unknown  Treatment of Patients With Neovascular AMD Using Indocyanine Green-Mediated Photothrombosis (i-MP).
Condition: Maculopathy, Age-Related
Intervention: Procedure: Indocyanine Green-Mediated Photothrombosis
Outcome Measures: Compare the groups in respect to proportion of eyes that lost less than 15 letters in ETDRS BCVA from baseline at week-54;   Compare the groups in respect to proportion of eyes that did not present any loss in ETDRS BCVA (2 letters change) from baseline at week-54;   Compare the groups in respect to mean change in ETDRS BCVA;   Compare the groups in respect to neovascular complex activity (size and CNV leaking area)
10 Unknown  Indocyanine Clearance Rate and Septic Liver Injury
Condition: Sepsis
Outcome Measures: Plasma clearance of Indocyanine green;   Transaminase;   Bilirubin;   Prothrombin time;   Lactate;   γ-glutamyl transpeptidase;   Cholinesterase
11 Not yet recruiting Lymphatic Mapping for Sentinel Node Identification and Analysis
Condition: Colorectal Cancer
Intervention: Drug: Indocyanine green
Outcome Measures: The proportion of subjects in which the SLN(s) are identified;   Sensitivity and specificity of tumour-bearing status of SLN(s) as a measure of lymph node status when assessed by standard techniques
12 Unknown  Brillant Blue Versus Indocyanine Green for Macular Hole Surgery
Condition: Idiopathic Macular Holes
Interventions: Procedure: Brillant Blue;   Procedure: Indocyanine Green
Outcome Measures: Macular Hole Closure Rate;   Visual Acuity Microperimetry Optical Coherence Tomography
13 Not yet recruiting Detection of Lymph Nodes by Means of Intraoperative Fluorescence Lymphography Using Indocyanine Green (ICG) During the Radical Robot-assisted Prostatectomy
Condition: Prostate Cancer
Intervention: Procedure: ICG
Outcome Measures: The total number of detection rate of (positive) lymph nodes using ICG;   Measurements of the time, that takes to remove the lymph nodes
14 Recruiting Application of Indocyanine Green Angiography for Closed Operative Calcaneus Fractures
Conditions: Fractures, Comminuted;   Surgical Wound Dehiscence;   Necrosis
Intervention: Drug: ICG (Indocyanine Green)
Outcome Measure: a statistically relevant correlation between operative site perfusion patterns and development of wound healing complications post operatively.
15 Recruiting The Use of Laser-Assisted Indocyanine Green Dye Angiography to Predict Mastectomy Skin Flap Viability
Conditions: Breast Cancer;   Breast Reconstruction;   Mastectomy
Intervention: Device: Laser-Assisted ICG Dye Angiography (SPY System)
Outcome Measures: Mastectomy Skin Flap Necrosis;   Infection;   Wound Dehiscence or Implant Extrusion;   Seroma/Hematoma;   Removal or Loss of Implant
16 Recruiting ICG Distribution Using NIF Imaging After IV Injection of ICG in Benign and Malignant Breast Cancer Tissue.
Condition: Breast Cancer.
Intervention: Drug: Indocyanine Green
Outcome Measures: Study of the evantual difference of Indocyanine in mammalian tissue in patients mastocmemezied for breast canrcinoma.;   Microscopical detection of Indocyanine green in breast tissue.
17 Recruiting Near-Infrared Imaging of Peritoneal Carcinomatosis From Colorectal Cancer
Conditions: Colorectal Cancer;   Peritoneal Carcinomatosis
Intervention: Drug: Indocyanine Green
Outcome Measure: fluorescence intensity of tumoral and healthy tissues after IV injection of ICG to patients with peritoneal carcinomatosis from colorectal origin.
18 Recruiting Potential Use of Indocyanine Green as a Fluorescent Agent for Definition of Surgical Margins in Cancer
Condition: Surgical Resection of Tumor for Patients Whose Cancer Will be Treated Surgically
Intervention: Drug: Indocyanine green (ICG)
Outcome Measure: The contrast ratio (CR, defined as the integrated fluorescence intensity measured in a known tumor area divided by the integrated fluorescence intensity of a known "not tumor" area)
19 Recruiting Intraoperative Utility of Brilliant Blue g (Bbg) and Indocyanine Green (Icg) Assisted Chromovitrectomy
Condition: Macular Edema
Intervention: Procedure: Use of intraoperative filters in vitrectomy
Outcome Measures: ILM thickness, stiffness and roughness;   Contrast between the stained ILM and the underlying tissue
20 Not yet recruiting A Multimodality Image-guided System for Peripheral Lung Cancer Diagnosis and Therapy
Conditions: Lung Neoplasms;   Thoracic Neoplasms;   Neoplasms by Site;   Neoplasms;   Lung Diseases
Interventions: Device: MIMIG System;   Drug: Indocyanine Green (ICG)
Outcome Measure: Technical Success Rate of Biopsy Using the MIMIG system With + Without Fiber-Optical Imaging

These studies may lead to new treatments and are adding insight into Indocyanine etiology and treatment.

A major focus of Indocyanine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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