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Infection Medical Research Studies

Up-to-date List of Infection Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Infection Medical Research Studies

Rank Status Study
1 Recruiting CPP Bone Infection Registry
Conditions: Bone Infection;   Staphylococcus Aureus
Intervention:
Outcome Measures: Details on occurence and treatment of bone Infection;   Surgical approach, implants and technology;   Patient outcome;   Post-procedure complications and revisions
2 Recruiting Invasive Group A Streptococcus (GAS) Infection in Children: Bacterial Virulence Factors and Detection of Host Immunological and/or Genetic Factors of Predisposition to Infections
Condition: Invasive GAS Infection
Intervention: Genetic: DNA samples, GAS strains
Outcome Measures: virulence factors of GAS;   Assess the frequency and type of hereditary immune deficiency or Mendelian susceptibility to Infections associated with invasive GAS Infections in children without risk factors;   describe and compare the GAS emm genotypes and virulence factors with the profiles of strains isolated with invasive GAS Infection with known risk factors and with the profile of strains isolated with a non-invasive GAS Infections;   compare GAS emm genotypes and profiles of virulence strains responsible for invasive SGA Infections with strains causing noninvasive Infections
3 Recruiting Evaluation of the Safety and Efficacy of Standard Intravenous Immunoglobulins in Pregnant Women With Primary Cytomegalovirus Infection
Condition: Cytomegalovirus Congenital Infection
Intervention: Biological: standard intravenous immunoglobulin
Outcome Measures: Prevention of neurological damage due to Cytomegalovirus congenital Infection;   Evaluate safety of aspecific immunoglobulins in pregnant women with primary CMV Infection
4 Unknown  Impact of HIV Infection on Latent Tuberculosis (TB) Among Patients With HIV-TB Co-Infection
Conditions: Latent Tuberculosis Infection;   HIV Infections;   Tuberculosis
Intervention:
Outcome Measures: Precise component(s) of T cell response against M.tuberculosis compromised by HIV Infection which leads to the development of severe forms of clinical tuberculosis.;   Elucidation of critical events of the cellular and molecular interactions that would be useful for developing newer therapeutic strategies and vaccination.
5 Recruiting Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee Infection
Conditions: Osteoarthritis;   Knee Infection;   Prosthetic Joint Infection;   Complications; Arthroplasty, Infection or Inflammation;   Complications; Arthroplasty
Interventions: Procedure: Static Spacer;   Procedure: Articulating Spacer
Outcome Measures: Range of motion;   Knee Society Score;   Operative time
6 Recruiting Ceftaroline in the Treatment of Bone and Joint Infections
Conditions: Osteomyelitis;   Joint Infections
Intervention: Drug: Ceftaroline
Outcome Measures: Sustained clinical remission from the treated osteoarticular Infection;   Initial clinical success from the treated osteoarticular Infection
7 Not yet recruiting Randomized Controlled Trial of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section
Condition: Postoperative Infection
Intervention: Drug: Cefuroxime
Outcome Measures: Women: The incidence of post-CS Infection (endometritis, urinary tract Infections, and wound Infections);   Infant: admission to special care unit;   Women: length of the primary and any secondary hospitalization;   Women: readmissions to hospital/contact to the general practitioner on suspicion of Infection after Caesarean Section;   Women: antibiotic treatment on suspicion of Infection after Caesarean Section;   Infant: use of antifungal treatment against oral thrush;   Infant: necrotizing enterocolitis;   Infant: antibiotic treatment during hospital stay;   Infant: the need for intensive care treatment and length of stay in hospital;   Infant: Neonatal sepsis;   Women: Number of Participants with Adverse Events as a Measure of Safety and Tolerability
8 Unknown  Hospital Design and Risk of Nosocomial Infections: A Prospective Controlled Trial
Conditions: Hospital-Acquired Infection With Clostridium Difficile;   Hospital-Acquired VRE Infection or Colonization;   Hospital-Acquired MRSA Infection or Colonization
Intervention: Other: Admission to a novel hospital ward
Outcome Measures: Incidence of hospital-acquired Infection with Clostridium difficile, and hospital-acquired Infection or colonization with vancomycin-resistant Enterococcus (VRE), or methicillin-resistant Staphylococcus aureus (MRSA).;   Incidence of the same Infections in room-mates of study subjects. (i.e., event rates in non-study patients who have contact with infected study subjects).
9 Unknown  Value of PET/CT Imaging in the Diagnosis of Permanent Central Venous Catheters Infection
Condition: Infection
Intervention:
Outcome Measures: Diagnostic value (sensitivity and sensibility, positive/negative predictive value) of F-18-FDG PET/CT imaging in the detection of CVCP Infection;   Diagnostic value (sensitivity and sensibility, positive/negative predictive value) of microcalorimetry in the detection of CVCP Infection
10 Recruiting Hospital Stay and Respiratory Infection
Condition: Respiratory Infection
Intervention: Other: Respiratory Infection
Outcome Measures: Strength in upper and lower limbs;   Quality of life;   Lung function;   Activity monitoring;   Quality of sleep;   Mood
11 Recruiting Detection and Characterization of Infections and Infection Susceptibility
Conditions: Immune Disorders;   Chronic Granulomatous Disease;   Genetic Immunological Deficiencies;   Hyperimmunoglobulin-E Recurrent Infection Syndrome;   Recurrent Infections
Intervention:
Outcome Measure: The primary endpoint of this study will be determination of a discretediagnosis of an infecting agent, an underlying susceptibility trait, or both.
12 Not yet recruiting Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
Conditions: Cardiovascular Disease;   Healthcare Associated Infectious Disease;   Sternal Superficial Wound Infection;   Deep Sternal Infection;   Mediastinitis;   Thoracotomy;   Conduit Harvest or Cannulation Site;   Sepsis;   Pneumonia
Intervention: Other: There is no intervention. The investigators are interviewing cardiac surgery staff with knowledge of Infection prevention.
Outcome Measure: Preventive Strategies
13 Recruiting Host Factors in Invasive and Recurrent Staphylococcus Aureus Infection
Conditions: Staphylococcal Aureus Infection;   Recurrent Staphylococcal Infection;   Invasive Staphylococcal Infection
Intervention:
Outcome Measure:
14 Recruiting Incisional Negative Pressure Wound Therapy for Prevention of Postoperative Infections Following Caesarean Section
Conditions: Surgical Wound Infection;   Infection; Cesarean Section;   Cesarean Section; Dehiscence;   Complications; Cesarean Section;   Complications; Cesarean Section, Wound, Dehiscence;   Wound; Rupture, Surgery, Cesarean Section
Interventions: Device: PICO from Smith&Nephew;   Other: Standard postoperative wound dressing
Outcome Measures: The incidence of post-CS wound Infection in each study group;   Length of the primary and any secondary hospitalization;   Readmissions to hospital/contact to the general practitioner on suspicion of Infection following Caesarean Section;   Number of Participants with a decreased health-related quality of life score as a measure of satisfaction and tolerability;   Antibiotic treatment on suspicion of Infection after Caesarean Section;   The cosmetic outcome as a measure of satisfaction
15 Recruiting The Amputation Surgical Site Infection Trial (ASSIT)
Conditions: Wound Infection;   Amputation Wound
Interventions: Drug: Co-amoxiclav;   Drug: Iodine;   Drug: Metronidazole;   Drug: Chlorhexidine;   Drug: Teicoplanin;   Drug: Clindamycin
Outcome Measures: Surgical Site Infection;   Impact of different skin preparations on Infection rates;   Rate of re-intervention;   Mortality;   Satisfactory healing rates;   Quality of life;   Resource use;   • Rate of C. Diff., MSSA (Methicillin Sensitive Staphylococcus Aureus), MRSA (Methicillin Resistant Staphylococcus Aureus) Infection;   Mobility;   Pain Control
16 Recruiting Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement
Conditions: Osteoarthritis;   Hip Infection;   Prosthetic Joint Infection;   Complications; Arthroplasty, Infection or Inflammation;   Complications; Arthroplasty
Interventions: Procedure: Implantation of a static, non-articulating cement spacer.;   Procedure: Implantation of an articulating spacer.
Outcome Measures: Harris Hip Score;   Operative time;   Hip dislocation rates
17 Not yet recruiting Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae
Condition: Human Hookworm Infection
Intervention: Biological: Necator americanus Human Hookworm Larvae
Outcome Measures: Study product-related adverse events;   Fecal egg counts;   Number of adult hookworms in feces post-treatment
18 Recruiting Contribution of Real Time Analyses of CARdio-RESpiratory Signals to the Diagnosis of Infection in PREterM Infants
Condition: Bacterial Infection
Intervention: Procedure: Analysis of the heart rate and respiratory characteristics / Telemonitoring system prototype developed by INSERM U-642
Outcome Measures: Diagnosis of proven or suspected bacterial Infection;   Inflammation without proven or suspected bacterial Infection defined as follows: a 6 hours period with CRP> 5 mg/L not classified as proven or suspected bacterial Infection.;   Periods of discomfort defined as at least two EDIN scores above 3 in a 6 hours period
19 Recruiting Antibiotics and Gut Microbiota Among Newborn Infants
Conditions: Surgical Wound Infection;   Infection; Cesarean Section;   Complications; Cesarean Section
Intervention: Drug: Cefuroxime
Outcome Measures: Maternal: incidence of post-CS Infection (endometritis, urinary tract Infections and wound Infection) in each study group;   Infant: fecal microbiota at the tenth day of life;   Maternal: Length of hospitalization;   Maternal: readmissions to hospital on suspicion of postpartum Infection following cesarean section;   Antibiotic treatment;   Infant: concentration of cefuroxime in blood samples;   Infant: immunological analyses in blood samples on day 3
20 Recruiting Dilute Betadine Lavage in the Prevention of Postoperative Infection
Conditions: Prosthesis-Related Infections;   Arthroplasty
Interventions: Procedure: Betadine Lavage;   Procedure: Saline Lavage
Outcome Measure: Infection Rate

These studies may lead to new treatments and are adding insight into Infection etiology and treatment.

A major focus of Infection research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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