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Initial Medical Research Studies

Up-to-date List of Initial Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Initial Medical Research Studies

Rank Status Study
1 Not yet recruiting The Severity of Newly Diagnosed Asthma Patients and the Result of Initial 12 Weeks Treatment in China
Condition: Asthma
Intervention:
Outcome Measures: Asthma Severity assessment based on GINA definition (GINA 2006 update) at baseline in the total population;   evaluate the control level of Initial 12 weeks treatment based on Assessment of Current Clinical Control in GINA (GINA 2012 update).
2 Unknown  The ARTERY FIRST Approach for Resection of Pancreatic Head Cancer
Condition: Pancreatic Head Cancer
Interventions: Procedure: Artery first procedure;   Procedure: No artery first procedure
Outcome Measures: Rate of R1 resections;   Exploratory analyses
3 Not yet recruiting Delayed or Direct Ureteroscopy in the Treatment of Pediatric Calcular Anuria
Conditions: Acute Renal Failure;   Anuria;   Obstructive Uropathy;   Ureteric Stones
Interventions: Procedure: Initial urinary drainage;   Procedure: direct ureteroscopy
Outcome Measures: Return to normal creatinine;   stone free status;   operative and early post operative complications;   ureteric stricture;   period to reach stone free status bilaterally;   number of times of exposure to general anesthesia
4 Not yet recruiting Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device
Condition: Septicemia
Interventions: Device: Initial Specimen Diversion Device (ISDD);   Device: Lab standard practice (LSP)
Outcome Measures: Rate of blood culture contamination when using the Initial Specimen Diversion Device (ISDD) compared to Laboratory Standard Procedures (LSP);   Occurrence rate of adverse device effects
5 Unknown  Validation of Pharmacogenetics Plus Drug Combination Guided Initial Tacrolimus Dosage in Renal Transplant Recipients
Condition: Renal Transplantation
Interventions: Other: drug (tacrolimus and SchE) and genetics;   Drug: tacrolimus
Outcome Measures: C0 of tacrolimus after the Initial dose, the percentage of out-of-range C0 after Initial dose, the number of dose adjustments made to achieve therapeutic range (5-10 ng/ml) and the dose requirement to reach therapeutic range;   acute rejection rate within two weeks after transplantation;   serum creatinine at fourteen days after transplantation
6 Recruiting Study to Evaluate the Effectiveness of the Initial Specimen Diversion Device When Collected Through Peripheral Intravenous Catheters
Condition: Septicemia
Interventions: Device: Initial Specimen Diversion Device (ISDD);   Procedure: Lab standard practice (LSP);   Device: Peripheral Intravenous Catheters (PIVC)
Outcome Measures: Evaluate the rate of blood culture contamination using the Initial Specimen Diversion Device (ISDD) compared to Laboratory Standard Procedures (LSP) when collected through PIVC;   Evaluate the occurrence of any adverse device effects
7 Recruiting Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study
Condition: Vestibular Schwannoma
Intervention: Radiation: Initial Gamma knife radiosurgery
Outcome Measures: The numbers of participants with preserve hearing;   Tumor control
8 Recruiting Retrospective Examination of Initial Care of Severe Bacterial Infections of the Child
Condition: Bacterial Infection
Intervention: Other: Retrospective examination by experts whether care given fo child admitted at the ICU for suspicion of bacterial infection (not nosocomial) was optimal or not
Outcome Measures: Frequency of optimal care and of non optimal care in the Initial care (before arrival at the intensive care unit) of children (from West France regions) suffering of severe bacterial infections.;   characteristics of sub-optimal cares;   determinants of sub-optimal cares;   consequences of Initial sub-optimal cares
9 Recruiting Optimization of Initial Energy for Cardioversion of Atrial Fibrillation With Biphasic Shocks
Conditions: Atrial Fibrillation;   Cardioversion
Interventions: Procedure: 100 joule as first biphasic shock energy;   Procedure: 120 joule as first biphasic shock energy
Outcome Measures: Electrical cardioversion success;   Complications rate
10 Unknown  Relationship Between Initial Plaque Characteristics and Stent Surface Coverage Patterns
Condition: Coronary Artery Disease
Intervention: Device: Polymer-based sirolimus-eluting stent (Partner stent )
Outcome Measures: To investigate the relationship between Initial plaque characteristics and stent surface coverage after sirolimus-eluting stent implantation.;   Relationship between tissue prolapse and Initial plaque characteristics;   Comparison of the differences in vascular response (surface coverage and malapposition) between CTO and non- CTO lesions.;   Late stent malapposition( by OCT and IVUS ).;   Relationship between Initial lesion characteristics and stent surface coverage pattern after SES implantation.;   Comparison of the differences in stent surface coverage between CTO and non- CTO lesions.
11 Recruiting First-Voided Urinary LH vs. GnRH-stimulation in Differentiating Slowly- From Rapidly Progressive-Precocious Puberty
Condition: Precocious Puberty, Gonadotropin-dependent
Interventions: Other: Measurement of LH in first-voided urine;   Other: collection of first-voided urine sample for LH level
Outcome Measures: Identification of first-voided urinary LH cutoff for the detection of pubertal advancement by comparison with GnRH stimulated gonadotropins;   Levels first-voided urinary LH measurements in monitoring gonadotropin suppression during GnRHa therapy
12 Unknown  Initial Versus Delayed Operation for Treatment of Complicated Appendicitis In Children
Condition: Perforated Appendicitis
Interventions: Procedure: Initial appendectomy;   Procedure: Interval appendectomy
Outcome Measure: cost effectiveness
13 Recruiting Olaparib Monotherapy in Patients With BRCA Mutated Ovarian Cancer Following First Line Platinum Based Chemotherapy.
Conditions: Newly Diagnosed;   Advanced Ovarian Cancer;   FIGO Stage III-IV;   BRCA Mutation;   Complete Response;   Partial Response;   First Line Platinum Chemotherapy
Intervention: Drug: Olaparib 300mg tablets
Outcome Measures: Progression Free Survival (PFS) by central review of RECIST data;   Efficacy in patients following First Line Platinum Based Chemotherapy by assessment of overall survival.;   Time to deterioration of Health-Related Quality of Life (HRQoL) as assessed by TOI and FACT-O.;   Efficacy in patients with a deleterious or suspected deleterious variant in either of the BRCA genes by assessment of progression free survival.;   Safety and tolerability of olaparib by assessment of the number of AEs;   Efficacy in patients following First Line Platinum Based Chemotherapy by assessment of time to earliest progression by RECIST or Cancer Antigen-125 (CA-125).;   Efficacy in patients following First Line Platinum Based Chemotherapy by assessment of time from randomisation to second progression.;   Safety and tolerability of olaparib by assessment and review of laboratory parameters.;   Efficacy of olaparib by time to first subsequent therapy or death (TFST).;   Efficacy of olaparib by time to second subsequent therapy or death (TSST).;   Efficacy of olaparib by time from randomisation to study treatment discontinuation or death (TDT).
14 Recruiting Monotherapy Versus Dual Therapy for Initial Treatment for Hypertension
Conditions: Hypertension, Resistant to Conventional Therapy;   Essential Hypertension
Interventions: Drug: Losartan and hydrochlorothiazide;   Drug: Hydrochlorothiazide switched over with Losartan at 8 weeks
Outcome Measures: Change in mean home systolic BP for the group treated Initially with monotherapy compared to the group treated Initially with combination therapy.;   A comparison the proportion of patients who drop out of the trial at any stage after randomisation or who require further antihypertensive treatment
15 Recruiting Treating Prediabetes in the First Trimester
Conditions: Prediabetes;   Gestational Diabetes
Intervention: Other: Treatment of Prediabetes
Outcome Measures: Umbilical Cord C-Peptide >90th percentile;   Neonatal fat mass;   Adherence to the Institute of Medicine (IOM) guidelines for gestational weight gain;   Return to prepregnancy weight;   Placental SirT-1;   Maternal adiponectin;   Umbilical cord blood adiponectin
16 Recruiting Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO)
Conditions: Macular Edema;   Central Retinal Vein Occlusion
Interventions: Drug: Ozurdex;   Drug: Avastin
Outcome Measures: The change in visual acuity (number of ETDRS letters), at Month 6 as compared with baseline in each treatment arm;   The total number of additional Avastin injections following Initial treatment in each treatment arm;   Presence of macular edema, as measured by ocular coherence tomography (OCT) and fluorescein angiography
17 Unknown  Multi-center Trial of Revlimid® and Rituximab, for First-Line Treatment of Chronic Lymphocytic Leukemia (CLL)
Conditions: Chronic Lymphocytic Leukemia;   CLL;   Untreated;   Front-line;   First-Line;   Initial Therapy
Intervention: Drug: Lenalidomide and Rituximab
Outcome Measures: Efficacy to be assessed by clinical response rate following 3 cycles of treatment and the NCI-CLL working group response rate assessed after completion of all treatment.;   Safety - type, frequency, severity, and relationship of adverse events to study treatment;   Time To Progression;   Evaluate response to lenalidomide in relationship to molecular and genetic prognostic features in CLL; including ZAP-70 status, IgVH gene mutational status, and FISH.;   Compare the efficacy and tolerability of the combination of Revlimid and rituximab for patients younger than 65 years, and for those 65 and older. •;   Evaluate change in hematological parameters including neutropenia, anemia, and thrombocytopenia following treatment with the combination of Revlimid and rituximab.
18 Recruiting Safety and Efficacy of Ginsenoside Rg3 in Combination With First-line Chemotherapy in Advanced Gastric Cancer
Condition: Self Efficacy
Interventions: Drug: Ginsenoside Rg3 plus First-line Chemotherapy;   Drug: First-line Chemotherapy
Outcome Measures: Progression-free survival (PFS);   Objective Response Rate (ORR);   Overall Survival (OS)
19 Recruiting Hepatectomy Versus Chemoembolization as the Initial Treatment for Resectable Hepatocellular Carcinoma Beyond Milan Criteria
Condition: Resectable Hepatocellular Carcinoma Beyond Milan Criteria
Interventions: Procedure: Chemoembolization and Response-Dependent Resection;   Procedure: Immediate Resection
Outcome Measures: overall survival time;   disease free survival;   Number of Adverse Events
20 Recruiting Initial Antibiotics and Delayed Appendectomy for Acute Appendicitis
Condition: Acute Appendicitis
Intervention: Drug: Piperacillin + Amoxicillin
Outcome Measures: Number of treatment failures;   Cost-saving of Initial nonoperative treatment for early appendicitis

These studies may lead to new treatments and are adding insight into Initial etiology and treatment.

A major focus of Initial research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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