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Intestinal Anastomosis Medical Research Studies

Up-to-date List of Intestinal Anastomosis Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Intestinal Anastomosis Medical Research Studies

Rank Status Study
1 Recruiting Pancreaticoduodenectomy With or Without Braun Enteroenterostomy: Comparison of Postoperative Pancreatic Fistula and Delayed Gastric Emptying
Conditions: Postoperative Pancreatic Fistula;   Delayed Gastric Emptying
Interventions: Procedure: pancreaticoduodenectomy without Braun enteroenterostomy;   Procedure: Braun enteroenterostomy
Outcome Measures: Decreased rates of pancreatic fistula in surgeries adding Braun enteroenterostomy;   Reduced incidence of delayed gastric emptying in patients with Braun enteroenterostomy
2 Recruiting Magnamosis First-in-human Study of Feasibility and Safety
Condition: Intestinal Anastomosis for Intestinal Continuity
Intervention: Device: Magnamosis
Outcome Measures: Number of subjects who experience occurrence of anastomotic leak;   Number of subjects who experience other device-related complications;   Number of patients who have an adequate anastomosis
3 Recruiting Fluorescent Evaluation of Colorectal Anastamoses
Conditions: Rectal Neoplasms;   Colon Neoplasms;   Diverticulitis
Intervention: Device: Indocyanine Green
Outcome Measure: Evaluate the vascular supply to bowel anastomoses
4 Recruiting Pre-operative Diet: Effect of Wound Healing After Bariatric Surgery
Condition: Obese
Intervention: Dietary Supplement: Diet group 800 Kcal diet
Outcome Measures: Collagen 1/3 ratio after diet and surgery;   Is there any difference in wound healing between patients undergoing aggressive calorie restriction and those without a dietary intervention prior to bariatric surgery?;   Change in body composition between control group and patients with diet
5 Unknown  Prevention of Anastomotic Leak in Gastrointestinal (GI) Anastomosis With the Application of Tisseal in the Anastomotic Line
Condition: Anastomotic Leak
Intervention: Drug: Fibrin glue
Outcome Measures: Occurence of anastomotic leak;   Evidence of infectious collections in the anastomotic area
6 Recruiting A RETROspective Data Collection of comPRESSion Anastomosis Using the ColonRing
Conditions: Diverticulum, Colon;   Colorectal Neoplasms;   Crohn Disease;   Colitis, Ulcerative;   Colostomy;   Ileostomy - Stoma;   Rectal Prolapse;   Intestinal Polyposis;   Lymphoma;   Endometriosis;   Intestinal Volvulus
Outcome Measures: The rate of anastomotic leakage.;   Rate of other device related complications and measures during hospitalization and post procedure.
7 Recruiting Long or Very Long-Limb Gastric Bypass in Superobese
Condition: Obesity
Intervention: Procedure: laparoscopic gastric Roux-en-Y gastric bypass
Outcome Measures: weight loss- we will compare percentage of excess body weight loss (%EWL) between groups.;   To compare body mass index changes and absolute weight loss. To evaluate obesity-related medical problems. To obtain data about impromvement of metabolic syndrom. To compare quality of life changes between treatment arms.
8 Recruiting Prospective Controlled Trial on Surgical Treatment of Type 2 Diabetes Patients With BMI 25-30 by Means of Biliopancreatic Diversion
Conditions: Type 2 Diabetes Mellitus;   Bariatric Surgery;   Biliopancreatic Diversion
Interventions: Procedure: biliopancreatic diversion;   Drug: antidiabetics
Outcome Measures: Diabetes control as defined by FSG and HbA1c;   Assessment of prevalence and severity of diabetes complications;   Assessment of patient BMI
9 Recruiting Multicentric Prospective Randomized Trial on Surgery Versus Standard Medical Care in Type 2 Diabetic Patients BMI 30-35
Condition: Diabetes Mellitus
Intervention: Procedure: Bariatric surgery
Outcome Measures: Proportion of patients achieving diabetes complete remission (HbA1c 6% or below) or diabetes control (HbA1c between 7% and 6.1%) on free diet and with no antidiabetic medical therapy.;   Stable reduction of preoperative HbA1c; BMI; mortality/morbidity; Major components of the metabolic syndrome; Diabetes complications; Improvement of beta-cell function; insulin resistance reduction ; Overall and CV disease mortality.
10 Recruiting Internal Hernias After Gastric Bypass Can be Prevented Safely With Primary Closure of All Mesenteric Defects With Clips
Condition: Internal Hernias
Intervention: Procedure: Closing the mesenteric defects with clips during opration
Outcome Measures: To avoid the risk of Internal Hernias in patient with a Gastric bypass;   Postoperative pain score (VAS);   Operative time consumption, the amount of clips, trocar and sutures used
11 Recruiting A Study Into the Effect of Seprafilm in Open Total Thyroidectomy
Condition: Focus of Study: Prevent Pulling Sensation and/or Swallowing Difficulty in Patients Received Total Thyroidectomy.
Intervention: Device: Seprafilm (Sanofi, USA)
Outcome Measures: Cricoid elevation;   Hyoid elevation;   Crico-hyoid distance;   Videotaping measurement;   Swallowing Quality of Life questionaire
12 Unknown  Bowel Prep vs Non-Bowel Prep for Laparoscopic Colorectal Surgery
Conditions: Anastomotic Leak;   Surgical Site Infection
Interventions: Procedure: low residue diet/no standard bowel preparation;   Procedure: standard bowel preparation
Outcome Measure: Whether anastomotic leaks, and surgical site infection rates are equivalent in patients having laparoscopic resections without bowel prep versus prepped patients.
13 Recruiting Observational Analysis of the Cause of Leaks When Bowel is Cut and Reconnected
Condition: Anastomotic Leaks
Outcome Measures: All cause bowel leaks after surgery;   Reoperation;   Sepsis;   Length of hospital stay;   Mortality
14 Recruiting Best Management of Sigmoid Volvulus: A Prospective Randomized Trial
Conditions: Intestinal Volvulus;   Colon, Sigmoid
Interventions: Procedure: Resection and anastomosis;   Procedure: Resection and colostomy;   Procedure: Mesosigmoidopexy
Outcome Measures: Mortality;   Recurrence of Sigmoid Volvulus;   Surgical Site Infection
15 Unknown  J-Pouch Colorectal Anastomosis or Straight Colorectal Anastomosis in Treating Patients With Rectal Cancer Who Have Undergone Surgery to Remove the Tumor
Conditions: Colorectal Cancer;   Gastrointestinal Complications;   Perioperative/Postoperative Complications
Interventions: Other: intraoperative complication management/prevention;   Procedure: assessment of therapy complications;   Procedure: gastrointestinal complications management/prevention;   Procedure: quality-of-life assessment;   Procedure: therapeutic conventional surgery
Outcome Measures: Major anastomotic leak rate;   Percentage of the colonic J-pouch reconstruction performed with respect to the total number of patients selected for the J-pouch treatment arm;   Global anastomotic leak rate;   Anastomotic complications rate in addition to anastomotic leak;   Bowel function, fecal incontinence, and quality of life, evaluated with validated questionnaires
16 Not yet recruiting Side-to-end Anastomosis Versus Colon J Pouch for Reconstruction After Low Anterior Resection for Rectal Cancer (SAVE)
Condition: Rectal Cancer
Interventions: Procedure: side-to-end anastomosis;   Procedure: colon j pouch
Outcome Measures: Side-to-end anastomosis is not inferior not colon J pouch in terms of fecal incontinence. fecal incontinence (Wexner score);   anorectal function;   quality of life;   postoperative complications;   sexual function;   urinary function;   operation time;   institutional costs;   local recurrence;   cancer related deaths
17 Unknown  INtracorporeal Versus EXTracorpoREal anastoMOsis After Laparoscopic Right Colectomy for Cancer
Condition: Colorectal Cancer
Intervention: Procedure: Laparoscopic right hemicolectomy for cancer
Outcome Measures: Overall surgical morbidity;   Operative time;   Largest incision length;   Numbers of node harvested;   Intraoperative complicatons;   Mortality;   Non surgical site complications;   Bowel movement;   First flatus;   First stool canalization;   Time to solid diet;   Naso gastric tube reintroduction;   Days of analgesic usage;   Length of hospital stay;   Readmission
18 Not yet recruiting The Interaction Between Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis
Condition: Pouchitis
Outcome Measures: Differences in the intestinal microbiota composition between pouch patients with and without pouchitis;   The expression of defensins in the intestinal mucosa;   The intestinal permeability;   Inflammatory mediators;   The expression of tight-junction associated proteins
19 Recruiting Prospective Multicenter Randomized Controlled Trial On Two-Stage Turnbull-Cutait Coloanal Anastomosis For Rectal
Condition: Rectal Neoplasm
Interventions: Procedure: Hand-sewn coloanal anastomosis;   Procedure: Two staged Turnbull-Cutait procedure;   Procedure: Ultralow anterior rectal resection with total mesorectal excision
Outcome Measures: post-operative morbidity;   quality of life;   Fecal incontinence;   local and/or distant recurrence of neoplasm
20 Recruiting Trial on Mechanical Bowel Preparation in Laparoscopic Colorectal Surgery
Conditions: Rectal Cancer;   Colon Cancer
Interventions: Drug: polyethylene glycol;   Other: No Preparation
Outcome Measures: anastomotic leak;   surgical site infection;   Intraoperative parameters assessment;   bowel recovery;   drain removal;   Re-exploration;   Hospital stay;   Readmission

These studies may lead to new treatments and are adding insight into Intestinal Anastomosis etiology and treatment.

A major focus of Intestinal Anastomosis research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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