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Intralipid Medical Research Studies

Up-to-date List of Intralipid Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Intralipid Medical Research Studies

Rank Status Study
1 Unknown  Intralipid for Repeated Implantation Failure
Condition: Infertility
Intervention: Drug: Intralipid
Outcome Measures: clinical pregnancy rate;   implantation rate;   ongoing pregnancy rate
2 Recruiting Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial
Condition: Pregnancy Complicated by Low Implantation
Intervention: Drug: Intralipid
Outcome Measures: The effectiveness of Intralipid on normalization of nk level and rate of clinical pregnancy .;   the rate of continuation of pregnancy beyond 12 weeks of pregnancy,the adverse effects related to the drug.
3 Recruiting Single Dose Intralipid for Recurrent Unexplained Miscarriage
Conditions: Abortion, Spontaneous;   Abortion, Habitual
Intervention: Drug: Intralipid
Outcome Measures: chemical pregnancy rate;   clinical pregnancy rate,
4 Recruiting Intralipid Therapy for Women 35-40 Years With Positive Natural Killer Cells Undergoing Intracytoplasmic Sperm Injection (ICSI)
Condition: Infertility
Intervention: Drug: Intralipid infusion
Outcome Measures: Clinical pregnancy rate;   Chemical pregnancy;   implantation rate;   ongoing pregnancy rate;   Miscarriage rate;   Ectopic rate
5 Recruiting Intravenous Nutrition in Hospitalized Patients: Comparison of Two Oils
Conditions: Obstruction;   Cancer;   Ileus;   Malnutrition;   Surgery
Interventions: Drug: Intralipid;   Drug: ClinOleic
Outcome Measures: Length of stay;   Mortality;   Body mass index;   Infections;   hand-grip strength;   mid-arm circumference;   Subjective global assessment (SGA);   prealbumin;   Antibiotic days;   high sensitivity C-reactive Protein (hs-CRP)
6 Recruiting Evaluation of OMEGAVEN 10%® (n-3 EFA Lipid Emulsion) in Home Parenteral Nutrition-associated Liver Disease
Condition: Liver Diseases
Interventions: Drug: Intralipid 20%®;   Drug: OMEGAVEN 10%®
Outcome Measure: The five liver function tests (LFT)
7 Recruiting Low Dose Fat for the Prevention of Liver Disease in Babies With Gastrointestinal Disorders
Condition: Cholestasis
Intervention: Drug: Intralipid/Liposyn
Outcome Measures: presence of cholestasis;   mortality rate;   anthropometric measurements
8 Recruiting Fish Oil for Patients With Liver Disease Due to Parenteral Nutrition
Condition: Total Parenteral Nutrition-induced Cholestasis
Interventions: Drug: Soybean oil based emulsion;   Drug: Soybean oil based emulsion+Fish oil based emulsion
Outcome Measures: Response to treatment at 3 months;   Change in total and conjugated bilirubin over time;   Changes in liver function test (ALP, AST, GGT) over 6 months;   Changes in liver histology between baseline and 6 months on Omegaven;   Changes in liver fatty acid composition between baseline and 6 months on Omegaven;   Changes in liver oxidative stress between baseline and 6 months;   Changes in hepatic gene expression between baseline and 6 months on Omegaven
9 Unknown  Minimization of Intralipid Versus Omegaven
Conditions: Cholestasis;   Parenteral Nutrition Associated Liver Disease (PNALD)
Interventions: Dietary Supplement: Omegaven;   Dietary Supplement: Lipid minimization
Outcome Measures: Feasibility;   Clinical endpoint;   Total duration of parenteral nutrition;   Growth
10 Recruiting Preventing Cholestasis Using SMOFLipid®
Conditions: Cholestasis;   Psychomotor Disorders, Developmental
Interventions: Drug: mixed lipid emulsion containing fish oil;   Drug: Soy bean based lipid emulsion
Outcome Measures: Incidence of parenteral nutrition associated cholestasis (PNAC);   Bailey Scales of Infant Development III
11 Recruiting Use of Omega-3 Fat Emulsion (Omegaven) in Infants With Parenteral Nutrition Associated Liver Disease
Condition: Parenteral Nutrition Associated Liver Disease
Intervention: Drug: Omegaven
Outcome Measure: Resolution of the direct hyperbilirubinemia
12 Unknown  Low Dose Parenteral Fat for Prevention of Parenteral Nutrition Associated Cholestasis in Preterm Neonates
Condition: Parenteral Nutrition-Associated Cholestasis
Interventions: Other: Intravenous fat emulsion;   Other: Restriction of intravenous fat emulsion to 1 gm/kg/d
Outcome Measures: The presence of cholestasis at age of 28 days or when full enteral nutrition is achieved, whichever is longer.;   Mortality rate;   Incidence of bronchopulmonary dysplasia (BPD);   Incidence of necrotizing enterocolitis (NEC);   Incidence of retinopathy of prematurity (ROP);   Late onset sepsis;   Length of stay;   Time to regain birth weight;   Anthropometric measurements(body weight, length, head circumference)
13 Recruiting Effect of Increased Free Fatty Acids on Leptin Function
Conditions: Obesity;   Leptin Resistance
Interventions: Drug: Saline;   Drug: Intralipid;   Dietary Supplement: Water;   Dietary Supplement: Soybean oil;   Drug: Heparin
Outcome Measures: Change in intracellular messengers of leptin signaling;   Change in circulating levels of gut hormones (GLP-1, GIP, ghrelin, PYY);   Change in circulating hormone levels
14 Recruiting Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion
Condition: Preterm Infants
Interventions: Drug: ClinOleic;   Drug: Intralipid
Outcome Measures: liver function;   bile acid
15 Unknown  Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis
Condition: Severe Acute Pancreatitis
Interventions: Drug: Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;   Drug: Fat emulsion with MCT and LCT
Outcome Measures: Inflammatory markers;   Evolution of the degree of severity of acute severe pancreatitis;   Complications of acute severe pancreatitis
16 Recruiting Compassionate Use of Omegaven IV Fat Emulsion
Conditions: Cholestasis;   Parenteral Nutrition Associated Liver Disease
Intervention: Drug: Omegaven
Outcome Measures: Decline in serum direct bilirubin levels below 2 on two serial measures.;   Improving liver function tests.
17 Recruiting Effects of Parenteral Nutrition With Different Lipid Emulsions in Preterm Infants
Condition: Preterm Infant
Interventions: Drug: ClinOleic;   Drug: Lipofundin;   Drug: Intralipid
Outcome Measures: lipometabolism;   oxidative stress
18 Recruiting A Study to Evaluate the Effect of Lipid Infusion on TLR4 Signaling
Conditions: Diabetes;   Obesity
Interventions: Drug: Intralipid 20%;   Drug: Saline
Outcome Measures: Muscle insulin sensitivity;   TLR4 signaling
19 Not yet recruiting Parenteral Fish Oil in Major Laparoscopic Abdominal Surgery
Conditions: Gastric Tumor;   Pancreatic Tumor;   Liver Tumor
Interventions: Drug: MCT/LCT and fish oil;   Drug: MCT/LCT
Outcome Measures: infective complications;   length of hospital stay;   plasma immunological markers
20 Recruiting Omegaven® in the Treatment of Parenteral Nutrition (PN) Induced Liver Injury
Condition: Parenteral Nutrition Associated Liver Disease
Intervention: Drug: Omegaven®
Outcome Measure: Efficacy of parenteral administration of fish oil derived fat emulsion (Omegaven®) to reverse established parenteral nutrition associated liver disease

These studies may lead to new treatments and are adding insight into Intralipid etiology and treatment.

A major focus of Intralipid research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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