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Intuniv Medical Research Studies

Up-to-date List of Intuniv Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Intuniv Medical Research Studies

Rank Status Study
1 Recruiting Efficacy of Intuniv Extended Release as Adjunctive Therapy With Psycho-stimulant on Executive Function in Children With ADHD
Condition: Attention Deficit Hyperactivity Disorder
Interventions: Drug: Guanfacine extended release;   Drug: Placebo
Outcome Measures: To evaluate the effect of adjunctive Intuniv extended release treatment on executive function as assessed by the BRIEF-parent questionnaires;   To evaluate the effect of adjunctive Intuniv extended release treatment on quality of life as assessed by the KINDL®-child and KINDL®-parent questionnaires.;   To examine the congruency of the perceived effect of treatment on EF and quality of life from the perspective of the subject, parent, and teacher.;   To evaluate the effect of adjunct therapy on ADHD symptom control as assessed by the ADHD Rating Scale (ADHD-RS-IV) and Clinical Global Impression (CGI) of Severity (CGI-S) and of Improvement (CGI-I) questionnaires.;   To compare the percentage of subjects experiencing suicidal ideation, suicidal behaviour and self-injurious behaviour without suicidal intent and incident of Serious Adverse Events in each treatment arm
2 Recruiting Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder
Conditions: Intermittent Explosive Disorder;   Childhood Aggression;   Oppositional Defiant Disorder;   Attention Deficit Disorder
Interventions: Behavioral: Parent Management Training;   Other: Placebo;   Drug: Intuniv
Outcome Measures: Responder vs Non-Responder Assessment Form;   Percent change in score on the Attention Deficit Hyperactivity Disorder [ADHD] Rating Scale;   Percent change in the Modified Overt Aggression Scale;   Percent Change in the Score on Hostility Subscale of the Hopkins Symptom Checklist
3 Recruiting Guanfacine for the Treatment of Hyperactivity in Pervasive Developmental Disorder
Condition: Pervasive Development Disorders
Interventions: Drug: methylphenidate;   Other: placebo;   Drug: extended-release guanfacine
Outcome Measures: Aberrant Behavior Checklist Hyperactivity Subscale;   ADHD Rating Scale
4 Recruiting Open-Label Pilot Study of Guanfacine-Extended Release for the Treatment of Cannabis Dependence
Condition: Cannabis Dependence
Intervention: Drug: Guanfacine
Outcome Measure: Reduction in cannabis use
5 Recruiting Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance
Condition: Chronic Pain
Interventions: Drug: Guanfacine;   Drug: Morphine;   Drug: Placebo
Outcome Measures: Quantitative Sensory Testing (QST);   Heat Pain Threshold;   Heat Pain Tolerance;   Temporal Pain Summation;   Detecting Diffuse Noxious Inhibitory Control (DNIC);   Heat Sensation
6 Recruiting Guanfacine Clinical Trial for Smoking Cessation
Condition: Smoking Cessation
Interventions: Drug: Guanfacine;   Drug: Placebo
Outcome Measures: Rates of prolonged smoking abstinence;   7-day point prevalence and continuous abstinence;   Prolonged smoking abstinence, 7-day point prevalence and continuous abstinence
7 Recruiting Neurobiological Basis of Response to Guanfacine Extended Release in Children and Adolescents With ADHD
Conditions: ADHD;   Attention Deficit Hyperactivity Disorder
Interventions: Drug: Guanfacine Hydrochloride XR;   Drug: Placebo
Outcome Measures: Change in fMRI activation from pre to post treatment;   Clinical Global Impressions;   Atomoxetine Stimulant Side Effects Rating Scale (ASSERS);   Neuropsychological assessments;   Attention Deficit Hyperactivity Disorder Rating Scale IV (ADHDRS IV)
8 Unknown  Guanfacine to Treat Borderline Personality Disorder
Condition: Borderline Personality Disorder
Intervention: Drug: guanfacine (Tenex)
Outcome Measures: measures of impulsive aggression;   measures of affective disturbance;   measures of social and occupational functioning;   measures of overall clinical status
9 Unknown  Guanfacine for the Treatment of Spatial Neglect and Impaired Vigilance
Conditions: Stroke;   Hemispatial Neglect
Interventions: Drug: Guanfacine;   Drug: Placebo
Outcome Measures: Performance on tests of hemispatial neglect and sustained attention;   Performance on Motor Tasks
10 Unknown  Single Versus Combination Medication Treatment for Children With Attention Deficit Hyperactivity Disorder
Condition: Attention Deficit Disorder With Hyperactivity
Interventions: Drug: Guanfacine;   Drug: Methylphenidate (MPH);   Drug: Combined methylphenidate and guanfacine
Outcome Measures: Score on ADHD IV Rating Scale (ADHD-RS);   Score on behavioral ratings CGI-Improvement, Conners Global Index and cognitive test measures
11 Recruiting Inuniv and Working Memory
Condition: Attention Deficit Hyperactivity Disorder
Intervention: Drug: extended release guanfacine
Outcome Measures: Central Nervous System-Vital Signs (CNS-VS);   Wide Range Assessment of Memory and Learning(WRAML)
12 Recruiting A Single-Center, Study Evaluating the Efficacy and Safety of Guanfacine Hydrochloride in Combination With Psychostimulants in Adults Aged 18-65 Years With a Diagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD)
Condition: Adult Attention-Deficit Hyperactivity Disorder
Interventions: Drug: Guanfacine Hydrocholride;   Drug: Placebo
Outcome Measures: Safety and efficacy of GH as adjunctive medication to psychostimulants in adult ADHD;   Assess safety and tolerability of GH.
13 Recruiting Modeling Stress-precipitated Smoking Behavior for Medication Development
Condition: Smoking
Interventions: Drug: guanfacine;   Drug: placebo;   Drug: Carvedilol
Outcome Measures: latency to initiate ad-lib smoking session;   number of cigarettes smoking during the ad-lib period;   success rates in smoking cessation attempt;   gender differences in medication effects
14 Recruiting Pharmacology of Cognition in Schizotypal Personality Disorder
Conditions: Schizotypal Personality Disorder;   Personality Disorders
Interventions: Drug: Guanfacine;   Drug: Placebo
Outcome Measures: Performance on tests of sustained attention, episodic memory, and working memory;   Hamilton Depression Rating Scale;   Positive and Negative Symptom Scale;   Clinical Global Impression Scale
15 Recruiting Interventions for Children With Attention and Reading Disorders
Conditions: Attention Deficit Hyperactivity Disorder;   Reading Disabilities
Interventions: Drug: Methylphenidate;   Behavioral: Intensive reading instruction;   Behavioral: Parent Training;   Drug: Mixed Salt Amphetamine;   Drug: Atomoxetine;   Drug: Guanfacine
Outcome Measures: Wechsler Individual Achievement Test of Word Reading and Pseudoword Decoding;   Swanson, Nolan, and Pelham checklist for DSM-IV;   Stop-Signal Test;   Test of Word Reading Efficiency;   Wechsler Individual Achievement Test of Reading Comprehension;   Dynamic Indicators of Basic Early Literacy Skills Oral Reading Fluency
16 Recruiting Treatment of Supine Hypertension in Autonomic Failure
Condition: Hypertension
Interventions: Drug: Clonidine;   Drug: Nitroglycerin transdermal;   Drug: Dipyridamole/ Aspirin (Aggrenox);   Drug: Desmopressin (DDAVP);   Drug: Sildenafil;   Drug: Nifedipine;   Drug: Hydralazine;   Drug: Hydrochlorothiazide;   Drug: Placebo;   Drug: Bosentan;   Drug: Diltiazem;   Drug: Eplerenone;   Drug: guanfacine;   Dietary Supplement: L-arginine;   Drug: captopril;   Drug: carbidopa;   Drug: losartan;   Drug: metoprolol tartrate;   Drug: nebivolol hydrochloride;   Drug: prazosin hydrochloride;   Drug: tamsulosin hydrochloride;   Other: Head-up tilt.;   Drug: aliskiren;   Other: Local heat stress
Outcome Measures: Decrease in supine systolic blood pressure;   Decrease in pressure natriuresis

These studies may lead to new treatments and are adding insight into Intuniv etiology and treatment.

A major focus of Intuniv research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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