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Johnson Medical Research Studies

Up-to-date List of Johnson Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Johnson Medical Research Studies

Rank Status Study
1 Recruiting Phase III Clinical Trial of NPB-01 in Patients With Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis Unresponsive to Corticosteroids.
Conditions: Stevens-Johnson Syndrome;   Toxic Epidermal Necrolysis
Intervention: Drug: Intravenous immunoglobulin
Outcome Measures: disease evaluation score;   avulsed skin area;   erythematous area
2 Recruiting Infliximab to Improve Retention of the Boston Keratoprosthesis in Patients After Stevens Johnson Syndrome/ Toxic Epidermal Necrolysis (SJS/TENS)
Conditions: Stevens-Johnson Syndrome;   Corneal Blindness
Intervention: Drug: Infliximab
Outcome Measures: Occurrence of corneal ulceration;   Occurrence of systemic adverse events;   Period Of Prosthesis Retention;   Vision Recovery
3 Recruiting Comparing Cetaphil Restoraderm System Versus Standard Skin Care in Infants
Condition: Atopic Dermatitis
Interventions: Other: Cetaphil Restoraderm;   Other: Standard of Care
Outcome Measures: Incidence of atopic dermatitis;   Effects on infants' skin barrier
4 Unknown  Optical Coherence Tomography for Drug Eluting Stent Safety
Condition: Coronary Artery Disease
Interventions: Device: sirolimus drug eluting coronary stent Cypher™ (Cordis Corp, Johnson & Johnson Co);   Device: paclitaxel polymer drug eluting stent Taxus Libertè™ (Boston Scientific, Natick MS);   Device: zotarolimus drug eluting coronary stent Endeavor™ (Medtronic, Santa Rosa, CA);   Device: Libertè bare metal coronary stent Libertè™ BMS(Boston Scientific, Natick, MS)
Outcome Measures: Number of uncovered and/or malapposed stent struts at overlapping versus non overlapping sites in drug eluting vs bare metal stents;   Ischemia Driven Target Vessel Failure;   Number of uncovered and/or malapposed stent struts at overlapping sites in sirolimus-, paclitaxel- or zotarolimus eluting stents
5 Recruiting Evaluation of the TruMatch® System in Knee Prosthetic Surgery
Condition: Osteoarthritis, Knee
Intervention: Device: TruMatch® patient specific cutting guide
Outcome Measures: Femorotibial mismatch angle;   Knee function
6 Unknown  Metabolics of Roux-en-Y Gastric Bypass (RYGB) With Gastrostomy
Conditions: Type II Diabetes Mellitus;   Obesity
Intervention:
Outcome Measure:
7 Unknown  Single Port Laparoscopic Cholecystectomy Versus Four Port Laparoscopic Cholecystectomy: Impact on Postoperative Pain
Condition: Postoperative Pain
Interventions: Device: Single port laparoscopic cholecystectomy SINGLE SITE LAPAROSCOPY ACCESS SYSTEM (Johnson & Johnson Medical Spa);   Procedure: Four port laparoscopic cholecystectomy surgery
Outcome Measures: Post-operative pain scores (visual analogue pain scale from 0-10);   Patient-assessed cosmesis on the Visual Analogue Scale
8 Recruiting Study to Evaluate the Use of Palifermin to Treat Toxic Epidermal Necrolysis
Conditions: Toxic Epidermal Necrolysis;   Stevens-Johnson Syndrome
Intervention: Drug: Palifermin
Outcome Measures: Time-to-cutaneous re-epithelialization;   Time-to-mucosal re-epithelialization;   Time-to-cessation of epidermal necrosis
9 Not yet recruiting Topical Infliximab in Autoimmune Eyes With Keratoprosthesis
Conditions: Stevens-Johnson Syndrome;   Toxic Epidermal Necrolysis (Lyell) Syndrome;   Mucous Membrane Pemphigoid
Intervention: Drug: topical infliximab
Outcome Measures: Tolerability;   Adverse events;   rate of corneal melting;   KPro retention;   Visual acuity;   Ocular surface symptoms;   Ocular surface inflammation;   tear matrix metalloproteinase (MMP);   graft thickness
10 Not yet recruiting Effect of Andosan in Patients With Rheumatoid Arthritis
Condition: Rheumatoid Arthritis
Intervention: Dietary Supplement: Mushroom extract
Outcome Measures: Symptom score;   Cytokine levels in harvested blood from the patients
11 Recruiting Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease
Condition: Peripheral Vascular Diseases
Interventions: Device: Stenting (Smart Stent);   Device: Stenting after PEB (Smart Stent, Invatec);   Procedure: Atherectomy (SilverHawk device)
Outcome Measures: Percentage diameter stenosis;   All-cause mortality;   Major adverse peripheral events (MAPE) defined as acute thrombosis of SFA or ipsilateral amputation or revascularization (PTA or bypass surgery);   Time to onset of any of MAPE.;   Binary restenosis rate;   Percentage diameter stenosis in duplex ultrasound;   Change from baseline in functional status and health related quality of life (Walking Impairment Questionaire)
12 Recruiting A Study to Evaluate the Effect of Oral Paliperidone Extended-Release and Oral Risperidone Immediate-Release on Cognitive Function in Clinically Stable Patients With Schizophrenia
Condition: Schizophrenia
Interventions: Drug: Paliperidone extended-release;   Drug: Risperidone immediate-release
Outcome Measures: Change in category fluency score of cognitive function scale (Cognitive Abilities Screening Instrument, Chinese version [CASI C-2.0]) from baseline to Week 24;   Change from baseline to Week 24 in score of Modified Wisconsin Card Sorting Test (MWCST) short version;   Change from baseline in score of Continuous Performance Test (CPT);   Change from baseline in score of Personal and Social Performance (PSP) scale;   Change from baseline in score of Positive and Negative Syndrome Scale (PANSS);   Change from baseline in score of Clinical Global Impression-severity (CGI-S) scale;   Change from baseline in score of Medication Satisfaction Questionnaire (MSQ)
13 Recruiting Study of Abiraterone Acetate in Patients With Advanced Prostate Cancer
Conditions: Prostate Neoplasms;   Genital Neoplasms, Male;   Urogenital Neoplasms;   Genital Diseases, Male
Intervention: Drug: Abiraterone Acetate
Outcome Measure: The number and type of adverse events reported by the investigator or the patient.
14 Recruiting Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
Conditions: Chemical Injuries;   Unspecified Complication of Corneal Transplant;   Autoimmune Diseases;   Ocular Cicatricial Pemphigoid;   Stevens Johnson Syndrome;   Lupus Erythematosus, Systemic;   Rheumatoid Arthritis;   Other Autoimmune Diseases
Intervention: Drug: Riboflavin
Outcome Measures: Changes in corneal thickness;   Lack of sterile ulcers via slit lamp;   Ocular safety;   Systemic safety
15 Recruiting Effect of Kinesiotaping on Ankle Stability
Condition: Sprain and Strain of Ankle
Interventions: Device: Leukotape K;   Device: Sham kinesiotape;   Other: Control
Outcome Measures: Effect of kinesiotaping on postural stability;   EVA scale to evaluate the sensation of postural stability
16 Recruiting A Study Comparing Long-acting Methylphenidate (ConcertaTM) vs. Placebo in the Treatment of Memory Loss Due to HIV
Condition: HIV Dementia
Interventions: Drug: Long acting methylphenidate;   Drug: Matched placebo
Outcome Measures: Change in rate of reaction time as measured by neuropsychological testing;   Number of Subjects with Adverse Events as Measures of Safety and Tolerability of Concerta in HIV infected adults
17 Recruiting A Clinical Assessment of the Hemacopolymer Daily Disposable Limbal Ring Soft Contact Lens
Condition: Myopia
Interventions: Device: Hema-copolymer Lens;   Device: etafilcon A Lens
Outcome Measure: Subjective Assessment: Changes in overall comfort preference, Overall score measured by Vertical Visual Analog Scales (0-100)
18 Not yet recruiting Docosahexaenoic Acid Supplementation of Women With Hypertension in Pregnancy to Improve Endothelial Health
Condition: Hypertension in Pregnancy
Interventions: Dietary Supplement: Docosahexaenoic acid 200 mg;   Drug: Docosahexaenoic acid 1000 mg
Outcome Measures: Improve maternal endothelial health;   Improve immune homeostasis
19 Unknown  Non-Invasive Biomarkers For Early Detection Of Lung Cancers
Condition: Lung Cancer
Intervention:
Outcome Measure:
20 Recruiting Proteolytic Enzyme Induction Within the Human Myocardial Interstitium
Condition: Heart Disease
Intervention:
Outcome Measure: Changes in Interstitial Metalloproteinase Activity From Pre-Bypass Levels

These studies may lead to new treatments and are adding insight into Johnson etiology and treatment.

A major focus of Johnson research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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