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Kivexa Medical Research Studies

Up-to-date List of Kivexa Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Kivexa Medical Research Studies

Rank Status Study
1 Recruiting Changes in Cerebral Function in Treatment Naive HIV-1 Infected Subjects Commencing Either Boosted Atazanavir With Truvada or Boosted Darunavir With Maraviroc and Kivexa
Conditions: HIV;   Impaired Cognition
Interventions: Drug: standard care;   Drug: novel treatment
Outcome Measures: cognitive function;   brain function
2 Not yet recruiting Study to Evaluate Darunavir/Ritonavir + Lamivudine Versus Continuing With Darunavir/Ritonavir + Tenofovir/Emtricitabine or Abacavir/Lamivudine in HIV Infected Subject
Condition: HIV Infection
Interventions: Drug: Darunavir/Ritonavir;   Drug: Lamivudine;   Drug: Emtricitabine/tenofovir or abacavir/lamivudine
Outcome Measures: Proportion of patients with undetectable viral load;   Proportion of patients with viral load < 200 copies/ml;   Proportion of patients who present viral load ≥ 50 copies /ml one time;   Proportion of patients who present viral load ≥ 50 copies /ml more tan two times;   Proportion of patients who maintained viral load < 50 copies/ml in all determinations;   Median of change cells CD4/µl count from basal to week 48;   Median of change in triglycerides , LDL-cholesterol, HDL-cholesterol and total cholesterol from basal to week 48;   Change in renal function;   Change in proportion of patients with renal tubular dysfunction
3 Recruiting Multicentre Study To Assess Changes In Bone Mineral Density Of The Switch From Protease Inhibitors To Dolutegravir In HIV-1-Infected Subjects With Low Bone Mineral Density
Condition: HIV-1 Infection
Interventions: Drug: Dolutegravir, 50mg every 24 hours;   Drug: Protease Inhibitor/ritonavir
Outcome Measures: Compare changes in Bone Mineral Density (BMO) measured by Dual-energy X-ray absorptiometry;   Compare changes in femur T-score measured by DEXA;   Compare changes in lumbar spine (L1-L4) T-score measured by DEXA;   HIV-1 viral load;   CD4+/CD8+ T lymphocytes count.;   Genotypic test if virological failure occurs.;   Compare changes in total cholesterol;   Compare changes in HDL cholesterol;   Compare changes in LDL cholesterol;   Compare changes in triglyceride levels.;   Compare changes in filtrate glomerular rate by MDRD equation;   Compare changes in creatinine;   Compare changes in albumine/creatinine ratio;   Compare changes in proteinuria/creatinine ratio;   Adverse events related to antiretroviral treatment (Toxicity).;   Patient withdrawal;   Compare changes in osteocalcin;   Compare changes in alkaline phosphatase;   Compare changes in telopeptide

These studies may lead to new treatments and are adding insight into Kivexa etiology and treatment.

A major focus of Kivexa research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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