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Lactated Medical Research Studies

Up-to-date List of Lactated Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Lactated Medical Research Studies

Rank Status Study
1 Recruiting High Volume Lactated Ringer's Solution and Pancreatitis
Condition: Pancreatitis
Intervention: Other: Administration of Lactated Ringer's (LR) Solution
Outcome Measures: Change from Recovery in Development of Post-ERCP Pancreatitis at 5 and 29 Days;   Number of Participants with Adverse Events Related to Fluid Overload
2 Recruiting Lactated Ringer Versus Albumin in Early Sepsis Therapy
Conditions: Septic Shock;   Severe Sepsis
Interventions: Drug: Lactated Ringer;   Drug: Albumin
Outcome Measures: Mortality in 7 days for any cause;   Evaluation of sequential organ failure assessment (SOFA) score;   ICU length of stay;   hospital length of stay;   ventilator-free days;   Needing of renal replacement therapy;   days free of vasopressor;   Mortality in 28-days
3 Recruiting Efficacy of Steroid Supplementation After TMJ Rinsing for Pain Management
Condition: Pain
Interventions: Drug: Lactated Ringers;   Drug: Triamcinolone hexacetonide
Outcome Measures: Change from Pre-Treatment in TMJ Loading Pain Rating at 12 Weeks;   Change from Pre-Treatment in TMJ Loading Pain Rating at 2 Weeks;   Change from Pre-Treatment in TMJ Loading Pain Rating at 6 Weeks;   Change From Pre-Treatment in Mandibular Range of Motion at 2 Weeks;   Change From Pre-Treatment in Mandibular Range of Motion at 6 Weeks;   Change From Pre-Treatment in Mandibular Range of Motion at 12 Weeks;   Change From Pre-Treatment Palpable Muscle Tenderness at 2 Weeks;   Change From Pre-Treatment Palpable Muscle Tenderness at 6 Weeks;   Change From Pre-Treatment Palpable Muscle Tenderness at 12 Weeks;   Change From Pre-Treatment Pain Location at 2 Weeks;   Change From Pre-Treatment Pain Location at 6 Weeks;   Change From Pre-Treatment Pain Location at 12 Weeks;   Change From Pre-Treatment Joint Sounds in 2 Weeks;   Change From Pre-Treatment Joint Sounds in 6 Weeks;   Change From Pre-Treatment Joint Sounds in 12 Weeks;   Change From Pre-Treatment Functional Pain (Chewing) at 2 Weeks;   Change From Pre-Treatment Functional Pain (Chewing) at 6 Weeks;   Change From Pre-Treatment Functional Pain (Chewing) at 12 Weeks;   Change From Pre-Treatment Jaw Opening Pain at 2 weeks;   Change From Pre-Treatment Jaw Opening Pain at 6 weeks;   Change From Pre-Treatment Jaw Opening Pain at 12 weeks;   Change From Pre-Treatment Jaw Opening Pattern at 2 Weeks;   Change From Pre-Treatment Jaw Opening Pattern at 6 Weeks;   Change From Pre-Treatment Jaw Opening Pattern at 12 Weeks
4 Recruiting Effects of Colloid and Crystalloid on the Microcirculatory Alterations During Off-pump Coronary Artery Bypass Surgery
Condition: Cardiac Surgery
Interventions: Drug: Lactated Ringer's solution;   Drug: Volulyte;   Drug: Hextend
Outcome Measures: Recovery slope;   lactate;   StO2 (tissue oxygen saturation);   Cytokine
5 Recruiting The Use of a Restrictive Fluid Regimen With Hypertonic Saline for Patients Undergoing Pancreaticoduodenectomy
Condition: Pancreaticoduodenectomy
Interventions: Drug: 3% NaCl Solution;   Drug: Lactated Ringers Solution
Outcome Measures: Anastomotic Leak;   Delayed Gastric Emptying;   Myocardial Infarction;   Pneumonia;   Wound Infection
6 Recruiting Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate Changes
Conditions: Pregnancy;   Labor Pain
Interventions: Drug: Lactated Ringers bolus of 1000 mL;   Drug: Lactated Ringers infusion @ 125 ml/hr;   Drug: Routine oxytocin;   Drug: Half-dose oxytocin
Outcome Measure: Incidence of non-reassuring fetal heart rate tracings during the first 60 minutes after the placement of epidural analgesia
7 Recruiting Safety and Feasibility Trial of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia
Condition: Myocardial Ischemia
Interventions: Device: ADRCs processed by the Celution System;   Device: Placebo Comparator: Lactated Ringer's and Subject's Blood
Outcome Measure: Treatment emergent serious adverse events (SAEs), major adverse cardiac events (MACE), arrhythmia assessment, change in cardiac function and symptoms, and resource utilization
8 Recruiting Crystalloids Versus Colloids During Surgery
Conditions: Fluid Therapy;   Morbidity
Interventions: Drug: Lactated Ringer's Solution;   Drug: Hydroxyethylstarch 6% 130/0.4
Outcome Measures: combined perioperative morbidity;   Tissue oxygenation, Wound Infection, Incidence of postoperative nausea and vomiting (PONV) and pain, pulmonary function,
9 Not yet recruiting PolyArginine Treated vEiN grafTs II (PATENT II)
Condition: Atherosclerosis
Interventions: Drug: Polyarginine;   Drug: Lactated Ringers Solution
Outcome Measure: To study the effects of arginine on saphenous vein graft patency rates
10 Recruiting A Double Blind Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for TMJ
Conditions: Temporomandibular Joint Dysfunction;   Pain;   Arthrocentesis
Interventions: Drug: Hyaluronic acid;   Drug: Corticosteroid;   Drug: Lactated Ringers
Outcome Measures: Pain;   Function
11 Not yet recruiting A Phase IIa, Single-blind, Placebo-controlled, Crossover, Multi-center, Randomized Study to Assess the Safety, Tolerability, and Preliminary Efficacy of a Single Intravenous Dose of Ischemia-tolerant Allogeneic Mesenchymal Bone Marrow Cells to Subjects With Heart Failure of Non-ischemic Etiology
Condition: Non-ischemic Heart Failure
Interventions: Drug: Human Allogeneic Mesenchymal Stem Cells;   Drug: Placebo
Outcome Measures: To assess the safety of human ischemia-tolerant allogeneic mesenchymal bone marrow cells (aMBMC) administered intravenously to subjects with heart failure (HF) of non-ischemic etiology (N-IHF).;   Change in Left Ventricle Ejection Fraction (LVEF) from baseline to day 90 post infusion
12 Recruiting Study of Concentration and Antimicrobial Activity of Antibiotics Used for Catheter-Related Infections
Conditions: Catheter-related Bloodstream Infection.;   Bacteremia.
Interventions: Drug: Administration of vancomycin in antibiotic lock solution;   Drug: Administration of teicoplanin in antibiotic lock solution;   Drug: Administration of linezolid in antibiotic lock solution;   Drug: Administration of daptomycin in antibiotic lock solution;   Drug: Administration of tigecycline in antibiotic lock solution
Outcome Measures: Antibiotic concentration in catheter-lock solutions at the end of day 1.;   Antibiotic concentration in catheter-lock solutions at the end of day 3.;   Antibiotic concentration in catheter-lock solutions at the end of day 5.;   Antibiotic concentration in catheter-lock solutions at the end of day 7.;   Antibiotic concentration in catheter-lock solutions at the end of day 10.;   Antimicrobial activity of antibiotics in lock solutions at the end of lock time assigned.;   Anticoagulant activity of heparin in antibiotic lock solutions at the end of lock time assigned.
13 Unknown  Fluid Infusion During Breast Surgery
Condition: Breast Surgery
Interventions: Drug: Hydroxyethylstarch 130/0,4;   Drug: Lactated Ringer's solution
Outcome Measures: To investigate orthostatic function, measured by Finapress;   To investigate the occurrence of postsurgery nausea/vomiting.;   To investigate the amount of time until discharge criteria from the Postanaesthetic Care Unit have been achieved.;   To investigate balance function, measured by BalanceMaster
14 Recruiting Randomized Trial of Aggressive Fluid Hydration to Prevent Post ERCP Pancreatitis
Condition: Pancreatitis
Interventions: Other: Aggressive Intravenous Hydration Group;   Other: Standard Fluids Arm
Outcome Measures: Acute Pancreatitis;   Clinical volume overload;   Serum amylase three times the upper limit of normal;   Increased abdominal pain
15 Not yet recruiting Effects of Oxytocin on Bleeding Outcomes During Dilation and Evacuation
Conditions: Abortion;   Dilation and Evacuation;   Hemorrhage;   Blood Loss
Intervention: Drug: intravenous oxytocin
Outcome Measure: Rate at which providers intervene to control blood loss during D&E procedures.
16 Recruiting Hypothermic Perfusion During Hemihepatectomy
Condition: Hepatic Ischemia-reperfusion Injury
Intervention: Procedure: In situ hypothermic perfusion
Outcome Measures: Postoperative hepatocellular damage;   Intraoperative blood loss;   Postoperative complications;   Regeneration of liver function and volume
17 Recruiting Effect of Goal- Directed Crystalloid Versus Colloid Administration on Major Postoperative Morbidity
Condition: Postoperative Complications
Interventions: Other: Crystalloid;   Other: Colloid
Outcome Measures: Non-fatal postoperative complications;   Perfusion;   Oxygenation;   collagen;   Orthogonal polarization spectral (OPS) imaging;   cardiac function;   renal function;   Post Operative Nausea and Vomiting (PONV);   pain;   return to function;   ICU Admission;   duration of ICU stay;   duration of mechanical ventilation;   duration of hospitalization;   readmission
18 Unknown  Early Fluid Resuscitation With Balanced HES 130/0.4 [6%] in Severe Burn Injury
Condition: Burns
Interventions: Drug: Fluid resuscitation;   Drug: HES 130/0.4 (6%), Voluven balanced vs. Lactated Ringer's solution
Outcome Measure: Reduced amount of fluids given
19 Recruiting Trial Of Normal Saline Versus Ringer's Lactate In Paediatric Trauma Patients
Condition: Trauma
Interventions: Drug: Normal Saline;   Drug: Ringer's Lactate
Outcome Measures: The difference in serum sodium change over 24 hours between patients receiving NS versus RL;   The difference in serum pH;   The difference serum chloride;   The differences in serum bicarbonate;   The differences in serum inflammatory biomarker change: Erythrocyte Sedimentation Rate (ESR);   The differences in serum inflammatory biomarker change: C-Reactive Protein;   The differences in serum inflammatory biomarker change: InterLeukin-6;   The differences in serum inflammatory biomarker change InterLeukin-8;   The differences in serum inflammatory biomarker change: G-CSF;   The differences in serum inflammatory biomarker change: MCP-1
20 Not yet recruiting Vascular Changes During Colorectal Surgery
Condition: Patients Undergoing Open Resection of Colorectal Tumours
Intervention: Drug: Hartmann's solution
Outcome Measure: Changes in microvascular blood flow during colorectal surgery

These studies may lead to new treatments and are adding insight into Lactated etiology and treatment.

A major focus of Lactated research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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