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Lactose Medical Research Studies

Up-to-date List of Lactose Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Lactose Medical Research Studies

Rank Status Study
1 Recruiting The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population
Conditions: Lactose Intolerance;   Irritable Bowel Syndrome
Intervention: Dietary Supplement: dietary restriction
Outcome Measures: To assess the effects of Lactose intolerance on gastrointestinal function and symptoms;   To measure the intake of dietary Lactose in the adult general population and in patients with IBS;   To assess genetic factors, tolerance to Lactose challenge and visceral sensitivity.;   To assess appropriate dosage of Lactose hydrogen breath test;   To determine the impact of a determined dietary intervention on abdominal symptoms compatible with D-IBS.;   To explore the association of visceral sensitivity induced by LI with mucosal immune activation and psychological factors in D-IBS patients
2 Recruiting Secondary Lactose Intolerance Due to Chronic Norovirus Infection
Condition: Chronic Diarrhea
Intervention: Behavioral: Lactose H2 breath test (LH2BT)
Outcome Measure: Lactose intolerance
3 Not yet recruiting The Effect of Probiotics on Lactose Intolerance
Condition: Lactose Intolerance
Intervention: Dietary Supplement: Bio-25
Outcome Measure: Change of hydrogen levels measured due to probiotics administration
4 Unknown  Effect of Lactose in Patients With Chronic Liver Disease and Minimal Hepatic Encephalopathy
Conditions: Hepatic Encephalopathy;   Liver Cirrhosis
Intervention: Dietary Supplement: whole milk vs Lactose-free milk
Outcome Measures: Reversion of Minimal Hepatic Encephalopathy (psychometric test);   Quality of life and blood ammonium
5 Recruiting Lactose, Sucrose & Corn Syrup Tolerance
Condition: Focus of Study: Oral Tolerance Test With Glucose, Lactose, Sucrose
Interventions: Dietary Supplement: corn syrup solids;   Dietary Supplement: sucrose
Outcome Measures: Postprandial changes in plasma insulin, glucagon, triglycerides and amino acids.;   Postprandial changes in plasma fatty acids.
6 Unknown  Efficacy of L-Ornithine L-Aspartate in Acute Hepatic Encephalopathy.
Condition: Hepatic Encephalopathy
Interventions: Drug: L-ornithine-L-aspartate;   Drug: Lactose
Outcome Measures: Sustained improvement of at least one grade in mental state based on the West Haven criteria;   Severity of hepatic encephalopathy assessed by the West Haven criteria;   Severity of hepatic encephalopathy assessed by the Glasgow Coma Scale;   Severity of hepatic encephalopathy assessed by the Clinical Hepatic Encephalopathy Staging Scale (CHESS);   Decrease in venous ammonia levels;   Improvement in electroencephalographic tracing
7 Not yet recruiting A Placebo Controlled Study of Homeopathic Treatment of Children and Youth With ADHD
Condition: Attention Deficit Hyperactivity Disorder
Interventions: Drug: Lactose/sucrose granule (Individualized homeopathic medicine treatment);   Drug: Unmedicated Lactose/sucrose pill;   Behavioral: Homeopathic consultation
Outcome Measures: Change from baseline in Conners 3 Global Index - Parent;   Change from baseline in Conners ADHD Index Probability score;   Change from baseline in Conners Content Scale for Inattention and Hyperactivity/Impulsivity;   Change from baseline in Conners DSM-IV-TR Symptom Scale for the ADHD Inattentive and ADHD Hyperactive-Impulsive subtypes;   Clinical Global Impression-Improvement scale;   Change from baseline in the Pediatric Quality of Life Inventory;   Change from baseline in Consultation and Relational Empathy measure;   Change from baseline in RTI Provider Support Measure;   Change from baseline in the Resiliency Scales for Children & Adolescents - Mastery sub-scale;   Change from baseline in Coping Efficacy Scale;   Change from baseline in Control Beliefs Inventory - Mastery sub-scale
8 Recruiting Fructans, Lactitol and Lactose in Minimal Hepatic Encephalopathy
Condition: Liver Cirrhosis
Interventions: Dietary Supplement: Red cereal bar;   Dietary Supplement: Green cereal bar;   Dietary Supplement: White cereal bar
Outcome Measures: Minimal hepatic encephalopathy;   Nutritional Status
9 Unknown  Colchicine Treatment for Chronic Shoulder Pain Related to Calcific Tendonitis
Condition: Calcific Tendonitis
Interventions: Drug: Colchicine;   Drug: Lactose
Outcome Measures: VAS for shoulder pain;   shoulder range of motion;   shoulder pain and disability index
10 Recruiting SLOS: The Effect of Simvastatin in Patients Receiving Cholesterol Supplementation
Condition: Smith-Lemli-Opitz Syndrome
Interventions: Drug: Simvastatin;   Dietary Supplement: Lactose
Outcome Measures: Intellectual quotient (IQ);   Development Quotient (DQ);   Whole body cholesterol pool size, synthesis & absorption using stable isotope testing;   Plasma and urine markers of sterol metabolism;   Apparent diffusion coefficient (ADC) and fractional anisotopy FA and MRS lipids (brain MRI/MRS);   Log of response amplitude (electroretinogram)
11 Recruiting An N-of-1 Study of Homeopathic Treatment of Fatigue in Patients Receiving Chemotherapy
Conditions: Fatigue;   Effects of Chemotherapy
Interventions: Other: Homeopathic medicine;   Other: Unmedicated Lactose/sucrose globule
Outcome Measures: Multidimensional Fatigue Inventory (MFI);   EORTC-QLQ-C30
12 Unknown  Comparing the Efficacy of Pregabalin and Hydroxyzine on the Anxiety Score
Condition: Feeling Anxious
Interventions: Drug: hydroxyzine;   Drug: Pregabalin;   Drug: Lactose
Outcome Measures: Efficacy treatment;   Efficacy of pregabaldin
13 Not yet recruiting Efficacy Study of Multiple Micro Nutrients Supplementation
Condition: Anemia, Iron-deficiency
Interventions: Dietary Supplement: Multi-micronutrients;   Dietary Supplement: Maltodextrin and Lactose
Outcome Measures: Haemoglobin level;   Anemia prevalence;   Anthropometric;   Micronutrients
14 Recruiting Small and Large Bowel Transit Tests Using MRI (Study 1)
Condition: Irritable Bowel Syndrome
Intervention:
Outcome Measures: Study 1:Correlation between mean orocaecal transit time as assessed by MRI and Lactose C13-ureide;   Study 1: Correlation between colonic transit as assessed by from the geometric centre of the PTFE capsule at time 24 and 48 hours and Metcalf Radio-opaque marker method;   Study 2: Fasting small bowel water content;   Study 1:To assess reproducibility of the using MRI for orocaecal transit time and colonic transit time;   Study 2: Orocaecal transit time using Lactose C13-ureide;   Study 2: Area under the curve (AUC) post prandial SBWC;   Study 2: Ascending colon water content (ACWC) and colonic water index (CWI);   Study 2: Colonic volumes both fasting and post prandial (divided into ascending transverse and descending colon);   Study 2: Whole gut transit time assess by MRI marker capsule from study 1;   Study 2: Correlation between the Hospital Anxiety & Depression Scale (HADS) and other measures of anxiety and stress score and (a) Oro-caecal transit time and (b)whoe gut transit time
15 Recruiting Donepezil Effect on Visual Attention and Training
Condition: Healthy
Interventions: Drug: Donepezil administration;   Drug: Placebo administration
Outcome Measures: Measure of the speed threshold, baseline;   Change from baseline of the speed threshold at 1 week;   Change from baseline of the speed threshold at 2 weeks;   Change from baseline of the speed threshold at 3 weeks;   Change from baseline of the speed threshold at 4 weeks
16 Recruiting The Effect of Short-term Atorvastatin Treatment on Immune Responses to Pneumovax 23
Condition: Healthy Controls
Interventions: Drug: Atorvastatin;   Drug: Pneumovax 23;   Other: Placebo (Lactose pill)
Outcome Measures: Determine the effect of atorvastatin treatment on pneumococcal antigen specific antibody production.;   Determine the effect of atorvastatin treatment on immunogenic cytokine levels following pneumococcal vaccination.
17 Unknown  Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination
Condition: Pain, Postoperative
Interventions: Drug: Ibuprofen + Paracetamol;   Drug: Ibuprofen + Paracetamol + Codeine;   Drug: Paracetamol + Codeine;   Drug: Placebo
Outcome Measures: Sum pain intensity SPI (0-10 Numerical Rating Scale);   Sum pain intensity difference score (PID);   Overall assessment of efficacy (4-point Verbal Rating Scale);   Adverse effects AE (Specific reporting of AE - type, duration and severity)
18 Recruiting Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction
Condition: Nicotine Dependence
Interventions: Drug: Gemfibrozil;   Drug: Placebo
Outcome Measures: Nicotine Reinforcement and Smoking Cue Reactivity;   Smoking abstinence during quit-attempt weeks
19 Unknown  Vitamin D Replacement in Statin-Induced Myopathy
Condition: HMG COA Reductase Inhibitor Adverse Reaction
Interventions: Drug: Vitamin D (Cholecalciferol );   Drug: Placebo
Outcome Measures: lack of need to stop statin medication due to myalgia;   reduction of visual analog pain score
20 Recruiting The Effect of Melatonin on Nocturnal Enuresis
Condition: Nocturnal Enuresis
Interventions: Drug: Melatonin;   Drug: Lactose
Outcome Measures: number of incontinence episodes;   nocturnal blood pressure;   activity level;   bladder capacity;   nocturnal urine production

These studies may lead to new treatments and are adding insight into Lactose etiology and treatment.

A major focus of Lactose research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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