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Laryngeal Medical Research Studies

Up-to-date List of Laryngeal Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Laryngeal Medical Research Studies

Rank Status Study
1 Recruiting Evaluation of Laryngeal Ultrasonography Performance in Predicting Major Post Extubation Laryngeal Edema in Intensive Care Patients
Conditions: Laryngeal Edema;   Acute Respiratory Failure Requiring Reintubation
Outcome Measures: Performance of Laryngeal ultrasonography in predicting major post extubation Laryngeal edema in intensive care patients.;   Performance of Laryngeal ultrasonography in predicting post-extubation stridor in intensive care patients.;   Frequency of major post-extubation Laryngeal edema and post-extubation stridor;   Risk factors of major post-extubation Laryngeal edema in intensive care unit;   Evolution of ultrasonic parameters with corticotherapy after reintubation for a major post-extubation Laryngeal edema;   Evaluation of impact of major post-extubation Laryngeal edema occurence on mechanical ventilation duration, hospitalization duration and mortality in intensive care unit;   Inter-observer reproductibility of ultrasound scanning and ultrasonic air-leak volume measurement
2 Unknown  Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway
Condition: Respiratory Distress Syndrome, Newborn
Interventions: Procedure: Use tracheal intubation for surfactant therapy;   Procedure: Use of Proseal Laryngeal mask airway for surfactant therapy
Outcome Measures: Fraction of inspired oxygen;   Hormonal evaluation of pain;   Proseal Laryngeal mask surfactant treatment failure;   Rate of respiratory distress syndrome complications
3 Recruiting Laryngeal Mask Supreme During Laparoscopic Gynecologic Surgery
Condition: Anaesthesia
Interventions: Device: Laryngeal Mask Airway-Supreme;   Device: Endotracheal Tube
Outcome Measures: To asses the effective ventilation parameters without neuromuscular agents;   Surgeon wiev;   Evaluation of gastric distention;   Number of attempts taken for successful placement of gastric tube;   Haemodynamic response to insertion of airway device;   Incidence of post-operative sore throat
4 Recruiting Value of Narrow Band Imaging (NBI) Endoscopy in the Early Diagnosis of Laryngeal Cancer and Precancerous Lesions
Conditions: Chronic Inflammation of Hypopharynx;   Hoarseness;   Macroscopic Laryngeal Lesions;   Histological Confirmation of Dysplasia;   Carcinoma in Situ;   Invasive Carcinoma of Larynx;   Invasive Carcinoma of Hypo Pharynx;   Recurrent Respiratory Papillomatosis
Intervention: Device: NBI endoscopy
Outcome Measures: The number of patients with larger extent of the Laryngeal lesison on NBI examination when compared to standard white light endoscopy;   The number of patients with histologically proven Laryngeal cancer
5 Not yet recruiting Induction Docetaxel/Cisplatin/5-fluorouracil (TPF) as Selector for Chemo Radiation Therapy (RT) Versus Partial Laryngectomy in Advanced Laryngeal Cancer
Condition: Larynx Cancer
Interventions: Procedure: laryngoscopy;   Drug: Taxotere (Docetaxel), Cisplatin, 5FU
Outcome Measures: Improvement in larynx preservation free survival;   Improvement in overall survival in patients treated under this regimen in comparison to historical control
6 Recruiting Evaluation of the Intubating Laryngeal Airway in Children
Condition: Intubating Laryngeal Airway
Intervention: Device: AirQ Intubating Laryngeal Airway
Outcome Measure: Oropharyngeal leak pressure is the most commonly reported primary outcome measure of LMA performance. If fresh gas destined for the lung alveoli leaks around the LMA, inadequate ventilation may result, leading to respiratory acidosis.
7 Recruiting Randomized Clinical Trial Assessing Laryngeal Mask Airway Versus Face-mask Ventilation in Neonatal Resuscitation
Condition: Asphyxia Neonatorum
Interventions: Device: Laryngeal Mask Airway;   Device: Face mask ventilation
Outcome Measures: time to spontaneous ventilation;   proportion of infants who require advanced resuscitation;   the proportion of infants with adverse birth outcome
8 Recruiting Comparison of Clinical Performance of the Guardian Laryngeal Mask With LMA Proseal
Condition: Focus:Efficacy of Oropharyngeal Seal Pressure
Interventions: Device: Guardian Laryngeal Mask;   Device: Proseal Laryngeal Mask Airway
Outcome Measures: Oropharyngeal seal pressure;   Anatomic position
9 Not yet recruiting The Yield of Laryngeal Ultrasound in the Diagnosis of Laryngomalacia
Conditions: Stridor;   Laryngomalacia
Intervention: Other: Laryngeal ultrasound
Outcome Measures: The yield of US in diagnosing laryngomalacia in comparison to FLB.;   The yield of US in diagnosing other causes of congenital stridor compared to FLB.
10 Not yet recruiting Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants
Conditions: Disorder of Upper Respiratory System;   Laryngostenosis;   Tracheal Stenosis
Intervention: Other: Stem cell based tissue engineered partial Laryngeal implants
Outcome Measures: Safety of tissue engineered lyryngotracheal replacement;   Efficacy of tissue engineered lyryngotracheal replacement
11 Recruiting Superior Laryngeal Nerve Block For Awake Endotracheal Intubation Study
Conditions: Awake Endotracheal Intubation;   Difficult Intubation;   Airway Anesthesia
Intervention: Procedure: Superior Laryngeal Nerve Block using the Thyrohyoid Membrane as an Anatomic Landmark
Outcome Measures: The primary outcome measure is to assess the efficacy of blocking the superior Laryngeal nerve by using cough at the vocal cords on a 4 point scale;   Time to placement of block
12 Recruiting Blind Intubation Through The Self-Pressurised Disposable Air-Q Laryngeal Intubation Mask: An International Multicentre Trial
Condition: Elective Surgery Requiring Tracheal Intubation Using an Oral Tracheal Tube
Intervention: Device: Air-Q Intubation Laryngeal Mask
Outcome Measures: Success rate of blind intubation via the disposable Air-Q self-inflating Laryngeal intubation mask.;   Time for insertion of the Air-Q Laryngeal mask;   Time for insertion of the tube;   First attempt rate and second attempt rate;   Time for removal of the Air-Q ILA device after successful intubation;   Rate of misplacement of the ILA;   Rate of misplacement of the tube;   risk factors of insertion failures;   Rate of airway injuries;   Tightness during leak test before relaxation;   Tightness during leak test after relaxation;   Maximum drop of saturation during airway management;   Rate of adverse events;   Rate of necessity of alternative airway device;   Rate of blood stained devices after removal of the ILA;   Postoperative coughing after 2 hours and the next morning;   Postoperative hoarseness after 2 hours and the next morning
13 Recruiting Laryngeal Mask Airway (LMA) for Surfactant Administration in Neonates
Condition: Respiratory Distress Syndrome
Interventions: Device: Nasal continuous positive airway pressure (nCPAP);   Device: Laryngeal Mask Airway (LMA) to deliver surfactant
Outcome Measures: Need for intubation and mechanical ventilation in the first seven days of life.;   Duration of CPAP therapy;   Duration of oxygen therapy;   Incidence of pulmonary airleaks;   Incidence of severe IVH or PVL;   Incidence of Chronic Lung Disease;   Time, number of attempts, and physiologic stability
14 Recruiting Observational Study of Swallowing Function After Treatment of Advanced Laryngeal Cancer
Conditions: Squamous Cell Carcinoma;   Laryngeal Cancer
Outcome Measures: Swallowing Function Scores;   General Quality of Life;   Speech Assessment;   Head and Neck Quality of Life
15 Unknown  Comparison of Two Insertion Techniques of Proseal Laryngeal Mask Airway by Unskilled Personnel in Children
Condition: Airway Management
Intervention: Procedure: McIvor retractor
Outcome Measures: the success rate of proseal Laryngeal mask airway (PLMA) insertion;   the incidence of complications following PLMA insertion
16 Recruiting The Influence of Degree of Head Elevation on Insertion Success for ProSeal Laryngeal Mask Airway Insertion
Condition: Anesthesia
Intervention: Device: Insertion of ProSeal Laryngeal mask airway
Outcome Measures: insertion success rate;   complication
17 Recruiting Air-Q® SP Versus Air-Q® and I-gel
Condition: Laryngeal Masks
Interventions: Device: air-Q SP;   Device: air-Q;   Device: i-gel
Outcome Measures: Airway seal pressure after device placement;   Device placement time;   Device placement success rate;   Device ease of insertion;   Device position in relation to the vocal cords;   Incidence of gastric insufflation;   Incidence of gastric aspiration;   Incidence of oropharyngeal injury;   Incidence of device repositioning and/or replacement;   Hemodynamic measures at baseline;   Hemodynamic measures at 1 minute after device placement;   Hemodynamic measures at 2 minutes after device placement;   Hemodynamic measures at 3 minutes after device placement;   Hemodynamic measures at 4 minutes after device placement;   Hemodynamic measures at 5 minutes after device placement;   Overall clinical usefulness;   OropharyngoLaryngeal morbidity at discharge;   OropharyngoLaryngeal morbidity at 24 hours post-operatively
18 Recruiting Thyroidectomy Using Ultrasonic Dissector: Is Superior Laryngeal Nerve Really Safe ?
Condition: Goiter
Interventions: Device: Thyroidectomy using harmonic focus (r);   Procedure: Conventional thyroidectomy
Outcome Measures: Assessment of superior Laryngeal nerve function;   Assessment of inferior Laryngeal nerve function;   Assessment of other complications
19 Recruiting Evaluation of the Intubating Laryngeal Airway in Children
Condition: Device - Intubating Laryngeal Airway
Outcome Measure:
20 Recruiting Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome
Condition: Respiratory Distress Syndrome, Newborn
Interventions: Device: Endotracheal intubation;   Device: Laryngeal mask airway
Outcome Measures: Avoidance of invasive mechanical ventilation;   Number of surfactant doses;   Days on any respiratory support;   Rate of Pneumothorax;   Rate of bronchopulmonary dysplasia (O2 dependence at the later of 28 days of age or 36 weeks postmenstrual age);   Complications during insertion of LMA or endotracheal tube;   Mortality rate

These studies may lead to new treatments and are adding insight into Laryngeal etiology and treatment.

A major focus of Laryngeal research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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