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Lescol Medical Research Studies

Up-to-date List of Lescol Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Lescol Medical Research Studies

Rank Status Study
1 Recruiting Fluvastatin AmelIorates aTHerosclerosis Study
Conditions: Coronary Heart Disease;   Atherosclerosis
Intervention: Drug: Fluvastatin extended release tablet
Outcome Measures: carotid IMT;   lipid variables:TC, TG, LDL-C, HDL-C, apo B, apo A-I
2 Unknown  Randomized Study to Evaluate the Efficacy of Fluvastatin on Inflammatory Markers in Patients With Aortic Stenosis.
Condition: Aortic Valve Stenosis
Intervention: Drug: Fluvastatin
Outcome Measures: To study changes in CRP (mg/dL) concentration at the end of the study (12 months);   To study changes in other inflammatory biomarkers (specify in the protocol) at the end of the study (12 months);   To study changes in these biomarkers in the different grades of aortic stenosis at the end of the study (12 months);   To study changes change in aortic valve area and medium aortic transvalvular gradient at the end of the study (12 months);   To study the safety and tolerability of fluvastatin in patients with aortic stenosis.
3 Recruiting Novel Window of Opportunity Trial to Evaluate the Impact of Statins to Oppose Prostate Cancer
Condition: Prostate Cancer
Interventions: Drug: Fluvastatin;   Drug: Pimonidazole
Outcome Measures: Pre and post treatment effect on the Ki-67 proliferation index;   Comparison of immunohistochemical staining in Biopsy and post-RP tissues
4 Not yet recruiting Safety of Fluvastatin-Celebrex Association in Low-grade Optico-chiasmatic Gliomas
Condition: Gliomas.
Interventions: Drug: Fluvastatine;   Drug: Celebrex
Outcome Measures: Maximum tolerated dose (MTD) of Fluvastatine combined to a fixed-dose of Celebrex;   Safety;   Efficacy;   Progression-free;   Potential interactions between the two drugs
5 Unknown  Statin Therapy in Asymptomatic Aortic Stenosis
Condition: Aortic Valve Stenosis
Intervention: Drug: fluvastatin
Outcome Measures: Progression of calcified aortic stenosis measured by:;   Transthoracic echocardiography (P max/ mean; V max; AVA);   Catheterization (peak to peak gradient, LV-function, compliance);   Number of cardiovascular events
6 Recruiting Statin Recapture Therapy Before Coronary Artery Bypass Grafting
Condition: Coronary Artery Disease
Interventions: Drug: Statin Recapture Therapy;   Drug: Placebo
Outcome Measures: Major adverse cardiocerebral events (MACCE) within 30 days after CABG.;   Major adverse cardiac events;   Length of stay;   Repeat coronary revascularisation;   Mortality at 12 months;   Wound Infections;   Atrial fibrillation
7 Unknown  The Role of the "Inflammatory/ Pathogen Burden" for Cardiac Ageing
Conditions: Aging;   Inflammation
Intervention: Drug: fluvastatin
Outcome Measures: reduced narrowing of heart rate variability (measured by SDNN of a standardised 20 minute- resting-ecg) via lowering inflammatory/ pathogen burden by anti-inflammatory measures (standardized physical activity and statin administration);   quality of life;   inflammatory parameters;   major adverse cardiac events (MACE)including death, non lethal myocardial infarction and hospitalisation for cardiovascular reason;   inflammatory parameters in vaccinated and unvaccinated probands;   heart rate variability in vaccinated and unvaccinated probands;   evidence of reduced narrowing of heart rate variability (measured by SDNN of a 24-hours-holter-ecg) via lowering inflammatory/ pathogen burden by anti-inflammatory measures (standardized physical activity and statin administration)
8 Recruiting Efficacy and Safety Evaluation of Alirocumab in Patients With Heterozygous Familial Hypercholesterolemia or High Cardiovascular Risk Patients With Hypercholesterolemia on Lipid Modifying Therapy
Condition: Hypercholesterolemia
Interventions: Other: placebo;   Drug: alirocumab SAR236553 (REGN727);   Drug: pravastatin;   Drug: simvastatin;   Drug: fluvastatin;   Drug: atorvastatin;   Drug: pitavastatin;   Drug: rosuvastatin
Outcome Measures: The percent change in calculated LDL-C;   The proportion of patients reaching LDL-C goal
9 Unknown  Intensive Medical Treatment for Nephropathy Caused by Type 2 Diabetes With Hypertension
Conditions: Type 2 Diabetes Mellitus;   Hypertension
Intervention: Drug: Intensive therapy Valsartan,Fluvastatin
Outcome Measures: Proteinuria;   Serum Creatinine;   e-GFR;   Fasting Plasma Glucose;   HbA1c;   Lipid profile;   Blood pressure;   Smoking;   Progression of renal dysfunction;   Urinary 8-OHdG,type 4 collagen,high molecular weight adiponectin;   Serum angiotensinogen
10 Recruiting Optimal Blood Pressure and Cholesterol Targets for Preventing Recurrent Stroke in Hypertensives
Conditions: Stroke;   Transient Ischemic Attack;   Hypertension
Intervention: Drug: all approved antihypertensive drugs; all approved statins
Outcome Measures: Recurrent stroke;   Major cardiovascular (CV) events;   Cognitive impairment and dementia
11 Recruiting A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High Risk Patients With Hypertriglyceridemia and on Statin. The Primary Objective is to Evaluate the Effect of 4 g/Day AMR101 for Preventing the Occurrence of a First Major Cardiovascular Event.
Condition: Cardiovascular Diseases
Interventions: Drug: AMR101;   Drug: Placebo
Outcome Measures: Composite endpoint of CV death, MI, stroke, coronary revascularization, and hospitalization for unstable angina.;   Incidence of additional cardiovascular events, lipid and lipoprotein levels, subgroup analyses such as: diabetics, etc.
12 Unknown  Evaluation of Patients With Statin Myopathy Using an N of 1 Trial Design
Condition: Statin Myopathy
Intervention: Drug: Individual-specific statin causing myopathy
Outcome Measures: To assess the reliability and reproducibility of subjective symptoms of myalgias to active statin therapy.;   To delineate the relation of objective changes in non-invasive neuromuscular testing to subjective symptoms during the first exposure to active or placebo therapy, in subset of 5 patients with prior history of statin myopathy.
13 Recruiting Anti-Inflammatory Treatment of Schizophrenia
Condition: Schizophrenia
Interventions: Drug: Anti-inflammatory Combination Therapy;   Drug: Placebo
Outcome Measures: Change in persistent positive symptoms;   Change in neuropsychological test performance;   Side effects;   Change in depressive symptoms;   Change in negative symptoms;   Change in pro-inflammatory cytokines

These studies may lead to new treatments and are adding insight into Lescol etiology and treatment.

A major focus of Lescol research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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