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Levocarnitine Medical Research Studies

Up-to-date List of Levocarnitine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Levocarnitine Medical Research Studies

Rank Status Study
1 Recruiting Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants
Conditions: Prematurity;   Neurodevelopmental Disorder;   Carnitine Deficiency
Interventions: Drug: L-carnitine;   Drug: 5% Dextrose
Outcome Measures: Time to regain birthweight in infants who receive L-carnitine supplementation compared to controls;   Measure motor development indices in infants who receive L-carnitine supplementation compared to controls;   Measure mental development indices in infants who receive L-carnitine supplementation compared to controls;   Measure brain maturation as measured by amplitude-integrated EEG measurement in infants who received L-carnitine supplementation compared to controls;   Measure white matter development, brain volumes and brain metabolism in infants who received L-carnitine supplementation compared to controls;   Measure rate of head growth in infants who receive L-carnitine supplementation compared to controls
2 Not yet recruiting Identification of Carnitine-Responsive Cardiomyopathy
Condition: Carnitine Deficiency
Intervention: Drug: Carnitine
Outcome Measures: Serum Carnitine Concentration;   Echocardiographic Measures;   B-Natriuretic Peptide (BNP)
3 Not yet recruiting Effect of Carnitine Deficiency on Myocardial Function in Children Receiving Continuous Renal Replacement Therapy
Condition: Acute Renal Failure
Intervention: Drug: Carnitine
Outcome Measures: Cardiac function of children receiving carnitine compared with controls during CRRT;   Prevalence of carnitine deficiency in children receiving CRRT
4 Recruiting Valproate and Levocarnitine in Children With Spinal Muscular Atrophy
Condition: Spinal Muscular Atrophy
Interventions: Drug: Valproate, Levocarnitine;   Drug: Placebo
Outcome Measures: Change in muscle power on a 5 point scale as per the principles of manual muscle testing at 12, 24, 36 and 52 weeks;   a) Change in functional measure using modified Hammersmith Functional Motor Scale (MHFMS) score at 12, 24, 36 and 52 weeks 12, 24, 36 and 52 weeks.
5 Not yet recruiting The Effect of Oral Carnitine Supplementation on MRS-derived Mitochondrial Function
Conditions: Elderly;   Pre-diabetic
Interventions: Dietary Supplement: Carnitor;   Other: Acute Exercise
Outcome Measures: Change in Acylcarnitine/Carnitine ratio;   Change in Protein acetylation;   Change in Insulin Sensitivity;   Change in Mitochondrial Function
6 Recruiting Levocarnitine in Treating Patients With Vismodegib-Associated Muscle Spasms
Condition: Musculoskeletal Complications
Interventions: Dietary Supplement: Levocarnitine;   Other: placebo;   Other: questionnaire administration
Outcome Measures: Mean difference in muscle spasm number in a week;   Mean severity of muscle spasm;   Proportion of participants who answered "yes" to functional and psychosocial effects of muscle spasms
7 Not yet recruiting Carnitine for the Treatment of Atherosclerosis.
Condition: Metabolic Syndrome
Interventions: Dietary Supplement: L-carnitine capsules;   Dietary Supplement: Lactose capsules
Outcome Measures: Change in carotid Total Plaque Volume;   Change in LDL size profile
8 Not yet recruiting Aberrations in Carnitine Homeostasis in Congenital Heart Disease With Increased Pulmonary Blood Flow
Conditions: Heart Septal Defects, Ventricular;   Atrioventricular Septal Defect
Intervention: Drug: IV L-carnitine
Outcome Measures: Blood carnitine level (free, total, and acylcarnitine);   Bioavailable nitric oxide;   Plasma levels of superoxide;   Carnitine Palmityl Transporter-1 and -2 expression;   Cardiopulmonary bypass;   Echocardiographic measurements;   Blood BNP level;   Duration of mechanical ventilation;   Vasopressor infusions;   Need for inhaled nitric oxide;   Incidence of low cardiac output syndrome;   Need for extracorporeal life support;   Plasma H202 levels;   Aortic cross clamp times
9 Not yet recruiting Preventing Contrast-induced Nephropathy: Evaluating Hydration Strategies and L-carnitine Administration
Conditions: Acute Kidney Injury;   Renal Insufficiency
Interventions: Drug: Hydration strategy using saline;   Drug: Hydration strategy using sodium bicarbonate;   Drug: L-carnitine;   Procedure: Coronarography
Outcome Measures: Change in glomerular filtration rate;   Contrast induced nephropathy?;   Change in creatinemia;   % Change in creatinemia;   Change in glomerular filtration rate compared to baseline;   Quantity of contrast material injected / glomerular filtration rate;   Quantity of iodine injected / glomerular filtration rate;   Hemodialysis necessary?;   Mortality;   Change in serum ngal
10 Recruiting Rapid Administration of Carnitine in sEpsis
Condition: Septic Shock
Interventions: Drug: Levo-Carnitine;   Drug: placebo
Outcome Measures: delta SOFA;   Mortality
11 Recruiting Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis
Condition: Non-alcoholic Steatohepatitis
Interventions: Drug: Atorvastatin;   Drug: L-Carnitine;   Drug: Placebo
Outcome Measures: improvement in liver stiffness;   improvement in liver enzyme levels;   Adverse drug events
12 Recruiting Effect of an L-carnitine-containing Peritoneal Dialysis (PD) Solution on Insulin Sensitivity in Patients on Continuous Ambulatory Peritoneal Dialysis (CAPD)
Conditions: End Stage Renal Disease;   Insulin Resistance
Interventions: Drug: PD solution;   Drug: PD solution containing L-carnitine
Outcome Measures: To assess the efficacy of L-Carnitine containing PD solution on insulin sensitivity evaluated by euglycemic hyperinsulinemic clamp;   To assess the efficacy of L-Carnitine containing PD solution on plasma lipids and lipoprotein profile;   To assess the efficacy of L-Carnitine containing PD solution on hematological parameters (hemoglobin and EPO requirements)
13 Recruiting Effect of an L-Carnitine-Containing Peritoneal Dialysis (PD) Solution on Insulin Sensitivity in Diabetic Patients on Continuous Ambulatory Peritoneal Dialysis (CAPD)
Conditions: End Stage Renal Disease;   Diabetes
Interventions: Drug: PD Solution;   Drug: PD solution containing L-carnitine
Outcome Measures: To assess the efficacy of L-Carnitine containing PD solution on insulin sensitivity evaluated by measuring insulin requirement;   To assess the efficacy of L-Carnitine containing PD solution on plasma lipids and lipoprotein profile;   To assess the efficacy of L-Carnitine containing PD solution on hematological parameters (hemoglobin and EPO requirements)
14 Unknown  The Effects of L-carnitine on Fatigue in Spinal Cord Injury
Condition: Spinal Cord Injury (SCI)
Intervention: Drug: L-Carnitine
Outcome Measures: Fatigue Severity Scores (FSS) will be completed by subjects biweekly;   Fatigue VAS-F will be completed by subjects biweekly;   Pain VAS-P will be completed by subjects biweekly;   Depression CES-D will be completed by subjects biweekly
15 Recruiting L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis
Condition: Acute Pyelonephritis(APN)
Intervention: Drug: L-carnitine
Outcome Measures: Development of renal scar by doing DMSA renal scan;   Severity of pyelonephritis and response to treatment.
16 Not yet recruiting Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome
Conditions: Carpal Tunnel Syndrome;   Compression Neuropathy
Interventions: Drug: Acetyl-l-carnitine;   Drug: placebo
Outcome Measures: Change in motor unit number estimates;   Change in two point discrimination;   Change in pressure sensitivity using Semmes-Weinstein Monofilaments;   Change in cold detection threshold;   Change in pain detection thresholds;   Change in hand dexterity using the Purdue Pegboard;   Change in disability scores using the Disability of Arm, Shoulder and Hand estionnaire;   Change in hand symptoms using the Levine questionnaire for carpal tunnel syndrome
17 Unknown  Oral Carnitine for Cramps in Pregnancy
Condition: Muscle Cramp
Interventions: Dietary Supplement: L-Carnitine;   Dietary Supplement: Placebo
Outcome Measure: Complete elimination of muscle cramps
18 Recruiting The Effect of Combination Ultra Q10 and L-carnitine on the Course of Myelodysplastic Syndrome
Condition: Myelodysplastic Syndrome
Intervention: Dietary Supplement: Coenzyme Q10U, L-carnitine
Outcome Measures: Change from baseline Hemoglobin, Platlets,White blood counts;   Overall response rate;   Progression free survival;   Duration of response;   Quality of life.
19 Unknown  A Randomized, Double Blind, Placebo Controlled Trial L-carnitine and Piracetam in the Treatment of Weakness, Muscle Fatigue and Muscle Pain in the Postpoliomyelitis Syndrome
Condition: Postpoliomyelitis Syndrome
Interventions: Drug: L-carnitine and piracetam;   Drug: Placebo
Outcome Measures: Changes in Muscle Weakness;   Changes in fatigue;   Changes in muscle pain;   Changes in daytime sleepiness;   Changes in quality of life;   Changes in daily function;   Changes in depressive mood;   Changes in oxidative capacity in skeletal muscle;   Occurrence of adverse events
20 Unknown  Evaluation of the Effects of L-Carnitine Injection in Patients Undergoing Hemodialysis
Conditions: Cardiac Complications;   Signs and Symptoms;   Muscle Weakness;   Anemia;   Hypotension
Intervention: Drug: L-Carnitine Injection
Outcome Measures: weakness;   improvement of hypotension and hematology profile;   reduction of erythropoietin requirement;   increase of plasma carnitine concentration;   including all the components of the primary endpoints for their further assessment;   improvement of the nutritional indexes;   intradialytic complications (muscle symptoms, dyspnea, palpitations);   quality of life

These studies may lead to new treatments and are adding insight into Levocarnitine etiology and treatment.

A major focus of Levocarnitine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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