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Levofloxacin Medical Research Studies

Up-to-date List of Levofloxacin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Levofloxacin Medical Research Studies

Rank Status Study
1 Recruiting Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation
Conditions: Acute Leukemias of Ambiguous Lineage;   Bacterial Infection;   Diarrhea;   Fungal Infection;   Musculoskeletal Complications;   Neutropenia;   Recurrent Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Acute Myeloid Leukemia;   Secondary Acute Myeloid Leukemia;   Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Intervention: Drug: Levofloxacin
Outcome Measures: Occurrence of at least 1 episode of true bacteremia among AL and HSCT subjects, respectively;   Susceptibility of E. coli, K. pneumoniae, and P. aeruginosa to cefepime, imipenem, and Levofloxacin;   Susceptibility of S. mitis to cefepime, Levofloxacin, and penicillin;   Presence of carbapenem-resistant Enterobacteriaceae;   Duration of parenteral antibiotic administration;   Incidence of febrile neutropenia, severe infection, and death from bacterial infection;   Incidence of severe infection;   Incidence of death from bacterial infection;   Incidence of CDAD, defined as a positive C. difficile toxin assay result and diarrhea, CTCAE version 4, grade 2 and higher
2 Recruiting "Efficacy and Safety of Levofloxacin vs Isoniazid in Latent Tuberculosis Infection in Liver Transplant Patients".
Conditions: Latent Tuberculosis Infection;   Infection in Solid Organ Transplant Recipients
Interventions: Drug: Levofloxacin;   Drug: Isoniazid
Outcome Measures: Difference in incidence of tuberculosis disease;   Mortality;   Toxicity;   Retransplantation;   Graft dysfunction;   Transplant rejection
3 Recruiting Comparison of the Efficacy of Levofloxacin-based Sequential Therapy and Triple Therapy as Second Line Therapy
Condition: Eradication Rate for Helicobacter
Interventions: Drug: Levofloxacin-based sequential therapy;   Drug: Levofloxacin-based triple therapy for 10 days
Outcome Measures: Eradication rate in the second line therapy;   Incidence of adverse effect
4 Recruiting Pharmacokinetics of Levofloxacin in Intensive Care Unit
Conditions: Intensive Care Unit Syndrome;   Community-acquired Pneumonia
Intervention: Drug: Levofloxacin
Outcome Measures: Levofloxacin dosage regimen, time of administration and time of blood sampling, Levofloxacin serum concentrations.;   Efficiency (clinical,bacteriological, pharmacodynamic)
5 Recruiting Comparison Between Levofloxacin and Prulifloxacin, in Internal Medicine Patients With Acute Exacerbation of COPD
Condition: COPD Exacerbation
Interventions: Drug: Levofloxacin 1 tablet 500 mg once a day;   Drug: Prulifloxacin 1 tablet 600 mg once a day
Outcome Measures: The primary objective of the study is to determine the percentage of patients with "therapeutic success" at the end of the cycle of antibiotic therapy (10 days), in the two treatment groups (Levofloxacin and prulifloxacin).;   Percentage of successful treatment to day 7 of treatment
6 Recruiting A Multi-center, Randomized, Double-blind, Double-dummy Clinical Study to Evaluate the Safety and Efficacy of Prulifloxacin Film-coated Tablet for the Treatment of Acute Exacerbations of Chronic Bronchitis With Levofloxacin Hydrochloride Tablet as Active Control
Condition: Acute Exacerbations of Chronic Bronchitis
Interventions: Drug: Prulifloxacin;   Drug: Levofloxacin;   Drug: Levofloxacin Placebo;   Drug: Prulifloxacin placebo
Outcome Measures: To evaluate the efficacy and safety of prulifloxacin film-coated tablet in the treatment of acute exacerbations of chronic bronchitis.;   safety of treatment
7 Recruiting Efficacy and Safety Study of Eravacycline Compared With Levofloxacin in Complicated Urinary Tract Infections
Condition: Complicated Urinary Tract Infections (cUTI)
Interventions: Drug: Eravacycline;   Drug: Levofloxacin
Outcome Measure: Clinical and microbiological response vs failure
8 Not yet recruiting Efficacy and Safety of Levofloxacin for the Treatment of MDR-TB
Condition: Tuberculosis, Multidrug-Resistant
Interventions: Drug: Levofloxacin;   Drug: Optimized background regimen (OBR)
Outcome Measures: Efficacy;   Safety
9 Recruiting Pharmacodynamic of Ceftaroline and Levofloxacin Against Pathogens Associated With Community Acquired Bacterial Pneumonia
Conditions: Pneumonia, Bacterial;   Community-acquired
Interventions: Drug: Ceftaroline;   Drug: Levofloxacin
Outcome Measure: Pharmacodynamics (time kill curves)
10 Recruiting Short Antibiotic Treatment Versus Duration Guided by Markers of Inflammation in the Treatment of AECOPD
Condition: Chronic Obstructive Pulmonary Disease
Intervention: Drug: Levofloxacin 500mg
Outcome Measures: mortality;   Rate of additional antibiotherapy course
11 Unknown  Pharmacokinetic Evaluation of Fluoroquinolone Antibiotics Administered Intravenously in Intensive Care Patients With Normal Renal Function and With Renal Hyperfiltration
Condition: Infection
Intervention: Drug: intravenous administration of Levofloxacin
Outcome Measure: to evaluate the pharmacokinetics of Levofloxacin in patients with hyperfiltration, in comparison with critically ill patients with normal renal function.
12 Unknown  Trial of Levofloxacin as Prophylaxis After Allogeneic Stem Cell Transplantation (SCT)
Conditions: Malignancy;   Allogeneic Stem Cell Transplantation
Intervention: Drug: Levofloxacin
Outcome Measure:
13 Unknown  Efficacy and Safety Trial to Assess Moxifloxacin in Treating Community-Acquired Pneumonia (CAP) With Aspiration Factors
Condition: Community-Acquired Pneumonia
Interventions: Drug: moxifloxacin;   Drug: Levofloxacin;   Drug: metronidazole
Outcome Measure: Clinical response
14 Recruiting The Efficacy of Solifenacin Succinate as Adjuvant Therapy for Urinary Tract Infection in Females
Condition: Urinary Tract Infection
Interventions: Drug: Levofloxacin;   Drug: Solifenacin succinate;   Drug: Placebo (for Solifenacin succinate)
Outcome Measure: Number of participants with storage symptoms
15 Not yet recruiting Phase II Investigation of Antimycobacterial Therapy on Progressive, Pulmonary Sarcoidosis
Condition: Sarcoidosis; Antimycobacterial Therapy;
Interventions: Drug: Levofloxacin;   Drug: Ethambutol;   Drug: Azithromycin;   Drug: Rifampin;   Drug: Placebo
Outcome Measures: Determine the effect of CLEAR therapy versus placebo on the change in percent predicted absolute forced vital capacity (FVC) in participants with pulmonary sarcoidosis, comparing baseline with performance after completion of 16 weeks of therapy.;   Radiographic improvement in sarcoidosis lung disease by frontal chest x-ray .;   Change in 6 minute walk distance, oxygen saturation and level of dyspnea;   Change in the Saint George's Respiratory Questionnaire (SGRQ; King's Sarcoidosis Questionnaire (KSQ) for the assessment of health status; The Fatigue Assessment Scale (FAS).;   Safety profile of regimen as evidenced by adverse events and abnormal lab values, tolerability and toxicity of the treatment regimen including comparison of reported adverse events and abnormal laboratory values compared to placebo.;   Change in FEV1;   Failure of standard Therapy
16 Recruiting Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations
Condition: Chronic Rhinosinusitis
Interventions: Drug: oral Levofloxacin;   Drug: nebulized Levofloxacin
Outcome Measures: Change in Rhinosinusitis Disability Index (RSDI) scores;   Endoscopy findings using POSE scores;   Change in the total bacterial community following treatment as determined by RNA pyrosequencing.;   Change in aerobic bacterial cultures performed via traditional microbiology plating techniques
17 Unknown  Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate
Condition: Infection
Interventions: Drug: ofloxacin;   Drug: gentamicin
Outcome Measure: no infection
18 Recruiting Corneal Epithelium Repair and Therapy Using Autologous Limbal Stem Cell Transplantation
Conditions: Corneal Disease;   Pterygium;   Myopia;   Hyperopia
Interventions: Procedure: LSCs and amniotic membrane (Modified Technique);   Procedure: Amniotic membrane only (Traditional Technique);   Procedure: PRK, LSCs, and amniotic membrane (Modified Technique);   Procedure: PRK only (Traditional Technique);   Drug: Levofloxacin;   Drug: Betamethasone;   Drug: Limbal stem cells (LSCs)
Outcome Measures: Composite measure of visual function in eyes treated for corneal ocular surface disease.;   Composite measure of visual function in eyes after photo-refractive keratectomy (PRK);   Incidence of transparency of the cornea
19 Recruiting Efficacy of a Short-term Sequential Therapy in Non-complicated Catheter Related Bacteremia by Methicillin- Susceptible S.Aureus.
Condition: Staphylococcus
Interventions: Drug: Cloxacilin;   Drug: Cloxacillin;   Drug: Levofloxacin
Outcome Measures: Reduce the rate of late complications of catheter-related bacteremia by S. aureus methicillin sensitive below 2%.;   Reducing hospital stay associated with the treatment of uncomplicated bacteremia MS S. aureus.;   Reduce the transesophagic echocardiography
20 Not yet recruiting Patients Response to Early Switch To Oral:Osteomyelitis Study
Condition: Osteomyelitis
Interventions: Drug: oral antibiotics;   Procedure: intravenous antibiotics
Outcome Measures: Clinical Failures;   Evaluation of adverse events related to the use of antibiotics;   Cost of care from the hospital perspective

These studies may lead to new treatments and are adding insight into Levofloxacin etiology and treatment.

A major focus of Levofloxacin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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