sponsored
PatientsVille.com Logo

PatientsVille

Limb Medical Research Studies

Up-to-date List of Limb Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Limb Medical Research Studies

Rank Status Study
1 Unknown  Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation
Conditions: Phantom Limb;   Residual Limb Pain;   Traumatic Amputation;   Amputation
Intervention: Procedure: Acupuncture
Outcome Measures: Presence/absence of phantom Limb pain (PLP) and/or residual Limb pain (RLP) pre/post each treatment;   Level (Visual Analogue Scale [VAS]) of PLP and/or RLP pre/post each treatment;   Level (VAS) of PLP and/or RLP one hour post each treatment;   Presence/absence and level of PLP and/or RLP two weeks after final treatment;   Changes in medication regimen during treatment period and after final treatment;   Changes in sleep habits during treatment period and after final treatment;   Any change in phantom Limb sensation (PLP) after final treatment;   Length of time for each treatment;   Any discomfort associated with each treatment;   Overall satisfaction at the end of the study
2 Unknown  Study to Assess the Efficacy of Direct Observation and Mental Visualization of Foot Movements to Treat Bilateral Lower Limb Phantom Limb Pain
Condition: Phantom Limb Pain
Interventions: Behavioral: direct observation;   Behavioral: mental visualization
Outcome Measures: Significant decrease in the level of phantom Limb pain at 4 weeks.;   Significant decrease in the number and duration of daily phantom Limb pain episodes at 4 weeks.
3 Recruiting Study to Identify the Genetic Variations Associated With Phantom Limb Pain
Condition: Phantom Limb
Intervention: Procedure: Blood Draw
Outcome Measures: Identification of Unique Single Nucleotides Polymorphisms (SNPs) associated with Phantom Limb Pain (PLP);   Correlation between Phantom Limb Pain (PLP) and Blood Levels of Antibodies Associated with Peripheral Nerve Damage;   Correlation between Phantom Limb Pain (PLP) and Serum Levels of Brain-derived Neurotrophic Factor (BDNF);   Correlation between Phantom Limb Pain (PLP) and Unique Transcribed RNA
4 Not yet recruiting Limb Cooling in Essential Tremor
Condition: Essential Tremor.
Intervention: Procedure: Limb Cooling Assessment of ET
Outcome Measures: Hand writing assessment battery on Limb cooling at 60 minutes post-cooling;   Tremor rating scale on Limb cooling at 40 minutes post-cooling;   Functional dexterity test on Limb cooling at 60 minutes post-cooling;   Hand writing assessment battery on Limb cooling at 15 minutes post-cooling;   Hand writing assessment battery on Limb cooling at 40 minutes post-cooling;   Tremor rating scale on Limb cooling at 15 minutes post-cooling;   Functional dexterity test on Limb cooling at 15 minutes post-cooling;   Functional dexterity test on Limb cooling at 40 minutes post-cooling;   Tremor rating scale on Limb cooling at 60 minutes post-cooling;   Effect of Limb cooling on the physiological characteristics of essential tremors.
5 Recruiting Technology That Permits Focal Dose of Antibiotics to be Delivered to Lower Limb(s) of Diabetic Patients
Conditions: Diabetes;   Infection
Interventions: Procedure: Percutaneous Isolated Limb Perfusion (PILP) delivery intervention;   Drug: Timentin
Outcome Measure: Reduction of microbiological load in diabetic subjects with significant lower Limb infections including assessment of CFU, infection type and antibiotic (Timentin) sensitivity between two groups over time.
6 Recruiting Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
Condition: Phantom Limb Pain
Intervention: Drug: Perineural infusion [continuous peripheral nerve block(s)]
Outcome Measures: Phantom Limb pain intensity 4 weeks following initiation of an ambulatory CPNB (as measured by the Numeric Rating Scale within the Brief Pain Inventory).;   Perception of well-being 4 weeks following an ambulatory CPNB (as measured with the Patient Global Impression of Change Scale).;   Physical and emotional functioning 4 weeks following initiation of an ambulatory CPNB (as measured with the Brief Pain Inventory).;   Depression 4 weeks following initiation of an ambulatory CPNB (as measured with the Beck Depression Inventory).
7 Unknown  Examining Brain Changes Using Functional Magnetic Resonance Imaging (fMRI) in Amputees With Phantom Limb Pain Following Mirror Therapy
Condition: Phantom Limb Pain
Interventions: Device: mirror-box treatment;   Behavioral: observation
Outcome Measures: The identification of brain regions activated before and after treatment with mirror therapy.;   phantom Limb pain as measured using the VAS and McGill
8 Unknown  A Study to Test the Effectiveness of Mirror-Box and Mental Visualization Treatments on Phantom Limb Pain
Conditions: Amputation;   Phantom Limb;   Pain
Interventions: Device: mirror-box treatment;   Behavioral: Mental visualization
Outcome Measures: Significant decrease in the level of phantom Limb pain at 4 weeks.;   Significant decrease in the number and duration of daily phantom Limb pain episodes at 4 weeks.
9 Recruiting Comparison of Limb Size of Transverse Coloplasty Pouch
Condition: Colon Cancer
Interventions: Procedure: Transverse coloplasty pouch (Long Limb);   Procedure: Transverse coloplasty pouch (Short Limb)
Outcome Measures: Pouch function 4 month after closure of protective ileostomy.;   Pouch function 2 and 12 month respectively after closure of protective ileostomy.
10 Recruiting Randomized Trial of Exercise on Lower Extremity Edema After Lymphadenectomy in Gynecologic Cancer
Condition: Gynecologic Cancer
Intervention: Other: Pelvic and lower extremity exercise
Outcome Measures: Change in lower extremity edema-related symptoms after pelvic and lower extremities exercise;   the compliance rate of management guidelines for lower extremity edema, the performance rate for pelvic and lower extremity exercise
11 Not yet recruiting Effect of Upper Limb Posture on Limb Volume as Expressed in Circumference Measurement in Healthy Women and in Women With Breast Cancer Related Lymphedema
Conditions: Breast Cancer;   Lymphedema
Intervention: Other: circumferential measurements in different upper Limb positions.
Outcome Measure: Circumferential upper Limb measurement
12 Not yet recruiting Long-term Effects of Transcranial Direct Current Stimulation (tDCS) on Patients With Phantom Limb Pain (PLP)
Condition: Phantom Limb Pain
Intervention: Device: Transcranial Direct Current Stimulation (tDCS)
Outcome Measures: Reduced phantom Limb pain;   Adverse effects of treatment;   Effects of treatment on the electrical activity of the brain
13 Recruiting Virtual Integrated Environment in Decreasing Phantom Limb Pain
Condition: Phantom Limb
Intervention: Device: Virtual Integration Environment (VIE)
Outcome Measures: Change in Phantom Limb Pain Severity;   Consistency of sEMG recordings
14 Unknown  Human Adipose Derived Mesenchymal Stem Cells for Critical Limb Ischemia in Diabetic Patients
Conditions: Critical Limb Ischemia;   Diabetes
Intervention: Drug: Autologous adipose derived mesenchymal stem cells
Outcome Measures: Angiographic assessment of neovasculogenesis (angiogenesis plus arteriogenesis);   Major adverse event (death, target Limb amputation);   Ankle Brachial Index;   University of Texas Classification at target Limb
15 Recruiting Human-Machine System for the H2 Lower Limb Exoskeleton
Conditions: Stroke;   Hemiparesis
Interventions: Behavioral: Robot-assisted training with the H2 lower Limb powered exoskeleton;   Behavioral: Supervised motor practice
Outcome Measures: Change from baseline in Fugl-Meyer Assessment - Lower Extremity Motor Function;   Change from baseline in Functional Gait Assessment;   Change from baseline in Lower Limb joint kinematics during walking;   Change in cortical dynamics measured by Electroencephalography (EEG);   Change in robotic measure of performance measured by the H2;   Change from baseline in Berg Balance Scale score;   Change from baseline in distance walked during the 6-minute walk test;   Change from baseline in Timed Up and Go Test score
16 Not yet recruiting Acupuncture for the Treatment of Phantom Limb Syndrome
Condition: Phantom Limb Syndrome
Interventions: Other: Acupuncture;   Other: Usual care
Outcome Measures: Change in Numerical Rating Scale;   Change in Short Form McGill Pain Questionnaire 2 (SF-MPQ-2);   Change in EQ-5D-5L;   Change in Hospital Anxiety and Depression Scale (HADS);   Change in The Insomnia Severity Index (ISI);   Patient Global Impression of Change (PGIC);   Change in Perceived Stress Scale (PSS)
17 Recruiting Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting
Conditions: Stroke;   Transient Ischemic Attack
Interventions: Procedure: remote Limb ischemic preconditioning;   Procedure: sham RIPC;   Procedure: Carotid Artery Stenting
Outcome Measures: Composite measure of serum NSE, S-100b and Hs-CRP at baseline.;   Composite measure of serum NSE, S100-b and hs-CRP at 1hour after carotid artery stenting.;   Composite measure of serum NSE, S100-b and hs-CRP at 24 hours after carotid artery stenting.;   The Incidence of Brain or Cardiac Ischemic Events and Death;   the Percentage of Participants Who Got New Brain Lesions After Carotid Artery Stenting (CAS)
18 Not yet recruiting Impact of Limb Remote Ischemic Preconditioning on Mortality and Quality of Life During Abdominal Aortic Aneurysm Repair
Condition: Abdominal Aortic Aneurysm
Intervention: Procedure: Limb RIPC
Outcome Measures: all cause mortality;   hospitalization costs
19 Unknown  The Validity and Reliability of Self Measurement of Upper Limb Volume
Condition: Limb Volume Measurement
Intervention: Other: Self measurement of Limb volume +water displacement
Outcome Measures: Comparison of self measurement of Limb volume to water displacement;   validity of self measurement
20 Recruiting Prevention of Phantom Limb Pain After Transtibial Amputation
Conditions: Phantom Limb Pain;   Chronic Pain;   Prevention
Intervention: Procedure: Sciatic name block
Outcome Measure: Point prevalence of chronic phantom Limb pain

These studies may lead to new treatments and are adding insight into Limb etiology and treatment.

A major focus of Limb research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


Discuss Limb