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Lopirin Medical Research Studies

Up-to-date List of Lopirin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Lopirin Medical Research Studies

Rank Status Study
1 Unknown  Rapid Versus Prolonged Inpatient Up-Titration of Captopril
Condition: Heart Disease
Intervention: Drug: Captopril
Outcome Measure: The number of patients reaching a target dose of 1mg/kg/dose (given three times a day).
2 Unknown  Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin Activity
Condition: Primary Aldosteronism
Intervention: Drug: captopril test
Outcome Measure: Determination of ARC in contrast to PRA offers advantage with regard to processing and standardization, knowing the postcaptopril sensitivity and specificity
3 Recruiting Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure
Conditions: Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy
Interventions: Drug: Losartan;   Drug: Captopril;   Drug: Placebo
Outcome Measures: Changes in plasma renin activity and subsequent components of the circulating renin-angiotensin system;   Changes in blood pressure;   Changes in heart rate, cardiac output, stroke volume and systemic vascular resistance
4 Unknown  Acute Haemodynamic Effects of Treatment With Angiotensin Converting Enzyme (ACE)-Inhibitors in Patients With Symptomatic Aortic Stenosis
Condition: Aortic Stenosis
Interventions: Drug: Captopril and Trandolapril;   Drug: Captopril Test Dose and Trandolapril
Outcome Measures: Treatment with ACE-inhibitors improves haemodynamic parameters in patients with severe aortic stenosis.;   Treatment with ACE-inhibitors:;   Increases working capacity in patients with severe aorta stenosis.;   Improves systolic and diastolic function on left ventricle.;   In patients with severe aortic stenosis is safe.;   Degrease wall stress in left ventricle.
5 Unknown  Kallikrein-Kinin (KKS) and Renin-Angiotensin-Aldosterone System (RAAS) in Primary Aldosteronism
Condition: Hyperaldosteronism
Intervention: Drug: captopril, Losartan (drug)
Outcome Measures: Diagnosis of primary aldosteronism;   Subgroup analysis of primary aldosteronism
6 Recruiting Eye Blood Flow and the Kidney
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Captopril;   Drug: placebo
Outcome Measure: Change in ophthalmic artery blood flow from baseline
7 Recruiting Treatment of Supine Hypertension in Autonomic Failure
Condition: Hypertension
Interventions: Drug: Clonidine;   Drug: Nitroglycerin transdermal;   Drug: Dipyridamole/ Aspirin (Aggrenox);   Drug: Desmopressin (DDAVP);   Drug: Sildenafil;   Drug: Nifedipine;   Drug: Hydralazine;   Drug: Hydrochlorothiazide;   Drug: Placebo;   Drug: Bosentan;   Drug: Diltiazem;   Drug: Eplerenone;   Drug: guanfacine;   Dietary Supplement: L-arginine;   Drug: captopril;   Drug: carbidopa;   Drug: losartan;   Drug: metoprolol tartrate;   Drug: nebivolol hydrochloride;   Drug: prazosin hydrochloride;   Drug: tamsulosin hydrochloride;   Other: Head-up tilt.;   Drug: aliskiren;   Other: Local heat stress
Outcome Measures: Decrease in supine systolic blood pressure;   Decrease in pressure natriuresis
8 Not yet recruiting Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery
Condition: Hypertension
Interventions: Drug: Take ACE-I;   Drug: Hold ACE-I
Outcome Measures: Intraoperative Hypotension;   Acute Renal Failure;   Low blood pressure subgroup;   Older age subgroup;   Postoperative Hypertension
9 Recruiting The Renin-Angiotensin-Aldosterone System and Parathyroid Hormone Control: The RAAS-PARC Study
Condition: Hyperparathyroidism
Interventions: Drug: captopril;   Drug: Lisinopril
Outcome Measures: Parathyroid hormone, before and after, ACE inhibitor administration;   Serum and urinary aldosterone measurements before and after ACE inhibitor use;   Serum calcium before and after ACE inhibitor administration
10 Unknown  Is There a Benefit to Optimize Heart Failure (HF) Treatment in Aged Over 80 Year's Old Patients?
Condition: Heart Failure
Intervention: Drug: - Angiotensin conversing enzyme inhibitors: enalapril, captopril, lisinopril, ramipril, trandolapril.
Outcome Measures: Change from baseline in quality of life;   Mortality;   Rehospitalisation;   Cardiovascular events;   Cardiac fibrosis;   Quality of life
11 Recruiting RAS Blockade at Bedtime Versus on Awakening for Aldosterone Breakthrough
Condition: Chronic Kidney Disease
Intervention: Other: Randomization that determine the time of treatment
Outcome Measures: Serum aldosterone levels at one year;   Serum aldosterone/renin ratio;   Significant aldosterone breakthrough Significant aldosterone breakthrough

These studies may lead to new treatments and are adding insight into Lopirin etiology and treatment.

A major focus of Lopirin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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