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Loss Of Consciousness Medical Research Studies

Up-to-date List of Loss Of Consciousness Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Loss Of Consciousness Medical Research Studies

Rank Status Study
1 Recruiting Measurement of Glucose Metabolism in Humans Using Magnetic Resonance at 4 Tesla. Substudy: Hypoglycemia Unawareness
Conditions: Type 1 Diabetes;   Hypoglycemia Unawareness
Intervention: Drug: somatostatin
Outcome Measure: Brain glucose concentration as measured by NMR spectroscopy
2 Not yet recruiting A Phase IV Study Investigating the Effects of Remifentanil Concentrations on Propofol Requirements for Loss Of Consciousness, Response to Painful Stimuli, Bispectral Index and Associated Haemodynamic Changes
Condition: Induction of Anaesthesia
Interventions: Drug: Remifentanil;   Drug: Propofol;   Other: Bispectral index
Outcome Measures: Effect site concentration of propofol at time of Loss Of Consciousness for each of the three groups;   Effect site concentration of propofol at loss of response to painful stimuli for each of the three groups;   Time to loss of consciousness;   EEG Bispectral index BIS;   heart rate;   blood pressure
3 Recruiting Alteration of Temporal Organization of EEG Microstate Sequences During Propofol-induced Loss Of Consciousness
Condition: Loss of Consciousness
Intervention: Device: Target Controlled Infusion system (Orchestra Base Primea, Fresenius, France)
Outcome Measure: EEG microstates
4 Recruiting The Effect of Hypoglycaemia on Brain Lactate Accumulation and Cerebral Blood Flow
Conditions: Type 1 Diabetes Mellitus;   Hypoglycemia Unawareness
Interventions: Other: hypoglycemia;   Other: euglycemia
Outcome Measures: Brain lactate concentration;   Plasma lactate levels;   Hormone response
5 Recruiting Measuring Depth of Unconsciousness at the End of Life Using Bispectral Index (BIS)
Condition: Loss of Consciousness at End of Life.
Intervention:
Outcome Measures: Measuring the accuracy of BIS monitoring in assessing the evolution of the level of consciousness in pre-terminal patients;   Determining the evolution of BIS values, measured in pre-terminal patients
6 Recruiting Closed-loop Control of Overnight Glucose Levels (Artificial Pancreas) in Type 1 Diabètes Adults With Hypoglycemia Unawareness and Documented Nocturnal Hypoglycemia
Condition: Type 1 Diabetes
Intervention: Other: Overnight intervention
Outcome Measures: Percentage of time of plasma glucose levels spent below 4 mmol/L;   Percentage of time of plasma glucose levels spent between 4 and 8 mmol/L;   Percentage of time of plasma glucose levels spent between 4 and 10 mmol/L;   Percentage of time of plasma glucose levels spent below 3.5 mmol/L;   Percentage of time of plasma glucose levels spent below 3.3. mmol/L;   Percentage of time of plasma glucose levels spent above 8 mmol/L;   Percentage of time of plasma glucose levels spent above 10 mmol/L;   Area under the curve of plasma glucose levels spent below 4 mmol/L;   Area under the curve of plasma glucose levels spent below 3.5 mmol/L;   Area under the curve of plasma glucose levels spent below 3.3 mmol/L;   Area under the curve of plasma glucose levels spent above 8 mmol/L;   Area under the curve of plasma glucose levels spent above 10 mmol/L;   Mean plasma glucose levels;   Standard deviation of plasma glucose levels;   Total insulin delivery;   Total glucagon delivery;   Number of subjects experiencing at least one hypoglycemic event requiring oral treatment;   Total number of hypoglycemic events requiring treatment
7 Unknown  NICE Guideline 'Red Flags' to Predict Serious Outcome After Transient Loss Of Consciousness
Condition: Syncope
Intervention:
Outcome Measure: serious outcome
8 Unknown  Study of Comparison Between Pentacam and locs3
Condition: Cataract
Intervention:
Outcome Measure:
9 Recruiting Glucose Counterregulation in Long Standing Type 1 Diabetes
Conditions: Hypoglycemia Unawareness;   Type 1 Diabetes;   Healthy
Intervention: Device: RT-CGM
Outcome Measures: Endogenous glucose production;   Endogenous Glucose Production;   Magnitude and Glycemic thresholds for counter-regulatory Hormonal and Symptom Responses
10 Not yet recruiting The Role of Endogenous Lactate in Brain Preservation and Counterregulatory Defenses Against Hypoglycemia
Conditions: Type 1 Diabetes Mellitus;   Hypoglycemia Unawareness
Interventions: Behavioral: High intensity exercise;   Behavioral: Lay down comfortably
Outcome Measures: Plasma level of adrenaline in response to hypoglycemia (Adrenaline, measured in arterial plasma);   Plasma levels of other counter-regulatory hormones (Levels of counter-regulatory hormones measured in arterial plasma);   Glucose infusion rate (Amount of glucose 20% necessary to maintain plasma glucose at steady state values);   Plasma lactate levels (Lactate levels measured in arterial plasma);   Cognitive functioning, as measured by cognitive tests;   Plasma levels of inflammatory markers (levels of cytokines);   Brain perfusion measured with ASL-MRI;   Brain lactate accumulation measured with 1H-MRS
11 Recruiting A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients
Conditions: Type 1 Diabetes;   Severe Hypoglycemic Unawareness
Intervention: Biological: Islet Cell Transplant
Outcome Measures: To demonstrate the safety and efficacy of islet transplantation under alemtuzumab induction for treatment of Type-1 Diabetes (T1D) in subjects with hypoglycemia unawareness and a history of severe hypoglycemic episodes.;   To relate clinical transplant outcomes based upon islet quantity/quality to organ donor characteristics.
12 Not yet recruiting A Randomized Double Blinded Study to Examine the Use of N-acetyl Cysteine for the Prevention and Treatment of HAAF in Patients With Type 1 Diabetes
Conditions: Type 1 Diabetes;   Hypoglycemia Unawareness
Interventions: Drug: N-acetyl cysteine;   Drug: Placebo
Outcome Measure: difference in epinephrine secretion during the morning episodes of hypoglycemia on days one and two under the two treatment conditions
13 Recruiting The Effects of RT-CGM on Glycemia and QoL in Patients With T1DM and IHA
Conditions: Type 1 Diabetes Mellitus;   Impaired Hypoglycemia Awareness;   Hypoglycemia Unawareness
Intervention: Device: Real-time continuous glucose monitor
Outcome Measures: Time spent in the euglycemic range;   Quality of life;   Glycemia variables;   Hypoglycemic episodes;   Changes in hypoglycemia awareness score
14 Recruiting Comparative Evaluation of Three Airway Maneuvers in the Unconscious Apneic Person
Condition: Airway Morbidity
Intervention: Procedure: airway maneuver
Outcome Measures: Air exchange;   Hemodynamic change
15 Recruiting BAsel Syncope EvaLuation (BASEL IX) Study
Condition: Syncope
Intervention:
Outcome Measure: diagnostic and prognostic value of various novel and established biomarkers, clinical assessment and detailed patient history
16 Unknown  Propofol in Obese Children
Conditions: Pharmacodynamics;   Obesity
Intervention: Drug: Propofol
Outcome Measures: Loss of consciousness;   Depth of sedation
17 Not yet recruiting The Effects of Remifentanil on Attenuating the Hemodynamic Responses After Electroconvulsive Therapy
Condition: Haemodynamic Rebound
Interventions: Drug: Sevoflurane;   Drug: Remifentanil;   Drug: Saline
Outcome Measures: The effects of remifentanil on the heart rate after electroconvulsive therapy;   Seizure duration;   The effects of remifentanil on the mean arterial pressure after electroconvulsive therapy
18 Recruiting Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla
Condition: Type 1 Diabetes
Intervention: Drug: somatostatin
Outcome Measure: determine the effects of diabetes and the hypoglycemic consequences of intensive therapy on in vivo brain glucose metabolism
19 Recruiting The Median Effective Dose (ED50) of Dexmedetomidine in Cesarean Surgery
Condition: PREGNANCY
Intervention: Drug: Dexmedetomidine
Outcome Measure: The assessment of sedation
20 Recruiting Comparision of Blood Pressure Variability Between Amlodipine and Losartan
Condition: Hypertension
Interventions: Drug: Amlodipine;   Drug: Losartan
Outcome Measures: SD of visit-to-visit systolic blood pressure variability;   Central systolic blood pressure;   Augmentation index of central blood pressure;   Standard deviation of within-visit systolic blood pressure variability;   Coefficient of variation of visit-to-visit systolic blood pressure variability;   Variation independent of the mean of visit-to-visit systolic blood pressure variability;   24-h ambulatory blood pressure monitoring;   Home systolic blood pressure

These studies may lead to new treatments and are adding insight into Loss Of Consciousness etiology and treatment.

A major focus of Loss Of Consciousness research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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