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Lovastatin Medical Research Studies

Up-to-date List of Lovastatin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Lovastatin Medical Research Studies

Rank Status Study
1 Unknown  A Phase II Study of Interaction of Lovastatin and Paclitaxel For Patients With Refractory or Relapsed Ovarian Cancer
Condition: Ovarian Cancer
Intervention: Drug: Lovastatin and Paclitaxel
Outcome Measures: Response rate of the combination of Lovastatin and paclitaxel.;   The duration of response and time to progression using the combination of Lovastatin and paclitaxel.
2 Recruiting Trial to Evaluate the Safety of Lovastatin in Individuals With Neurofibromatosis Type I (NF1)
Condition: Neurofibromatosis 1
Interventions: Drug: Lovastatin;   Drug: placebo pill
Outcome Measures: Non-verbal learning;   attention;   tolerability of medication
3 Recruiting Dose Escalation Phase I/II Study of Lovastatin With High-Dose Cytarabine for Refractory or Relapsed AML
Condition: Acute Myeloid Leukemia
Intervention: Drug: Lovastatin and Cytarabine
Outcome Measure: Complete remission rate
4 Recruiting Neuroprotection With Statin Therapy for Acute Recovery Trial Phase 2
Conditions: Stroke;   Rhabdomyolysis;   Jaundice
Interventions: Drug: Lovastatin;   Other: Placebo
Outcome Measures: Increase in Liver Function Tests (LFTs);   Increase in Creatine Kinase (CK);   Score on NIH Stroke Scale;   Barthel Index Score;   Modified Rankin scores
5 Unknown  Phase II Study of Cholesterol- and Cholestanol-Free Diet, Lovastatin, and Chenodeoxycholic Acid for Cerebrotendinous Xanthomatosis
Condition: Cerebrotendinous Xanthomatosis
Interventions: Drug: chenodeoxycholic acid;   Drug: Lovastatin
Outcome Measure:
6 Recruiting Effects of a Supplement Derived From Palm Oil on Cholesterol Levels and Chinese Red Yeast Rice in the Blood
Condition: Cholesterol Lowering
Interventions: Drug: Sugar Pill;   Drug: Chinese Red Yeast Rice (CRYR);   Drug: CRYR + TRF;   Device: Tocotrienol-enriched Fraction of Palm Oil (TRF)
Outcome Measure: Effects of TRF vs. CRYR
7 Recruiting Genetic Influence on Statin Pharmacokinetics
Conditions: Hyperlipidemia;   Hypercholesterolemia;   Dyslipidemia
Intervention:
Outcome Measure: statin concentration in plasma
8 Recruiting Genetic Influence on Statin Pharmacodynamics
Conditions: Hyperlipidemia;   Hypercholesterolemia;   Dyslipidemia
Intervention:
Outcome Measure: carotid intimal media thickness (CIMT)
9 Recruiting A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High Risk Patients With Hypertriglyceridemia and on Statin. The Primary Objective is to Evaluate the Effect of 4 g/Day AMR101 for Preventing the Occurrence of a First Major Cardiovascular Event.
Condition: Cardiovascular Diseases
Interventions: Drug: AMR101;   Drug: Placebo
Outcome Measures: Composite endpoint of CV death, MI, stroke, coronary revascularization, and hospitalization for unstable angina.;   Incidence of additional cardiovascular events, lipid and lipoprotein levels, subgroup analyses such as: diabetics, etc.
10 Not yet recruiting Cholesterol-lowering Effects of nutraceuticaLs Versus Ezetimibe in Statin-intolerant Patients
Condition: Coronary Artery Disease
Interventions: Drug: Ezetimibe;   Dietary Supplement: Nutraceuticals
Outcome Measures: Reasons for treatment discontinuation;   Effects on lipid profile

These studies may lead to new treatments and are adding insight into Lovastatin etiology and treatment.

A major focus of Lovastatin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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