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Lozol Medical Research Studies

Up-to-date List of Lozol Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Lozol Medical Research Studies

Rank Status Study
1 Not yet recruiting Comparison of Losartan Associated With Indapamide Versus Indapamide for Treatment of Hypertension
Condition: Hypertension
Interventions: Drug: Indapamide / Losartan;   Drug: Indapamide
Outcome Measures: Changes in systemic blood pressure measurements during 12 weeks;   Percentage (%) of patients with blood pressure < 140 / 90 mmHg during 12 weeks, will be obtained comparing the differences between initial blood pressure (initial visit) and final (final visit).;   Percentage (%) of patients excluded from the study because of treatment failure;   Time to appropriate control of systolic blood pressure and diastolic blood pressure (BP <140/90 mmHg.;   Incidence of any adverse events;;   Incidence of hypotension;   Incidence of serious adverse events and unexpected drug reactions
2 Unknown  Indapamide Versus Hydrochlorothiazide in Elderly Hypertensive Patients With Renal Insufficiency
Conditions: Hypertension;   Renal Insufficiency
Interventions: Drug: Indapamide;   Drug: Hydrochlorothiazide
Outcome Measures: renal function;   endothelial function;   blood pressure variability
3 Recruiting Non-invasive Haemodynamic Assessment in Hypertension
Condition: Arterial Hypertension
Interventions: Drug: lisinopril;   Drug: Telmisartan;   Drug: Nebivolol;   Drug: Indapamide/hydrochlorothiazide;   Drug: Amlodipine
Outcome Measures: 24-h mean Systolic Blood Pressure (in ABPM);   24-h mean Diastolic Blood Pressure (in ABPM);   daytime mean Systolic Blood Pressure (in ABPM);   daytime mean Diastolic Blood Pressure (in ABPM);   night-time mean Systolic Blood Pressure (in ABPM);   night-time mean Diastolic Blood Pressure (in ABPM);   Systolic Blood Pressure (in OBPM);   Diastolic Blood Pressure (in OBPM);   change from baseline in Systolic Blood Pressure (in OBPM) at 3 months;   change from baseline in Diastolic Blood Pressure (in OBPM) at 3 months;   change from baseline in 24-h Systolic Blood Pressure (in ABPM) at 3 months;   change from baseline in 24-h Diastolic Blood Pressure (in ABPM) at 3 months;   change from baseline in daytime Systolic Blood Pressure (in ABPM) at 3 months;   change from baseline in daytime Diastolic Blood Pressure (in ABPM) at 3 months;   change from baseline in night-time Systolic Blood Pressure (in ABPM) at 3 months;   change from baseline in night-time Diastolic Blood Pressure (in ABPM) at 3 months
4 Recruiting Treatment for Calcium Phosphate Kidney Stone Disease
Condition: Calcium Phosphate Kidney Stones
Interventions: Drug: Placebo;   Dietary Supplement: Citric Acid;   Dietary Supplement: Potassium Citrate;   Drug: Indapamide
Outcome Measure: Urinary calcium phosphate saturation
5 Recruiting Comparision of Blood Pressure Variability Between Amlodipine and Losartan
Condition: Hypertension
Interventions: Drug: Amlodipine;   Drug: Losartan
Outcome Measures: SD of visit-to-visit systolic blood pressure variability;   Central systolic blood pressure;   Augmentation index of central blood pressure;   Standard deviation of within-visit systolic blood pressure variability;   Coefficient of variation of visit-to-visit systolic blood pressure variability;   Variation independent of the mean of visit-to-visit systolic blood pressure variability;   24-h ambulatory blood pressure monitoring;   Home systolic blood pressure
6 Recruiting Renal Denervation in Diabetic Nephropathy
Conditions: Diabetic Nephropathy;   Persistent Proteinuria With Type II Diabetes
Interventions: Procedure: Percutaneous renal denervation and TMNS;   Drug: Standardized antiproteinuric medication regimen includes an angiotensin receptor blocker , a diuretic , 25OH vitamin D3 and a statin
Outcome Measures: proteinuria/creatininuria ratio;   Number of patients with a decrease of the PU/CrU >50% ratio;   Evaluation of the slope of decay of the PU/CrU;   eGFR is estimated by the MDRD formula, and is expressed in mL/min/1.73m². The direct GFR will be assessed by measuring the 51Cr-EDTA plasmatic clearance;   Outcome of the GFR assessed by 51Cr-EDTA clearance;   Decrease of the blood pressure assessed on ABPM;   Anti-hypertensive regimen score;   Evaluation of the renal arterial anatomy;   Evaluation of safety and tolerance of renal denervation in diabetic patients with overt proteinuria;   Evaluate the outcome of biological parameters;   Evaluate the diabetic neuropathy/dysautonomy;   Evaluate the outcome of specific kidney injury markers
7 Recruiting Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart
Conditions: Hypertension;   Left Ventricular Diastolic Dysfunction
Intervention: Drug: Nebivolol
Outcome Measures: Improvement in exercise tolerance;   E velocity indexed to e' (E/e' ratio) of the left ventricle;   Untwist rate of the left ventricle

These studies may lead to new treatments and are adding insight into Lozol etiology and treatment.

A major focus of Lozol research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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