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MESH Medical Research Studies

Up-to-date List of MESH Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest MESH Medical Research Studies

Rank Status Study
1 Recruiting Randomized Trial of Y Mesh vs Dual Mesh
Condition: Prolapse
Interventions: Device: Y Mesh;   Device: Dual flat Mesh
Outcome Measures: Total suturing time for Mesh placement = time from insertion of Y Mesh or first flat Mesh arm into pelvis to last sacral suture placed;   Total OR time = operating room time of entry and exit;   Total case time = incision to end of closure;   Perioperative complications;   Hospital costs (Y Mesh v. dual Mesh and stratified by RA LSC v. LSC);   Post-operative patient outcomes at 6 weeks and 6 months
2 Recruiting Biologic Mesh Versus Synthetic Mesh in Repair of Ventral Hernias
Condition: Ventral Hernia
Interventions: Device: Davol Bard ®Soft Mesh;   Device: LifeCell Strattice® Reconstructive Tissue Matrix
Outcome Measures: The number of participants with be absence of surgical site occurence requiring procedural intervention and fewer recurrent hernias;   The direct and indirect costs associated with the use of either polypropylene or biologic Mesh.
3 Recruiting The eSVS® Mesh Post-Marketing Trial
Conditions: Coronary Artery Disease;   Myocardial Ischemia;   Coronary Disease;   Heart Diseases;   Cardiovascular Diseases;   Arteriosclerosis;   Arterial Occlusive Diseases;   Vascular Diseases
Intervention: Device: eSVS Mesh
Outcome Measures: Patency and number of stenosis and their degree in eSVS Mesh SVG versus Control SVG;   Incidence of MACCE;   Evaluation and comparison of vein characteristics of SVGs pre-operatively using duplex-sonography versus intraoperatively by standard vein harvest
4 Recruiting Comparative Effectiveness Multicenter Trial for Adhesion Characteristics of Ventral Hernia Repair Mesh
Conditions: Ventral Hernia;   Adhesions
Intervention: Procedure: Clinically-Indicated Abdominal Re-Exploration Surgery
Outcome Measures: Mesh adhesiolysis time:Mesh surface area;   Mesh Contracture;   Mesh adhesion tenacity;   Percentage Mesh surface area covered with adhesions;   Adhesiolysis time to abdominal wall;   Adhesiolysis time to Mesh;   Incidence of adhesiolysis-related intra-operative complications;   Length of stay of hospital admission;   Length of stay in ICU;   Interval to return to bowel function;   Interval to return to independent ambulation or activities of daily living;   Interval to return to work or routine physical activity;   Incidence of postoperative complications;   Incidence of surgical site infection;   Incidence of initiation of antibiotics, blood and total parenteral nutrition;   Incidence of bedside procedures to address a postoperative surgical complication;   Incidence of surgery under local anesthesia to address a postoperative complication;   Incidence of single system organ failure;   Incidence of multiple-system organ failure;   Mortality rate
5 Not yet recruiting Reducing Mesh Infections in Open Hernia Repairs
Conditions: Patients Undergoing Open Hernia Repair;   Patients Undergoing Ventral or Inguinal Hernia Repair
Interventions: Procedure: vancomycin-soaked Mesh;   Procedure: plain Mesh
Outcome Measures: Mesh infections;   hernia recurrence;   postoperative seroma formation
6 Recruiting Biological Meshes in Infected Fields: a Randomized Controlled Trial
Condition: Ventral Hernia
Interventions: Biological: Biological Mesh;   Procedure: without biological Mesh
Outcome Measures: 6-month postoperative morbidity;   Day 45 wound infection rate;   1-year recurrent hernia rates;   postoperative pain;   quality of life;   time to cure;   need for wound reoperation due to infection or hernia recurrence;   impact of the cross-linked Mesh structure on the primary objective;   medico-economic evaluation taking into account direct costs related to infected ventral hernia treatment.;   3 months wound infection rate;   1 year wound infection rate;   2-year recurrent hernia rates;   3-year recurrent hernia rates;   impact of the cross-linked Mesh structure on the 1-year infection rate;   impact of the cross-linked Mesh structure on the 1-year recurrence rate;   impact of the cross-linked Mesh structure on the 3-year recurrence rate
7 Recruiting Biological Mesh Closure of the Pelvic Floor After Extralevator Abdomino Perineal Resection for Rectal Cancer
Condition: Rectal Cancer
Interventions: Procedure: Biological Mesh assisted perineal closure;   Procedure: Primary perineal closure
Outcome Measures: The primary endpoint is the percentage of uncomplicated perineal wound healing;   Perineal wound healing according to the Southampton wound grading;   Incidence of persistent perineal or presacral sinuses, both clinically and by imaging;   Need for re-intervention or re-admission related to pre-sacral abscess or other perineal wound problems;   Length of hospital stay;   Need for nursing home admission;   Need for home nursing wound care: frequency per week and total period of time;   Use of wound care material and devices like vacuum assisted closure;   Incidence of symptomatic and asymptomatic perineal hernia;   Quality of life;   Costs
8 Recruiting Laparoscopic Lightweight Mesh Repair of Large Hiatal Hernias
Condition: Hernia, Hiatal
Interventions: Procedure: Laparoscopic hiatal repair with sub-lay partially absorbable lightweight Mesh;   Procedure: Laparoscopic primary posterior crural repair
Outcome Measures: Anatomical and functional recurrence of hiatal hernia and GERD;   Repair-related dysphagia/oesophageal stricture/prosthetic erosion;   Quality of life and satisfaction;   Operative time;   Morbidity;   Postoperative hospital stay;   Influence on extra-oesophageal complications
9 Recruiting The Flemish Umbilical Nitinol Mesh Trial, a Multicenter Trial
Condition: Umbilical Hernia
Interventions: Procedure: Intraperitoneal Mesh placement;   Procedure: Preperitoneal Mesh placement
Outcome Measures: Operation time between preperitoneal Mesh placement versus intraperitoneal Mesh placement.;   Surgical wound morbidity complication rate.;   Recurrence Rate;   Pain evaluation;   Discomfort evaluation.
10 Recruiting Laparoscopic Repair of Giant Hiatal Hernias With Nitinol-framed Lightweight Polytetrafluoroethylene Mesh
Condition: Hernia, Hiatal
Interventions: Device: Nitinol-framed lightweight PTFE Mesh for hiatal repair;   Device: Partially absorbable lightweight Mesh for hiatal repair
Outcome Measures: Anatomical and functional recurrence of hiatal hernia and GERD;   Repair-related dysphagia/oesophageal stricture/prosthetic erosion;   Quality of life and satisfaction;   Morbidity;   Time to discharge;   Number of participants completely recovered from extra-oesophageal complications of hiatal hernia following surgical procedure
11 Recruiting Comparative Study Matching Intraperitoneal Onlay Mesh (IPOM) and Sublay Mesh to Treat Umbilical Hernia
Condition: Umbilical Hernia
Interventions: Procedure: intraperitoneal onlay Mesh repair;   Procedure: sublay Mesh repair
Outcome Measures: early wound complications;   late wound complications;   complication rate perioperative;   duration of operation;   hospital stay;   umbilical hernia recurrence rate;   navel site seroma;   complication rate postoperative;   pain score (Visual Analog Scale - VAS);   Quality of life (SF-36)
12 Recruiting TIGR vs Polypropylene (Permanent) Mesh: Randomised Trial
Condition: Hernia
Intervention: Device: TIGR Mesh
Outcome Measures: Shrinkage profiles of the implant;   Amount of tissue ingrowth
13 Recruiting Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh
Conditions: Hernia, Inguinal;   Unilateral Inguinal Hernia
Intervention: Procedure: Self-fixating Parietex Progrip Mesh
Outcome Measures: Incidence of chronic post-operative inguinal pain;   Recurrence rate
14 Recruiting Evaluation of Mesh Integration and Mesh Contraction After Open Preperitoneal Inguinal Hernia Repair Using a Memory Ring Containing Device
Condition: Unilateral Inguinal Hernia
Intervention: Device: Rebound HRD Mesh
Outcome Measures: Calculation and measurement of shrinkage (%) of Mesh surface after surgical Mesh implantation.;   Pain assessment.;   Discomfort assessment.;   Use of oral analgetics.;   Wound morbidity.;   Recurrence of hernia.
15 Recruiting Absorbable Mesh Pleurodesis in Thoracoscopic Treatment of Spontaneous Pneumothorax
Conditions: Spontaneous Pneumothorax;   Surgery
Interventions: Procedure: Thoracoscopic bullectomy and pleural abrasion;   Biological: Mesh coverage of the staple line
Outcome Measures: the rates of ipsilateral pneumothorax recurrence;   Safety of Mesh coverage;   long-term safety of Mesh coverage
16 Recruiting Role of Prosthetic Mesh in Preventing Parastomal Hernias
Condition: Parastomal Hernia
Interventions: Device: Definitive end colostomy with Mesh;   Other: Conventional definitive end colostomy
Outcome Measures: Compare the incidence of parastomal hernias between groups;   Compare the overall and specific postoperative morbidity and mortality between groups;   Compare the difference in surgical time between the conventional technique and the prosthetic Mesh group;   Compare hospital stay between the groups
17 Recruiting Efficacy and Safety of Reduced Pelvic Floor Mesh Implants
Conditions: Post Operative Pain;   Complication of Surgical Procedure
Intervention: Other: reduced Mesh implants
Outcome Measures: Intra-operative and post operative adverse effects;   Efficacy
18 Unknown  Comparative Study on Self-adhesive Mesh for Open Inguinal Hernia Repair
Condition: Inguinal Hernia Repair
Interventions: Device: PROGRIP;   Device: POLYPROPYLENE
Outcome Measures: Operating time from skin incision to wound closure;   Seroma formation, post-operative pain, analgesic used, recurrence rate, chronic discomfort, patients satisfaction
19 Recruiting Modified "Open Intraperitoneal Mesh" Technique of Incisional Ventral Hernia Repair
Conditions: Incisional Ventral Hernia;   Recurrent Ventral Hernia
Intervention: Procedure: modified "open Mesh technique"
Outcome Measures: number/frequency of early postoperative complications (wound infections, seroma, hematoma);   postoperative hernia recurrence
20 Recruiting Comparison of Self-Fixating vs Non-Fixating Hernia Mesh
Condition: Inguinal Hernia
Interventions: Procedure: Use of self-fixating Mesh for inguinal hernia repair;   Procedure: Use of non-fixating Mesh for inguinal hernia repair;   Procedure: Absorbable tacks may be used in hernias >2cm
Outcome Measures: Chronic postoperative pain;   Incidence of hernia recurrence

These studies may lead to new treatments and are adding insight into MESH etiology and treatment.

A major focus of MESH research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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