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Meladinine Medical Research Studies

Up-to-date List of Meladinine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Meladinine Medical Research Studies

Rank Status Study
1 Recruiting A Safety and Efficacy Study of Uvadex and Extracorporeal Photopheresis (ECP) in Chronic Graft Versus Host Disease
Condition: Chronic Graft Versus Host Disease
Interventions: Drug: ECP(Methoxsalen)+Corticosteroids+Cyclosporine or Tacrolimus;   Drug: Corticosteroids/Cyclosporine/Tacrolimus
Outcome Measures: Overall response (complete or partial response) in cGvHD according to NIH Response Criteria;   Proportion of patients in each treatment group achieving response rates (complete or partial) by organ system involvement;   Correlation between total skin score and skin assessment (% of skin involvement);   Quality of Life (QoL) Questionnaire SF 36 short version scores;   QoL questionnaire, Bone marrow Transplant scores;   Relapse of underlying malignancy;   Results from clinical laboratory tests;   Adverse Events Reported
2 Recruiting PUVA Maintenance Therapy in Mycosis Fungoides
Condition: Patch/Plaque Stage Mycosis Fungoides
Intervention: Drug: 8-methoxypsoralen
Outcome Measures: Recurrence after complete remission within 12 months post therapy;   Quality of life;   HADS;   Cytokine response in serum;   Levels of regulatory T cells;   Function of regulatory T cells;   Microscopic alterations;   Cytokine expression in the skin
3 Recruiting Extracorporal Photopheresis Pilot Study
Condition: Hematological Malignancies
Interventions: Drug: methoxsalen;   Procedure: Extracoporal Photopheresis (ECP)
Outcome Measures: Evaluation of the toxicity at Day 100 (NCI/NIH Common Toxicity Criteria) of Extracorporal Photopheresis (ECP) administered for Graft-versus-host-disease (GVHD) prophylaxis and introduced early (Day 21) after an HSCT from a genoidentical donor.;   Efficacy: decrease in incidence of acute GVHD and chronic GVHD;   Incidence of Infection (clinically et/or bacteriologically proved);   Documentation of chimerism [quantification of donor-type chimerism in bone marrow and/ or in peripheral blood (total blood, CD3+)];   Transplant-related Mortality;   Toxicity at Day 180 after HSC transplantation;   Disease-free survival (DFS);   progression-free survival (PFS);   Overall survival (OS);   cumulative incidence of relapse
4 Unknown  A Trial of Extracorporeal Photopheresis, Pentostatin, and Total Body Irradiation in Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation for the Treatment of Malignancies
Condition: Hematologic Malignancies
Interventions: Procedure: extracorporeal photopheresis;   Drug: Pentostatin;   Radiation: Total Body Irradiation
Outcome Measures: Incidence of grade 2-4 acute graft versus host disease following allogeneic stem cell transplantation in patients randomized to photopheresis vs. no photopheresis;   Determining time to neutrophil and platelet engraftment, nonrelapse mortality, disease response, failure free survival, and overall survival
5 Recruiting Extracorporeal Photopheresis After Liver Transplant
Condition: Hepatic Insufficiency
Intervention: Procedure: Extracorporeal photopheresis
Outcome Measures: Serious Adverse Events associated with the procedure;   Non Serious Adverse Events;   Allograft Rejection;   Immunosuppressant level;   Liver function test;   Renal Function test;   Hematological Parameters;   Immunological evaluation
6 Recruiting Outcomes of Cutaneous T-Cell Lymphoma and Graft-Versus-Host Disease With Extracorporeal Photopheresis Treatment
Conditions: Cutaneous T Cell Lymphoma;   Graft Versus Host Disease
Intervention:
Outcome Measures: Response rates;   Complications
7 Unknown  Extracorporeal Photopheresis for Acute Graft Versus Host Disease
Conditions: Graft Versus Host Disease;   Cancer;   Stem Cell Transplantation
Intervention: Procedure: Extracorporeal Photopheresis
Outcome Measures: To evaluate the safety and feasibility of extracorporeal photopheresis (ECP) in the treatment of steroid-refractory acute graft-versus-host disease (GVHD) in children.;   To estimate the response rate of ECP in steroid-refractory acute GVHD in children.;   To evaluate the immunological mechanisms of ECP in acute GVHD.

These studies may lead to new treatments and are adding insight into Meladinine etiology and treatment.

A major focus of Meladinine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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