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Menopausal Medical Research Studies

Up-to-date List of Menopausal Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Menopausal Medical Research Studies

Rank Status Study
1 Unknown  Effectiveness of Licorice Extract Dietary Supplement on the Treatment of Postmenopausal Symptoms
Conditions: Postmenopausal Symptoms;   Vaginal Dryness
Intervention: Dietary Supplement: Calmera-Licorice Root Extract (Licogen)
Outcome Measures: A beneficial effect of the licorice extract on Postmenopausal symptoms (vasomotor symptoms, and nocturnal episodes) in symptomatic Postmenopausal women;   A beneficial effect of the licorice extract on vaginal complaints in symptomatic Postmenopausal women
2 Unknown  Physical Activity and Metabolic Risk Factors in Postmenopausal Women
Condition: Postmenopausal Women
Intervention: Other: A longitudinal intervention
Outcome Measure: Postmenopausal women's daily energy expenditure
3 Recruiting Incidence of Malignant and Premalignant Endometrial Polyp in Asymptomatic and Symptomatic Postmenopausal Women
Conditions: Endometrial Polyp.;   Malignant and Pre-malignant Changes in the Polyp
Intervention: Procedure: Hysteroscopic polypectomy
Outcome Measures: Incidence of malignant and pre-malignant changes in polyps removed from symptomatic and asymptomatic post-menopausal women;   Sonographic characteristics and histo-pathologic measures of endometrial polyp;   Rate of complications during or around the operation;   Correlation between the sonographic characteristics and histopathological findings
4 Recruiting Raloxifene as an Adjuvant Treatment of the Negative Symptoms of Schizophrenia in Post-menopausal Women
Condition: Negative Symptoms of Schizophrenia in Post-menopausal Women.
Interventions: Drug: Raloxifene;   Drug: Lactosa (placebo arm)
Outcome Measures: To assess the efficacy of raloxifene (SERM - Selective Estrogen Receptor Modulator) as an adjuvant of antipsychotic treatment in the management of negative symptoms of schizophrenia in post-menopausal women.;   To assess the efficacy of raloxifene as an adjuvant of antipsychotic treatment in the management of global symptoms of schizophrenia in Postmenopausal women.;   To assess the efficacy of raloxifene as an adjuvant of antipsychotic treatment in the global functioning of Postmenopausal women with schizophrenia.;   To assess the efficacy of raloxifene as an adjuvant of antipsychotic treatment in the neuropsychological functioning of post-menopausal women with schizophrenia;   To control response to treatment as a function of genetic variants in the form of SNP (Single Nucleotide Polymorphisms) that patients present in the alfa (ESR1) and beta (ESR2) estrogenic receptor genes.;   To assess the safety of the medication used in this patient population.
5 Recruiting A Double-blind Study to Assess the Efficacy and Safety of Denosumab Produced by Two Different Processes in Postmenopausal Women With Osteoporosis.
Condition: Postmenopausal Osteoporosis
Interventions: Drug: Denosumab (CP2);   Drug: Denosumab (CP4)
Outcome Measures: Bone Mineral Density by Dual-Energy X-ray Absorptiometry at the lumbar spine;   Serum concentration of biomarkers of Bone Turnover (CTX and P1NP)
6 Not yet recruiting Bone Healing in Healthy and Post-menopausal Osteoporotic Women
Condition: Post-menopausal Osteoporosis
Interventions: Procedure: tooth extraction;   Radiation: CBCT scan;   Radiation: DXA scan;   Radiation: Panoramic radiograph
Outcome Measures: alveolar bone width and height alveolar bone changes in width and height;   clinical changes of soft and hard tissue and of periodontal parameters in the neighboring teeth
7 Unknown  Effects of Different Exercise Training Dose on Exercise Performance and Noninvasively Estimated Muscle Oxygen Extraction in Diabetic Postmenopausal Women
Condition: Postmenopausal Diabetes
Intervention: Other: exercise
Outcome Measure: skeletal muscle oxygenation response
8 Recruiting Creatine on Bone Mass in Postmenopausal Women
Condition: Postmenopausal Women
Interventions: Dietary Supplement: Creatine supplementation;   Dietary Supplement: dextrose (placebo)
Outcome Measures: bone mineral density (BMD);   bone markers;   history of falls
9 Recruiting A Pharmacokinetic and Randomized Trial of Neoadjuvant Treatment With Anastrozole Plus AZDO530 in Postmenopausal Patients With Hormone Receptor Positive Breast Cancer
Condition: Breast Cancer
Interventions: Drug: Anastrozole;   Drug: ADZ0530;   Drug: Placebo;   Procedure: Pharmacokinetic studies;   Procedure: Definitive Surgery;   Procedure: Core Biopsy;   Genetic: Tumor Tissue Collection for Genetic and Molecular Studies
Outcome Measures: Phase I Cohort A: To determine if a well tolerated dose of AZD0530 can be used in combination with anastrozole for Postmenopausal women with ER+/PR+ metastatic breast cancer;   Phase II - Cohort B: Compare treatment groups (AZD0530 + Anastrozole versus Anastrozole alone with respect to clinical response.;   Phase I - Cohort A: To test the effects of giving AZD0530 and Anastrozole together on pharmacokinetics of both drugs;   Phase II - Cohort B: Evaluation of pathologic complete response (pCR);   Phase II - Cohort B: Clinical Response (complete (CR), or partial (PR) responses);   Phase II - Cohort B: Clinical Benefit (complete (CR), or partial (PR) responses or stable disease (SD));   Phase II - Cohort B: Qualitative and Quantitative Toxicities;   Phase II - Cohort B: Progression-Free Survival;   Phase II - Cohort B: Overall Survival;   Phase II - Cohort B: To identify molecular/biologic correlates as indicators of treatment response
10 Recruiting Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis
Condition: Postmenopausal Women With Osteoporosis
Interventions: Drug: Romosozumab;   Drug: Alendronate
Outcome Measures: Incidence of clinical fracture;   Incidence of new vertebral fracture;   Incidence of fracture;   Percent changes in DXA Bone Mineral Density from baseline to 12 months;   Percent changes in DXA Bone Mineral Density from baseline to 24 months;   Percent changes in DXA Bone Mineral Density from baseline to 36 months
11 Recruiting Study on the microRNA Expression Level in Postmenopausal Osteoporosis
Condition: Postmenopausal Osteoporosis
Intervention: Other: osteoporosis
Outcome Measure: microRNA expression lever in the Peripheral Blood
12 Unknown  The Roles of SAH Gene Family in Athrogenic Dyslipidemia in Postmenopausal Women
Conditions: Disorder Associated With Menstruation and/or Menopause;   Dyslipidemia
Intervention:
Outcome Measures: the differences in haplotype frequencies of the SAH gene between two groups of subjects with different levels of non-HDL-C.;   the differences in haplotype frequencies of other members of the SAH gene family between two groups of subjects with different levels of non-HDL-C.
13 Recruiting Effect of Azilsartan on Aldosterone in Postmenopausal Females
Condition: Hypertension
Interventions: Drug: Azilsartan medoximil;   Drug: Placebo
Outcome Measures: To evaluate the effect of an angiotensin receptor blocker (azilsartan medoximil) on blood pressure in Postmenopausal females.;   To evaluate the effect of an angiotensin receptor blocker (azilsartan medoximil) on urinary aldosterone levels in Postmenopausal females.
14 Recruiting Radius Loading in Primary Hyperparathyroidism
Conditions: Hyperparathyroidism, Primary;   Bone Diseases, Metabolic;   Osteoporosis, Postmenopausal;   Bone Loss, Postmenopausal
Interventions: Other: Forearm exercise program;   Other: Walking program
Outcome Measure: Increase in bone mass and bone quality
15 Recruiting Study of ARN-810 in Postmenopausal Women With Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer
Condition: Breast Cancer
Intervention: Drug: ARN-810
Outcome Measures: Maximum Tolerated Dose (MTD);   To determine the safety of ARN-810 and its O-glucuronide metabolite in Postmenopausal women with locally advanced or metastatic ER+ (HER2-) breast cancer;   Pharmacokinetics (PK) of ARN-810 and its O-glucuronide metabolite
16 Recruiting A Study of Blosozumab ( LY2541546) in Postmenopausal Female Participants
Condition: Osteoporosis, Postmenopausal
Intervention: Drug: Blosozumab
Outcome Measures: Pharmacokinetics (PK): Maximum Concentration (Cmax) of Blosozumab;   Pharmacokinetics (PK): Area Under the Concentration Curve of Blosozumab
17 Unknown  The Effects of Potassium Citrate on Bone Metabolism
Conditions: Bone Diseases, Metabolic;   Osteoporosis, Postmenopausal
Intervention: Drug: potassium citrate
Outcome Measures: Bone turnover markers;   Bone Density by DEXA
18 Unknown  Adherence and Health Effects of Video Dance in Postmenopausal Women
Condition: Post Menopausal
Interventions: Behavioral: videodance;   Behavioral: Brisk Walking;   Behavioral: delayed entry control
Outcome Measures: Adherence;   Endurance;   body composition;   vascular health;   balance;   personality;   sleep quality;   visuospatial/constructional function;   attention domain;   Useful Field of View;   step reaction time
19 Recruiting Bone Healing After Dental Extraction in Postmenopausal Osteoporotic Women Treated With Alendronate Per os Weekly
Condition: Alveolar Bone Healing After Dental Extraction
Intervention: Procedure: Dental extraction
Outcome Measures: Alveolar socket filled by new bone;   Mucosal injury
20 Recruiting Mediterranean Diet for Post-menopausal Women: Effects on Bone Turnover
Conditions: Osteoporosis;   Postmenopausal Bone Loss
Intervention: Other: Mediterranean Diet
Outcome Measures: study adherence;   Bone turnover markers

These studies may lead to new treatments and are adding insight into Menopausal etiology and treatment.

A major focus of Menopausal research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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