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Mestinon Medical Research Studies

Up-to-date List of Mestinon Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Mestinon Medical Research Studies

Rank Status Study
1 Recruiting The Dose-Response Relationship of Rocuronium in Patients Taking Pyridostigmine
Condition: Neuromuscular Agents
Intervention:
Outcome Measure: Dose of the muscle relaxant rocuronium that will lead to 50% decrease in the force of the evoked muscle contraction in patients taking pyridostigmine.
2 Recruiting Orthostatic Dysregulation and Associated Gastrointestinal Dysfunction in Parkinson's Disease -Treatment
Condition: Autonomic Disturbances in Parkinson`s Disease
Interventions: Drug: Pyridostigmine bromide;   Drug: fludrocortisone
Outcome Measures: Changes in diastolic blood pressure drop on Schellong manoeuvre;   Changes in half emptying time t50 on 13C-sodium octanoate breath test;   Efficacy of Pyridostigmine bromide;   Safety & Tolerability of Pyridostigmine bromide
3 Recruiting Droxidopa / Pyridostigmine in Orthostatic Hypotension
Condition: Orthostatic Hypotension
Interventions: Drug: Droxidopa;   Drug: Pyridostigmine Bromide
Outcome Measures: The primary endpoint is the improvement in diastolic BP fall at the end of 5 minutes of standing.;   Evaluate the effect of Droxidopa alone versus Droxidopa combined with pyridostigmine versus placebo on supine NE and its orthostatic increment.;   Evaluate the effect of Droxidopa alone versus Droxidopa combined with pyridostigmine on orthostatic symptoms.
4 Recruiting Safety Study of Pyridostigmine in Heart Failure
Condition: Heart Failure
Intervention: Drug: Pyridostigmine Bromide
Outcome Measures: Post Exercise Heart Rate Recovery;   Resting Heart Rate Variability;   Cardiovagal baroreceptor function;   Kansas City Cardiomyopathy Questionnaire;   Cholinergic Symptom Score;   Spirometry;   Electrocardiogram
5 Recruiting A Study of Pyridostigmine in Postural Tachycardia Syndrome
Condition: Postural Tachycardia Syndrome
Interventions: Drug: pyridostigmine;   Drug: Placebo
Outcome Measures: Change in orthostatic symptoms using Composite Autonomic Symptom Scale (COMPASS) change;   Heart rate response to head-up tilt;   Plasma norepinephrine change
6 Recruiting Treatment of Orthostatic Hypotension in Autonomic Failure
Conditions: Autonomic Failure;   Orthostatic Hypotension
Interventions: Drug: Atomoxetine;   Drug: Acarbose;   Drug: Pyridostigmine Bromide;   Drug: Yohimbine;   Drug: Midodrine HCl;   Drug: placebo;   Drug: Modafinil;   Drug: Octreotide;   Other: water intake;   Drug: Diphenhydramine Hydrochloride;   Drug: Ranitidine HCL;   Drug: Tranylcypromine;   Drug: Ergotamine/ Caffeine;   Drug: Celecoxib;   Drug: Pseudoephedrine;   Drug: Methylphenidate;   Drug: Indomethacin;   Drug: Ibuprofen;   Drug: Oxymetazoline 0.05% nasal solution;   Dietary Supplement: Bovril;   Drug: Acetazolamide;   Drug: Rivastigmine tartrate;   Drug: Carbidopa/levodopa;   Device: Inflatable abdominal binder;   Device: inflatable abdominal binder (sham)
Outcome Measures: Increase in seated systolic blood pressure 1-hr post drug compared to baseline.;   Increase in standing time 1-hr post drug compared to baseline
7 Recruiting The Efficacy and Safety of Leflunomide or Azathioprine Therapy in Myasthenia Gravis Patients After Expand Thymectomy
Condition: Myasthenia Gravis
Interventions: Drug: Azathioprine;   Drug: Leflunomide
Outcome Measures: the percent of achieving good response;   level of the AChR-Ab
8 Recruiting Long Acting FSH Plus Antagonist Versus Daily FSH Plus Antagonist Versus Short Agonist Protocol in Poor Responders Undergoing IVF
Conditions: Female Infertility;   Poor Responder
Interventions: Drug: Long acting FSH and GnRH antagonist;   Drug: Daily FSH and GnRH antagonist;   Drug: Triptorelin and recombinant FSH
Outcome Measures: Clinical pregnancy rate;   Implantation rate

These studies may lead to new treatments and are adding insight into Mestinon etiology and treatment.

A major focus of Mestinon research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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