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Methenamine Hippurate Medical Research Studies

Up-to-date List of Methenamine Hippurate Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Methenamine Hippurate Medical Research Studies

Rank Status Study
1 Recruiting Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement
Condition: Sciatica Due to Intervertebral Disc Disorder
Interventions: Other: Electroacupuncture (EA);   Other: Traction;   Drug: Voltaren;   Drug: Vitamin B1
Outcome Measures: Visual Analog Scale(VAS) of Leg Pain;   Visual Analog Scale(VAS) of Low Back Pain;   Simplified McGill Pain Questionnaire (ST-MPQ);   Improved Roland Functional questionaire(RDQ);   Likert Overall Recovery Self Rating Scale (7 points);   The Medical Outcomes Study 36-Item Short -Form Health Survey Questionnaire (SF-36);   Sciatica Frequency and Bothersome Index (SFBI)
2 Recruiting Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Lumbar Intervertebral Disc Degeneration
Condition: Lumbar Intervertebral Disc Degeneration
Intervention: Procedure: Autologous Adipose Tissue derived MSCs Transplantation
Outcome Measures: Magnetic Resonance Imaging;   Changes of Neurological Functions;   Safety evaluation
3 Recruiting Tissue Collection for Understanding Intervertebral Disc Degeneration and Back Pain
Conditions: Intervertebral Disc Degeneration;   Back Pain
Intervention:
Outcome Measure: Inflammatory profile
4 Recruiting Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease
Conditions: Intervertebral Disc Degeneration;   Modic I Discopathy;   Back Pain;   Low Back Pain;   Magnetic Resonance Imaging (MRI)
Interventions: Drug: Pamidronate;   Other: Placebo
Outcome Measures: back pain assessed on a100mm VAS;   - Functional status using EIFEL, Dallas, FABQ, MacTar, and MCII/PASS questionnaires;   Back stiffness assessed by Schober's test and finger-to-floor distance;   Inflammatory pain pattern;   assess the efficacy of a rigid back brace in treating back pain;   Tolerance based on the number and types of side-effects
5 Recruiting A Study of SI-6603 in Patients With Lumbar Disc Herniation
Conditions: Intervertebral Disc Disease;   Lumbar Disc Disease
Interventions: Drug: Condoliase;   Drug: placebo
Outcome Measures: Leg pain;   Responder rate evaluation
6 Recruiting Is Treatment of the Intervertebral Disc More Effective at Short-term Than the Nerve Root in Patients With a Neck Hernia?
Condition: Contained Cervical Disc Herniation
Interventions: Procedure: Percutaneous Cervical Nucleoplasty;   Procedure: Pulsed Radio Frequency
Outcome Measures: Change in pain scores using a VAS-100 mm and VRS-5;   Change in general health status using the Short Form 12-item questionnaire (SF-12);   Change in neck functioning during activities of daily living using the Neck Disability Index (NDI);   Change in chronic pain experience using the Multidimensional Pain Inventory - Dutch Language Version (MPI-DLV);   Change in limitations in sports and work using multiple choice questions;   Occurence of (serious) adverse events ((S)AEs) post-operatively;   Cost-effectiveness evaluation of both treatments using patient's study diary;   Change in pain medication usage;   Post-operative change in patient's treatment satisfaction using a dichotomous question and VAS-100 mm
7 Recruiting Safety and Efficacy With NOVOCART® Disc Plus (ADCT) for the Treatment of Degenerative Disc Disease in Lumbar Spine
Conditions: Intervertebral Disc Displacement;   Intervertebral Disc Degeneration
Interventions: Drug: NOVOCART® Disc plus;   Device: NOVOCART® Disc basic
Outcome Measures: Oswestry Disability Index (ODI);   MRI-signal (disc height, disc volumetry, signal intensity);   Oswestry Disability Index;   VAS for back pain and leg pain;   Health-related quality of life as measured by the SF-36;   Healthy Questionnaire EQ-5D;   Neurological status;   Functional status;   Return to work (days);   Analgesic Medication Use during the previous 14-day-time period;   Physician assessments of ease of transplantation;   Surgical parameters, including length of procedure;   Prevalence of subsequent surgical interventions;   Any unanticipated adverse event;   Specific laboratory parameters according to product compatibility and availability: CRP, IL-6, LTE4;   Histology of the tissue explant;   Gene expression by quantitative realtime PCR of expanded cells, and cell culture medium metabolites during expansion;   Biomarkers of blood and urine samples (SOX9, MMP-3, collagen type I, collagen type II, collagen type X, IL-1, aggrecan, BMP receptor Ia, BSP-2, FLT-1, collagen crosslinks, and yet to be defined additional elements)
8 Recruiting Efficacy of a Human Amniotic Tissue-derived Allograft, NuCel, in Patients Undergoing Posteriolateral Lumbar Fusions for Degenerative Disc Disease
Conditions: Lumbar Degenerative Disc Disease;   Spinal Stenosis;   Spondylolisthesis;   Spondylosis;   Intervertebral Disk Displacement;   Intervertebral Disk Degeneration;   Spinal Diseases;   Bone Diseases;   Musculoskeletal Diseases;   Spondylolysis
Interventions: Biological: NuCel;   Biological: Deminaralized Bone Matrix
Outcome Measures: Oswestry Disability Index;   Radiological
9 Recruiting Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine
Conditions: Intervertebral Disc Disease;   Intervertebral Disc Degeneration;   Spondylosis;   Spondylolisthesis;   Spinal Stenosis
Intervention: Other: NuCel with Autograft
Outcome Measures: Spinal Fusion;   Change from baseline pain using Visual Analogue Scale (VAS);   Change from baseline Oswestry Disability Index (Ver. 2.1);   X-ray to compare to baseline preoperative X-ray
10 Recruiting Lumbar Intervertebral Disc Herniation
Condition: Lumbar Disc Herniation
Interventions: Device: Dynamic Stabilization;   Procedure: Discectomy;   Device: Instrumentation and fusion
Outcome Measures: Range of motion in sagittal plane at the operated level;   Mean Change in Oswestry Disability Index (ODI);   Change in Lumbar Pain Numeric Rating Scale (NRS);   Change in Leg Pain NRS
11 Unknown  Safety Study of Preservon-Treated Bone Implants for Cervical Fusion in the Treatment of Cervical Radiculopathy or Myelopathy
Conditions: Cervical Radiculopathy;   Myelopathy
Intervention: Procedure: Anterior Cervical Discectomy and Fusion
Outcome Measures: Degree of subsidence;   Rate of fusion
12 Recruiting Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device
Conditions: Prolapsed Lumbar Disc;   Prolapsed Cervical Disc;   Intervertebral Disc Degeneration;   Spondylolisthesis, Grade 1;   Decreased Disc Height
Intervention:
Outcome Measures: Change in Oswestry Disability Index/Neck Disability Index;   Change in VAS Pain;   Radiological Assessment
13 Recruiting Cervical Spine; Movement Before and After Anterior Cervical Discectomy, With or Without a Cervical Disc Prosthesis
Conditions: Diskectomy;   Intervertebral Disk Displacement
Interventions: Device: Activ C disc prosthesis;   Procedure: Anterior cervical discectomy
Outcome Measures: Order of movement;   Segmental mobility;   Treatment of symptoms (pain, neurological assessment);   Influence on subjects functioning (social, work)
14 Unknown  Efficacy of Gabapentin or Amitriptyline to Reduce Postoperative Pain After Lumbar Laminectomy and Diskectomy
Conditions: Herniated Disc;   Intervertebral Disc Displacement
Intervention: Drug: Gabapentin , Amitriptyline
Outcome Measures: 30% reduction in opium consumption in either study arms compared to the placebo group;   30% reduction in pain according to visual analogue scale in either study arms compared to the placebo group
15 Recruiting The Effect of Integrated CAM Treatment in Hospitalized Patients
Conditions: Low Back Pain;   Neck Pain;   Knee Pain;   Shoulder Pain;   Intervertebral Disc Herniation;   Spinal Stenosis
Interventions: Drug: Herbal medicine;   Procedure: Acupuncture;   Procedure: Pharmacopuncture;   Procedure: Bee venom pharmacopuncture;   Procedure: Chuna manipulation
Outcome Measures: NRS of low back pain (LBP);   NRS of radiating leg pain;   NRS of neck pain;   NRS of radiating arm pain;   NRS of knee pain;   NRS of shoulder pain;   Oswestry disability index (ODI);   Vernon-Mior Neck Disability Index (NDI);   The Korean Western Ontario McMaster Index;   Shoulder Pain and Disability Index;   Physical and neurological examinations
16 Recruiting Steroid Injections Given at the "Level of MRI Pathology" Versus at the "Level of Clinical Symptoms" to See if One is More Effective Than the Other.
Conditions: Radiculopathy;   Spinal Stenosis;   Intervertebral Disc Displacement
Intervention: Procedure: Transforaminal Epidural Steroid Injection
Outcome Measures: Visual Analog Scale;   Short Form 36 Health Survey;   Oswestry Disability Index
17 Recruiting Patient Positioning in Lumbar Fusion Surgery and Its Impact on Spinal Sagittal Balance and Surgeon Satisfaction
Condition: Intervertebral Disk Degeneration
Intervention: Other: Hyperlordotic Positioning
Outcome Measures: To assess if the specific intra-operative positioning affects post-operative sagittal alignment;   Surgeon satisfaction with operative patient positioning
18 Recruiting Predicting the Outcome of Total Knee Arthroplasty and Spinal Surgeon
Conditions: Osteoarthritis;;   Intervertebral Disc Degeneration
Intervention:
Outcome Measures: Change of functional score over time in the patients after operation;   Change of quality of life score over time in the patients after operation
19 Recruiting Post-Market Study Evaluating the Safety and Effectiveness of NuNec® Cervical Arthroplasty System
Condition: Cervical Intervertebral Disc Degeneration
Intervention: Device: NuNec Cervical Disc
Outcome Measures: Neck disability index (NDI) score improvement of at least 15 points;   Visual analog scale (VAS) improvement of 2.0 cm for neck pain;   Maintenance or improvement in neurological status;   No serious adverse events related to the device;   No device failures or removals, revisions, reoperations or supplemental fixation at the index level;   Improvement in Neck Disability Index (NDI) by 15 points;   A 10 point improvement in physical component score on SF-36 quality of life questionnaire.;   Patient satisfaction;   Medication usage and work status;   Disc height is maintained;   Absence of device migration or subsidence
20 Recruiting Lumbar Fusion With The Icotec CF/PEEK Pedicle System In Combination With The Icotec CF/PEEK TLIF Cage ETurn™
Conditions: Degeneration of Lumbar Intervertebral Disc;   Degenerative Lumbar Spondylolisthesis
Intervention: Procedure: 1- or 2-level spinal fusion
Outcome Measures: Overall fusion rate;   Rate of pedicle system implant failures;   Rate of implant related, surgery related, postoperative and general complications;   Rate of subsequent surgical interventions;   Change of the mean total Oswestry Low Back Pain Disability Questionnaire (ODI);   Change of the mean Visual Analogue Scale (VAS) on low back pain;   Change of the mean Visual Analogue Scale (VAS) on pain in the leg and buttock (experienced in the pain-dominant leg);   Visual Analogue Scale (VAS) on patient's satisfaction with the surgery;   Change of the mean disc height at index level;   Rate of symptomatic adjacent segment disease

These studies may lead to new treatments and are adding insight into Methenamine Hippurate etiology and treatment.

A major focus of Methenamine Hippurate research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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