sponsored
PatientsVille.com Logo

PatientsVille

Mirtazapine Medical Research Studies

Up-to-date List of Mirtazapine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Mirtazapine Medical Research Studies

Rank Status Study
1 Unknown  Evaluation of Mirtazapine and Folic Acid for Schizophrenia:
Conditions: Schizophrenia;   Negative Symptoms
Interventions: Drug: Mirtazapine and folic acid;   Drug: Mirtazapine, folic acid placebo;   Drug: Mirtazapine placebo, folic acid;   Drug: Mirtazapine placebo, folic acid placebo
Outcome Measures: To compare the efficacy of Mirtazapine and placebo for treatment of symptoms associated with schizophrenia;   To compare the efficacy of folic acid and placebo for treatment of symptoms of schizophrenia;   To compare the efficacy of Mirtazapine and placebo for treatment of negative symptoms of schizophrenia;   To compare the efficacy of folic acid and placebo for treatment of negative symptoms of schizophrenia;   To compare the safety and tolerability of Mirtazapine and placebo in patients with schizophrenia;   To compare the safety and tolerability of folic acid and placebo in patients with schizophrenia
2 Recruiting Effectiveness Study of Mirtazapine Combined With Paroxetine in Major Depressive Patients Without Early Improvement
Condition: Major Depression
Interventions: Drug: Mirtazapine, paroxetine;   Drug: Mirtazapine;   Drug: paroxetine 20mg QD
Outcome Measures: Change of 17-item Hamilton Depression Scale (HAMD-17) total score;   The proportion of subjects at endpoint with HAMD-17≤7;   The incidence and nature of overall adverse events;   The incidence and nature of drug-related adverse events;   The number of subject withdrawal due to adverse events during double-blind phase
3 Recruiting Pharmacogenetic Study of Mirtazapine Response in Depressed Patients
Condition: Depression
Intervention: Drug: Mirtazapine
Outcome Measures: Mirtazapine response at 2,4,6 weeks and adverse events (A/E) monitoring at 1,2,4,6 weeks;   Biological value at 0 and 6 weeks
4 Unknown  Mirtazapine Versus Placebo in Functional Dyspepsia
Condition: Functional Dyspepsia
Intervention: Drug: Mirtazapine
Outcome Measures: Difference in dyspepsia symptom scores week 8 versus week 0;   Individual symptom severities;   Nepean dyspepsia index for quality of life in functional dyspepsia
5 Recruiting Mirtazapine Plus Gemcitabine Versus Gemcitabine in Metastasis Pancreatic Cancer
Condition: Pancreatic Cancer
Interventions: Drug: Mirtazapine plus gemcitabine;   Drug: Gemcitabine, placebo
Outcome Measures: quality of life;   anxiety and depression scores;   objective response rate;   progress free survival,;   overall Survival;   chemotherapy induced nausea and vomiting
6 Recruiting Mirtazapine for Sleep Disorders in Alzheimer's Disease
Conditions: Alzheimer's Disease;   Sleep Disorders
Intervention: Drug: Mirtazapine
Outcome Measures: Change From Baseline in Nighttime Total Sleep Time;   Change From Baseline in Nighttime Number Of Awakenings;   Change From Baseline in Nighttime Wake After Sleep Onset;   Change From Baseline in in Daytime Total Sleep Time;   Change From Baseline in Number of Daytime Naps;   Change in Cognitive Function (as Measured by the Mini-Mental State Examination);   Change in Activities of Daily Living (The Index of ADL - Katz);   Change of Baseline in Behavioral Variables (BAHAVE-AD Scale);   Change From Baseline in Cognitive Function (Digit Symbol Substitution Test)
7 Recruiting LEPR Polymorphism Weight Gain by Mirtazapine in Late Life Depression
Condition: Major Depressive Disorder
Intervention: Drug: Mirtazapine
Outcome Measures: increase in weight as measured in the clinic;   Proportion of population achieving clinical response as measured by rate of fall in HAM-D 24 item scores;   Proportion of patients achieving remission at end of study on HAM-D 24 (<11);   Frequency of adverse events;   Percentage adhering to medication
8 Recruiting Efficacy Study of Mirtazapine to Treat Interferon-related Depression During Antiviral Therapy for Hepatitis C
Condition: Depression
Interventions: Drug: Mirtazapine;   Other: Supportive psychotherapy
Outcome Measures: Change from baseline in Hamilton Depression Rating Scale (HAMD)-17 at 8 weeks;   Change from baseline in quality of life at 8 weeks;   Genetic polymorphism
9 Recruiting Mirtazapine for the Treatment of Methamphetamine Dependence Among MSM (M2.0)
Condition: Methamphetamine
Interventions: Drug: Mirtazapine;   Drug: Placebo
Outcome Measures: Number of methamphetamine-positive urine tests;   Sexual risk (see description)
10 Recruiting Mirtazapine Treatment of Anxiety in Children and Adolescents With Pervasive Developmental Disorders
Condition: Autism Spectrum Disorders
Interventions: Drug: Placebo;   Drug: Mirtazapine
Outcome Measures: Pediatric Anxiety Rating Scale (PARS);   Clinical Global Impressions (CGI)
11 Unknown  Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy
Condition: Depressive Disorder, Major
Interventions: Drug: Mirtazapine;   Drug: Venlafaxine
Outcome Measures: Categorial response to the medication. Categorial response is defined on the basis of CGI Improvement scale and 50% reduction in MADR-S score;   Tolerability of treatment as assessed using the DOTES scale;   Cognitive deficits as judged by the SKT system;   Self assessment of depression and anxiety using Beck's Depression/Anxiety Inventory (BDI/BAI);   Changes is blood levels of homocysteine, folate, vit B12, P11
12 Recruiting Algorithm Guided Treatment Strategies for Major Depressive Disorder
Condition: Major Depressive Disorder
Interventions: Drug: Escitalopram;   Drug: Mirtazapine;   Other: modified electroconvulsive therapy;   Other: repetitive transcranial magnetic stimulation;   Drug: Fluoxetine;   Drug: Citalopram;   Drug: Paroxetine;   Drug: Sertraline;   Drug: Fluvoxamine;   Drug: Venlafaxine;   Drug: Duloxetine;   Drug: Bupropion;   Drug: Trazodone
Outcome Measures: Remission defined as endpoint 17-item Hamilton Rating Scale for Depression (HRSD-17) total score ≤ 7;   Remission defined as endpoint the Quick Inventory of Depressive Symptomatology (16-item) (QIDS-SR16) total score ≤ 5;   Frequency and intensity of adverse events;   Quality of life
13 Unknown  Study of Methylphenidate as Add on Therapy in Depressed Cancer Patients
Condition: Depression
Interventions: Drug: Methylphenidate;   Drug: Placebo
Outcome Measures: depressive symptoms;   Distress level
14 Recruiting Strategic Use of New Generation Antidepressants for Depression
Condition: Unipolar Major Depressive Episode
Interventions: Drug: Sertraline;   Drug: Mirtazapine
Outcome Measures: Observer-rated depression severity (PHQ-9);   Self-rated depression severity (BDI-II);   Global rating of side effects (FIBSER)
15 Recruiting Predict Antidepressant Responsiveness Using Pharmacogenomics
Conditions: Depression;   Depressive Symptoms
Interventions: Drug: SSRI class antidepressant;   Drug: non-SSRI class antidepressant
Outcome Measure: Presences of each individual symptom of depression at 1,2,4,6,12 weeks
16 Recruiting Pharmacogenomic Study to Predict Antidepressant Responsiveness in Depressed Patients
Conditions: Depression;   Adverse Reaction to Drug
Interventions: Drug: SSRI class antidepressant;   Drug: non-SSRI class antidepressant
Outcome Measures: Antidepressant Response at 2,4,6 weeks A/E monitoring at 1,2,4,6 weeks;   Biological value at 0 and 6 weeks
17 Recruiting Development of Pharmacogenomic Method to Predict Antidepressant Responsiveness
Conditions: Depression;   Antidepressant Drug Adverse Reaction
Interventions: Drug: SSRI class antidepressant;   Drug: non-SSRI class antidepressant
Outcome Measures: all pharmacogenetic and biological marker variables cause drug response;   all clinical cause drug response
18 Recruiting Interpersonal Psychotherapy for Treatment Resistant Depression
Condition: Treatment Resistant Depression
Interventions: Other: IPT+ antidepressant drugs;   Drug: fluoxetine;   Drug: sertraline;   Drug: paroxetine;   Drug: Citalopram;   Drug: escitalopram;   Drug: fluvoxamine;   Drug: Venlafaxine;   Drug: Duloxetine;   Drug: Bupropion;   Drug: Lithium;   Drug: Risperidone;   Drug: tranylcypromine;   Drug: Imipramine;   Drug: amitriptyline;   Drug: Clomipramine;   Drug: nortriptyline;   Drug: trazodone;   Drug: Mirtazapine;   Drug: sulpiride
Outcome Measures: Hamilton Depression Scale (HAM-D) - continuous;   Beck depression Inventory (BDI)
19 Recruiting Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)
Condition: Lumbar Spinal Stenosis
Interventions: Drug: NSAIDs; adjunctive analgesics; adjunctive anti-depressants;   Procedure: Lumbar epidural injection;   Other: Joint Mobilizations (spine, sacroiliac, hip);   Other: Individualized exercises: clinical setting;   Other: Group Exercise: community setting
Outcome Measures: Swiss Spinal Stenosis Questionnaire Score;   Self Paced Walking Test
20 Unknown  Continuation Electroconvulsive Therapy (C-ECT) for Relapse Prevention in Major Depression
Condition: Depression
Interventions: Device: Thrymatron System IV device (CONSOLIDATION ELECTROCONVUsLIVE THERAPY) plus PHARMACOTHERAPY;   Drug: PHARMACOTHERAPY
Outcome Measures: Hamilton Depression Rating Scale 21 items (HDRS-21);   Mini-Mental State Examination (MMSE 35);   UKU - Adverse effects rating scales;   Demographical Data Memory (MEDABI-20);   Rey Figure;   Trail Making Test A;   Trail Making Test B;   Stroop Test;   Direct and inverse digits (WAIS, Weschler Adults Intelligence Sacle).;   Vocabulary WAIS (Weschler Adults Intelligence Scale);   Frequency Hospitalization Quotient;   Hospital Day Quotient (HDQ)

These studies may lead to new treatments and are adding insight into Mirtazapine etiology and treatment.

A major focus of Mirtazapine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


Discuss Mirtazapine