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Murine Medical Research Studies

Up-to-date List of Murine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Murine Medical Research Studies

Rank Status Study
1 Recruiting Mouse Allergen and Asthma Intervention Trial
Conditions: Asthma;   Mouse Allergy;   Mouse Allergen Exposure
Interventions: Other: Integrated Pest Management;   Other: Education
Outcome Measure: change in asthma symptoms
2 Unknown  Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R)
Condition: Acute Otitis Externa
Intervention: Device: Natural Ear Comfort(TM), a botanical ear drops product
Outcome Measures: Ear Comfort(TM) kills pain in AOE patients within how many hours?;   Does Ear Comfort(TM) heal the inflamation in AOE patients?
3 Recruiting Human Heterologous Liver Cells for Infusion in Children With Urea Cycle Disorders
Condition: Urea Cycle Disorders
Intervention: Biological: HHLivC
Outcome Measures: Changes in 13C urea formation from baseline to 2 and 4 months after first HHLivC infusion;   Frequency and severity of metabolic crises
4 Recruiting Vaginal Fluid Wash in Pre-labour Rupture of Membranes
Condition: Disorder of Amniotic Cavity and/or Membrane
Interventions: Procedure: Urea and creatinine;   Procedure: Nitrazine;   Drug: 5ml saline
Outcome Measures: Urea and creatinine in vaginal fluid;   Nitrazine test
5 Recruiting Detection of Pseudomonas Aeruginosa in the Airways of Patients With CF
Condition: Cystic Fibrosis
Intervention: Device: 13C urea breath test Kit
Outcome Measures: The primary objective is to assess the safety of 13C urea administered by inhalation.;   The secondary objective is to assess the kinetics of 13C carbon dioxide production by measuring the isotopic ratio of 13C to 12C in exhaled carbon dioxide.
6 Recruiting Human Heterologous Liver Cells for Infusion in Children With Urea Cycle Disorders
Conditions: Urea Cycle Disorders;   Carbamoylphosphate Synthetase I Deficiency;   Ornithine Transcarbamylase Deficiency;   Citrullinemia
Intervention: Biological: Human Heterologous Liver Cells
Outcome Measures: Safety of the application of liver cells, safety of the placement of an application catheter to the portal vein.;   Changes in 13C urea formation. Changes in the respective enzyme activity in liver biopsies from the explanted organ compared to the enzyme activity in the liver before cell application.
7 Recruiting Nitric Oxide Flux and Ureagenesis in Argininosuccinate Synthetase Deficiency (ASSD)(Citrullinemia I)
Condition: Citrullinemia
Intervention: Other: stable isotope infusion
Outcome Measures: Flux of citrulline and nitrate through the urea cycle pathway will be measured in conjunction with an independent measure of total plasma arginine flux.;   Total body urea production will be measured by the isotopic dilution of constantly infused [18O][13C]urea.
8 Recruiting Longitudinal Study of Urea Cycle Disorders
Conditions: Brain Diseases, Metabolic, Inborn;   Amino Acid Metabolism, Inborn Errors;   Urea Cycle Disorders
Intervention:
Outcome Measures: Prevalence of specific morbid indicators of disease severity;   Relationship between various biomarkers and disease severity and progression;   Safety and efficacy of currently used and new UCD therapies
9 Recruiting Comparative Efficacy of Phenylbutyrate vs. Benzoate in Urea Cycle Disorders
Conditions: Urea Cycle Disorders;   Ornithine Transcarbamylase Deficiency
Interventions: Drug: Sodium Benzoate;   Drug: Sodium Phenylbutyrate
Outcome Measure: Ammonia, hippuric acid and phenylacetylglutamine levels of urea cycle disorder patients taking benzoate or NaPBA
10 Recruiting Observational Study That Will Collect Information on Patients With Urea Cycle Disorders (UCDs)
Condition: Urea Cycle Disorder
Intervention:
Outcome Measure: Assessment of UCD specific disease characteristics
11 Unknown  Study of Treatment and Metabolism in Patients With Urea Cycle Disorders
Condition: Amino Acid Metabolism, Inborn Errors
Interventions: Behavioral: Protein and calorie controlled diet;   Genetic: Ornithine transcarbamylase vector
Outcome Measure:
12 Recruiting Oxidative Stress, Inflammation and Acute Decompensation in Urea Cycle Disorders
Condition: Urea Cycle Disorders
Intervention:
Outcome Measure: Laboratory values indicating oxidative stress
13 Recruiting Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Condition: T-Lymphocytopenia, Idiopathic CD4-Positive
Intervention:
Outcome Measure: to assess peripheral CD4 T cell and CD34 plus hematopoietic progenitor cell numbers and functions in ICL patients compared to controls following G-CSF and plerixafor administration.
14 Recruiting Validation of a Mouse Model of Pancreatic Carcinogenesis
Condition: Pancreatic Cancer
Intervention:
Outcome Measures: BRCA1 vs. BRCA2 mutations;   Interaction of other cancer genes with BRCA1 and BRCA2
15 Recruiting Effects of Prednisolone and Pentoxifylline on the Regulation of Urea Synthesis in Alcoholic Hepatitis
Condition: Alcoholic Hepatitis
Intervention:
Outcome Measures: Functional Hepatic Nitrogen Clearance;   Clinical and biochemical measures of inflammation
16 Recruiting Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007)
Condition: Acute Otitis Media
Interventions: Drug: AR01;   Drug: Glycerin ear drops
Outcome Measures: Complete ear pain relief;   time to complete ear pain relief (score of 0 on pain scales);   The proportion of subjects with complete ear pain relief;   The percent change in FPS-R and FAECC pain scores from baseline to post dose scores;   Sum of pain intensity differences (SPID) using FPS-R and FAECC pain scores;   Time from baseline to in-clinic use of analgesic/antipyretic to relief ear pain;   The number of subjects who receive analgesic/antipyretic medications for relief of ear pain during the clinic visit;   Number of adverse events reported as a measure of safety and tolerability
17 Recruiting Nonrandomized, Open-Label Phase IIb Efficacy Trial of Cancer Macrobeads Compared With Best Supportive Care in Patients With Treatment-Resistant Colorectal Cancer
Condition: Colorectal Cancers
Intervention: Biological: RENCA macrobeads
Outcome Measures: Overall Survival;   Change in levels of tumor markers (CEA and CA19-9);   Change in clinical status, as measured by ECOG performance status score and Global clinical assessment;   Change in quality of life, as measured by the EORTC QLQ C30 Questionnaire;   Tumor marker response rate;   Change in quality of life, as measured by the KPS
18 Recruiting Developing and Treating a Mouse Model of Acute Myeloid Leukemia Using Tissue Samples From Younger Patients With Acute Myeloid Leukemia
Condition: Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies
Interventions: Other: laboratory biomarker analysis;   Drug: quizartinib;   Drug: sorafenib tosylate
Outcome Measures: Engraftment ratio of human AML cells to Murine cells;   Efficacy of sorafenib or quizartinib to inhibit AML proliferation in vivo
19 Recruiting Combined Treatment for Mixed Incontinence
Condition: Mixed Urinary Incontinence
Interventions: Procedure: Miduretheral Sling;   Other: Miduretheral Sling combined with peri-operative behavioral/pelvic floor therapy
Outcome Measures: Severity of MUI symptoms;   OAB symptom outcomes;   SUI symptom outcomes
20 Recruiting Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants
Conditions: Urea Cycle Disorders;   Organic Acidemias
Interventions: Other: Therapeutic Hypothermia;   Other: Standard of care therapy
Outcome Measures: Number of Participants with unexpected Serious Adverse Events as a Measure of Safety and Tolerability;   Feasibility of hypothermia therapy as adjunct therapy to the complex standard of care therapy;   Time to normalization of ammonia level

These studies may lead to new treatments and are adding insight into Murine etiology and treatment.

A major focus of Murine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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