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Muscles Medical Research Studies

Up-to-date List of Muscles Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Muscles Medical Research Studies

Rank Status Study
1 Not yet recruiting Muscle Injury Prevention & Rehabilitation in Military Personnel
Condition: Muscle Injury
Interventions: Procedure: Healthy Muscle Group;   Procedure: Stretch-Contract Pre-rehabilitation Group;   Procedure: Stretch-Contract Control Group;   Procedure: Muscle Atrophy
Outcome Measures: Change from Baseline in T2 relaxation time of skeletal muscle in the lower leg;   Change from Baseline in Creatine Kinase levels;   Change from Baseline in Muscle water proton T2;   Change from Baseline in Muscle contractile area;   Change from Baseline in Isometric muscle strength of the ankle dorsiflexors;   Change from Baseline in Pain scores on a visual analog scale;   Change from Baseline in ankle Range of Motion (ROM)
2 Recruiting Endomysial Fibrosis, Muscular Inflammatory Response and Calcium Homeostasis Dysfunction in Duchenne Muscular Dystrophy
Condition: Duchenne Muscular Distrophy (DMD)
Intervention: Other: Muscle biopsy
Outcome Measures: Quantification of endomysial fibrosis;   quantification of the muscle inflammation
3 Unknown  The Effects of the Inspiratory Muscle Plus Aerobic Training Compare to Aerobic Training Alone in Heart Failure Patients.
Condition: Heart Failure
Intervention: Other: Inspiratory muscle added by aerobic to aerobic alone
Outcome Measures: To compare effects of inspiratory muscle training added by aerobic training to aerobic training alone in heart failure patients with inspiratory muscle weakness.;   To compare effects between the training groups evaluating strength and endurance of inspiratory Muscles; functional capacity; the physical and psychological perceptions of quality of life and heart rate variability and sleep apnea.
4 Unknown  Inspiratory Muscle Training in Patients Receiving Allogenic Stem Cell Transplantation
Conditions: Inspiratory Muscle Training;   Stem Cell Transplantation;   Respiratory Muscle Training
Interventions: Procedure: Inspiratory Muscle Training;   Other: inspiratory muscle training
Outcome Measures: Change of PI max-value from baseline at 30 days after stem cell transplantation;   Change of MVV-value from baseline at 30 days after transplantation;   inpatient days;   Incidence of pneumonia
5 Recruiting Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.
Condition: Polyneuropathy
Intervention: Procedure: Muscular electrostimulation and percutaneus muscular biopsy.
Outcome Measures: muscular weakness;   time of weaning
6 Recruiting Effects of Inspiratory Muscle Training on Dyspnea Perception During Exercise in Patients With COPD
Conditions: COPD;   Severe Systemic Illness-induced Respiratory Muscle Wasting
Interventions: Device: Inspiratory Muscle Strength Training;   Device: Inspiratory Muscle Endurance Training
Outcome Measures: Dyspnea (Borg CR-10 scale);   Maximal inspiratory pressure (Pi,max);   Inspiratory Muscle Endurance during a constant load breathing task;   Endurance capacity during a constant load cycling exercise test;   Pulmonary Function;   Daily Physical Activity;   Health related Quality of Life
7 Recruiting Congenital Muscle Disease Study of Patient and Family Reported Medical Information
Conditions: Muscular Dystrophy;   Congenital Muscular Dystrophy;   Fukutin-related Protein Gene;   Limb Girdle;   FKRP Gene;   Childhood Onset LGMD;   Adult Onset LGMD;   POMT1;   POMT2;   POMGnT1;   LARGE;   Alpha Dystroglycan;   Dystroglycanopathy;   Centronuclear;   Multiminicore;   Multicore;   Minicore;   Congenital Fiber Type Disproportion;   Myotubular;   Nemaline;   Congenital Myopathy;   Neuromuscular;   Rigid Spine;   Phenotype-Genotype Correlation;   Cough Assisted Device;   Neuromuscular Disease;   Respiratory Exacerbation;   Invasive Ventilation;   Chest Physiotherapy;   Congenital Myopathies;   Genetic Mutations;   Hypertrophic Cardiomyopathy;   Wheelchair Use;   Cataract;   Opthalmoplegia;   Ullrich Congenital Muscular Dystrophy;   Intermediate Collagen VI Myopathy;   Laminin Alpha 2 Related Congenital Muscular Dystrophy;   MDC1A;   Merosin Deficient Congenital Muscular Dystrophy;   Congenital Muscular Dystrophy Undiagnosed;   Congenital Muscular Dystrophy Merosin Positive;   Walker Warburg Syndrome;   Muscle Eye Brain Disease;   Fukuyama;   Integrin Alpha 7 Deficiency;   Integrin Alpha 9 Deficiency;   Laminopathy;   Lamin AC;   SEPN 1 Related Myopathies;   Bethlem Myopathy;   Dystroglycanopathies;   LGMD2K;   LGMD2I;   LGMD2L;   LGMD2N;   Actin Aggregation Myopathy;   Cap Disease;   Central Core Disease;   Centronuclear Myopathy;   Core Rod Myopathy;   Hyaline Body Myopathy;   Multiminicore Myopathy;   Myotubular Myopathy;   Nemaline Myopathy;   Tubular Aggregate Myopathy;   Zebra Body Disease Myopathy;   Congenital Myopathy Other;   Reducing Body Myopathy;   Sarcotubular Myopathy;   Spheroid Body Myopathy
Intervention:
Outcome Measure:
8 Recruiting Respiratory Muscle Training in Subacute Stroke Patients
Condition: Muscle Weakness
Interventions: Other: Inspiratory Muscle Training (IMT);   Other: High-intensity IMT
Outcome Measures: Respiratory muscle strength;   Handgrip strength assessment;   Lower limb strength measurement;   Serum aminoacids analysis;   Adverse events as a measure of safety and tolerability
9 Recruiting Trial Study of the Efficacy of Intensive Preoperative Pelvic Floor Muscle Training to Decrease Post-prostatectomy Urinary Incontinence
Condition: Urinary Incontinence
Interventions: Behavioral: Pelvic floor muscle training 3 weeks before radical prostatectomy;   Behavioral: Intensive preoperative pelvic floor muscle training
Outcome Measures: Change in grams of urine loss at different intervals post surgery;   Change in patients' sense of self control in urination and quality of life at different intervals post surgery
10 Unknown  Effects Antioxidants Supplementation on Muscular Function Patients Facioscapulohumeral Dystrophy (FSHD)
Condition: Facioscapulohumeral Muscular Dystrophy
Interventions: Procedure: Taking of blood;   Dietary Supplement: needle biopsy of the vastus lateralis muscle;   Dietary Supplement: Vit C Vit E Zn Se;   Dietary Supplement: Placebo Vit E Placebo Vit C Zn Se
Outcome Measures: Improvement of muscle effort tolerance after antioxidant supplementation;   Changes in inflammatory and oxidative stress parameters after antioxidant supplementation;   Changes in muscular function after antioxidant supplementation
11 Recruiting Effects of Inspiratory Muscle Training After Lung Cancer Surgery, a Randomized Controlled Trial
Conditions: Lung Cancer;   Surgery
Interventions: Other: Inspiratory muscle training;   Other: Placebo comparator: standard physiotherapy
Outcome Measures: Change in inspiratory muscle strength;   Change in expiratory muscle strength;   Incidence of postoperative pulmonary complications
12 Recruiting Double Push Acoustic Radiation Force (DP ARF) Ultrasound for Monitoring Degeneration in Duchenne Muscular Dystrophy
Condition: Muscular Dystrophy, Duchenne
Intervention:
Outcome Measures: Change in DP ARF marginal peak displacement;   Rate of change in DP ARF marginal peak displacement;   Change in quantitative muscle testing score of maximum voluntary isometric contraction (MVIC);   Change in time to rise from supine position to standing;   Change in distance walked in six minutes;   Change in time to walk 30 feet;   Rate of change in maximum voluntary isometric contraction (MVIC);   Rate of change in time to rise from supine to standing position;   Rate of change in distance walked in six minutes;   Rate of change in time to walk 30 feet;   Age at loss of ambulation;   Change in percent degenerative muscle composition;   Change in percent necrotic tissue area;   Change in percent fat tissue area;   Change in percent fibrotic tissue area
13 Recruiting Whole Body Vibration Therapy in Boys With Duchenne Muscular Dystrophy
Condition: Duchenne Muscular Dystrophy
Intervention: Device: Whole Body Vibration Therapy
Outcome Measures: Assess the safety of using whole body vibration therapy in boys with Duchenne muscular dystrophy. To assess whether whole body vibration therapy can improve muscle strength and prolong ambulation from baseline to 8 weeks of therapy. To asses.;   Does WBVT result in any change in muscle strength.;   Does WBVT result in any muscle function change.;   Does WBVT result in any measurable change in muscle endurance.;   Quality of life changes.;   Gait changes.;   Bone health
14 Recruiting Transforming Growth Factor Beta Signalling in the Development of Muscle Weakness in Pulmonary Arterial Hypertension
Conditions: Muscle Weakness;   Pulmonary Arterial Hypertension
Intervention:
Outcome Measures: Plasma growth and differentiation factor 15 levels in participants with and without muscle wasting;   Correlation of plasma Growth and differentiation factor 15 levels with muscle strength;   Change in fibre type in muscle biopsy;   GDF-15 levels in biopsy specimens;   Correlation of plasma Growth and differentiation factor 15 levels with brain natriuretic protein levels;   Correlation of plasma Growth and differentiation factor 15 levels with fat free mass index;   Correlation of plasma Growth and differentiation factor 15 levels with quality of life;   Correlation of plasma Growth and differentiation factor 15 levels with exercise tolerance;   Correlation of plasma Growth and differentiation factor levels 15 with physical activity levels;   Correlation of plasma Growth and differentiation factor levels 15 with echocardiographic measures of severity of pulmonary hypertension;   Correlation of GDF-15 levels in biopsy specimens with muscle wasting and weakness;   Determine the contribution of atrophy and autophagy to muscle wasting in PAH;   Determine the contribution of SMAD and non-SMAD signalling pathways to the development of muscle weakness and wasting in PAH
15 Recruiting Low Level Laser Therapy in Muscle Fatigue and Muscle Recovery
Conditions: Muscle; Fatigue, Heart;   Skeletal Muscle Recovery
Intervention: Device: Low Level Laser (LLL)
Outcome Measures: Exercise performance (MVC and peak torque);   Blood tests (composite measures)
16 Recruiting Muscle Ultrasound Signifies Condition Upgrade Leading Approach to Recovery
Conditions: Acute Respiratory Failure;   Critical Illness
Intervention: Procedure: Ultrasound
Outcome Measure: Days of Hospitalization
17 Recruiting Muscle Training Induced Angiogenesis in COPD
Conditions: Peripheral Muscle Dysfunction;   COPD
Interventions: Procedure: Muscular biopsy;   Other: 5-10 weeks sport training
Outcome Measures: Capillary-o-fiber ratio assessed by immunochemistry on a muscle biopsy of the vastus lateralis of the quadriceps;   quadriceps endurance;   mitochondrial density;   muscle citrate synthase activity
18 Recruiting Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
Condition: Duchenne Muscular Dystrophy
Intervention:
Outcome Measures: Change from baseline in intramuscular lipid at 1 year;   Change from baseline in muscle T2 at 3 months;   Change from baseline in muscle T2 at 1 year;   Change from baseline in muscle contractile area at 1 year;   Change from baseline in muscle T2 at 6 months
19 Recruiting Effect of Different Electric Muscle Stimulation in Patients With Severe Sepsis and Respiratory Failure
Conditions: Severe Sepsis;   Acute Respiratory Failure;   Muscle Hypotonia;   Inflammation;   Weakness
Intervention: Device: EMS
Outcome Measures: ventilator-dependant days;   Muscle strength improvement
20 Recruiting Measurement of the Distribution of Optical Properties in Adult Human Muscle
Conditions: Muscle Weakness Conditions;   Cachexia;   Hypothermia;   Vascular Occlusion
Intervention: Device: Diffuse Optical Spectroscopy
Outcome Measure: Measurement of the Distribution of Optical Properties in Adult Human Muscle

These studies may lead to new treatments and are adding insight into Muscles etiology and treatment.

A major focus of Muscles research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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