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NAIL Medical Research Studies

Up-to-date List of NAIL Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest NAIL Medical Research Studies

Rank Status Study
1 Recruiting Intramedullary Nail Versus Sliding Hip Screw Inter-Trochanteric Evaluation
Conditions: Femoral Neck Fractures;   Intertrochanteric Fracture
Interventions: Procedure: Gamma3 Intramedullary Nails (Stryker);   Procedure: Sliding Hip Screws
Outcome Measures: Health Related Quality of Life;   Fracture healing rates;   Fracture-related adverse events;   Revision surgery rates
2 Recruiting Comparison Between Gamma 3 Nail and ACE Trochanteric Nail
Condition: Pertrochanteric and Subtrochanteric Femur Fractures
Intervention: Device: Gamma 3 nail versus ACE trochanteric nail
Outcome Measure: Consolidation of the fracture
3 Recruiting Randomised Study Between Intramedullary Locking Nails and Locking Plates for Treatment of Proximal Humerus Fractures
Condition: Proximal Humerus Fractures
Interventions: Procedure: Intramedullary nail;   Procedure: Locked plate
Outcome Measures: Constant and MURLEY Score;   Quick Dash, complication (mal union, necrosis, infection)
4 Recruiting Proximal Humerus Fractures: Randomized Study Between Locking Nails and Locking Plates for Neer 2 and 3 Parts
Conditions: Humerus;   Proximal Humeral Fracture;   Fractures, Bone;   Humeral Fractures;   Wounds and Injuries;   Arm Injuries
Interventions: Device: Locked plate;   Device: Intramedullary locked nail
Outcome Measures: Shoulder function, pain, strength and range of motion, measured by Constant-Murley Score;   Superior limb function, measured by DASH score;   Shoulder function, pain, strength, range of motion and satisfaction with treatment, measured by UCLA score;   Shoulder function, pain, strength and range of motion compared with non-injuried shoulder, measured by Individual Relative Constant-Murley Score;   Number of patients with complications
5 Recruiting A Study to Evaluate the Safety and Efficacy of Adalimumab in Subjects With Chronic Plaque Psoriasis and Nail Psoriasis
Conditions: Nail Psoriasis;   Plaque Psoriasis
Interventions: Biological: Adalimumab (ADA);   Other: Placebo
Outcome Measures: Proportion of subjects achieving a total-fingernail modified Nail Psoriasis Severity Index (mNAPSI) 75 response;   For US regulatory purposes: Proportion of subjects with a Physician's Global Assessment of FingerNails of "clear" or "minimal";   For Ex-US sites: Percent change in total mNAPSI of all fingerNails;   For Ex-US: Proportion of subjects achieving mNAPSI = 0 in all fingerNails;   For Ex-US: Change in Nail Psoriasis Pain Numeric Rating Scale (NRS);   For Ex-US: Change in Nail Psoriasis Physical Functioning Severity Score;   For Ex-US: Proportion of subjects with at least 50% improvement in the scalp component of the Brigham Scalp Nail Inverse Palmo-Plantar Psoriasis Index (B-SNIPI);   For Ex-US: Proportion of subjects achieving Physician's Global Assessment of FingerNails (PGA-F) of "Clear" or "minimal";   For US: Proportion of subjects acheiving a total mNAPSI 75 response;   For US: Percent change in total mNAPSI of all fingerNails;   For US: Proportion of subjects achieving mNAPSI = 0 in all fingerNails;   For US: Change in Nail Psoriasis Pain Numeric Rating Scale (NRS);   For US: Change in Nail Psoriasis Physical Functioning Severity Score;   For US: Proportion of subjects with at least 50% improvement in the scalp component of the Brigham Scalp Nail Inverse Palmo-Plantar Psoriasis Index (B-SNIPI)
6 Recruiting Study of Safety, Tolerability, and Efficacy of Secukinumab in Subjects With Moderate to Severe Nail Psoriasis
Condition: Moderate to Severe Nail Psoriasis
Interventions: Biological: secukinumab 150 mg;   Biological: secukinumab 300 mg;   Biological: Placebo
Outcome Measures: Efficacy: change in Nail Psoriasis Severity Index after 16 weeks of treatment. Each treatment group will be compared to placebo;   Efficacy: change in NAPSI over time up to 16 weeks of treatment compared to placebo and over time up to 80 weeks;   Efficacy: change in Psoriasis Area and Severity Index 75 (PASI75) and change in Investigator Global Assessment (IGA mod 2011) over time up to 16 weeks of treatment compared to placebo and over time up to 80 weeks;   Number of subjects in treatment groups 150mg and 300mg with adverse events, safety labs, ECG, and vital signs as a measure of safety and tolerability;   Number and percentage of subjects who develop immunogenicity against secukinumab
7 Unknown  Topical Collagen-Silver Versus Standard Care Following Removal of Ingrown Nails
Condition: Ingrown Nail
Interventions: Device: oxidized regenerated cellulose collagen-silver;   Drug: topical silver sulfadiazine cream
Outcome Measures: time to healing;   time to return to regular shoe gear;   days unable to work
8 Recruiting A Randomized Study to Evaluate the Efficacy of Herbal Ingredients Combined With a Carrier System (Phytonail) Compared With Amorolfine 5% Nail Lacquer (Loceryl) in the Treatment of Toenail Onychomycosis
Condition: Onycomycosis
Interventions: Drug: Phytonail;   Drug: Loceryl
Outcome Measures: Mycological cure;   The treatment success rate of the target toenail;   The complete cure rate of the target toenail;   The CNG (clear nail growth) of the target great toenail
9 Recruiting Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail
Condition: Intertrochanteric Fracture
Interventions: Device: new type of intramedullary nail;   Device: The intramedullary nail of PFNA
Outcome Measures: Bone healing condition;   Rates of revision Rates of revision surgery;   Patient quality of life;   Complications
10 Recruiting Follow-up of Patients After Knee Arthrodesis With an Intramedullary Nail
Condition: Knee Arthrodesis With Intramedullary Nail
Intervention: Procedure: History taken and clinical examination
Outcome Measure: Follow-up of patients who underwent a knee arthrodesis with different types of intramedullary Nails
11 Unknown  InterTAN IM Nail Versus Sliding Hip Screw in Geriatric Fractures
Condition: Hip Fractures
Interventions: Device: sliding hip screw;   Device: IntertAn IM nail
Outcome Measures: Functional Independence Measure (FIM);   Timed up an go (TUG);   2-minute walk test (2MWT);   Geriatric Depression Scale (GDS);   Lower Extremity Measure (LEM);   Complications;   Femoral shortening;   Blood Loss;   Mortality
12 Recruiting Post Treatment Comparison Intramedullary Nail vs. Nonoperative Treatment
Condition: Fracture of Clavicle
Intervention: Device: CRx
Outcome Measures: DASH Score;   Range of Motion and Strength
13 Recruiting Pulsed Dye Laser Treatment of Onychomycosis
Condition: Onychomycosis
Intervention: Device: Pulsed Dye Laser for the treatment of nail fungus
Outcome Measure: Total Nail Clearance
14 Unknown  Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis
Condition: Onychomycosis
Interventions: Drug: Amorolfine (Antifungal);   Drug: RV4104A, Ciclopiroxolamine, Cyclopirox (Keratolytic Agents/Antifungal)
Outcome Measures: To evaluate and compare the efficacy of the sequential association RV4104A ointment-ciclopiroxolamine 1% cream-ciclopirox 8% film-forming solution versus amorolfine 5% nail lacquer alone in dermatophytic onychomycosis (toenail) without matrix involvement;   To evaluate and compare the local tolerability of the sequential association RV4104A-ciclopiroxolamine-ciclopirox versus amorolfine 5% alone in the treatment dermatophytic onychomycosis (toenail) without matrix involvement;   To evaluate and compare the cost-effectiveness of the sequential association RV4104A ointment-ciclopiroxolamine 1% cream-ciclopirox 8% film-forming solution vs amorolfine 5% alone in the treatment of dermatophytic onychomycosis without matrix involvement;   To evaluate and compare the clinical cure of the sequential association RV4104A ointment-ciclopiroxolamine-ciclopirox 8 versus amorolfine alone in the treatment dermatophytic onychomycosis (toenail) without matrix involvement;   Averse Events Reporting
15 Not yet recruiting Evaluation of the Proximal Femoral Nail Antirotation With Cement Augmentation in Osteoporotic Femoral Neck Fractures
Condition: Proximal Femur Fracture
Intervention: Device: Proximal Femoral Nail Antirotation(PFNA) with cement augmentation
Outcome Measure: Proportion of patients reaching union at the 3-month and 6-month follow up
16 Recruiting A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Proximal Tibial Fractures
Condition: Tibial Fractures
Interventions: Device: reamed, interlocking intramedullary nail;   Device: locking periarticular plate
Outcome Measures: SF-12v2;   EQ-5D;   SMFA;   Knee Society Score;   Clinical Assessment;   Re-operation (secondary procedures);   nonunion;   superficial infection rates (wound only);   deep infection (bone implant interface);   compartment syndrome;   malunion (>5 degrees varus/valgus);   >5 degrees anterior or posterior angulation;   >10 malrotation degrees, and >1cm shortening);   knee range of motion
17 Unknown  Comparison of Gamma Nail Versus Dynamic Hip Screw for the Treatment of Unstable Intertrochanteric Fractures
Condition: Intertrochanteric Femoral Fractures
Interventions: Device: Gamma-3 Nail;   Device: DHS
Outcome Measure: Clinical outcome as measured by the Merle d'Aubigne and Postel hip score
18 Recruiting Proximal Femoral Nail Antirotation (PFNA) Versus PFNA Augmentation
Conditions: Hip Fractures;   Closed Fracture of Hip
Interventions: Device: PFNA Augmentation (Synthes);   Device: PFNA (Synthes)
Outcome Measures: Mobility measured with the "timed up & go"-test during hospital stay.;   Description of surgical details as surgery time and fluoroscopy time, and of augmentation details (PFNA Augmentation group only).;   Pain;   Duration of hospital stay;   Walking ability;   Return to pre-fracture residential status;   Timed up & go-test at follow-ups;   Quality of life;   Local adverse events and revision rate;   Systemic adverse events;   Implant migration;   Mortality;   Fracture risk prior to injury;   Functional independence;   Comorbidity
19 Unknown  Comparing Weight Bearing After Intramedullary Fixation Devices for the Proximal Femur Fracture
Conditions: Closed Comminuted Oblique Intertrochanteric Fracture of Neck of Right Femur;   Closed Comminuted Oblique Intertrochanteric Fracture of Neck of Left Femur
Interventions: Device: PFNA proximal femur nail device (Synthes);   Device: INTERTAN proximal femur nail device (Smith&Nephew)
Outcome Measure: complication
20 Unknown  Comparison of the Results of Treatment by Gamma Nail Versus Dynamic Hip Screw for Unstable Intertrochanteric Hip Fractures
Condition: Intertrochanteric Fractures of the Hip
Intervention: Device: gamma nail stryker
Outcome Measures: hip function score;   x-ray, surgical outcome

These studies may lead to new treatments and are adding insight into NAIL etiology and treatment.

A major focus of NAIL research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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