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Naltrexone Medical Research Studies

Up-to-date List of Naltrexone Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Naltrexone Medical Research Studies

Rank Status Study
1 Recruiting Naltrexone and Hypoglycemia in Type 1 Diabetes
Conditions: Type 1 Diabetes;   Hypoglycemia Unawareness
Intervention: Drug: Naltrexone
Outcome Measures: Cerebral blood flow;   Rates of hypoglycemia
2 Recruiting Improved Strategies for Outpatient Opioid Detoxification
Condition: Opioid Dependence
Interventions: Drug: oral Naltrexone;   Drug: Buprenorphine;   Drug: Vivitrol
Outcome Measure: Percentage of patients in each group successfully inducted onto Vivitrol
3 Recruiting Low Dose Naltrexone-buprenorphine Transfer to Vivitrol Injection in Opioid Dependence
Condition: Opiate Dependence
Interventions: Drug: very low dose Naltrexone;   Drug: extended release Naltrexone;   Drug: buprenorphine/naloxone
Outcome Measures: Retention in Treatment;   Withdrawal Intensity (COWS);   Withdrawal Intensity (SOWS)
4 Not yet recruiting Extended-Release vs. Oral Naltrexone Alcohol Treatment in Primary Care
Condition: Alcohol Dependence
Interventions: Drug: XR-NTX (Extended-Release Naltrexone);   Drug: Oral Naltrexone (O-NTX)
Outcome Measures: Alcohol abstinence or moderate drinking;   Cost-effectiveness
5 Not yet recruiting Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence
Condition: Cannabis Dependence
Intervention: Drug: Long-acting injectable Naltrexone
Outcome Measures: Reduction in marijuana use;   Proportion of participants receiving the second injection of study medication;   Number and severity of adverse events associated with Naltrexone and its injection;   Reduction in marijuana use as measured by urine toxicology
6 Recruiting Dronabinol Naltrexone Treatment for Opioid Dependence
Condition: Opioid Dependence
Interventions: Drug: injectable Naltrexone plus dronabinol;   Drug: Naltrexone plus placebo
Outcome Measures: Opiate withdrawal and craving as measured by the SOWS and craving scales.;   Retention
7 Recruiting Naltrexone for Individuals of East Asian Descent
Condition: Alcohol Use Disorder
Interventions: Drug: Naltrexone;   Drug: Placebo
Outcome Measures: Subjective Effects of Alcohol;   Neural response to alcohol cues;   Alcohol self-administration
8 Recruiting Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment
Condition: Opioid Use Disorder
Interventions: Drug: Extended-Release Naltrexone;   Drug: Buprenorphine-Naloxone
Outcome Measures: Time to relapse;   Proportion successfully inducted onto assigned study medication (binary: did or did not receive first dose of XR-NTX, or achieve maintenance dose of BUP-NX);   Adverse Events related to study medications;   Opioid abstinence over time while on study medication (Weekly TLFB, confirmed by urine drug screens);   Alcohol and other drug use, over time (TLFB and UDS);   Cigarette smoking (FTND, Tobacco Use Questionnaire, VAS nicotine craving);   Opioid Craving (VAS) over time;   Subacute withdrawal symptoms over time (HAM-D, SOWS);   Problems related to drug abuse (ASI-Lite and EQ-5D);   HIV risk behavior over time (RAB and other HIV risk measures);   Cognitive function (Trails Making Test Parts A and B, Stroop);   Economic costs;   Quality-adjusted life year (QALY) outcomes;   Cost-effectiveness and cost-benefit
9 Recruiting Naltrexone and Memantine Effects on Alcohol Drinking Behaviors
Condition: Alcohol Drinking
Interventions: Drug: Naltrexone and memantine;   Drug: Naltrexone and Placebo
Outcome Measures: number of drinks consumed;   Stimulation and sedation responses to alcohol
10 Recruiting Control of Cognition
Conditions: Healthy;   Attention Deficit Hyperactivity Disorder;   Alcohol Dependence;   Attention Deficit Hyperactivity Disorder and Alcohol Dependence
Interventions: Drug: Methylphendiate;   Drug: Naltrexone;   Drug: Placebo
Outcome Measures: Identify abnormalities in prefrontal control neural circuits underlying attention control, motor control, and appetitive control;   Characterize effects of methylphenidate and Naltrexone on neural circuits in prefrontal cortex associated with attention control, motor control, and appetitive control;   Reaction time on the Multi-Source Interference Task;   Accuracy on the Multi-Source Interference Task;   Reaction time variability on the Multi-Source Interference Task
11 Unknown  Adherence to HIV Therapy in Heroin Addicts
Conditions: HIV;   Substance Abuse;   HIV Infections
Interventions: Drug: Oral Naltrexone (ON);   Drug: Implantable Naltrexone (IN)
Outcome Measures: Adherence Oral (ON) vs Implant (IN) Naltrexone;   Compare efficacy of the two treatments on:
12 Not yet recruiting Low Dose Naltrexone in Symptomatic Inflammatory Bowel Disease
Conditions: Inflammatory Bowel Disease;   Crohn's Disease;   Ulcerative Colitis
Interventions: Drug: Low dose Naltrexone;   Drug: Placebo
Outcome Measure: An increase in the subjects inflammatory bowel disease questionnaire score
13 Recruiting Low-Dose Naltrexone for Depression Relapse and Recurrence
Conditions: Major Depressive Disorder;   Depression, Unipolar;   Recurrence;   Relapse
Interventions: Drug: Naltrexone;   Drug: Placebo capsule
Outcome Measures: HAM-D-17 Total Score;   SDS Total Score
14 Recruiting Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice Populations
Conditions: HIV;   AIDS;   Opioid Dependence;   Drug Dependence
Intervention: Drug: Depot Naltrexone
Outcome Measures: HIV-1 RNA levels (copies/mL);   CD4 cell count (cells/mL);   time to opioid relapse;   addiction severity;   Craving for opioids
15 Not yet recruiting The Effects of Treatment With Naltrexone in Alcohol and Cannabis-dependent Patients
Condition: Alcohol-dependence
Intervention: Drug: Naltrexone
Outcome Measures: Verified abstinence from alcohol;   Changes in subjective responses to alcohol-cue reactivity and brain's metabolic rates
16 Recruiting Kappa-PET Imaging and Naltrexone in Alcohol Drinking Behaviors
Condition: Alcohol Drinking
Intervention: Drug: Naltrexone
Outcome Measures: Occupancy of KOR by NTX and drinking;   Relationship between NTX responsivity and occupancy of KOR;   Baseline KOR differences
17 Recruiting Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents
Condition: Opiate Addiction
Interventions: Drug: Buprenorphine/naloxone;   Drug: Naltrexone
Outcome Measures: Retention in treatment: (1-180 days) as measured by the date that participant was last seen by study personnel or date when participant completes study following the date of enrollment.;   Opioid craving: (1-10) as measured by a 10 point visual analog scale.;   Self-reported drug use: (days to first use and percent days abstinent) as measured by time line follow back.;   Urine toxicology: (yes/no) at baseline and monthly at 1, 2, 3, 4, 5, 6 months follow-up.
18 Recruiting Opioid Relapse & HIV Risk: 48 Versus 24 Weeks of Injectable Extended Release Naltrexone
Conditions: Opiate Dependence;   Human Immunodeficiency Virus
Interventions: Drug: injectable Naltrexone;   Drug: placebo comparator
Outcome Measures: Opiate positive urine tests;   HIV sex risk
19 Recruiting Depot Naltrexone Mechanism of Action in Heroin Dependent Patients Using fMRI and SPECT
Conditions: Opioid-Related Disorders;   Heroin Dependence
Intervention: Drug: Naltrexone
Outcome Measures: Brain functions;   Feasibility and potential efficacy
20 Recruiting Extended-Release Naltrexone to Treat Methamphetamine Dependence in Men Who Have Sex With Men (MSM)
Condition: Amphetamine-Related Disorders
Interventions: Drug: extended-release Naltrexone;   Drug: Placebo
Outcome Measures: urine meth positivity;   reduction in sexual risk behavior;   percentage of total expected injections administered;   rates of adverse events

These studies may lead to new treatments and are adding insight into Naltrexone etiology and treatment.

A major focus of Naltrexone research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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