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Nasopharyngeal Medical Research Studies

Up-to-date List of Nasopharyngeal Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Nasopharyngeal Medical Research Studies

Rank Status Study
1 Not yet recruiting Retrospective Study About Nasopharyngeal Carcinoma at C. S. Parc Tauli
Condition: Nasopharyngeal Carcinoma
Intervention:
Outcome Measure: Description of Nasopharyngeal Carcinoma Patients
2 Unknown  Nimotuzumab in Combination With Chemoradiation for Nasopharyngeal Cancer
Condition: Advanced Nasopharyngeal Cancer
Interventions: Drug: Nimotuzumab;   Drug: placebo plus chemoradiotherapy
Outcome Measures: To determine the local-regional control rates of the disease in the advanced Nasopharyngeal cancer patients subject to the treatment with Nimotuzumab in combination with chemoradiation;   To determine the safety of the treatment with Nimotuzumab in combination with chemoradiation;   To determine the Disease-free survival、Tumor control probability、Distant recurrence rate in the patients subject to the treatment at years 1,2,3;   To determine the Progression free suivival、Diease free survival、Overall survival in the patients subject to the treatment
3 Not yet recruiting Efficacy of Nasopharyngeal Ventilation With Endotracheal Tube for Otolaryngologic and Oral Maxillofacial Surgery
Conditions: Oto-laryngeal Surgery;   Maxillo-facial Surgery
Interventions: Other: Mask then Nasopharyngeal;   Other: Nasopharyngeal then mask
Outcome Measures: Tidal volume;   Airway pressure
4 Not yet recruiting Optimal Positioning of Nasopharyngeal Temperature Probes: A Prospective Cohort Study
Condition: Hypothermia
Intervention: Procedure: Nasopharyngeal
Outcome Measure: insertion depth of Nasopharyngeal probe for core temperature
5 Recruiting Correlation of Nasopharyngeal (NP) and Lower Oesophageal (LO) Temperatures in Ventilated Children
Condition: Child
Intervention: Device: Nasopharyngeal and oesophageal temperature probes
Outcome Measures: Temperature difference (in degrees celsius) between 2 body sites in children undergoing general anaesthesia. The 2 sites are: (1) lower oesophagus; (2) nasopharynx;   Temperature difference in the presence of a small leak (fractional volume loss < 21%) and large leak (fractional volume loss > 21%)
6 Recruiting Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
Conditions: Epstein-Barr Virus Infection;   Stage II Lymphoepithelioma of the Nasopharynx;   Stage II Squamous Cell Carcinoma of the Nasopharynx;   Stage III Lymphoepithelioma of the Nasopharynx;   Stage III Squamous Cell Carcinoma of the Nasopharynx;   Stage IV Lymphoepithelioma of the Nasopharynx;   Stage IV Squamous Cell Carcinoma of the Nasopharynx
Interventions: Radiation: intensity-modulated radiation therapy;   Drug: cisplatin;   Drug: fluorouracil;   Drug: gemcitabine hydrochloride;   Drug: paclitaxel;   Other: clinical observation;   Other: quality-of-life assessment;   Other: laboratory biomarker analysis
Outcome Measures: Progression-free survival (PFS) (Detectable Plasma EBV DNA Cohort Phase II);   Overall survival (OS) (Undetectable Plasma EBV DNA Cohort Phase III);   Time to distant metastasis (DM) (Phase II and III);   Time to local progression (Phase II and III);   Time to regional progression (Phase II and III);   PFS (Undetectable Plasma EBV DNA Cohort Phase III);   OS (Detectable Plasma EBV DNA Cohort Phase II);   Incidence of acute grade 3-5 adverse events (Phase II and III);   Incidence of late grade 3-5 adverse events (Phase II and III);   Incidence of death (Phase II and III);   Changes in pure tone audiometry (Phase II and III);   Changes in quality of life (QOL) (general and physical well-being) assessed using the Functional Assessment of Cancer Therapy (FACT)-Nasopharyngeal (NP) (Phase II and III);   Changes in QOL (hearing) as assessed by the Hearing Handicap Inventory for the Elderly-Screening version (HHIE-S) (Phase II and III);   Changes in QOL (peripheral neuropathy) as assessed by the FACT-Taxane (Phase II and III);   Cost effectiveness as assessed by the health-related QOL (HRQOL) from the EuroQol (EQ-5D) instrument (Phase II and III)
7 Recruiting Screening for Nasopharyngeal Carcinoma in High Risk Populations
Conditions: Nasopharyngeal Cancer;   Screening
Intervention:
Outcome Measures: Improve early diagnosis rate and reduce mortality rate of Nasopharyngeal carcinoma;   Cost-effectiveness of screening
8 Recruiting Prospective Nasopharyngeal Carcinoma Screening Using Plasma Epstein-Barr Virus DNA Analysis
Condition: Nasopharyngeal Carcinoma
Intervention:
Outcome Measures: Stage distribution of Nasopharyngeal carcinoma at the time of diagnosis;   Incidence of Nasopharyngeal carcinoma in screened negative group
9 Recruiting Safety and Efficacy Study of Icotinib With Intensity-modulated Radiotherapy in Nasopharyngeal Carcinoma
Condition: Nasopharyngeal Carcinoma
Interventions: Drug: Icotinib;   Radiation: intensity-modulated radiotherapy;   Drug: Paclitaxel and Cisplatin;   Other: Quality of life;   Genetic: Epidermal growth factor receptor status
Outcome Measures: Phase I: the maximum tolerated dose of Icotinib in combination with IMRT for NPC;   Phase II: 2 years locoregional control rate;   The overall response rate (complete and partial response);   The acute and late toxicity profile associated with the study regimen;   The duration of control of locoregional disease;   Overall survival, disease-free survival, and distant relapse rates;   EGFR status in tissue and blood before treatment
10 Unknown  Positron Emission Tomography Scanning and Epstein-Barr Virus DNA Levels in the Staging and Follow-Up of Nasopharyngeal Carcinoma.
Condition: Nasopharyngeal Carcinoma
Intervention:
Outcome Measure:
11 Recruiting GC Regimen Chemotherapy Plus CIK Cells for Metastatic Nasopharyngeal Carcinoma
Condition: Stage IV Nasopharyngeal Carcinoma
Interventions: Drug: GC chemotherapy plus CIK cells (Gemcitabine, Cisplatin, Autologous CIK cells);   Drug: GC chemotherapy (Gemcitabine, Cisplatin)
Outcome Measures: Complete remission (CR);   Partial remission (PR);   Stable disease (SD);   Progressive disease (PD);   overall survival time (OS);   time to progression (TTP);   progression free survival(PFS)
12 Not yet recruiting The Role of Concurrent Chemotherapy for Lower Risk Locally Advanced Nasopharyngeal Carcinoma(NPC) in the Era of IMRT
Condition: Nasopharyngeal Carcinoma
Interventions: Radiation: SIB-IMRT;   Drug: Cisplatin
Outcome Measures: overall survival;   Acute and late toxicities;   3 year Progression-free survival (PFS)
13 Recruiting A Multicenter Trial Comparing Multi-course Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
Condition: Nasopharyngeal Carcinoma
Intervention: Drug: neoadjuvant chemotherapy plus concurrent chemoradiotherapy
Outcome Measures: distant metastasis free survival,disease free survival;   overall survival
14 Recruiting A Multicenter Trial Evaluating the Efficacy of Nedaplatin in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
Condition: Nasopharyngeal Carcinoma
Interventions: Drug: nedaplatin and docetaxel;   Drug: cisplatin and docetaxel
Outcome Measures: complete response (CR) rate;   Acute toxicities;   Overall Survival;   cost-effectiveness ratio
15 Recruiting Effect and Safety Study of GP/FP Regimens in Advanced Nasopharyngeal Carcinoma
Condition: Nasopharyngeal Neoplasms
Interventions: Drug: gemcitabine and cisplatin;   Drug: 5-Fluorouracil and cisplatin
Outcome Measures: Progression free survival (PFS);   Overall survival (OS);   Objective response rate (ORR);   Number of Participants with Adverse Events;   Quality of life
16 Not yet recruiting Nasopharyngeal Carriage Study in Healthy Kenyan Toddlers
Condition: Pneumococcal Disease
Intervention: Procedure: Nasopharyngeal swab
Outcome Measures: Prevalence of SPn in nasopharynx;   Prevalence of serotype specific SPn in nasopharynx
17 Recruiting Phase II Sequential and Concurrent Chemoradiation for Advanced Nasopharyngeal Carcinoma (NPC)
Conditions: Stage II Lymphoepithelioma of the Nasopharynx;   Stage II Squamous Cell Carcinoma of the Nasopharynx;   Stage III Lymphoepithelioma of the Nasopharynx;   Stage III Squamous Cell Carcinoma of the Nasopharynx;   Stage IV Lymphoepithelioma of the Nasopharynx;   Stage IV Squamous Cell Carcinoma of the Nasopharynx
Interventions: Drug: docetaxel;   Drug: cisplatin;   Drug: carboplatin;   Drug: fluorouracil;   Radiation: 3-dimensional conformal radiation therapy;   Radiation: intensity-modulated radiation therapy
Outcome Measures: Progression free survival rate, using RECIST criteria;   Overall survival;   Rates of adverse events resulting in treatment discontinuation
18 Recruiting SOX as Salvage Treatment in Nasopharyngeal Carcinoma
Condition: Nasopharyngeal Carcinoma
Intervention: Drug: S-1 plus oxaliplatin
Outcome Measures: Median progression-free survival;   Overall response rate;   Median overall survival
19 Recruiting Dietary Nitrate on Plasma Nitrate Levels for Nasopharyngeal Carcinoma Patients
Condition: Nasopharyngeal Carcinoma
Interventions: Dietary Supplement: nitrate supplementation;   Dietary Supplement: Placebo
Outcome Measures: plasma nitrate level;   quality of life
20 Recruiting The Value of Concurrent Chemoradiotherapy for Stage II Nasopharyngeal Carcinoma
Condition: Nasopharyngeal Carcinoma
Intervention: Drug: cisplatin
Outcome Measures: Acute toxicities;   Long term treatment results

These studies may lead to new treatments and are adding insight into Nasopharyngeal etiology and treatment.

A major focus of Nasopharyngeal research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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