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Nebilet Medical Research Studies

Up-to-date List of Nebilet Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Nebilet Medical Research Studies

Rank Status Study
1 Recruiting Comparative Effects of Nebivolol and Metoprolol on Femal Sexual Function
Conditions: Hypertension;   Female Sexual Dysfunction
Interventions: Drug: nebivolol and metoprolol succinate;   Drug: metoprolol succinate and nebivolol
Outcome Measures: Change in FSF and CSFQ, two validated questionnaires for assessment of sexual function.;   The effects of nebivolol and metoprolol on sexual function and to compare the effects of both drugs on vitality, work and life performance, and work and life satisfaction.
2 Unknown  Comparative Effects of Nebivolol Versus Placebo on Sodium Sensitivity of Blood Pressure in Hispanic Postmenopausal Women With Hypertension
Condition: Hypertension
Interventions: Drug: nebivolol;   Drug: Nebivolol
Outcome Measures: Change and percentage change in systolic, diastolic and mean blood pressure by ABPM from final day of low sodium to the final day of high sodium in nebivolol versus placebo;   Differences in renal sodium excretion in response to an acute sodium load during treatment with either nebivolol or placebo.
3 Unknown  Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients
Condition: Marfan Syndrome
Interventions: Drug: Losartan and nebivolol;   Drug: Losartan;   Drug: Nebivolol
Outcome Measures: BSA and age-adjusted aortic root diameter (sinuses of Valsalva);   The pharmacokinetics of the two drugs by age and dosages;   Comparative evaluation of the serum levels of total and active TGFb;   Quantitative assessment of the expression of the mutated gene (FBN1, both 5' and 3');   Pharmacogenetic bases of drug responsiveness (Losartan: CYP2C9 gene) (Nebivolol: CYP2D6 gene);   Aortic valve regurgitation severity;   Left ventricular end-diastolic diameter;   Left ventricular ejection fraction;   Spirometric lung volumes and flows;   QoL evaluation basing on SF-36 questionnaire;   Arterial stiffness (carotids)
4 Recruiting Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
Condition: Hypertension
Interventions: Drug: Metoprolol succinate;   Drug: Nebivolol;   Drug: Hydrochlorothiazide;   Drug: DEFINITY®;   Procedure: Non-invasive measurement of Cardiac Output (CO);   Procedure: Flow mediated vasodilation;   Procedure: Endothelial cell collection;   Procedure: Microvascular perfusion assessment using Definity
Outcome Measures: Endothelial cell protein expression;   Microvascular blood flow;   Flow mediated dilation (FMD)
5 Recruiting Nebivolol Effects on Endothelial Function and Erectile Function
Condition: Erectile Dysfunction
Interventions: Drug: Nebivolol;   Drug: Sugar Pill
Outcome Measures: Primary objective is to determine if treatment with nebivolol improves endothelial function and erectile function in men with pre-hypertension and stage 1 hypertension. This will be assessed by change in IIEF-5 at baseline, 2 and 3 months;   Change in Endopat score;   Change in SphygmoCor results;   Change in SQOLM score
6 Recruiting Study to Evaluate Effect of Nebivolol on Angina in Women With Microvascular Disease
Condition: Microvascular Angina
Intervention: Drug: Nebivolol
Outcome Measures: Seattle Angina Questionnaire Score;   peak VO2 measured by cardiopulmonary exercise testing;   resource utilization questionnaire;   SF36
7 Recruiting Comparative Study of the Effects of Telmisartan and Nebivolol
Condition: Hypertension
Interventions: Drug: TELMISARTAN;   Drug: NEBIVOLOL
Outcome Measures: Change from baseline in 24h blood pressure;   Change from baseline in arterial stiffness
8 Unknown  Regression of Myocardial Steatosis by Nebivolol
Condition: Cardiac Steatosis and Lipotoxicity
Intervention: Drug: Nebivolol
Outcome Measures: Myocardial triglyceride content;   Cardiac function;   Regression of concentric cardiac remodeling;   Regression of steatosis in other non-adipocyte tissue;   Regression of subcutaneous fat
9 Recruiting A Study Examining the Effects of Nebivolol Compared to Atenolol on Endothelial Function
Condition: Hypertension
Interventions: Drug: Nebivolol;   Drug: atenolol;   Drug: placebo
Outcome Measures: Comparing effects of nebivolol against atenolol and placebo on endothelial function;   Evaluate effects of nebivolol as compared to atenolol and placebo
10 Recruiting Nebivolol for the Prevention of Left Ventricular Systolic Dysfunction in Patients With Duchenne Muscular Dystrophy
Conditions: Duchenne Muscular Dystrophy;   Cardiomyopathy;   Heart Failure
Interventions: Drug: Nebivolol;   Drug: Placebo
Outcome Measures: Left ventricular systolic dysfunction;   Right ventricular ejection fraction;   NT-ProBNP;   Left ventricular dysfunction;   Hospitalizations;   Mortality
11 Not yet recruiting CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients.
Conditions: Hypertension;   Endothelial Dysfunction;   Obstructive Sleep Apnea
Interventions: Drug: Nebivolol;   Device: Continuous positive airway pressure (CPAP)
Outcome Measures: change in mean arterial blood pressure;   change in endothelial function
12 Unknown  Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)
Conditions: Prehypertension;   Hypertension
Interventions: Drug: Nebivolol;   Drug: Metoprolol;   Drug: Placebo
Outcome Measure: Changes from baseline in endothelial t-PA release
13 Recruiting Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart
Conditions: Hypertension;   Left Ventricular Diastolic Dysfunction
Intervention: Drug: Nebivolol
Outcome Measures: Improvement in exercise tolerance;   E velocity indexed to e' (E/e' ratio) of the left ventricle;   Untwist rate of the left ventricle
14 Unknown  Nebivolol and the Endothelin (ET)-1 System
Conditions: Prehypertension;   Hypertension
Interventions: Drug: Nebivolol;   Drug: Metoprolol;   Drug: Placebo
Outcome Measure: ET-1-mediated vasoconstrictor tone
15 Recruiting Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure
Conditions: Peripheral Artery Disease;   Hypertension
Interventions: Drug: nebivolol;   Drug: Metoprolol succinate
Outcome Measures: Peak Walking Time;   Walking Impairment Questionnaire;   Ankle-brachial index;   markers of inflammation.;   Claudication Onset Time
16 Recruiting Safety Study of Nebivolol for COPD Patients
Condition: High Blood Pressure
Interventions: Drug: Placebo;   Drug: Nebivolol
Outcome Measures: to assess blood pressure control;   to assess pulmonary function tests
17 Unknown  Influence of Nebivolol on Postmenopausal Women
Conditions: Hot Flashes;   Heart Rate;   Blood Pressure;   Endostatin;   Sexual Function
Intervention:
Outcome Measures: Number of hot flashes/palpitations;   Hemodynamic changes;   Sexual function;   Endostatin;   Quality of life
18 Recruiting Nebivolol Versus Sustained Release Metoprolol Succinate in Patients With Chronic Kidney Disease
Condition: Chronic Kidney Disease
Intervention:
Outcome Measures: Primary Efficacy;   Secondary Efficacy
19 Recruiting Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure
Conditions: Pulmonary Hypertension;   Diastolic Heart Failure;   Heart Failure With Preserved Ejection Fraction
Intervention: Drug: Nebivolol
Outcome Measures: Changes in pulmonary vascular pressure;   Changes in 6-minute walk distance
20 Recruiting Treatment of Supine Hypertension in Autonomic Failure
Condition: Hypertension
Interventions: Drug: Clonidine;   Drug: Nitroglycerin transdermal;   Drug: Dipyridamole/ Aspirin (Aggrenox);   Drug: Desmopressin (DDAVP);   Drug: Sildenafil;   Drug: Nifedipine;   Drug: Hydralazine;   Drug: Hydrochlorothiazide;   Drug: Placebo;   Drug: Bosentan;   Drug: Diltiazem;   Drug: Eplerenone;   Drug: guanfacine;   Dietary Supplement: L-arginine;   Drug: captopril;   Drug: carbidopa;   Drug: losartan;   Drug: metoprolol tartrate;   Drug: nebivolol hydrochloride;   Drug: prazosin hydrochloride;   Drug: tamsulosin hydrochloride;   Other: Head-up tilt.;   Drug: aliskiren;   Other: Local heat stress
Outcome Measures: Decrease in supine systolic blood pressure;   Decrease in pressure natriuresis

These studies may lead to new treatments and are adding insight into Nebilet etiology and treatment.

A major focus of Nebilet research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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