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Neostigmine Medical Research Studies

Up-to-date List of Neostigmine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Neostigmine Medical Research Studies

Rank Status Study
1 Unknown  Comparative Study of Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade in Morbidly Obese Patients
Conditions: Morbid Obesity;   Neuromuscular Blockade
Interventions: Drug: Sugammadex;   Drug: Neostigmine
Outcome Measure: Speed of reversal of neuromuscular blockade after administration of different sugammadex/Neostigmine doses to TOF values = 0.9 in adductor pollicis and corrugator supercilii
2 Recruiting Appropriate Dose of Neostigmine for Reversal of Rocuronium and Cisatracurium
Condition: Observation of Neuromuscular Block
Intervention: Drug: Injection of Neostigmine
Outcome Measures: time to reverse from light muscle relaxation;   time to reverse from TOF ratio 0.5 to 0.9
3 Recruiting A Double-blind, Randomized, Parallel Design Study to Compare the Effectiveness of Sugammadex Versus Neostigmine in Improving Surgical Condition in Subjects Undergoing Laryngeal Microsurgery
Condition: General Anesthesia
Interventions: Drug: Sugammadex;   Drug: Neostigmine
Outcome Measure: surgical condition
4 Not yet recruiting CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity
Conditions: Obesity;   Laparoscopic Gastric Bypass Surgery;   Surgical Conditions;   Respiratory Function;   Cerebral Tissue Oxygenation
Interventions: Drug: deep neuromuscular blockade with rocuronium, reversal with sugammadex;   Drug: normal neuromuscular blockade reversal with rocuronium, reversal with Neostigmine
Outcome Measures: Subjective evaluation of the view on the operating field by the surgeon;   Number of intra-abdominal pressure rises > 15cmH2O;   Respiratory function;   Oxygen saturation;   Effect of pneumoperitoneum on cerebral tissue oxygenation.;   Effect of neuromuscular blockade on cerebral tissue oxygenation;   The effect of reversal of neuromuscular blockade (with sugammadex or Neostigmine) on cerebral tissue oxygenation
5 Unknown  Comparison of Two Neuromuscular Anesthetics Reversal in Obese Patient Undergoing Bariatric Surgery
Conditions: Anesthesia;   Surgery
Intervention: Drug: Sugammadex vs. Neostigmine
Outcome Measures: Safety of Sugammadex reversal - number of drug-related adverse events with Sugammadex <= that of Neostigmine.;   Use of Sugammadex for neuromuscular anaesthesia reversal higher patient satisfaction compared to Neostigmine.
6 Recruiting Reversal of Neuromuscular Blockade in Thoracic Surgical Patients
Condition: Residual Neuromuscular Blockade
Interventions: Drug: Neostigmine;   Drug: Sugammadex
Outcome Measures: Residual neuromuscular block (train-of-four ratio (TOF) < 0.9);   Time in operating room;   Hypoxemic events;   Tests of muscle weakness;   Length of stay in the PACU
7 Unknown  The Impact of an Epidural Ropivacaine-Neostigmine Injection for Perineal Analgesia at the End of Labor.
Conditions: Pregnancy;   Vaginal Delivery
Intervention: Drug: Neostigmine
Outcome Measures: acute pain (VAS);   chronic pain (questionnaire)
8 Not yet recruiting Sugammadex Compared With Neostigmin/Atropin for Neuromuscular Block Reversal in Patients With Obstructive Sleep Apnea
Condition: Obstructive Sleep Apnea
Interventions: Drug: Sugammadex;   Drug: Neostigmine
Outcome Measures: TOF0.9 time;   desaturation;   bradycardia;   tachycardia
9 Recruiting Optimal Relaxation Technique for Laparotomies With Rocuronium Infusion Followed by Sugammadex Reversal
Conditions: Underdosing of Skeletal Muscle Relaxants for Laparotomy;   Reversal of Skeletal Muscle Relaxant
Interventions: Drug: Neostigmine, atropine;   Drug: Sugammadex
Outcome Measures: speed of reversal;   Vital signs, i.e. heart rate and blood pressure;   intraoperative events;   incidence of residual neuromuscular blockade
10 Unknown  Street Fitness in Surgical Patients Undergoing General Anesthesia After Reversal of Neuromuscular Blockade
Condition: Anesthesia Recovery Period
Interventions: Drug: Sugammadex;   Drug: Neostigmine/Glycopyrrolate;   Other: Placebo
Outcome Measure: Street Fitness in surgical patients undergoing general anesthesia after reversal of neuromuscular rest blockade.
11 Recruiting Modern Myorelaxation Procedure and Reversal of Neuromuscular Blockade With General Anesthesia for Caesarean Section
Conditions: Caesarean Section;   Pregnancy
Interventions: Drug: Rocuronium + sugammadex;   Drug: Succinylcholine + Neostigmine
Outcome Measures: time needed to tracheal intubation;   total procedure time
12 Recruiting Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex
Conditions: Diaphragmatic Dysfunction;   Muscle Weakness;   Muscle Fatigue
Interventions: Drug: sugammadex 2mg/kg;   Drug: Neostigmine;   Drug: sugammadex 4mg/kg;   Drug: placebo;   Drug: Single rocuronium dose;   Drug: Repeated rocuronium dose;   Drug: Continuous rocuronium infusion
Outcome Measures: Electric activity of the diaphragm (microvolts) and tidal volume (milliliter) in a breath-by-breath analysis;   Number of events with oxygen saturation below 90% measured by pulse oximetry
13 Recruiting Does Residual Muscular Weakness Lead to an Increase in Respiratory Complications in Bariatric Patients?
Conditions: Respiratory Complication;   Morbid Obesity
Interventions: Device: Accelomyography;   Drug: Neostigmine;   Device: Qualitative Monitor
Outcome Measure: Respiratory Events (RE)
14 Recruiting A Prospective, Randomized Controlled Trial Comparing Traditional Methods of Neuromuscular Block Reversal to Sugammadex for Extubation in the Operating Room in ASA 4 and 4E Patients
Condition: Neuromuscular Blockade
Interventions: Drug: Sugammadex Reversal;   Drug: Atropine/Neostigmine
Outcome Measures: Extubation in the operating room before transfer to the PACU or ICU versus keeping the patient intubated when transferred.;   Time to extubation - measure the difference in time from application of the surgical dressing until extubation.;   Atelectasis - comparison of chest x-rays (CXR): prior to surgery, on admission to PACU or ICU and 24 hours after admission to PACU or ICU (This is the routine practice at Hadassa hospital for ASA IV patients.)
15 Not yet recruiting The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy
Condition: Robot-Assisted Laparoscopic Radical Prostatectomy
Interventions: Procedure: deep neuromuscular blockade;   Procedure: moderate neuromuscular blockade;   Drug: Rocuronium;   Drug: Sugammadex;   Drug: Atracurium;   Drug: Neostigmine
Outcome Measure: compare the influence of surgical visibility through deep neuromuscular blockade on intraocular pressure in patients undergoing Robot-Assisted Laparoscopic Radical Prostatectomy.
16 Unknown  Neuromuscular Blockade and Surgical Conditions
Condition: Morbid Obesity
Intervention: Drug: Profound neuromuscular blockade (Rocuronium, Rocuronium bromide, sugammadex, Bridion)
Outcome Measures: Subjective surgeon feedback on the exposure and surgical field.;   Incidence of respiratory adverse events
17 Recruiting Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy
Conditions: Intubating Conditions;   Performance With Respiratory Exercise Device;   Postoperative Myalgia
Interventions: Drug: Succinylcholine;   Drug: Mivacurium
Outcome Measures: Intubating condition;   Postoperative Myalgia;   postintervention performance with a expiration exercise device
18 Recruiting Recovery Effect of Sugammadex Measured by Bispectral and Neurosense Indices
Condition: Anesthesia
Interventions: Drug: Sugammadex - Nacl 9/00;   Drug: Nacl 9/00 - sugammadex
Outcome Measures: modification of bispectral and neurosenses indices following sugammadex injection;   efficacy of sugammadex to reverse myorelaxation;   clinical signs of recovery after sugammadex injection;   residual myorelaxation in the post-anesthesia care unit;   score of White and Song during the three first postoperative hours;   duration of stay in the postanesthesia care unit;   occurence of explicit memorisation
19 Not yet recruiting The Effect of Deep Block Versus Moderate Block on the Stress Response After Laparoscopic Gastrectomy
Condition: Neuromuscular Blockade
Interventions: Drug: moderate block;   Drug: deep block;   Device: deep block;   Device: moderate block
Outcome Measures: IL-6;   TNF-α;   IL-1β;   IL-8;   CRP
20 Recruiting Recovery After Laparoscopic Surgery
Condition: Laparoscopy
Outcome Measures: Change in postural sway area 30 min after extubation (closed eyes);   Change in sway area when ready to be discharge form the postoperative care unit (PACU)(closed eyes);   change in sway area 30 min after extubation (open eyes);   Change in sway area when ready to be discharged from the PACU (open eyes);   Change in sway velocity 30 min after extubation (closed eyes);   Change in sway velocity 30 min after extubation (open eyes);   Change in sway velocity when ready to be discharged from the PACU (closed eyes);   Change in sway velocity when ready to be discharged from the PACU (open eyes);   Change in mean sway 30 min after extubation (closed eyes);   Change in mean sway 30 min after extubation (open eyes);   Change in mean sway when ready to discharge from the PACU (closed eyes);   Change in mean sway when ready to be discharged from the PACU (open eyes);   Change in subjective balance 30 min after extubation;   Change in subjective balance when ready to be discharged from the PACU;   Change in muscle weakness 30 min after extubation;   Change in muscle weakness when ready to be discharged from the PACU;   Incidence of critical respiratory events from extubation until discharge from the PACU;   Duration of stay at the PACU;   Duration of postoperative hospitalization

These studies may lead to new treatments and are adding insight into Neostigmine etiology and treatment.

A major focus of Neostigmine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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