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Nesina Medical Research Studies

Up-to-date List of Nesina Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Nesina Medical Research Studies

Rank Status Study
1 Recruiting Efficacy and Safety of Alogliptin and Metformin Fixed-dose Combination in Patients With Type 2 Diabetes
Condition: Diabetes Mellitus
Interventions: Drug: Alogliptin;   Drug: Metformin HCl;   Drug: Alogliptin and Metformin fixed-dose combination (FDC);   Drug: Alogliptin placebo;   Drug: Metformin placebo;   Drug: Alogliptin and metformin FDC placebo
Outcome Measures: Change From Baseline to Week 26 (or Early Termination) in Glycosylated Hemoglobin (HbA1c);   Change From Baseline in HbA1c Over Time;   Change From Baseline in Fasting Plasma Glucose Over Time;   Time to hyperglycemic rescue event;   Percentage of Participants Meeting Rescue Criteria;   Percentage of Participants With Marked Hyperglycemia;   Change From Baseline in Body Weight Over Time;   Percentage of Participants With Glycosylated Hemoglobin ≤ 6.5%;   Percentage of Participants With Glycosylated Hemoglobin ≤ 7.0%;   Percentage of Participants With Glycosylated Hemoglobin ≤ 7.5%;   Percentage of Participants With a Decrease in Glycosylated Hemoglobin ≥ 0.5%;   Percentage of Participants With a Decrease in Glycosylated Hemoglobin ≥ 1.0%;   Percentage of Participants With a Decrease in Glycosylated Hemoglobin ≥ 1.5%;   Percentage of Participants With a Decrease in Glycosylated Hemoglobin ≥ 2.0%
2 Not yet recruiting Double-blind Comparative Study of SYR-322-MET.
Condition: Diabetes
Interventions: Drug: SYR-322 + metformin hydrochloride;   Drug: SYR-322 + metformin hydrochloride placebo
Outcome Measures: HbA1c;   HbA1c and fasting blood glucose;   Adverse events
3 Recruiting Effects of Alogliptin on Pancreatic Beta Cell Function
Condition: Diabetes Mellitus, Type 2
Interventions: Drug: Alogliptin;   Drug: Metformin 750 mg
Outcome Measures: beta cell function evaluated from 75 g OGTT;   1,5-AG level
4 Not yet recruiting DPP-IV Inhibitors Underlying Mechanism of Cancer in Diabetic Patients
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Sitagliptin;   Drug: Alogliptin;   Drug: Vildagliptin
Outcome Measures: Frequency of cancers;   AGE concentration;   Receptor for AGE concentration
5 Unknown  A Feasibility Study of Dose-Dense FEC With G-CSF Support Followed by Dose-Dense Ixabepilone With G-CSF Support as Neoadjuvant Chemotherapy in ER-Negative Breast Cancer
Condition: Breast Cancer
Intervention: Drug: Ixabepilone
Outcome Measures: Pathologic Complete Response (pCR);   Feasibility/Tolerability for an individual patient is defined as the absence of hematologic toxicities requiring dose reduction as per protocol

These studies may lead to new treatments and are adding insight into Nesina etiology and treatment.

A major focus of Nesina research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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