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Neurosurgery Medical Research Studies

Up-to-date List of Neurosurgery Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Neurosurgery Medical Research Studies

Rank Status Study
1 Recruiting A Patient Registry at the Neurosurgery Department
Condition: Patients Treated at the Neurosurgery Department
Intervention: Procedure: Treatment at the Neurosurgery departement
Outcome Measure:
2 Recruiting Risk Factors of Complications Regarding Patients Undergoing Brain Tumour Neuro-surgery (Cranioscore).
Conditions: Neuro-surgery,;   Brain Tumor,;   Post-operative Complications,;   Neuro-ICU Stay
Intervention: Other: Collecting pre-operative, per-operative data, neuro-radiological data and post-operative neuro-surgery complications
Outcome Measures: Post-operative complications requiring Neuro-ICU stay ≥ 24 hours after surgery for neurosurgical reason.;   Describing post-operative complications in patients undergoing neuro-surgery for brain tumor.;   Duration of mechanical ventilation;   Length of ICU stay;   Length of hospital stay
3 Recruiting Dexmedetomidine on Intraoperative Somatosensory and Motor Evoked Potential Monitoring During Neurosurgery in Pediatric Patients
Conditions: Tethered Spinal Cord;   Brain Tumor;   Cranio Cervical Compression
Intervention: Other: Isoflurane, Propofol, Dexmedetomidine
Outcome Measure: Significant improvement of MEP and SSEP readings during Neurosurgery for pediatric patients while using dexmedetomidine as an adjunct to general anesthesia and therefore improvement in clinical decision making.
4 Not yet recruiting Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery
Condition: Patients Undergoing Elective Craniotomy
Interventions: Drug: Propofol;   Drug: Desflurane
Outcome Measures: Time from the discontinuation of anesthesia to extubation;   Time from the discontinuation of anesthesia to eye opening;   Cognitive function;   Time from the discontinuation of anesthesia to orientation
5 Recruiting Dynamic Preload Indicators in Sitting Position
Condition: Neurosurgery in Sitting Position
Intervention: Procedure: Sitting position (Neurosurgery)
Outcome Measures: PPV (Pulse pressure variation);   SVV (Stroke volume variation);   PVI (Plethysmographic variability index)
6 Recruiting MR-Guided Functional Ultrasound-Neurosurgery for Movement Disorders
Conditions: Essential Tremor;   Dystonia;   Parkinson's Disease
Intervention: Device: Non-invasive intervention with focused ultrasound (ExAblate 4000)
Outcome Measures: Lesion Size;   Patient Safety;   Clinical efficacy and QOL
7 Recruiting Incidence of Venous Thromboembolism in Children Undergoing Elective Neurosurgical Procedures
Condition: Deep Vein Thrombosis
Intervention:
Outcome Measure: formation of blood clot
8 Recruiting Neurological Surgery & Affiliated Services De-Identified Clinical Outcomes Database
Conditions: Central Nervous System Disorder;   Spinal Diseases;   Peripheral Neuropathy
Intervention:
Outcome Measure:
9 Not yet recruiting Neurosurgery Recruitment Maneuver Study
Condition: Subdural Pressure During Supratentorial Brain Tumour Resection
Interventions: Procedure: Recruitment maneuver;   Procedure: Sham recruitment maneuver
Outcome Measures: Subdural pressure;   Brain relaxation score;   Cerebral perfusion pressure
10 Recruiting Safety Study Using Transcranial MR Guided Focused Ultrasound in the Treatment of Neuropathic Pain
Condition: Functional Brain Disorders /Neuropathic Pain
Intervention: Device: ExAblate 4000 focused ultrasound brain intervention
Outcome Measures: Precision of lesioning;   Safety measurements;   Lesion characteristics;   Clinical Efficacy
11 Unknown  Neurosurgery Patient Outcomes in Treating Spinal Disorders
Conditions: Symptomatic Lumbar Disc Herniation;   Symptomatic Grade I Lumbar Spondylolisthesis
Interventions: Procedure: Lumbar Discectomy;   Procedure: Single-level lumbar fusion
Outcome Measures: SF-36 version 1;   Site and Physician Compliance;   Oswestry Disability Index (ODI);   Visual Analog Pain Score;   Return to Work;   30 day complications;   Delayed Surgical Complications
12 Recruiting Neurotransmitter Measurements Using Wireless Instantaneous Neurotransmitter Concentration System (WINCS) During Deep Brain Stimulation Neurosurgery
Conditions: Essential Tremor;   Parkinson's Disease;   Dystonia
Intervention: Device: WINCS (Wireless Instantaneous Neurochemical Concentration Sensing System)
Outcome Measures: adenosine release in brain as measured by WINCS (Wireless Instantaneous Neurochemical Concentration Sensing System)recording device;   dopamine release in brain as measured by WINCS (Wireless Instantaneous Neurochemical Concentration Sensing System)recording device
13 Not yet recruiting Treatment of Brain AVMs (TOBAS) Study
Conditions: Unruptured Brain Arteriovenous Malformation;   Ruptured Brain Arteriovenous Malformation;   Arteriovenous Malformations;   AVM;   BAVM
Interventions: Procedure: Neurosurgery;   Radiation: Radiation therapy;   Procedure: Embolization
Outcome Measures: composite event of death from any cause or disabling stroke;   occurrence of any neurological event;   Permanent disabling peri-operative complications
14 Unknown  Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection
Condition: Neurosurgery
Interventions: Drug: Vancomycin;   Drug: Teicoplanin;   Drug: Linezolid
Outcome Measure: Concentration of antibiotics in cerebrospinal fluid
15 Unknown  Prospective Randomized Endovascular Therapy in Multiple Sclerosis - PREMiSE
Condition: Multiple Sclerosis
Interventions: Device: Selective Venography followed by therapeutic balloon angioplasty;   Other: Control arm
Outcome Measures: Safety;   Preliminary efficacy
16 Recruiting Positron Emission Tomography (PET) With 3,4-dihydroxy-6-18F-fluoro-L-enylalanine (18F-FDOPA) Study
Condition: High-grade Glioma
Intervention: Procedure: Surgical neuronavigation with 18F-DOPA PET imaging
Outcome Measure: The proportion of subjects that have a complete resection of the volume of 18F-FDOPA PET tracer on their postoperative 18F-FDOPA PET scan.
17 Recruiting Observation of Neurosurgical Interventions With Intraoperative Neurophysiological Monitoring IONM
Condition: Patients Operated on at the Neurosurgery Department
Intervention: Device: Intraoperative Neurophysiological Monitoring IONM
Outcome Measure:
18 Not yet recruiting High Resolution Imaging of Cerebral Vasculature by Functional Micro-Doppler Sonography During Brain Surgery
Condition: Partial Drug-resistant Epilepsy
Intervention: Device: Functional micro-Doppler Sonography (fmDS)
Outcome Measures: Precise delineating of the dysplasic tissue in the white matter of patient with MRI-visible FCD using a 2D voxel-by-voxel analysis based on ultrasound B-Mode and micro-Doppler mode.;   Determine if the location of abnormal dysplasic tissue correlate with location of the epileptogenic zone in MRI-visible FCD
19 Recruiting Sub-thalamic Nucleus Stimulation in Parkinson Disease
Condition: Parkinson's Disease
Interventions: Procedure: New targeting procedure without electrophysiology;   Procedure: Classical neurosurgical procedure
Outcome Measures: the ratio of preoperative and postoperative UPDRS 3 score;   Efficacy;   The variance of improvement mean for the "high precision" technique;   Percentage of patients with an improvement of UPDRS III score;   The Calculated preoperative and post operative (6 months) equivalent dose of L-DOPA and the decrease of between preoperative and post operative period (6 months).;   Percentage of patients with failure of the new surgical technique defined with an improvement of less than 35 % with the UPDRS 3 score and an electrode located more than 4 mm from the target;   Quality of Life;   Non motor items of UPDRS score in the high precision technique under general anesthesia alone;   Adverse effects and complications;   Percentage of improvement in patients with the reference technique;   Compare the technical feasibility for both surgeries based on the number of electrodes implanted in the target;   Operative and postoperative surgical adverse effects.;   Evaluate the influence of two operative procedures on the onset and maintenance of post-operative PTSD;   Evaluate the influence of two operative procedures on the level of preoperative anxiety and the time course of this anxiety;   Differentiate thymic and cognitive factors potentially predictors of the occurrence of post-surgical PTSD;   Evaluate the long-term effects of the two operating procedures on thymic and cognitive state
20 Recruiting ShuntCheck-Micro-Pumper Pediatric Clinical Outcomes Study
Condition: Suspected CSF Shunt Obstruction
Interventions: Device: ShuntCheck-Micro-Pumper (SCMP);   Device: Imaging
Outcome Measures: Diagnostic accuracy compared with clinical outcomes;   Positive Predictive Value (PPV);   Negative Predictive Value (NPV);   Safety;   Rule Out for Low Risk Cases;   Increased PPV and NPV for Uncertain Cases

These studies may lead to new treatments and are adding insight into Neurosurgery etiology and treatment.

A major focus of Neurosurgery research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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