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Nicotrol Medical Research Studies

Up-to-date List of Nicotrol Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Nicotrol Medical Research Studies

Rank Status Study
1 Recruiting Pilot Pharmacokinetic Study of Investigational Sublingual Nicotine Tablet Versus COMMIT Nicotine Lozenge
Condition: Nicotine Pharmacokinetic Study
Intervention: Drug: Nicotine (Pharmaceutical Productions Inc.)
Outcome Measures: The primary outcome measure is to substantiate that the pharmacokinetics of this novel nicotine replacement therapy (NRT) resembles that of smoking a cigarette, wherein the average Tmax is about 15 minutes or less. ►;   The secondary outcome is to compare craving scores for this investigational nicotine replacement therapy (NRT) to the lozenge.;   A Product Preference Questionnaire
2 Recruiting Neural Mechanisms Underlying Nicotine and Alcohol Combinations
Condition: Focus: Effects of Nicotine and Alcohol on Brain Circuits
Interventions: Drug: Nicotine + Alcohol;   Drug: Placebo Nicotine + Alcohol;   Drug: Nicotine + Placebo Alcohol
Outcome Measures: Functional connectivity of reward-related brain circuit;   Functional connectivity of visual, motor, and sensorimotor brain circuits;   Exploratory investigation of oxygen metabolism and perfusion underlying the functional connectivity effects
3 Recruiting Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging
Condition: Nicotine Dependence
Interventions: Drug: Nicotine patch - transdermal;   Drug: placebo
Outcome Measures: Mu-opioid receptor binding potential;   Nicotine craving;   Nicotine withdrawal
4 Not yet recruiting Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders
Condition: Tobacco Dependence
Interventions: Drug: Reduced Nicotine Content Cigarettes;   Drug: Usual Nicotine Content Cigarettes
Outcome Measures: Plasma Cotinine Concentration;   Ratings of psychiatric and nicotine withdrawal symptoms
5 Not yet recruiting Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status
Condition: Tobacco Dependence
Interventions: Drug: Reduced Nicotine Content Cigarettes;   Drug: Same Nicotine Content Cigarettes
Outcome Measures: Urinary nicotine metabolites;   Participant dropout/relapse
6 Not yet recruiting Nicotine Metabolism and Low Nicotine Cigarettes
Condition: Smoking
Intervention: Other: Low nicotine cigarettes
Outcome Measures: Smoking topography- total puff volume;   Daily cigarette consumption;   Urine nicotine metabolite measures;   Carbon monoxide measurements
7 Recruiting Effects of IV Nicotine Induced Changes on BOLD fMRI Signal, Hormones, and Subjective Ratings of Stimulant Drug Effect
Condition: Nicotine Dependence
Intervention: Drug: Intravenous Nicotine
Outcome Measures: Effects of Nicotine on BOLD fMRI Signal;   Effects of Nicotine on the hypothalamic-pituitary-gonadal (HPG) axis;   Effects of Nicotine on hypothalamic-pituitary-adrenal axis (HPA) hormones;   Effects of Nicotine on Mood States on the Visual Analog Scale;   Effects of Nicotine on Cardiovascular Measures
8 Recruiting Electronic Cigarettes or Nicotine Inhaler for Smoking Cessation
Condition: Tobacco Use Disorder
Interventions: Other: electronic cigarette;   Drug: nicotine inhaler
Outcome Measures: Cigarettes smoked over 24 hours;   Symptoms of nicotine withdrawal;   Benefits from smoking cessation;   Adverse reaction to nicotine inhaler or electronic cigarette
9 Not yet recruiting Project 2: Strategies for Reducing Nicotine Content in Cigarettes
Conditions: Immediate Nicotine Reduction Group;   Gradual Nicotine Reduction Group;   Normal Nicotine Control Group
Intervention: Behavioral: Smoking Spectrum Brand Cigarettes for 20 weeks.
Outcome Measures: Toxicant exposure pattern;   Cigarettes per day;   Nicotine exposure;   Other toxicant exposure;   Effect biomarker;   Cessation rates;   Measure of acceptability;   Measure of acceptability: Non-compliance
10 Recruiting Effects of Electronic Cigarettes on Nicotine Concentrations
Condition: Health Behavior
Interventions: Other: Nicotine with Tobacco Flavor;   Other: Nicotine with Tobacco and Menthol Flavor
Outcome Measures: Effects E-cig use on venous nicotine concentrations before and 5, 10, 15,20 and 30 minutes after use;   Effects of E-cig use on measures of pulmonary resistance before and 5 minutes after use
11 Not yet recruiting Manipulating Tobacco Constituents in Female Menthol Smokers
Condition: Nicotine Dependence
Interventions: Other: Reduced Nicotine;   Other: Reduced Nicotine Content-Menthol;   Other: Conventional Nicotine-Menthol;   Other: Conventional Nicotine
Outcome Measures: The goal of the cigarette conditions is to find the impact of varying nicotine and menthol concentrations on smoking rate and abstinence.;   Toxicant Exposure
12 Recruiting Nicotine Replacement Therapy in the Intensive Care Unit
Conditions: Delirium;   Psychomotor Agitation;   Substance Withdrawal Syndrome;   Nicotine Replacement Therapy
Interventions: Drug: Transdermal nicotine patch;   Other: Cutaneous patch, containing no active substances
Outcome Measures: In-hospital mortality;   30-day mortality;   90-day mortality;   Patient location;   Total maximum SOFA score;   Delta SOFA score;   Mean RASS-score;   Highest RASS-score;   Lowest RASS-score;   Hours RASS-score outside optimal range (<-3 and/or >+1);   Hours RASS-score outside optimal range (<-3 and/or >+1) indexed by the overall duration of sedation;   Hours with delirium;   Number of self-extubations;   Number of self-removed catheters;   Number of new nosocomial infections (CDC criteria);   Total dose of sedatives, analgesics and antipsychotics in mg or μg/kg;   Hours of physical restraint;   Sedation-free hours;   Length of stay, ICU (hours);   Length of stay, hospital (hours);   Intensive Care Unit mortality
13 Not yet recruiting Acute and Chronic Nicotine Modulation of Reinforcement Learning
Condition: Nicotine Addiction.
Interventions: Drug: Nicotine polacrilex;   Drug: Placebo;   Other: satiety;   Other: abstinence
Outcome Measure: change in blood oxygen level dependent signal
14 Recruiting Smoking Cessation in Women With Gynecological Conditions
Condition: Cervical Dysplasia
Interventions: Other: Nicotine Replacement Therapy;   Device: Electronic Cigarettes
Outcome Measures: Composite set of questions about the feasibility of successfully using NRT and ENDS over time (assessing change in smoking habits) in Women with Serious Gynecological Conditions;   Feasibility of Study
15 Recruiting Providing Free Nicotine Patches to Quitline Smokers
Condition: Smoking Cessation
Interventions: Behavioral: Telephone counseling;   Behavioral: Voucher;   Drug: Nicotine patches
Outcome Measures: Smoking Status - six months prolonged abstinence;   Percentage of smokers making a 24-hour quit attempt;   Survival curves for the quit attempts
16 Unknown  Nicotinic Modulation of the Default Network
Conditions: Magnetic Resonance Imaging;   Cognition;   Nicotine;   Mecamylamine
Interventions: Drug: Nicotine;   Drug: Mecamylamine;   Drug: Placebo
Outcome Measures: Effects of nicotine on cognitive performance;   Effects of nicotine on default network activity;   Effects of mecamylamine on cognitive performance;   Effects of mecamylamine on default network activity;   Effects of nicotine on subjective state;   Effects of nicotine on vital signs;   Effects of mecamylamine on subjective state;   Effects of mecamylamine on vital signs
17 Recruiting Novel Determinants and Measures of Smokeless Tobacco Use: Study 2
Conditions: Tobacco Use Disorder;   Nicotine Dependence
Interventions: Other: Low nicotine;   Other: Medium nicotine;   Other: High nicotine
Outcome Measures: 1. To determine if switching to ST products with reduced toxicant levels will result in reduction of biomarkers of exposure and toxicity. 2. To determine the nicotine levels of ST that would lead to the greatest reduction in tobacco toxicant exposure.;   To determine the extent to which varying low nicotine ST products leads to compensatory tobacco use.
18 Recruiting Sensitivity to Intravenous Nicotine: Genetic Moderators
Condition: Influence of OPRM1 A118G Status on Subjective Responses to IV Nicotine.
Intervention: Drug: Nicotine
Outcome Measure: primary hypotheses will test the influence of OPRM1 A118G status on subjective responses to IV nicotine, which will be measured with the drug effects questionnaire (DEQ).
19 Recruiting Nicotine Replacement for Smoking Cessation During Pregnancy
Conditions: Nicotine Dependence;   Smoking Cessation
Intervention: Drug: Nicotrol Inhaler
Outcome Measures: 7 day point prevalence (PPA);   Birth weights, gestational age and cotinine concentrations;   Exhaled carbon monoxide and cigarettes per day (CPD);   Birth Weight and gestational age
20 Recruiting Randomized Controlled Trial of Mailed Nicotine Replacement Therapy to Canadian Smokers
Condition: Smoking
Intervention: Drug: Nicotine replacement therapy
Outcome Measures: Smoking cessation;   Reduction in smoking since baseline;   Compliance with course of nicotine patches provided;   Purchase and use of NRT and smoking cessation aids

These studies may lead to new treatments and are adding insight into Nicotrol etiology and treatment.

A major focus of Nicotrol research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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