Up-to-date List of Nitroderm Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Nitroderm Medical Research Studies

1 Recruiting Nitroglycerin in Non-small Cell Lung Cancer
Condition: Non Small Cell Lung Cancer (NSCLC)
Intervention: Drug: Nitroglycerin patch
Outcome Measures: Increase of 2 year overall survival of 15% vs historical controls;   Demonstrate effect on enhancement on tumor perfusion;   Toxicity;   Demonstrate the effect on enhancement of tumor oxygenation;   Evaluating the possible value of Perfusion CT and hypoxia scans on treatment with nitroglycerin of NSCLC
2 Recruiting GTN Therapy on Biomarkers of Immune Escape in Men With Biochemical Recurrence of Prostate Cancer After Primary Therapy
Condition: Prostate Cancer
Interventions: Other: Low Dose GTN 0.0285 mg/hr;   Other: High Dose GTN 0.057 mg/hr;   Other: Placebo
Outcome Measures: Change in the following biomarkers: inflammatory/immune markers uPAR, PAI-1, ULBP2, B7-H1, MIF, TGF-β; and PSA compared to placebo.;   Safety and tolerability of SR low-dose GTN patches in the proposed patient population.
3 Not yet recruiting Investigation Into the Role of GTN & RIPC in Cardiac Surgery
Condition: Myocardial Reperfusion Injury
Interventions: Other: Remote ischaemic preconditioning;   Drug: IV Normal saline;   Drug: IV Glyceryl trinitrate 2-5ml/h
Outcome Measures: Troponin T area under the curve;   Inotrope/Vasopressor requirements peri-operatively;   Ventilator dependence post operatively;   Incidence of Acute Kidney Injury assessed using biomarkers;   Length of ITU stay;   Length of hospital stay;   Incidence of post-operative atrial fibrillation
4 Not yet recruiting Treatment of Suspected Cholelithiasis With Nitroglycerin
Intervention: Drug: sublingual nitroglycerine
Outcome Measure: pain relief on visual analog scale
5 Not yet recruiting GOT-IT Trial: Glyceryl Trinitrate for Retained Placenta
Condition: Retained Placenta.
Interventions: Drug: Glyceryl Trinitrate;   Drug: Matched Placebo
Outcome Measures: Need for Manual Removal of Placenta;   Blood Loss;   Satisfaction with treatment;   Net incremental costs (or cost savings) to the National Health Service;   Fall in haemoglobin;   Time from randomisation to delivery of placenta.;   Need for Manual Removal of Placenta in theatre.;   Need for earlier than planned MROP on the basis of the clinical condition.;   Systolic and diastolic blood pressure.;   Need for blood transfusion;   Need for general anaesthesia;   Maternal Pyrexia;   Sustained uterine relaxation.;   Mean costs for each treatment allocation group
6 Recruiting Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure
Condition: Anal Fissure
Intervention: Drug: Nitroglycerin Ointment 0.4%
Outcome Measures: Noncompartmental pharmacokinetic analyses will be performed on the full pharmacokinetic curves for NTG and its metabolites (1,2 glyceryl dinitrate and 1,3 glyceryl dinitrate) on Day 5;   • Absolute change from baseline in 24-hour average anal fissure pain scores assessed by the Wong-Baker FACES® and the Numerical Rating Scale for pain after each evening dose over days 1 through 4
7 Not yet recruiting The Use of Glyceryl Trinitrate Patches in Arteriovenous Fistulas
Condition: Renal Failure
Interventions: Drug: GTN patch;   Drug: placebo comparator
Outcome Measures: Change to diameter of vein;   Number of participants with adverse events
8 Recruiting The Effect of Nitroglycerin on the Intrauterine Device (IUD) Insertion Experience in Nulliparous Women
Conditions: Contraception;   Pain
Interventions: Drug: Insertion of nitroglycerin ointment;   Drug: Insertion of placebo ointment
Outcome Measures: Patient-reported pain at passage of insertion device through cervix, as measured on a 100 mm VAS;   Provider ease with insertion measured on a 100 mm VAS;   Patient-reported pain at tenaculum placement, as measured on a 100 mm VAS;   Vital signs after insertion of nitroglycerin ointment;   Side effects after insertion of nitroglycerin ointment
9 Recruiting Nitroglycerin Infusion During Cardiac Surgery
Conditions: Lactic Acidosis;   Bleeding
Intervention: Drug: Nitroglycerin infusion
Outcome Measures: Plasma lactate level;   Perioperative blood loss;   Mean arterial blood pressure;   Inotropic doses;   Time to extubation
10 Recruiting Dose Escalation Trial of Nitroglycerin, 5-flourouracil and Rad Therapy for Rectal Cancer
Condition: Rectal Cancer
Intervention: Drug: nitroglycerin
Outcome Measures: Maximum tolerated dose (MTD);   Pathological complete response (pCR)
11 Unknown  Concurrent Chemotherapy and Radiotherapy With Nitroglycerin in Patients With Locally Advanced Non-Small Cell Lung Cancer
Condition: Locally Advanced Non Small-Cell Lung Canger
Intervention: Drug: Transdermal nitroglycerin
Outcome Measures: Time to progression, over-all survival;   Levels of oxidative stress through lipid peroxidation and quantification of VEGF Toxicity from treatment with chemotherapy and concurrent chemo-radiotherapy combined with transdermal nitroglycerin
12 Recruiting Paclitaxel-Carboplatin-Bevacizumab +/- Nitroglycerin in Metastatic Non-Squamous-Non-Small Cell Lung Cancer
Condition: Non Small Cell Lung Cancer
Interventions: Drug: carboplatin paclitaxel bevacizumab;   Drug: Standard treatment plus nitroglycerin
Outcome Measures: progression free survival;   objective response rate;   disease control rate;   duration of response;   safety;   prediction of early response;   decreased hypoxia
13 Recruiting Effect of Nitroglycerin Ointment on Mastectomy Flap Necrosis
Condition: Mastectomy Flap Necrosis
Interventions: Drug: nitroglycerin ointment;   Drug: Polysporin ointment
Outcome Measure: Mastectomy Flap Necrosis
14 Unknown  The Analgesic Effect of Nitroglycerin Patch for Postoperative Pain After Total Knee Replacement
Condition: Total Knee Arthroplasty
Intervention: Drug: Nitroderm patch
Outcome Measures: pain scores;   morphine use;   sedation score;   nausea and vomiting
15 Unknown  Paclitaxel and Carboplatin With or Without Nitroglycerin in Treating Patients With Previously Untreated Stage III or Stage IV Non-Small Cell Lung Cancer
Condition: Lung Cancer
Interventions: Drug: carboplatin;   Drug: nitroglycerin;   Drug: paclitaxel
Outcome Measures: Tumor response rate;   Progression-free survival;   Adverse event and its severity;   Overall survival;   Change in the plasma concentration of VEGF between before and after the three-day administration of nitroglycerin prior to the start of the administration of anticancer drugs in the first course of the treatment;   Change in the number of endothelial progenitor cells in blood between before and after the three-day administration of nitroglycerin prior to the start of the administration of anticancer drugs in the first course of the treatment;   Blood concentration of paclitaxel and carboplatin immediately and two hours after the administration of the anticancer drug (paclitaxel) in the first course of treatment
16 Not yet recruiting Study to Evaluate is ECV Success is Improved and the Side Effects Reduced With the Use of IV NTGL Versus Terbutaline
Condition: External Cephalic Version
Interventions: Drug: Intravenous Terbutaline;   Drug: Intravenous Nitroglycerine
Outcome Measures: Successful version of the fetus into the vertex position;   Hypotension;   need for cesarean delivery;   tachycardia
17 Recruiting Field Administration of Stroke Therapy-Blood Pressure Lowering
Conditions: Intracerebral Hemorrhage;   Ischemic Stroke
Intervention: Drug: Glycerly Trinitrate
Outcome Measure: Mean blood pressure change
18 Unknown  Effect of GTN and Diamox Measured by BOLD-Response.
Condition: Healthy
Intervention: Drug: Glyceryl trinitrate, azetazolamide
Outcome Measures: Changes in BOLD response;   Changes in a. cerebri media diameter;   Changes in CBF;   headache score
19 Recruiting Nitrates and Bone Turnover; Nitrates and Bone Turnover Bisphosphonate Sub-Study
Condition: Osteoporosis
Interventions: Drug: Nitrates (NABT Main trial);   Other: Placebo
Outcome Measures: Bone Turnover Markers;   Headache
20 Recruiting The Efficacy of Nitric Oxide in Stroke (ENOS) Trial
Condition: Stroke
Interventions: Drug: Transdermal glyceryl trinitrate patch;   Drug: Pre-stroke antihypertensives
Outcome Measure: Reduced death or dependency (modified Rankin score)

These studies may lead to new treatments and are adding insight into Nitroderm etiology and treatment.

A major focus of Nitroderm research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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