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Nitrofurant Medical Research Studies

Up-to-date List of Nitrofurant Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Nitrofurant Medical Research Studies

Rank Status Study
1 Not yet recruiting Study Comparing Nitrofurantoin to Fosfomycin for Acute Urinary Tract Infection in Women
Conditions: Urinary Tract Infections;   Cystitis
Interventions: Drug: Nitrofurantoin;   Drug: fosfomycin
Outcome Measures: Number of participants with clinical cure, clinical failure, or indeterminate clinical response (see description below);   Number of participants with bacteriologic cure and with bacteriologic recurrence
2 Unknown  Nitrofurantoin and Urinary Tract Infections (UTIs)
Condition: Urinary Tract Infections
Interventions: Drug: Nitrofurantoin;   Drug: Placebo
Outcome Measures: primary outcome: the frequency of symptomatic UTI's confirmed with a positive urine culture within 6 to 8 weeks after CISC teaching and implementation;   time (days after surgery) to development of symptomatic, culture documented UTI;   frequency of urine cultures positive for organism strains that are resistant to Nitrofurantoin and other commonly used antibiotics.;   adherence to CISC;   patient perceptions regarding CISC;   frequency of adverse events related to CISC such as urethral pain, irritative voiding symptoms, hematuria;   frequency of adverse events related to daily Nitrofurantoin exposure such as nausea, diarrhea, C. difficile colitis
3 Recruiting Antibiotic Prophylaxis for Clean Intermittent Catheterisation
Condition: Urinary Tract Infection: [Site Not Specified] or [Recurrent]
Interventions: Drug: Nitrofurantoin or Trimethoprim or Cefalexin;   Other: No prophylaxis
Outcome Measure: Relative incidence of symptomatic antibiotic‐treated UTI
4 Recruiting Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract
Conditions: Vesicoureteral Reflux;   Renal Hypodysplasia, Nonsyndromic, 1;   Chronic Kidney Disease
Interventions: Drug: Nitrofurantoin;   Other: No prophylaxis;   Drug: Amoxicillin-Potassium Clavulanate Combination;   Drug: Trimethoprim/sulfamethoxazole;   Drug: Cefixime
Outcome Measures: urinary tract infections rate;   febrile urinary tract infections;   renal scars;   serum creatinine (renal function);   hypertension;   proteinuria;   body mass index;   serum cystatin C (renal function)
5 Unknown  Examination of the Efficacy of Preventive Antibiotic Treatment During the Puerperium Among Pregnant Women With Recurrent Urinary Tract Infections
Condition: Pregnancy Complications
Interventions: Drug: Preventive antibiotic treatment- Nitrofurantoin;   Drug: Preventive antibiotic treatment- CEPHALEXIN;   Drug: PREVENTIVE TREATMENT- AMOXICILLIN;   Drug: PREVENTIVE TREATMENT- AMOXICILLIN AND CLAVULANATE POTASSIUM;   Drug: PREVENTIVE TREATMENT- CEFUROXIME;   Drug: PREVENTIVE TREATMENT SULFAMETHOXAZOLE AND TRIMETHOPRIM
Outcome Measure: Urinary tract complications
6 Not yet recruiting Patients Response to Early Switch To Oral:Osteomyelitis Study
Condition: Osteomyelitis
Interventions: Drug: oral antibiotics;   Procedure: intravenous antibiotics
Outcome Measures: Clinical Failures;   Evaluation of adverse events related to the use of antibiotics;   Cost of care from the hospital perspective
7 Recruiting Antibiotic Prophylaxis in Children With Pyelonephritis
Condition: Pyelonephritis
Interventions: Drug: Trimethoprim Sulfamethoxazole;   Drug: placebo
Outcome Measures: To determine whether antibiotic prophylaxis prevents recurrent urinary tract infections by assessing if there is a decreased incidence of urinary tract infections.;   To determine whether antibiotic prophylaxis prevents long-term renal scarring by assessing results of DMSA scans to look at long term renal scarring.;   To determine whether recurrent infections and involvement with the medical system impacts quality of life by assessing how this medical condition affects children using standardized quality of life questionnaires.
8 Recruiting Umbilical Cord Care for the Prevention of Colonization
Conditions: Line Insertion Site;   Central Line-associated Bloodstream Infection (CLABSI)
Interventions: Drug: Povidone-Iodine;   Drug: Chlorhexidine gluconate;   Drug: Pluronic Cream;   Other: control
Outcome Measures: Colonization of umbilical stump;   Late-onset infection;   Contact dermatitis of cord or skin base

These studies may lead to new treatments and are adding insight into Nitrofurant etiology and treatment.

A major focus of Nitrofurant research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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