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Nuedexta Medical Research Studies

Up-to-date List of Nuedexta Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Nuedexta Medical Research Studies

Rank Status Study
1 Recruiting Nuedexta for the Treatment of Adults With Autism
Condition: Autism
Intervention: Drug: Nuedexta
Outcome Measures: Reduction in Maladaptive Behaviors;   Reduction in Aggressive Behavior;   Safety and Tolerability
2 Recruiting Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA)
Conditions: Pseudobulbar Affect (PBA);   Stroke;   Dementia;   Traumatic Brain Injury (TBI)
Intervention: Drug: Nuedexta (DM 20 mg/Q 10 mg)
Outcome Measures: The primary efficacy endpoint is the mean change from baseline at 12 weeks in CNS-LS score.;   Safety and Tolerability;   PBA Episode Counts;   Patient Global Impression-Change (PGI-C);   Clinical Global Impression-Change (CGI-C);   Patient Satisfaction with Treatment Survey
3 Recruiting Nuedexta in the Treatment of Pseudobulbar Affect in Patients With Alzheimer's Disease
Conditions: Alzheimer's Disease;   Pseudobulbar Affect (PBA)
Intervention: Drug: Nuedexta (20/10)
Outcome Measures: reduction of PBA frequency;   reduction of PBA severity
4 Recruiting Clinical Trial Nuedexta in Subjects With ALS
Condition: Amyotrophic Lateral Sclerosis (ALS)
Interventions: Drug: Nuedexta;   Drug: Matching Placebo
Outcome Measures: Change in Center for Neurologic Study - Bulbar Function Scale (CNS-BFS) Score;   Change in Center for Neurologic Study - Lability Scale (CNS-LS) Score;   Change in ALS Functional Rating Scale- Revised (ALSFRS-R) Score;   Change in Slow Vital Capacity (SVC) Score;   Change in Visual Analog Scale (Bulbar Function) Score;   Change in Ashworth Spasticity Scale Score;   Change in Timed Reading of Test Paragraph Result;   Change in Water Swallowing Test (WST) Result;   Change in Timed Swallowing Test Result
5 Recruiting Nuedexta in Treatment-Resistant Major Depression
Conditions: Major Depressive Disorder;   Treatment Resistant
Intervention: Drug: dextromethorphan/quinidine
Outcome Measures: Change in Montgomery-Asberg Depression Rating Scale;   Change in Quality of Life Enjoyment and Satisfaction Questionnaire Short Form;   Change in Range of Impaired Functioning Tool;   Change in Sheehan Disability Scale;   Patient Rated Inventory of Side Effects (PRISE);   Columbia-Suicide Severity Rating Scale (C-SSRS);   Quick Inventory of Depressive Symptomatology, Self Report (QIDS-SR);   Clinical Global Impression (CGI) scale;   Change in Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire (CPFQ)
6 Recruiting Safety and Efficacy of AVP-923 in the Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease Patients
Conditions: Dyskinesia;   Parkinson's Disease
Interventions: Drug: AVP-923-45;   Drug: Placebo
Outcome Measures: Unified Dyskinesia Rating Scale (UDysRS), part 3;   UDysRS, part 4;   Movement Disorder Society- Unified Parkinson's Disease Rating Scale (MDS-UPDRS), part III-motor score;   Bradykinesia;   MDS-UPDRS part I, II, and IV;   UDysRS part 1 and 2;   PD Motor Diary
7 Recruiting Efficacy, Safety and Tolerability Study of AVP-923 (Dextromethorphan/Quinidine) for Treatment of Symptoms of Agitation in Alzheimer's Patients
Conditions: Agitation;   Alzheimer's Disease
Interventions: Drug: AVP-923 (dextromethorphan/quinidine);   Drug: Placebo
Outcome Measures: Neuropsychiatric Inventory (NPI);   Safety and Tolerability;   ADCS-CGIC (Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change Rating);   QoL-AD (Quality of Life - Alzheimer's Disease measure);   ADCS-ADL (Alzheimer's Disease Cooperative Study - Activities of Daily Living Inventory);   CSI (Caregiver Strain Index)

These studies may lead to new treatments and are adding insight into Nuedexta etiology and treatment.

A major focus of Nuedexta research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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