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Ossopan Medical Research Studies

Up-to-date List of Ossopan Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Ossopan Medical Research Studies

Rank Status Study
1 Unknown  Comparison of Individual Computer Aided Design/Manufactured (CAD/CAM) - Based Implants Consisting on Hydroxylapatite and Titanium to be Used in Cranioplasty
Conditions: Skull Defects;   Cranioplasty
Interventions: Device: Titanium implant (CranioConstruct™);   Device: Hydroxylapatite (CustomBone)
Outcome Measures: Comparison of the rate of local and/or systemic infections (acute/chronic) in both study arms within the first 6 months after operation.;   Comparison of the rate of re-operations with and without ex-plantation of the implant in both arms.;   Comparison of post-operative computer tomography (CT) (native and bone 5 mm) within 48 h in respect to bleeding, dislocation and further complications after cranioplasty in both arms.;   Comparison of health-related quality of life after cranioplasty in both arms using the SF36-questionnaire.;   Comparison between both groups referring to cosmetic result, period of hospitalization, costs, intra-operative features.;   Comparison of temperature sensitivity (cold/heat) six months after implantation in both groups.;   Description of osteointegration with CT and bone scan six months post-operative in both groups
2 Recruiting Cemented Versus Uncemented Stems in Total Hip Arthoplasty in Patients With Femoral Neck Fractures
Condition: Femoral Neck Fractures
Interventions: Device: Lubinus SPII / IP;   Device: Corail / Marathon
Outcome Measures: Time to mobilization.;   Cognitive status. Eventual confusion.;   Oxygen saturation levels peroperatively.;   Bone remodeling around the hip prosthesis.;   Biomarkers / inflammatory response.;   Fixation / migration / loosening of the hip prosthesis components.;   Reoperation.;   PROM - Patient Reported Outcome Measurements.
3 Recruiting Mesenchymal Stem Cells; Donor and Role in Management and Reconstruction of Nonunion Fracture
Condition: Healing of Fracture
Interventions: Drug: stem cells + hydroxy apatite;   Other: autograft taken from iliac crest
Outcome Measures: healing of fracture;   VAS
4 Recruiting Buccal Plate Augmentation With Different Hydroxyapatite Based Material
Condition: Edentulous
Intervention:
Outcome Measure:
5 Unknown  Hydroxyapatite Active Pro Healing Clinical Trial Program
Condition: Coronary Artery Disease
Intervention: Device: Intravascular Coronary Stent
Outcome Measure: In-stent late-loss at 4 and 12 months (as measured by QCA), defined as the difference between the post-procedure minimal lumen diameter (MLD) and the follow-up angiographic MLD
6 Recruiting Teriparatide (Forsteo) Treatment in Postmenopausal Women: Mechanism of Action
Condition: Osteoporosis
Intervention: Drug: Teriparatide
Outcome Measures: Volumetric bone mineral density (BMD) of the lumbar spine (mg hydroxyapatite/cm3);   Lumbar spine, total hip and whole body bone mineral density (g/cm2);   Biochemical markers of bone turnover;   Distal tibia and radius volumetric body bone mineral density (BMD) (mg hydroxyapatite/cm3)
7 Recruiting Effectiveness of Adipose Tissue Derived Mesenchymal Stem Cells as Osteogenic Component in Composite Grafts
Condition: Osteoporotic Fractures
Interventions: Procedure: Cellularized composite graft augmentation;   Procedure: Acellular composite graft augmentation
Outcome Measures: Development of secondary dislocation within 12 months postoperative;   Functional outcome 6 weeks, 6 and 12 months after fixation;   Safety;   bone mineral density;   Histology;   Dose-response
8 Recruiting Comparison of Two Resurfacing Prostheses in the Treatment of Osteoarthritis of the Shoulder
Condition: Osteoarthritis
Intervention: Procedure: Copeland or Global CAP resurfacing prosthesis
Outcome Measures: Migration of resurfacing prostheses;   Bone density around the prosthesis;   Pain;   Activities of Daily Living (ADL);   Range of Motion (ROM);   Muscle strength;   Correlation between bone density and prosthesis migration
9 Recruiting Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients
Condition: Cleft Lip and Palate
Intervention: Procedure: maxillary alveolar graft by tissue engineering
Outcome Measures: Amount of new bone mass formed;   Quality of bone regeneration
10 Recruiting Study for the Treatment of Knee Chondral and Osteochondral Lesions
Conditions: Knee Chondral Lesion;   Knee Osteochondral Lesion
Interventions: Procedure: Marrow stimulation - Drilling or Microfractures;   Device: MaioRegen Surgery
Outcome Measures: IKDC Subjective Knee Evaluation Form-2000;   IKDC Knee Examination Form-2000;   KOOS;   Tegner score;   VAS (Visual Analogue Scale) for pain evaluation;   MRI exam and MOCART score
11 Unknown  Ostoegenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling
Condition: Primary Disease
Intervention:
Outcome Measure:
12 Not yet recruiting Vertical Augmentation With Osteon at Dental Implant Placement
Conditions: Tooth Injuries;   Tooth Abnormalities
Intervention: Device: Osteon bone graft
Outcome Measure: The success of dental implants in alveolar bone augmented in the vertical direction with Osteon
13 Recruiting New Bone Grafting Technique in Paediatric Foot Surgery. Validation of Outcome Measures
Condition: Pes Planovalgus
Interventions: Device: ReproBone;   Procedure: calcaneal lengthening
Outcome Measures: Visual Analog Scale;   Radiographic stereometric assay (RSA)
14 Recruiting Baxter: Actifuse SHAPE vs DBX in ACC
Conditions: Cervical Spine Degenerative Disease Nos;   Cervical Spondylosis With Myelopathy
Interventions: Device: Actifuse SHAPE;   Device: Autograft with Demineralized Bone Matrix
Outcome Measures: Change in Fusion Rates;   Change in Clinical Outcomes
15 Recruiting Hip Fractures Treated With Uncemented Arthroplasties
Condition: Femoral Neck Fractures
Interventions: Procedure: cemented hemiarthroplasty;   Procedure: reverse hybrid total hip arthroplasty;   Procedure: cemented total hip arthroplasty;   Procedure: uncemented hemiarthroplasty
Outcome Measures: Harris Hip Score;   Health related quality of life;   Radiological follow up
16 Recruiting Amelogenesis Imperfecta
Condition: Amelogenesis Imperfecta
Intervention: Genetic: Salivary and blood sampling, as part of routine care. Collection of exfoliated teeth.
Outcome Measures: Natural history of Amelogenesis Imperfecta;   Phenotype of Amelogenesis Imperfecta
17 Not yet recruiting CERAMENT™/G - Bone Healing and Re-infection Prophylaxis
Condition: Osteomyelitis
Intervention: Device: Cerament G
Outcome Measures: Degree of device absorption after insertion of the device (during follow-up).;   Advances in bone in-growth after insertion of the device (during follow up).;   Bone healing;   Infection non-recurrence;   Serum gentamicin levels
18 Recruiting RCT of AttraX® Putty vs. Autograft in Instrumented Posterolateral Spinal Fusion
Conditions: Spinal Deformity;   Spinal Instability;   Instrumented Spinal Fusion
Interventions: Device: AttraX® Putty;   Other: Autologous bone graft
Outcome Measures: Posterior spinal fusion rate after one year;   Rate of (serious) adverse events with a potential relation with AttraX® Putty;   Resorption characteristics of AttraX® Putty compared to autograft during the first year;   Volume of bridging bone mass after one year;   Visual analogue pain scale of iliac crest pain;   Correlation of posterior fusion rate to the presence of interbody fusion after one year;   Posterior spinal fusion rate after two years
19 Recruiting Percutaneous Assisted Approach for Total Hip Replacement and it's Effect on Functional Rehabilitation.
Condition: Total Hip Arthroplasty
Interventions: Procedure: Ceramic on ceramic couple;   Procedure: Percutaneous assisted approach;   Procedure: Anterolateral approach;   Other: Usual care
Outcome Measures: change in time needed for the timed get up and go test;   surface electromyography (sEMG) of gluteus medius;   Change in hip abductor muscle strength measured by MicroFET 2;   Change in knee extensor muscle strength measured by MicroFET 2;   Score on the Trendelenburg test;   Change in score on the Oxford Hip Score;   Change in score on the SF-36 and it's subscales;   Change in time needed to complete the 5 times sit-to-stand test;   Change in distance walked during the 6 minute walking test;   Score on the trendelenburg test

These studies may lead to new treatments and are adding insight into Ossopan etiology and treatment.

A major focus of Ossopan research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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