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Osteoarthritis Medical Research Studies

Up-to-date List of Osteoarthritis Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Osteoarthritis Medical Research Studies

Rank Status Study
1 Recruiting Osteoarthritis Cardiovascular Risk Factors
Conditions: Osteoarthritis;   Cardiovascular Risk Factors;   Cardiovascular Disease;   Metabolic Syndrome
Interventions: Other: Cardiovascular risk factors diagnoses collection.;   Other: History of cardiovascular disease;   Other: Cardiovascular risk factors association
Outcome Measures: Prevalence of cardiovascular risk factors in hand or knee Osteoarthritis patients;   Prevalence of cardiovascular disease in hand or knee Osteoarthritis.
2 Recruiting Yoga as an Intervention for Women With Knee Osteoarthritis
Condition: Osteoarthritis
Intervention: Other: Yoga For Knee Osteoarthritis
Outcome Measures: Change in Knee Extensor Torque;   Change in Knee Pain;   Change in Six Minute Walk Test (6MWT);   Change in 30-second Chair Stand;   Change in Timed Up and Go (TUG);   Change in Stair Ascent and Descent;   Change in Subjective Scales;   Change in Cardiovascular Fitness;   Change in Biomechanical Outcomes
3 Recruiting The Effect of Structured Information and Individually Adapted Exercise on Levels of Physical Activity Measured by Accelerometer in Patients With Knee or Hip Osteoarthritis
Condition: Osteoarthritis
Intervention: Behavioral: A supported self management of Osteoarthritis program
Outcome Measures: Level of physical activity;   Quality of life;   Physical activity;   Pain;   Charnley score
4 Unknown  Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis
Condition: Osteoarthritis of the Knee
Interventions: Biological: Platelet Rich Plasma (Preparation Rich in Growth Factors);   Drug: Hyaluronic acid
Outcome Measure: Improvement in pain, function, quality of life and activity level in knee Osteoarthritis
5 Not yet recruiting Study of Association Between Digital Osteoarthritis and Lower Limb Osteoarthritis
Condition: Digital Arthrosis
Intervention: Radiation: Hand X-rays
Outcome Measures: Kellgren and Lawrence score;   Harris score
6 Not yet recruiting Osteoarthritis Structural Changes Assessed by Magnetic Resonance Imaging (MRI) and Neuropathic Pain in Knee Osteoarthritis
Conditions: Neuropathic Pain;   Knee Osteoarthritis
Intervention: Other: MRI
Outcome Measures: To correlate the level of neuropathic pain with the severity of OA structural changes (cartilage volume and defects, bone marrow lesions, meniscal tears and extrusion, synovitis).;   To assess the correlation between the presence of neuropathic pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores (total, pain, function, stiffness).
7 Unknown  A Comparison of Kneipp Hydrotherapy With Conventional Physiotherapy in the Treatment of Osteoarthritis of the Hip or Knee: Protocol of a Prospective Randomised Controlled Clinical Trial
Condition: Osteoarthritis of the Hip or Knee
Interventions: Procedure: Physiotherapy;   Procedure: Affusion;   Procedure: Affusion/ Physiotherapy
Outcome Measures: The primary outcome measure will be the pain intensity of the affected joint during inpatient care, as assessed by the patient and the investigator;   I) Mobility of the affected joint II) Quality of life rating for the patient with Osteoarthritis, on the basis of the German version of the Arthritis Impact Measurement Scale (AIMS2)
8 Recruiting Internet Intervention to Improve Physical Activity in Early Knee Osteoarthritis
Condition: Knee Osteoarthritis
Intervention: Behavioral: OPEN website
Outcome Measures: Modified Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ).;   Knee Injury and OA Outcome Score (KOOS).;   Rhode's 7-point Likert-type Theory of Planned Behaviour questionnaire;   Aerobic fitness (V02Peak)
9 Unknown  Intra-Articular Autologous Bone Marrow Mesenchymal Stem Cells Transplantation to Treat Mild to Moderate Osteoarthritis
Condition: Osteoarthritis
Interventions: Drug: Hyaluronic Acid;   Biological: Autologous bone marrow-derived mesenchymal stem cells
Outcome Measures: Change from baseline in cartilage thickness at 12 months by MRI;   Visual Analog Score;   IKDC Subjective Knee Evaluation Form (2000);   Change from baseline in progression of Osteoarthritis at 12 months by plain radiograph (X-ray)
10 Recruiting Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the Knee
Conditions: Osteoarthritis;   Knee Osteoarthritis;   Osteochondritis Dissecans;   Osteonecrosis
Intervention: Procedure: Transplantation of Bone Marrow Stem Cells Activated in Knee Arthrosis
Outcome Measures: IKS, International Knee Score;   KOOS, Knee Injury and Osteoarthritis Outcome Score
11 Recruiting Determination of Adipocytokine in Synovial Fluid of Osteoarthritis Patients
Condition: Osteoarthritis
Interventions: Other: arthrocentesis;   Other: ultrasonography of the knee
Outcome Measures: Determination of adipocytokine levels (adiponectin, leptin, resistin, visfatin, osteopontin) in synovial fluid;   Knee inflammation parameters detected by ultrasonography;   To determine additional classic parameters of inflammation in synovial fluid as Interleukine 1 beta, Interleukine 6 and tumor necrosis factor alfa
12 Recruiting Comparing the Clinical Effects of Posterior Approach Versus Lateral Approach in Osteoarthritis Patients With a THA
Condition: Unilateral Primary Osteoarthritis of Hip
Intervention: Procedure: Total hip arthroplasty
Outcome Measures: Hip Disability and Osteoarthritis Outcome Score (HOOS)-Physical Function Short form(HOOS-PS), 12 month;   Hip Disability and Osteoarthritis Outcome Score (HOOS)-pain, 12 month;   Hip Disability and Osteoarthritis Outcome Score (HOOS)-Hip related quality of life, 12 month;   University of California Los Angeles activity score (UCLA), 12 month;   EQ-5D self-rated health index -(using EQ VAS scores), 12 month;   The 20 meter walk-test (20MeWa);   "Timed Up and Go"- test (TUG), 3 month;   "Repeated chair rise"- test (RCR), 3 month;   30 seconds maximal repeated unilateral knee bending, 3 month;   Opioid consumption, 3 month;   Self-reported pain on a numerical ranking scale(NRS), 3 month;   Hip Disability and Osteoarthritis Outcome Score (HOOS)-pain, 3 month;   Hip Range of motion (ROM), 3 month;   Gait Deviation Index(GDI), 12 month;   Kinematic gait data, 12 month;   Temporospatial parameters, 12 month;   Electromyography (EMG) during walk, 12 month;   Isometric maximal voluntary muscle contraction(MVC), 12 month;   Hip Disability and Osteoarthritis Outcome Score (HOOS)-Activities of daily
13 Recruiting DIGItal Cohort Osteoarthritis Design
Condition: Arthrosis of Hand
Intervention: Other: GENETIC and radiographs
Outcome Measures: Baseline clinical, biological, genetic and imaging factors of clinical aggravation after 3 years of follow-up(AUSCAN VA3.0);   Kallman score, Verbruggen score, Kellgren-Lawrence grading and OARSI scoring (Altman score);   patients above 35 years old with symptomatic and radiographic hand Osteoarthritis
14 Recruiting Influence of Adipocytokines in Osteoarthritis
Conditions: Osteoarthritis, Knee;   Endocrine System Diseases;   Cardiovascular Risk Factors
Intervention: Other: Blood analyse, arthrocentesis, ultrasound examination
Outcome Measures: adipocytokine level;   Ultrasound inflammatory exploration of the knee;   Ultrasound of carotid artery;   Cardiovascular risk factors
15 Recruiting Hip Osteoarthritis: Effects of Exercise Programs on Pain and Disability
Condition: Hip Osteoarthritis
Interventions: Behavioral: Structured exercise program;   Behavioral: Waitlist, delayed intervention
Outcome Measures: Physical function: 6-minute walk test;   Pain: Visual analog scale;   Patient Global Assessment: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and The Short Form-36 (SF-36);   Joint Imaging: hip radiographs
16 Not yet recruiting Effects of Glucosamine on Joint Fluid in Osteoarthritis Patients
Condition: Knee Osteoarthritis
Interventions: Dietary Supplement: Glucosamine sulphate;   Other: Placebo
Outcome Measures: Changes in synovial fluid viscosity and viscoelasticity compared to baseline;   Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score
17 Recruiting APSS-33-00: A Multicenter, Pilot Study of Autologous Protein Solution (APS) in Knee Osteoarthritis (OA)
Condition: Osteoarthritis, Knee
Interventions: Device: APS;   Device: Placebo
Outcome Measures: Visual Analogue Scale - Pain;   Knee injury and Osteoarthritis Outcome Score - Function;   Knee injury and Osteoarthritis Outcome Score - Stiffness;   Radiographic Imaging - Joint Structure;   Quality of Life Questionnaires (QoL);   Number of patients with adverse events (Safety)
18 Unknown  Study With Chondroitin Sulfate and Glucosamine Sulfate (in Dosage Capsule and Sachet) in Treating Osteoarthritis
Condition: Osteoarthritis
Intervention: Drug: Chondroitin sulfate + Glucosamine sulfate
Outcome Measures: Promotion of pain relief in patients with Osteoarthritis.;   Functional capacity, overall assessment of clinical improvement, assessment of adverse events
19 Not yet recruiting Phenotype/Genotype Correlation in a Family With Early Onset Osteoarthritis
Condition: Osteoarthritis
Interventions: Radiation: radiography (X-ray);   Genetic: DNA sampling
Outcome Measure: Identification of new gene mutations associated with early onset of Osteoarthritis using NGS (Next Generation Sequencing)
20 Recruiting Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells
Conditions: Osteoarthritis, Knee;   Knee Arthrosis;   Knee Osteoarthritis
Interventions: Other: Injection of Mesenchymal Stromal Cells;   Drug: Hyaluronic Acid
Outcome Measures: Number of participants with adverse events as a measure of safety and tolerability;   Pain and disability evolution (WOMAC and SF-36 scores);   Evolution of cartilage degeneration by T2 relaxation measurements in MRI (Cartigram)

These studies may lead to new treatments and are adding insight into Osteoarthritis etiology and treatment.

A major focus of Osteoarthritis research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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