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Overdose Medical Research Studies

Up-to-date List of Overdose Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Overdose Medical Research Studies

Rank Status Study
1 Recruiting Project OOPEN: Opioid Overdose Prevention, Education and Intervention
Condition: Opioid Overdose
Intervention: Drug: OOPEN+BBCC
Outcome Measures: Opioid Overdose;   Change in Overdose risk;   Health care utilization;   Health care costs;   Change in HIV risk behaviors
2 Not yet recruiting Developing a Prescription Opioid Overdose Prevention Intervention in Addictions Treatment
Conditions: Drug Overdose;   Opioid Related Disorders
Intervention: Behavioral: Therapist-led brief intervention (TBI)
Outcome Measures: Overdose risk behavior;   HIV risk behavor
3 Recruiting Monitoring of Overdose Patients With and Without Supplemental Oxygen in the Emergency Department
Condition: Overdose
Outcome Measures: Airway Interventions Performed by ED Staff;   Pulse oximetry;   End tidal CO2
4 Recruiting Increasing Patient Knowledge of the Signs of Opioid Overdose and Naloxone in a Suburban Treatment Program
Conditions: Opioid Dependence;   Opioid Use Disorder
Intervention: Other: Naloxone Education Intervention
Outcome Measures: Opiate Overdose Knowledge Scale (OOKS);   History Survey;   Guilt and Shame Proneness Scale (GASP)
5 Not yet recruiting Nasal Naloxone for Narcotic Overdose
Condition: Drug Overdose
Interventions: Drug: Intranasal (IN) naloxone;   Drug: Intravenous (IV) naloxone;   Drug: Intramuscular (IM) naloxone;   Drug: Intraosseus (IO) naloxone
Outcome Measures: Proportion of patients with adequate respiration within 10 minutes;   Number of patients requiring second dose of naloxone;   Time to first naloxone administration;   Opioid Withdrawal Symptoms;   Naloxone Adverse Events;   Proportion of Patients breathing unassisted upon arrival to the hospital;   Days of hospitalization following naloxone administration;   Mortality rate
6 Not yet recruiting Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients
Conditions: Opioid-Related Disorders;   Drug Overdose
Interventions: Behavioral: Brief counseling Intervention;   Other: Information and referrals
Outcome Measures: Feasibility of a randomized trial with REBOOT;   Acceptability of REBOOT;   Influence of egocentric social network characteristics on Overdose events and naloxone use
7 Not yet recruiting Evaluation of a Computerized Opioid Overdose Prevention Program
Conditions: Computer + Fluency;   Computer Only;   Treatment as Usual
Interventions: Behavioral: Computer + Fluency;   Behavioral: Computer Only;   Behavioral: Treatment as Usual
Outcome Measures: Knowledge gain;   Self-reported change in behaviors, participant acceptance
8 Not yet recruiting Clinician-patient Interaction During Addiction Consultation
Condition: Drug Dependency
Intervention: Other: methadone replacement therapy
Outcome Measures: Number of days patients injected non-prescribed drugs;   Patient Satisfaction
9 Unknown  Naloxone Nasal Spray Pharmacokinetic Study
Condition: Opioid Overdose
Interventions: Drug: MVP005;   Drug: Naloxone hydrochloride solution for injection with mucosal atomization device
Outcome Measures: Pharmacokinetics;   Number of subjects with adverse events;   Physical Examination;   Vital signs;   ECGs;   Safety Laboratory Tests
10 Recruiting EtCO2 Monitoring in Acute Self-poisoning
Condition: Acute Intentional Overdose
Outcome Measure: ROC curve of maximal EtCO2 to predict poisoning complication
11 Recruiting Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure Due to Acetaminophen
Conditions: Acute Liver Failure;   Acute Liver Injury
Intervention: Drug: Ornithine phenylacetate
Outcome Measures: Number of Participants with Adverse Events as a Measure of Safety and Tolerability;   Measurement of OCR-002 Plasma Concentration;   Change in Venous Ammonia;   Neurological Function measured by the Glasgow Coma Scale (GCS);   Neurological Function measured by the West Haven Criteria (WHC);   Neurological Function measured by the Orientation log (O-log)
12 Recruiting Naltrexone vs Buprenorphine-Naloxone for Opioid Dependence in Norway
Condition: Opioid Dependence
Interventions: Drug: Naltrexone intramuscular suspension;   Drug: Buprenorphine-naloxone
Outcome Measures: Number of biological samples negative/positive for opioid agonists;   Retention;   Mortality;   Use of other substances of abuse;   Mental health;   Somatic health;   Psychosocial problems
13 Recruiting CARE Corrections: Technology for Jail HIV/HCV Testing, Linkage, and Care (TLC)
Condition: Human Immunodeficiency Virus
Interventions: Device: Intervention Arm (computer-based CARE+ Corrections tool);   Other: Educational video on opiate Overdose prevention
Outcome Measures: Plasma Viral Load Suppression;   Linkage to community care
14 Not yet recruiting Optimizing Propofol Dosing for (Preterm) Newborn Infants That Need Endotracheal Intubation
Conditions: Anesthesia Intubation Complication;   Premature Birth of Newborn;   Other Preterm Infants;   Propofol Overdose
Intervention: Drug: Propofol
Outcome Measures: adequate propofol dose;   Determine a valid sedation assessment scale;   to determine an age specific propofol PK/PD model;   aEEG / NIRS
15 Recruiting Acute Acetaminophen Ingestion: Does Repeated Acetaminophen Blood Test Have an Interest?
Condition: Acetaminophen Overdose
Outcome Measure:
16 Recruiting A Trial of Genotype-based Warfarin Initiation in Patients With Mechanical Prosthetic Heart Valve
Conditions: Anticoagulation Treatment Overdose;   Heart Valve Diseases
Interventions: Other: Genotype-based Warfarin Initiation model;   Other: clinical factor-based warfarin initiation model
Outcome Measures: time to steady dosage;   Time in Therapeutic Range;   first time to treatment window;   the ratio of INR≥3.0 and INR≤1.5;   the monitoring frequency of INR;   the whole-cause mortality;   major bleeding event;   major thrombosis rate;   absolute difference between the stable dose and initial dose;   the frequency of dosage change
17 Recruiting Skeletal Muscle Paralysis in Hypothermic Patients After Cardiac Arrest
Conditions: Cardiac Arrest With Successful Resuscitation;   Hypothermia;   Skeletal Muscle Relaxant Overdose
Interventions: Drug: rocuronium;   Other: placebo
Outcome Measures: Number of shivering episodes;   Elapsed time to target temperature;   Dissipated energy to reach the target temperature;   Changes in basal metabolism due to shivering or elevated stress levels;   Depth of relaxation;   Changes in serum levels of midazolam, fentanyl and rocuronium;   Number of necessary boli of rocuronium
18 Recruiting To Establish a Novel Prototype of Clinical Pharmacy Services by Warfarin Consultation in a Pharmacist Clinic
Condition: Intentional Warfarin Sodium Overdose
Intervention: Other: patient education
Outcome Measures: percentage of INR in therapeutic range and incidence of complications;   patient's warfarin knowledge improvement;   Patient's satisfaction to anticoagulation pharmacist clinic
19 Recruiting Safety and Efficacy Study of CENV3 Vaccine to Protect Against HCV Infection
Condition: Vaccine Overdose of Undetermined Intent
Interventions: Biological: prophylactic peptide vaccine;   Biological: therapeutic peptide vaccine
Outcome Measure: Safety and Efficacy Study of CENV3 Vaccine to Protect Against HCV Infection
20 Unknown  Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects
Condition: Poisoning
Interventions: Drug: Chlorphenamine and Ranitidine;   Drug: Paracetamol
Outcome Measures: Attenuation of NAC induced vasodilatation by histamine antagonists (H1 and H2 antagonists) and/or paracetamol;   Inhibition of the inflammatory cascade contributes to a paracetamol mediated protective role against NAC adverse reactions.

These studies may lead to new treatments and are adding insight into Overdose etiology and treatment.

A major focus of Overdose research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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