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Oxaliplatin) Medical Research Studies

Up-to-date List of Oxaliplatin) Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Oxaliplatin) Medical Research Studies

Rank Status Study
1 Recruiting Study of Subcutaneous Injection of Low-dose rhGM-CSF +/- WLL in PAP.
Condition: Pulmonary Alveolar Proteinosis
Interventions: Drug: rhGM-CSF;   Procedure: Whole Lung Lavage(WLL)
Outcome Measures: Improvements in double pulmonary diffuse lesions (Chest CT score );   Clinical symptoms observation: shod of breath, cough (according to each score standard);   Granulocyte Macrophage Colony Stimulating Factor(GM-CSF) Antibody titer change;   Improvements in pulmonary function;   Improvements in arterial blood gas, including alveolar-arterial oxygen difference(A-aDO2), partial pressure of oxygen(PaO2), partial pressure of carbon dioxide in artery(PaCO2), arterial oxygen saturation(SaO2).
2 Recruiting Fibered Confocal Fluorescence Microscopy Imaging in Patients With Diffuse Parenchymal Lung Diseases
Condition: Diffuse Parenchymal Lung Diseases
Intervention: Device: confocal microscopy
Outcome Measures: Univariate and multivariate logistic regression analysis of the FCFM image features identified to discriminate against HRCT features and pathology.;   Utilize receiver operating characteristic (ROC) curves to identify the FCFM image feature or combination of features which demonstrates the best sensitivity and specificity for each HRCT feature and pathology.;   Comparison of the areas under the curves for the interpretation of 2 still FCFM image frames of the same sequence recording of a single alveolar segment.;   Using Kappa values to quantify a high study agreement (kappa >0.8) between the assessors and within an assessor for FCFM image interpretation.;   Complication rate of fibered confocal fluorescence microscopy over and above standard bronchoscopy.
3 Recruiting Collecting and Storing Tissue From Young Patients With Cancer
Condition: Cancer
Interventions: Genetic: DNA analysis;   Genetic: reverse transcriptase-polymerase chain reaction;   Other: biologic sample preservation procedure;   Other: flow cytometry;   Other: laboratory biomarker analysis
Outcome Measures: Establishment and banking of cell lines and/or xenografts from pediatric patients with cancer;   Establishment of continuous cell lines, under carefully controlled conditions, from pediatric patients with cancer;   Establishment of transplantable xenografts in immunocompromised mice from tumor cells that are difficult to establish as continuous cell lines in vitro;   Creation of a bank of cell lines and generation of sufficient vials of cryopreserved cells for distribution to investigators with approved COG biology protocols;   Characterization of cell lines from childhood cancers with respect to DNA PCR molecular HLA profile as a "fingerprint" of original cell line identity;   Characterization of cell lines for the ability for sustained growth in tissue culture and/or as mouse xenografts;   Characterization of cell lines for mycoplasma contamination;   Characterization of cell lines for expression of molecular makers that confirm the tumor-type of the cell line and the immortal nature of the cells (telomerase) and the expression of molecular markers that may correlate with drug resistance
4 Unknown  Azathioprine and Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis
Condition: Idiopathic Pulmonary Fibrosis
Interventions: Drug: Placebo;   Drug: AZAPRED
Outcome Measures: Progression-free survival, defined as free of death or a decrease from baseline in the FVC of at least 10%.;   Number of Acute Exacerbations of IPF.;   Health Related Quality of life, measured with the Chronic Questionnaire (CRQ).;   PO2 at rest and at exercise from baseline.;   P(A-a)O2 at rest and at exercise from baseline.;   Predicted FEV1 from baseline.;   Forced expiratory volume in one second (FEV1) to FVC from baseline.;   Plethysmographic lung volumes from baseline.;   Diffusion capacity for carbon monoxide (DLco) from baseline.;   Six-Minute Walk test, from baseline: resting and 6 minute SpO2, presence or absence of desaturation to 88% or lower at the end of the six minute walk, walked distance d. Pre and post modified Borg dyspnea scores;   Scoring of extent of lung fibrosis on HRCT, according to two independent chest radiologists, form baseline.;   Number and severity of adverse effects.;   Number of protocol drop outs.

These studies may lead to new treatments and are adding insight into Oxaliplatin) etiology and treatment.

A major focus of Oxaliplatin) research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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