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Oxygen Medical Research Studies

Up-to-date List of Oxygen Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Oxygen Medical Research Studies

Rank Status Study
1 Recruiting Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High Energy Fracture Surgery
Condition: Post Operative Surgical Site Infection
Intervention: Procedure: Supplemental Perioperative Oxygen
Outcome Measures: Surgical Site Infection;   Catalog and Compare Bacterial Species;   Risk Factors for Infection;   Resource Utilization and Cost
2 Not yet recruiting Home Oxygen Therapy in Bronchiolitis
Condition: Bronchiolitis
Intervention: Other: Oxygen Therapy
Outcome Measures: Home Oxygen therapy in the ambulatory treatment of bronchiolitis;   daycare(patients) and work (parents) lost because of the illness.
3 Recruiting Estimating Apnea Phenotypes From Polysomnography: Oxygen
Condition: Sleep Apnea
Intervention: Drug: Inspired Oxygen (40%)
Outcome Measures: The reduction in severity of sleep apnea (Apnea-Hypopnea Index, Events/hour);   Overnight change in chemosensitivity;   Subjective sleepiness/alertness (Stanford Sleepiness Scale);   Overnight change in blood pressure;   Subjective sleep quality (Oxygen vs sham);   Frequency of EEG arousals (events per hour)
4 Recruiting Study on the Effects of Oxygen-ozone Therapy on Back Pain in Subjects Aged 65 or Older
Condition: Back Pain
Interventions: Drug: Intramuscular/paravertebral injections of Oxygen-Ozone;   Other: Simulated intramuscular/paravertebral injections
Outcome Measures: Oswestry Disability Index(ODI);   Oswestry Disability Index (ODI);   Comprehensive geriatric assessment by INTERRAI-MDS-HC/VAOR-ADI instrument;   intake of paracetamol;   oxidative stress
5 Recruiting Patients With Pulmonary Hypertension or Interstitial Lung Disease at Altitude - Effect of Oxygen on Breathing and Sleep
Conditions: Precapillary Pulmonary Hypertension;   Interstitial Lung Disease
Interventions: Behavioral: Moderate altitude sojourn;   Behavioral: Low altitude sojourn;   Drug: Oxygen;   Drug: Sham Oxygen (room air)
Outcome Measures: Mean nocturnal Oxygen saturation measured by pulse oximetry;   Apnea/hypopnea index measured by polysomnography;   Apnea/hypopnea index measured by polygraphy;   Sleep quality visual analog scale score;   Psychomotor vigilance test reaction time;   Severe hypoxemia;   Subjective sleep quality visual analog scale score
6 Recruiting Ambulatory Oxygen for ILD
Condition: Interstitial Lung Disease
Interventions: Device: Portable Oxygen concentrator;   Device: Portable Oxygen cylinder
Outcome Measures: Nadir SpO2;   6-min walk distance;   Borg dyspnoea score;   Borg fatigue score;   Partial pressure of Oxygen in arterial blood (PaO2) at rest;   Proportion of participants who desaturate to less than 80%
7 Unknown  Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU)
Conditions: Nervous System Diseases;   Respiratory Tract Diseases;   Cardiovascular Diseases;   Immune System Diseases
Intervention: Drug: Oxygen
Outcome Measures: Mortality in ICU;   Rate of organ dysfunctions (respiratory, circulation, renal, liver);   Rate of nosocomial blood and respiratory infections in intensive care unit and surgery site infections in hospital.
8 Recruiting Extubation Failure Prevention in High Risk Patients by High-flow Conditioned Oxygen Therapy vs. Standard Oxygen Therapy
Condition: Respiratory Failure
Interventions: Device: Optiflow (Fisher&Paykel);   Device: Nasal cannulae or controlled Oxygen concentration mask
Outcome Measures: Respiratory failure after extubation;   Survival
9 Recruiting Use of Oxygen Nebulizer for Preventing Post-operative Sore Throat
Condition: Pain, Postoperative
Intervention: Other: Oxygen
Outcome Measures: The effect of Oxygen nebulizer therapy on post-operative sore throat;   To evaluate the adverse events (pulmonary complications, wound infection, and mortality) of post-operative complications related to Oxygen therapy
10 Recruiting Trial of Portable Oxygen Cylinders Versus Battery Powered Portable Oxygen Concentrators
Condition: COPD
Intervention: Device: Portable Oxygen
Outcome Measures: Quality of life as measured through Chronic Respiratory Questionniar and PsyQol and;   Dyspnoea as measured through the Borg Scale;   Patient Prefterence;   Adverse Events through self report;   Mortality;   Cost effectiveness
11 Recruiting Solar Powered Oxygen Delivery
Conditions: Pneumonia;   Hypoxemia
Interventions: Device: Solar powered Oxygen;   Device: Oxygen from cylinders
Outcome Measures: Length of hospital stay;   Mortality;   Duration of supplemental Oxygen therapy;   Proportion of patients successfully Oxygenated;   Oxygen delivery system failure;   Cost;   Lambaréné Organ Dysfunction Score (LODS)
12 Recruiting STIT-2: Evaluation of Safety and Efficacy of Short-time TNI® Treatment in Patients With COPD and Hypercapnia
Conditions: COPD;   Hypercapnia
Interventions: Device: Nasal Oxygen insufflation with a TNI® 20 oxy device;   Device: Nasal insufflation of Oxygen
Outcome Measures: PaO2;   O2%;   PaCO2;   AaDO2;   RV and TLC
13 Recruiting The Performance of Two Oxygen Delivery Devices Used After General Anesthesia.
Condition: Hypoxemia
Interventions: Device: Oxygen mask;   Device: Oxygen cannula
Outcome Measures: The incidences of hypoxemia in both groups;   The causes of hypoxemia
14 Not yet recruiting Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS)
Conditions: Post-Concussion Syndrome;   Traumatic Brain Injury
Interventions: Drug: Hyperbaric Oxygen;   Drug: No Hyperbaric Oxygen
Outcome Measures: Working Memory;   Neurobehavioral Symptom Inventory (NSI);   Wechsler Abbreviated Scale of Intelligence II (WASI-II);   Wechsler Memory Scale-IV (WMS-IV;   Rey Auditory Verbal Learning Test (RAVLT);   Benton Visual Retention Test with Alternate Forms (Benton VRT);   Stroop Color-Word Interference Test;   Controlled Oral Word Association Test, Letters F, A, and S (COWAT-FAS);   Category Fluency Test (Animal);   Automated Neuropsychological Assessment Metrics-4 (ANAM-4);   Pittsburgh Sleep Quality Index (PSQI);   Quality of Life After Brain Injury (QOLIBRI)
15 Unknown  Using a Closed-loop System for Oxygen Delivery (FreeO2) to Optimize Oxygentherapy in Patients With COPD Exacerbation
Condition: COPD Exacerbation
Interventions: Device: Automated settings on the Oxygen delivery device;   Device: Manual settings with FreeO2 system in collection mode
Outcome Measures: Possibility to use a new closed-loop system for Oxygen delivery in common practice;   Time of Oxygen weaning between common Oxygen delivery and closed-loop automatic titration of Oxygen flow based on SpO2.;   Percentage of time with desaturation during the Oxygentherapy;   Percentage of time with hyperoxia during the Oxygentherapy
16 Recruiting Closed-loop System for Oxygen Delivery and Exercise in Chronic Obstructive Pulmonary Disease
Conditions: COPD;   Oxygen Therapy;   Hypercapnia
Interventions: Device: Automated settings on the Oxygen delivery device;   Device: Manual settings with FreeO2 system in collection mode
Outcome Measures: Change in Endurance time;   Change in Dyspnea during ESWT;   Change in Muscle fatigue during ESWT;   Change in Respiratory frequency during ESWT;   Change in PaCO2 during ESWT;   Hypercapnia level at baseline;   Change in Cardiac frequency during ESWT;   Change in SpO2 during ESWT
17 Recruiting Study of High-flow Oxygen Therapy Against Standard Therapy in Bronchiolitis
Condition: Bronchiolitis
Interventions: Procedure: High Flow Nasal Cannula Oxygen Therapy;   Other: Standard low flow Oxygen
Outcome Measures: Length of hospital stay;   Admission to Intensive Care Unit;   Work of breathing
18 Recruiting Evaluation of Safety and Efficacy of Shorttime TNI Treatment in Patients With COPD
Condition: Oxygen Inhalation Therapy
Interventions: Device: Nasal Oxygen insufflation with a TNI 20 oxy device;   Device: Standard Nasal Insufflation of Oxygen
Outcome Measures: PaO2;   O2 %;   PaCO2;   AaDO2;   RV and TLC
19 Recruiting Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Breathing and Sleep
Condition: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: Drug: Oxygen;   Drug: sham Oxygen (room air)
Outcome Measures: Mean nocturnal Oxygen saturation measured by pulse oximetry;   Apnea/hypopnea index measured by polysomnography;   Apnea/hypopnea index measured by polygraphy;   Subjective sleep quality visual analog scale score;   Psychomotor vigilance test reaction time;   Severe hypoxemia
20 Unknown  Effect of Establishing Functional Residual Capacity During Newborn Resuscitation on Oxygenation
Condition: Transition at Birth
Interventions: Other: continuous positive airway pressure;   Other: Free flow Oxygen
Outcome Measures: The primary outcome measure is the proportion of infants achieving a stable Oxygen saturation of ≥80%. To be considered stable, the Oxygen saturation must remain at or above the predetermined target saturation for at least 30 seconds.;   The secondary outcome measure is the proportion of infants achieving a stable Oxygen saturation of ≥90%.

These studies may lead to new treatments and are adding insight into Oxygen etiology and treatment.

A major focus of Oxygen research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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