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Pain Medical Research Studies

Up-to-date List of Pain Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Pain Medical Research Studies

Rank Status Study
1 Recruiting Improving Pain Management and Long Term Outcomes Following High Energy Orthopedic Trauma (Pain Study)
Condition: Pilon Fracture
Interventions: Drug: NSAID;   Drug: Gabapentinoids;   Drug: placebo
Outcome Measures: Opioid Utilization;   Persistent Pain;   Surgery for non-union;   Post Surgical Pain Intensity;   Pre Surgical Pain Intensity;   Length of Index Hospitalization;   Adverse Effects and Complications;   Functional Outcome;   Generic Health Status;   Depressive Symptoms;   Post Traumatic Stress (PTSD);   Medical Costs;   Fracture Severity;   Fracture Classification
2 Recruiting Literacy-Adapted Psychosocial Treatments for Chronic Pain --- "Learning About Mastering/My Pain"
Conditions: Chronic Pain;   Pain;   Widespread Chronic Pain;   Chronic Pain Syndrome;   Chronic Pain Due to Injury
Interventions: Behavioral: Pain Ed;   Behavioral: CBT for Pain;   Other: Usual Care
Outcome Measures: Brief Pain Inventory-Intensity (BPI-Intensity);   Brief Pain Inventory-Interference (BPI-Interference);   Patient Health Questionnaire - 9 (PHQ-9);   Patient Global Impression of Change (PGIC)
3 Recruiting A Multimodal Pain Pathway in Urogynecologic Surgery
Conditions: Pain;   Constipation;   Nausea
Intervention: Drug: Multimodal
Outcome Measures: Pain;   Pain;   Constipation
4 Unknown  Prevalence of Pain in Inpatient at the Hospital Italiano de Buenos Aires
Condition: Pain
Intervention:
Outcome Measures: Prevalence of Pain;   Response to analgesic treatment;   The cause of Pain during hospitalization;   Number of patients reporting Pain to heath care personnel;   Proportion of physicians who know the patient is in Pain according to the evolution in medical chart;   Number of nurses who know that the patient has Pain according to medical chart;   Proportion of hospitalized patients treated for Pain;   Type of analgesic treatment received;   Number of patients with Pain evaluated by a Pain specialist
5 Recruiting Pain - Postoperative Analgesia INvestigation
Condition: Postoperative Pain
Interventions: Drug: Exparel®;   Drug: Bupivacaine hydrochloride
Outcome Measures: Change in Postoperative Pain;   Overall opioid use;   Mean length of hospital stay;   Change from Baseline in Quality of Life
6 Recruiting Pain During Chest Tube Withdrawal: Evaluation Using Pan Monitor
Condition: Chest Pain
Interventions: Procedure: Chest drain withdrawal;   Device: Pain Monitor
Outcome Measures: Pain monitor evaluation of Pain;   Pain intensity
7 Recruiting Biomarkers for Pain in Spinal Cord Injury (SCI) Patients
Conditions: Traumatic Spinal Cord Injury;   Neuropathic Pain
Intervention: Other: blood samples
Outcome Measures: To identify candidate biomarkers for Pain in the chronic SCI samples.;   To identify the temporal relationship of the development of Pain and the manifestation of the biomarkers identified
8 Recruiting Neck Exercises, Training and Pain Management as a Treatment for Whiplash Patients With Chronic Neck Pain
Conditions: Neck Pain;   Chronic Pain Syndrome
Interventions: Other: Education and training;   Behavioral: Pain management
Outcome Measures: Medical Outcomes Study Short Form 36 (SF36) - Physical Component Summary (PCS);   craniocervical flexion test;   cervical range of motion;   neck positioning test;   Self-rated measure Global Perceived Effect;   Neck Disability Index;   Pain Bothersomeness;   Pain Specific Functioning Scale;   TAMPA scale of Kinesiophobia;   Impact of Event scale;   Euroqol-5D;   Mechanical allodynia
9 Not yet recruiting A Randomized-controlled Study of a Cognitive-behavioral Intervention for Children With Functional Abdominal Pain
Conditions: Functional Abdominal Pain Syndrome;   Abdominal Pain
Interventions: Behavioral: Intervention group;   Behavioral: Active control group
Outcome Measures: Change in Pain Symptoms;   Health-related quality of life;   Pain-related coping;   Pain-related cognitions
10 Not yet recruiting Effective Screening for Pain Study
Conditions: Pain;   Pain Management
Interventions: Behavioral: NRS Pain now;   Behavioral: PEG
Outcome Measures: Arm 1 (NRS now), to arm 2 (PEG), to arm 3 (usual care) pairwise difference scores in baseline and Pain disability detection at one week, and satisfaction with Pain management at one week;   Arm 1 (NRS now), to arm 2 (PEG), to arm 3 (usual care) pairwise differences in Pain missingness and rating variability;   Arm 1 (NRS now), to arm 2 (PEG), to arm 3 (usual care) pairwise difference scores in baseline and Pain disability detection at one week,
11 Recruiting The Underlying Mechanism of Spinal Manipulative Therapy and the Effect of Pain on Physical Outcome Measures
Conditions: Low Back Pain;   Degeneration of Lumbosacral Intervertebral Disc;   Muscle Weakness;   Spine Stiffness
Interventions: Other: SMT for low back Pain patients;   Other: Pain induction (optional)
Outcome Measures: Change of Modified Oswestry Low Back Pain Disability Index;   Change of 11-point Numeric Pain Rating Scale;   Change in Body Pain diagram;   Change in measurement of lumbar multifidus muscle thickness by rehabilitative ultrasound imaging;   Change of spinal stiffness testing by a mechanical indentation machine;   Electromyography of trunk muscles;   Magnetic resonance imaging of lumbar region;   Fear Avoidance Beliefs Questionnaire;   Change in Borg Category-Ratio Scale of Perceived Exertion;   Global Rating Of Change
12 Recruiting Lactobacillus Reuteri in Treatment of Functional Abdominal Pain and Chronic Constipation in Children
Conditions: Abdominal Pain;   Constipation - Functional
Interventions: Dietary Supplement: Administration of L.reuteri in children with abdominal Pain;   Dietary Supplement: Administration of placebo in children with abdominal Pain;   Dietary Supplement: Administration of L.reuteri in children with constipation;   Dietary Supplement: Administration of placebo in children with constipation
Outcome Measures: Intensity of abdominal Pain;   Severity of chronic constipation;   Intensity of abdominal Pain after treatment;   Severity of chronic constipation after treatment
13 Recruiting Post-market Study of Intrathecal Morphine Compared to Conventional Medical Management for Pain Control and Improvement of Opioid-related Side Effects
Conditions: Nonmalignant Pain;   Chronic Pain;   Chronic Intractable Pain
Intervention: Device: SynchroMed Infusion System and Intrathecal Morphine Sulfate
Outcome Measures: Clinical Success;   Pain Assessment;   Opioid-Related Side Effects
14 Recruiting Acupuncture in Acute Nonspecific Low Back Pain
Condition: Low Back Pain
Interventions: Procedure: Acupuncture and standard treatment in general practice;   Other: Standard treatment in general practice
Outcome Measures: Median time in days to recovery of Pain.;   Reduction in Pain;   Global measure of improvement;   Back specific functional status;   Sick leaves;   Use of medication;   Visits at the GP;   Side effects of treatment
15 Unknown  Bupivacaine Pain Pumps to Decrease Mastectomy Post-Operative Pain
Condition: Pain
Interventions: Drug: Bupivacaine;   Drug: Saline
Outcome Measures: Differences in post-operative static and moving Pain scores between patients randomized either to bupivacaine- (treatment) or saline- (placebo) filled, percutaneously-placed Pain pump analgesic administration for post-operative Pain control.;   Document long-term changes in QOL scores between patients randomized either to bupivacaine- (treatment) or saline- (placebo) filled, percutaneously-placed Pain pump analgesic administration for post-operative Pain control.
16 Recruiting Ketamine in Chronic Kid's PainKiCK Pain
Condition: Chronic Pain
Intervention: Drug: Ketamine
Outcome Measure: Dosage of ketamine that is most tolerable
17 Recruiting A Epidemiological Survey of Preoperative Pain Perception and Postoperative Pain in Chinese Population
Conditions: Pain;   Surgery
Intervention:
Outcome Measures: Pressure Pain threshold;   Pressure Pain tolerance;   PCA press frequency after operation;   Pain scores on visual analog scale after operation;   Opioid consumption dose after operation
18 Recruiting The Effect of an Inter-Disciplinary Program, Including MBSR, in Breast Cancer Survivors With Chronic Neuropathic Pain
Conditions: Breast Cancer;   Painful Neuropathy;   Chronic Pain;   Worries; Pain or Disability;   Quality of Life
Intervention: Behavioral: Mindfulness-Based Stress Reduction
Outcome Measures: Change from baseline in Pain-related disability, as measured by the Brief Pain Inventory - Pain Interference scale, at 3-month post-intervention.;   Change from baseline in neuropathic Pain intensity, as measured by the Neuropathic Pain Symptom Inventory, at 3 months post-intervention;   Change from baseline in Pain severity, as measured by the Brief Pain Inventory - Pain Severity scale, at 3 months post-intervention;   Change from baseline in mood states, as measured by the Profile of Mood States scale, at 3 months post-intervention;   Overall change in status from baseline, as measured by Patient Global Impression of Change scale, at 3 months post-intervention;   Change from baseline in stress, as measured by the Perceived Stress Scale, at 3 months post-intervention;   Change from baseline in depressive symptoms, as measured by the Patient Health Questionnaire - 9 scale, at 3 months post-intervention;   Change from baseline in Pain catastrophizing, as measured by the Pain Catastrophizing Scale, at 3 months post-intervention.;   Change from baseline in mindfulness, as measured by the Five Facet Mindfulness Questionnaire, at 3 months post-intervention.;   Change from baseline in quality of life, as measured by the Short-Form-12 Health Survey, at 3 months post-intervention.;   Change from pre-intervention in biomarkers of stress, as measured by hair cortisol levels, at 3 months post-intervention.;   Change from baseline in immune function, as measured by blood levels of interleukin-4, interleukin-6, interleukin-10, tumor necrosis factor - alpha, and C reactive protein, at 3 months post-intervention.;   Change from baseline in biomarkers of stress, as measured by telomere length, at 3 months post-intervention.;   Change from pre-intervention in neuronal health, as measured by white matter integrity, at 2 weeks post-intervention.;   Change from pre-intervention in brain areas associated with emotional regulation, as measured by blood flow in the brain seen in functional magnetic imaging, at 2 weeks post-intervention.;   Change from pre-intervention in brain structure, as measured by changes in structural volume different areas of the brain, at 2 weeks post-intervention.
19 Recruiting Characterizing the Role of Pain Sensitivity in Acute to Persistent Low Back Pain
Condition: Low Back Pain
Intervention:
Outcome Measures: Experimental Pain Threshold;   mRNA expression of Pain sensitivity genes
20 Recruiting Internet Intervention for Adolescents With Chronic Pain
Conditions: Chronic Pain;   Abdominal Pain;   Headache
Interventions: Behavioral: Online Behavioral Intervention;   Other: Education: Online Patient Education
Outcome Measures: Change in Activity Limitations from Baseline to Immediately Post-Treatment, 6-month follow-up, and 12-month follow-up;   Change in Pain from Baseline to Immediately Post-Treatment, 6-month follow-up, and 12-month follow-up;   Depression and Pain-specific anxiety;   Treatment Satisfaction;   Parental Response to Pain Behavior;   Sleep Quality;   Service Use;   Miscarried Helping

These studies may lead to new treatments and are adding insight into Pain etiology and treatment.

A major focus of Pain research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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