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Paraesthesia Medical Research Studies

Up-to-date List of Paraesthesia Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Paraesthesia Medical Research Studies

Rank Status Study
1 Not yet recruiting Study of TENS in Reducing Symptoms of Peripheral Neuropathy Induced by Chemotherapy
Conditions: Peripheral Neuropathy;   Pain;   Paresthesia;   Neuritis
Interventions: Device: active TENS;   Device: placebo TENS
Outcome Measures: Evaluate the effects of TENS in the reduction of symptoms related to peripheral neuropathy due to chemotherapy treatment of a high and moderate neurotoxic potential in cancer patients.;   Evaluate the therapeutic response of TENS in symptoms of paresthesia;   Evaluate the therapeutic response of TENS in activities of the daily lives of patients.;   Evaluate the therapeutic response of TENS in symptoms of neuropathic pain.;   Evaluate the factors associated with better treatment response in paresthesia, in pain and activities of daily living.
2 Recruiting Antibiotic Treatment of Multiple Erythema Migrans
Condition: Multiple Erythema Migrans
Interventions: Drug: ceftriaxone;   Drug: doxycycline;   Other: erythema migrans patients treated with doxycycline
Outcome Measures: Objective sequelae and post-treatment subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, dizziness, or irritability in patients treated for multiple erythema migrans with ceftriaxone or doxycycline for 15 days.;   Comparison of subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, or irritability between patients treated with antibiotic for multiple erythema migrans and control subjects without a history of Lyme borreliosis.;   Objective sequelae and post-treatment subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, dizziness, or irritability in patients with solitary versus multiple erythema migrans after antibiotic treatment.
3 Not yet recruiting The Pain Suppressive Effect of Alternative Spinal Cord Stimulation Frequencies
Conditions: Failed Back Surgery Syndrome;   Neuropathic Pain
Interventions: Device: Spinal Cord Stimulation;   Device: Group 1;   Device: Group 2
Outcome Measures: Pain suppression by means of Spinal Cord Stimulation;   Quality of Life and pain suppression (long term)
4 Unknown  Botulinum Toxin Injections for Thoracic Outlet Syndrome
Condition: Thoracic Outlet Syndrome
Interventions: Drug: Botulinum Toxin Type A;   Other: Normal Saline injection
Outcome Measures: Pain;   Paresthesias on Numeric Rating Scale;   Function on DASH scale
5 Not yet recruiting Spinal Stimulation to Treat Low Back Pain
Conditions: Low Back Pain;   Lumbar Back Pain;   Lumbago
Intervention: Procedure: Spinal Cord Stimulator Lead Placement
Outcome Measures: Did the participant have paresthesia coverage from the stimulation?;   Numeric Pain Rating Scale (NRS);   Patient preferred stimulation-Likert Scale
6 Recruiting Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy
Condition: Radiation Induced Brachial Plexopathy
Interventions: Drug: Pentoxifylline placebo;   Drug: Pentoxifylline;   Drug: Tocopherol acetate;   Drug: Clodronic Acid;   Drug: Tocopherol placebo;   Drug: Clodronate placebo
Outcome Measures: Sensory-motor neurological clinical assessment;   Pain VAS;   NPSI scale;   Paresthesia VAS;   Frequence of paresthesia;   ODSS;   Muscle testing;   Neurological examination;   Motor assessment of complex movements;   Quality of life;   Global clinical impression;   Electromyography;   Clinical symptoms evaluation;   Biological evaluation;   Cardiovascular evaluation
7 Unknown  Sensory Mapping Following Video-assisted Thoracic Surgery
Conditions: Paresthesia;   Dysesthesia;   Pain
Outcome Measures: Area (cm2);   Pain
8 Recruiting Optimal Location of Local Anesthetic Injection for Ultrasound Guided Interscalene Block
Conditions: Shoulder Arthroscopy;   Ultrasound-guided Interscalene Nerve Block
Intervention: Procedure: Interscalene block for shoulder arthroscopy
Outcome Measures: Onset of motor blockade;   Patient Satisfaction Score;   Opioid consumption;   Quality of Nerve block;   Incidence of post-operative nausea/vomiting;   Duration of nerve block;   Number of needle passes;   Number of paresthesias;   Residual paresthesia
9 Recruiting Clinical Outcomes Study Using a New Implantable Neurostimulation System for Chronic Intractable Pain
Condition: Chronic Pain
Intervention: Device: Neurostimulation device implantation
Outcome Measures: Patient satisfaction with treatment;   Global impression of change;   Overall pain intensity;   Pain relief responder rate;   Disability;   Pain-related medication use;   Percentage overlap of painful areas with stimulation-induced paresthesia (drawings);   Percentage overlap of painful areas with stimulation-induced paresthesias (verbal);   Patient treatment preference
10 Recruiting Neuroprotection by Tocotrienols in Type 1 and Type 2 Diabetes Mellitus
Conditions: Diabetic Neuropathy;   Cognitive Impairment
Interventions: Dietary Supplement: Tocotrienol;   Dietary Supplement: Placebo
Outcome Measures: Total Symptoms Score (TSS) (pain, paresthesia, burning, and numbness)of patients with diabetes type 1 and 2 neuropathy.;   Neuropathy Impairment Score (NIS) of patients with diabetes type 1 and 2 neuropathy
11 Recruiting Supraclavicular Versus Interscalene Block
Condition: Pain
Interventions: Procedure: Interscalene block;   Procedure: Supraclavicular block
Outcome Measures: pain duration;   diaphragmatic movement;   motor block;   paresthesia;   complications;   supplemental analgesia;   pain score;   patient satisfaction
12 Recruiting SUNBURST (Success Using Neuromodulation With BURST) Study
Condition: Chronic Pain
Interventions: Device: Tonic Stimulation;   Device: Burst Stimulation
Outcome Measures: Safety;   Efficacy;   Quality of Life;   Functional Disability;   Paresthesia;   Responder rate;   Pain Relief
13 Not yet recruiting Effects of Different Electrical Currents on Pressure Pain Threshold and Sensory Comfort.
Condition: Healthy
Interventions: Device: Interferential current;   Device: Aussie Current;   Device: TENS
Outcome Measures: Pressure Pain Threshold;   Sensory Discomfort
14 Recruiting Open Label Treatment With tDCS for Parkinson's and Related Disorders for Improvement of Speech, Gait and Mood
Condition: Parkinson's Disease
Intervention: Device: tDCS
Outcome Measures: Improvement of Motor and Speech Symptoms of Parkinson's Disease or Related Disorders;   Improvement of Neuropsychiatric Symptoms of Parkinson's Disease or Related Disorders
15 Not yet recruiting Dental Health, Diet, Inflammation and Biomarkers in Patients With Acute Intermittent Porphyria(AIP)
Condition: Acute Intermittent Porphyria
Outcome Measures: Blood pressure;   Diet registration;   Iron status;   Inflammatory status;   Dental health
16 Recruiting TNS for Major Depressive Disorder: a Phase II Randomized Controlled Trial
Condition: Depressive Symptoms
Intervention: Device: Trigeminal Nerve Stimulation (TNS)
Outcome Measures: Hamilton Depressive Rating Scale version 17 items (HDRS-17);   Montreal Cognitive Assessment (MOCA)
17 Unknown  Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache
Condition: Chronic Cluster Headache
Intervention: Device: occipital nerve stimulation
Outcome Measures: The mean attack frequency (MAF) over the last 4 weeks in the 100% and the 30% treatment groups;   The MAF;   The mean attack intensity (on a scale from 0-10) will be calculated and will be compared between and within the 2 groups.;   Rate of responders (>50% reduction in attack frequency in the last 4 weeks compared to baseline) will be calculated and compared between groups;   Economic evaluation;   Anticipated group randomisation;   Awareness of Paraesthesias;   The use of acute attack medication;   Patient satisfaction;   Responder identification;   Adverse events
18 Recruiting RELIEF - A Global Registry to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
Condition: Pain
Intervention: Device: neurostimulation system
Outcome Measures: Percent pain relief;   Change in pain intensity;   Change in physical functioning;   Change in QoL;   Global impression;   Subject global impression;   Depression;   Paresthesia Coverage;   Medications;   Subject Satisfaction;   Trial to Permanent Implantation;   Ease of Use
19 Not yet recruiting Comparison of Two Techniques of Sciatic Nerve Block With Levobupivacaine 0.5% in Orthopedic Surgery
Condition: Anesthesia
Interventions: Procedure: Sciatic nerve anesthesia blockade at bifurcation.;   Procedure: Sciatic nerve blockade 2 cm beyond the bifurcation;   Drug: Levobupivacaine 0.5%: 20 ml;   Device: Portable Ultrasound Machine: Sonosite, M-Turbo, Bothell, WA;   Device: Insulated Needle, (Stimuplex; Braun, Melsungen, Germany);   Drug: supplemental oxygen;   Drug: Midazolam;   Drug: Intravenous analgesics;   Procedure: Saphenous nerve block
Outcome Measures: Latency period of sciatic nerve block.;   Success of sciatic nerve block;   Patient satisfaction;   Sensory block;   Motor block;   First analgesic;   Visual analog scale at rest;   Dynamic visual analog scale;   Intraneural injection;   Vascular puncture;   Paresthesia during the procedure;   Systemic toxicity of local anesthetics;   Hematoma;   Muscle weakness;   Altered sensitivity;   Cramps postoperative;   Punctures;   Time for the execution of nerve block
20 Recruiting Prospective Evaluation of Interscalene Nerve Catheters vs. Single Injection Blocks
Condition: Pain
Interventions: Procedure: interscalene catheter;   Procedure: interscalene block
Outcome Measures: pain on post-operative day 1;   Pain post operative day 2 (POD2)

These studies may lead to new treatments and are adding insight into Paraesthesia etiology and treatment.

A major focus of Paraesthesia research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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